CS276833B6 - Functional derivatives of 4-(2,4-difluorobiphenylyl)-2-methyl -4- oxobutanoic acid - Google Patents
Functional derivatives of 4-(2,4-difluorobiphenylyl)-2-methyl -4- oxobutanoic acid Download PDFInfo
- Publication number
- CS276833B6 CS276833B6 CS903027A CS302790A CS276833B6 CS 276833 B6 CS276833 B6 CS 276833B6 CS 903027 A CS903027 A CS 903027A CS 302790 A CS302790 A CS 302790A CS 276833 B6 CS276833 B6 CS 276833B6
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- methyl
- oxobutanoic acid
- difluorobiphenylyl
- cation
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
- C07C211/35—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing only non-condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CS903027A CS276833B6 (en) | 1990-06-18 | 1990-06-18 | Functional derivatives of 4-(2,4-difluorobiphenylyl)-2-methyl -4- oxobutanoic acid |
US07/716,814 US5177204A (en) | 1990-06-18 | 1991-06-17 | Derivatives of 4-(2,4-difluorbiphenylyl)-2-methyl-4-oxobutanoic acid |
AT91109980T ATE130838T1 (de) | 1990-06-18 | 1991-06-18 | Derivate der 4-(2,4-difluorbiphenyl)-2-methyl-4- oxobutansäure. |
JP3146257A JPH04253936A (ja) | 1990-06-18 | 1991-06-18 | 4−(2,4−ジフルオロビィフェニリル)−2−メチル−4−オキソブタン酸誘導体[4−(2,4−difluorbiphenylyl)−2−methyl−4−oxobutanoic acid]およびその塩類 |
CA002044837A CA2044837A1 (en) | 1990-06-18 | 1991-06-18 | Derivatives of 4-(2,4-difluorobiphenylyl)-2-methyl-4-oxobutanoic acid |
EP91109980A EP0465879B1 (de) | 1990-06-18 | 1991-06-18 | Derivate der 4-(2,4-Difluorbiphenyl)-2-methyl-4-oxobutansäure |
DE69114927T DE69114927T2 (de) | 1990-06-18 | 1991-06-18 | Derivate der 4-(2,4-Difluorbiphenyl)-2-methyl-4-oxobutansäure. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CS903027A CS276833B6 (en) | 1990-06-18 | 1990-06-18 | Functional derivatives of 4-(2,4-difluorobiphenylyl)-2-methyl -4- oxobutanoic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
CS302790A3 CS302790A3 (en) | 1992-03-18 |
CS276833B6 true CS276833B6 (en) | 1992-08-12 |
Family
ID=5369145
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS903027A CS276833B6 (en) | 1990-06-18 | 1990-06-18 | Functional derivatives of 4-(2,4-difluorobiphenylyl)-2-methyl -4- oxobutanoic acid |
Country Status (7)
Country | Link |
---|---|
US (1) | US5177204A (de) |
EP (1) | EP0465879B1 (de) |
JP (1) | JPH04253936A (de) |
AT (1) | ATE130838T1 (de) |
CA (1) | CA2044837A1 (de) |
CS (1) | CS276833B6 (de) |
DE (1) | DE69114927T2 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5789434A (en) * | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
IL115995A0 (en) * | 1994-11-15 | 1996-01-31 | Bayer Ag | Substituted 4-biarylbutyric or 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors |
US5886022A (en) * | 1995-06-05 | 1999-03-23 | Bayer Corporation | Substituted cycloalkanecarboxylic acid derivatives as matrix metalloprotease inhibitors |
EP1031349A1 (de) * | 1999-02-25 | 2000-08-30 | Bayer Aktiengesellschaft | Verwendung von substituierten 4-Biarylbuttersäuren und 5-Biarylpentansäuren zur Behandlung von zerebralen Krankheiten |
KR100405914B1 (ko) * | 2000-04-25 | 2003-11-15 | 삼성전자주식회사 | 메트릭스 메탈로프로테이나제의 저해제로서의 비페닐부티릭산 유도체 |
KR100405913B1 (ko) * | 2000-04-25 | 2003-11-14 | 삼성전자주식회사 | 메트릭스 메탈로프로테이나제의 저해제로서의 비페닐부티릭산 유도체 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS243570B1 (en) * | 1984-08-31 | 1986-06-12 | Miroslav Kuchar | Omega-aryloxoalkane acids |
-
1990
- 1990-06-18 CS CS903027A patent/CS276833B6/cs unknown
-
1991
- 1991-06-17 US US07/716,814 patent/US5177204A/en not_active Expired - Fee Related
- 1991-06-18 AT AT91109980T patent/ATE130838T1/de not_active IP Right Cessation
- 1991-06-18 JP JP3146257A patent/JPH04253936A/ja active Pending
- 1991-06-18 CA CA002044837A patent/CA2044837A1/en not_active Abandoned
- 1991-06-18 DE DE69114927T patent/DE69114927T2/de not_active Expired - Fee Related
- 1991-06-18 EP EP91109980A patent/EP0465879B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0465879B1 (de) | 1995-11-29 |
DE69114927D1 (de) | 1996-01-11 |
US5177204A (en) | 1993-01-05 |
ATE130838T1 (de) | 1995-12-15 |
DE69114927T2 (de) | 1996-04-18 |
JPH04253936A (ja) | 1992-09-09 |
EP0465879A1 (de) | 1992-01-15 |
CS302790A3 (en) | 1992-03-18 |
CA2044837A1 (en) | 1991-12-19 |
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