KR930019676A - 약제 화합물 - Google Patents

약제 화합물 Download PDF

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Publication number
KR930019676A
KR930019676A KR1019930004440A KR930004440A KR930019676A KR 930019676 A KR930019676 A KR 930019676A KR 1019930004440 A KR1019930004440 A KR 1019930004440A KR 930004440 A KR930004440 A KR 930004440A KR 930019676 A KR930019676 A KR 930019676A
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KR
South Korea
Prior art keywords
pharmaceutically acceptable
acceptable salt
alkylamino
benzoyl
amino
Prior art date
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KR1019930004440A
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English (en)
Inventor
스테이시 고셋 린
쉬 추안
Original Assignee
리로이 휘테커
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 리로이 휘테커, 일라이 릴리 앤드 캄파니 filed Critical 리로이 휘테커
Publication of KR930019676A publication Critical patent/KR930019676A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 하기 일반식의 화합물, 그의 합성을 위한 중간체, 상기 화합물을 함유하는 약학 조성물, 및 종양치료제로서의 그의 용도에 관한 것이다.
상기식에서, Ar은 디하이드로피롤로, 피롤로, 피리도 또는 테트라하이드로피리도 이고; R1은 수소, 클로로, C1-C4알킬티오, C1-C4알콕시, C1-C4알킬아미노 또는 디(C1-C4) 알킬아미노이고; R2는 C2-C3알킬이다.

Description

약제 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 하기 일반식의 화합물 또는 그의 약학적으로 허용가능한 염:
    상기식에서, Ar은 디하이드로피롤로, 피롤로, 피리도 또는 테트라하이드로피리도이고; R1은 수소, 클로로, C1-C4알킬티오, C1-C4알콕시, C1-C4알킬아미노 또는 디(C1-C4) 알킬아미노이고; R2는 C2-C3알킬이다.
  2. N〔2-아미노-〔〔디하이드로피롤로〔2, 3-d〕피리미딘-5-일〕에틸〕벤조일-L-글루탐산 또는 그의 약학적으로 허용가능한 염.
  3. N〔2-아미노-〔〔피롤로〔2, 3-d〕피리미딘-5-일〕에틸〕벤조일〕-L-글루탐산 또는 그의 약학적으로 허용가능한 염.
  4. N〔2-아미노-〔〔테트라하이드로피리도〔2,3-d〕피라미딘-6-일〕벤조일〕-L-글루탐산 또는 그의 약학적으로 허용 가능한 염.
  5. 하나 이상의 약학적으로 허용가능한 담체, 부형제 또는 희석제와 함께, 활성성분으로 제 1, 2, 3 또는 4항에 청구된 화합물을 포함하는 약학 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930004440A 1992-03-24 1993-03-22 약제 화합물 KR930019676A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/856,611 US5196424A (en) 1992-03-24 1992-03-24 N-[2-amino-4-substituted[[(pyrrollo or pyrido)[2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acids
CN856,611 1992-03-24

Publications (1)

Publication Number Publication Date
KR930019676A true KR930019676A (ko) 1993-10-18

Family

ID=25324069

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930004440A KR930019676A (ko) 1992-03-24 1993-03-22 약제 화합물

Country Status (18)

Country Link
US (1) US5196424A (ko)
EP (1) EP0567223A1 (ko)
JP (1) JPH0625246A (ko)
KR (1) KR930019676A (ko)
CN (1) CN1078235A (ko)
AU (1) AU3542993A (ko)
BR (1) BR9301273A (ko)
CA (1) CA2091978A1 (ko)
CZ (1) CZ44093A3 (ko)
FI (1) FI931251A (ko)
HU (1) HUT70036A (ko)
IL (1) IL105100A0 (ko)
MX (1) MX9301544A (ko)
MY (1) MY131322A (ko)
NO (1) NO931008L (ko)
NZ (1) NZ247193A (ko)
TW (1) TW224098B (ko)
ZA (1) ZA931944B (ko)

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US5457056A (en) * 1993-07-06 1995-10-10 Fiberchem, Inc. Halohydrocarbon sensing chemistry with base modifier
US6537999B2 (en) * 1996-06-06 2003-03-25 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
JP2000516961A (ja) * 1996-08-30 2000-12-19 イーライ・リリー・アンド・カンパニー 非古典的ピロロ［２，３―ｄ］ピリミジン抗葉酸物質
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
US8030319B2 (en) * 2005-02-10 2011-10-04 Duquesne University Of The Holy Ghost Methods for treating cancer and other pathological proliferating disorders by inhibiting mitosis using pyrrolo[2 3-d]pyrimidines
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
CN1962658B (zh) * 2005-11-10 2010-05-12 北京大学 一种四氢吡啶并[3,2-d]嘧啶类化合物及制备抗肿瘤药物的用途
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
TWI556839B (zh) 2009-05-06 2016-11-11 研究室護膚股份有限公司 包含活性劑－磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法
KR20120103604A (ko) * 2009-11-06 2012-09-19 첼시 쎄라퓨틱스, 인코포레이티드 효소 저해성 화합물
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN102977107B (zh) * 2012-12-25 2015-04-22 山西普德药业股份有限公司 一种培美曲塞二钠化合物及其组合物

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EP0119591B1 (en) * 1983-03-17 1988-06-22 Takeda Chemical Industries, Ltd. Thiodeazapurine derivatives
JPS59170091A (ja) * 1983-03-17 1984-09-26 Takeda Chem Ind Ltd ６−チオ−７−デアザプリン誘導体およびその製造法
EP0166726B1 (en) * 1983-12-27 1988-11-17 Sri International 10-ethyl-8,10-dideazaminopterins
US5026851A (en) * 1985-03-08 1991-06-25 The Trustees Of Princeton University Pyrido[2,3-]pyrimidine derivatives
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ZA861235B (en) * 1985-03-08 1986-10-29 Univ Princeton Pyrido(2,3-d)pyrimidine derivatives
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US4902796A (en) * 1986-10-20 1990-02-20 The Trustees Of Princeton University 6-alkenyl and ethynyl derivatives of 2-amino-4-hydroxypyrido[2,3-d]pyrimidines
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Also Published As

Publication number Publication date
AU3542993A (en) 1993-09-30
CZ44093A3 (en) 1994-02-16
ZA931944B (en) 1994-09-18
FI931251A (fi) 1993-09-25
EP0567223A1 (en) 1993-10-27
TW224098B (ko) 1994-05-21
CA2091978A1 (en) 1993-09-25
NO931008L (no) 1993-09-27
CN1078235A (zh) 1993-11-10
MY131322A (en) 2007-08-30
BR9301273A (pt) 1993-09-28
FI931251A0 (fi) 1993-03-22
US5196424A (en) 1993-03-23
IL105100A0 (en) 1993-12-28
MX9301544A (es) 1994-07-29
NZ247193A (en) 1995-05-26
NO931008D0 (no) 1993-03-19
HUT70036A (en) 1995-09-28
HU9300804D0 (en) 1993-06-28
JPH0625246A (ja) 1994-02-01

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