ES2002668A6 - Preparacion liquida pulverizable de dihidropiridinas - Google Patents

Preparacion liquida pulverizable de dihidropiridinas

Info

Publication number
ES2002668A6
ES2002668A6 ES8603415A ES8603415A ES2002668A6 ES 2002668 A6 ES2002668 A6 ES 2002668A6 ES 8603415 A ES8603415 A ES 8603415A ES 8603415 A ES8603415 A ES 8603415A ES 2002668 A6 ES2002668 A6 ES 2002668A6
Authority
ES
Spain
Prior art keywords
grams
dihydropyridine
carbon atoms
spray
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8603415A
Other languages
English (en)
Inventor
Ahmed Hegasy
Klaus-Dieter Ramsch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES2002668A6 publication Critical patent/ES2002668A6/es
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PREPARACION LIQUIDA PULVERIZABLE DE DIHIDROPIRIDINAS DE FORMULA (I) DONDE R1 Y R2 SON IGUALES O DIFERENTES Y SIGNIFICAN ALQUILO C1©10, EN CASO DADO SUSTITUIDO POR ALCOXI C1©3, TRIFLUORMETILO, HALOGENO O N©METIL©N©BENCILAMINO; R3 ES ALQUILO C1©14, CIANO O HIDROXIMETILO Y X ES UN GRUPO NITRO, UNO O DOS GRUPOS CLORO O EL MIEMBRO DEL ANILLO FN©O©NF. LA PREPARACION CONTIENE DE 0,2 A 5 P.P. DE DEHIDROPIRIDINA (I); DE 10 A 40 P.P. DE POLIETILENGLICOL; DE 25 A 60 P.P. DE ETANO; DE 3 A 15 P.P. DE POLIVINILPIRROLIDONA Y OPCIONALMENTE, ADEMAS DE 2 A 25 P.P. DE OTROS PRODUCTOS AUXILIARES INERTES, ESTANDO DICHAS PROPORCIONES REFERIDAS A 100 PARTES EN VOLUMEN DE LA PREPARACION LIQUIDA. SE OBTIENEN POR DISOLUCION DE LA DIHIDROPIRIDINA EN EL POLIETILENGLICOL Y EN EL ETANOL Y POSTERIOR ADICION DE LA POLIVINILPIRROLIDINA Y DE LOS AGENTES AUXILIARES. ESTAS DIHIDROPIRIDINAS SON INFLUENCIADORAS DE LA CIRCULACION SANGUINEA Y MERCED A ESTAS PREPARACIONES PUEDEN APLICARSE EN FORMA DE SPRAY.
ES8603415A 1985-12-18 1986-12-12 Preparacion liquida pulverizable de dihidropiridinas Expired ES2002668A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853544692 DE3544692A1 (de) 1985-12-18 1985-12-18 Dihydropyridinspray, verfahren zu seiner herstellung und seine pharmazeutische verwendung

Publications (1)

Publication Number Publication Date
ES2002668A6 true ES2002668A6 (es) 1988-09-16

Family

ID=6288696

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8603415A Expired ES2002668A6 (es) 1985-12-18 1986-12-12 Preparacion liquida pulverizable de dihidropiridinas

Country Status (12)

Country Link
US (1) US4857312A (es)
JP (1) JPS62155216A (es)
BE (1) BE905954A (es)
CA (1) CA1281654C (es)
CH (1) CH667203A5 (es)
DE (1) DE3544692A1 (es)
ES (1) ES2002668A6 (es)
FR (1) FR2592378B1 (es)
GB (1) GB2184654B (es)
GR (1) GR862915B (es)
IT (1) IT1199680B (es)
ZA (1) ZA869448B (es)

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EP0579260A1 (en) * 1987-07-07 1994-01-19 Beecham Group Plc Use of a vasodilator for the treatment of pulmonary hypertension and/or right heart failure-related conditions
US5209933A (en) * 1990-01-10 1993-05-11 Syntex (U.S.A.) Inc. Long acting calcium channel blocker composition
US5141961A (en) * 1991-06-27 1992-08-25 Richrdson-Vicks Inc. Process for solubilizing difficulty soluble pharmaceutical actives
CN1054602C (zh) * 1993-04-19 2000-07-19 河北医学院 间-尼索地平及其合成方法
US5431916A (en) * 1993-04-29 1995-07-11 The Procter & Gamble Company Pharmaceutical compositions and process of manufacture thereof
US5484606A (en) * 1994-01-24 1996-01-16 The Procter & Gamble Company Process for reducing the precipitation of difficulty soluble pharmaceutical actives
US5478848A (en) * 1994-01-26 1995-12-26 Bayer Corporation Inhibition of arthritis by L-type calcium channel antagonists nimodipine, nisoldipine and nifedipine
HU214582B (hu) * 1994-07-26 1998-04-28 EGIS Gyógyszergyár Rt. Porlasztható, vérnyomáscsökkentő hatású gyógyszerkészítmény és eljárás előállítására
WO1996030738A1 (en) * 1995-03-28 1996-10-03 Innovex Biosciences Compositions and methods for permanently mounting biological specimens
IL122752A (en) * 1995-06-27 2001-07-24 Boehringer Ingelheim Kg Stable preparations for creating propellant-free sprays
ATE288255T1 (de) * 1996-04-12 2005-02-15 Novadel Pharma Inc Polares bukkales spray
CN1233169A (zh) * 1996-10-14 1999-10-27 弗·哈夫曼-拉罗切有限公司 一种粉末状制剂的制备工艺
US20030095927A1 (en) * 1997-10-01 2003-05-22 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating muscular and skeletal disorders
US20040136913A1 (en) * 1997-10-01 2004-07-15 Dugger Harry A. Buccal, polar and non-polar spray containing sumatriptan
US20030190286A1 (en) * 1997-10-01 2003-10-09 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating allergies or asthma
US20050002867A1 (en) * 1997-10-01 2005-01-06 Novadel Pharma Inc. Buccal, polar and non-polar sprays containing propofol
US20040136914A1 (en) * 1997-10-01 2004-07-15 Dugger Harry A. Buccal, polar and non-polar spray containing ondansetron
US20050163719A1 (en) * 1997-10-01 2005-07-28 Dugger Harry A.Iii Buccal, polar and non-polar spray containing diazepam
US20050287075A1 (en) * 1997-10-01 2005-12-29 Dugger Harry A Iii Buccal, polar and non-polar spray or capsule containing drugs for treating pain
US20030077229A1 (en) * 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing cardiovascular or renal drugs
US20050180923A1 (en) * 1997-10-01 2005-08-18 Dugger Harry A.Iii Buccal, polar and non-polar spray containing testosterone
US20040141923A1 (en) * 1997-10-01 2004-07-22 Dugger Harry A. Buccal, polar and non-polar spray containing alprazolam
US20030095926A1 (en) * 1997-10-01 2003-05-22 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the gastrointestinal tract or urinary tract
US20040136915A1 (en) * 1997-10-01 2004-07-15 Dugger Harry A. Buccal, polar and non-polar spray containing atropine
US7632517B2 (en) * 1997-10-01 2009-12-15 Novadel Pharma Inc. Buccal, polar and non-polar spray containing zolpidem
US20050281752A1 (en) * 1997-10-01 2005-12-22 Dugger Harry A Iii Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
AU4894697A (en) * 1997-10-01 1999-04-23 Flemington Pharmaceutical Corporation Buccal, polar and non-polar spray or capsule
US20030095925A1 (en) * 1997-10-01 2003-05-22 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating metabolic disorders
US20030077227A1 (en) * 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
US20090162300A1 (en) * 1997-10-01 2009-06-25 Dugger Iii Harry A Buccal, polar and non-polar spray containing alprazolam
US20030082107A1 (en) * 1997-10-01 2003-05-01 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating an infectious disease or cancer
US20030077228A1 (en) * 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating endocrine disorders
US20030185761A1 (en) * 1997-10-01 2003-10-02 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating pain
KR100315872B1 (ko) * 1999-03-08 2001-12-22 류덕희 디히드로피리딘 유도체를 포함하는 지속성 제제의 제조방법
DE10142416A1 (de) * 2001-08-31 2003-03-20 Molecular And Clinical Drug Re Verfahren zur Herstellung von Lösungen
DE10142417A1 (de) * 2001-08-31 2003-03-20 Molecular And Clinical Drug Re Arzneimittel
GB0215749D0 (en) * 2002-07-09 2002-08-14 3M Innovative Properties Co Medicinal suspension aerosol model systems
EP2767163A1 (en) 2005-02-17 2014-08-20 Abbott Laboratories Transmucosal administration of drug compositions for treating and preventing disorders in animals
CA2649895C (en) * 2006-04-19 2013-03-26 Novadel Pharma Inc. Stable hydroalcoholic oral spray formulations and methods
CA2673049C (en) * 2006-12-22 2016-02-23 Novadel Pharma Inc. Stable anti-nausea oral spray formulations and methods
AU2008251370A1 (en) * 2007-05-10 2008-11-20 Novadel Pharma Inc. Anti-insomnia compositions and methods
US7985325B2 (en) * 2007-10-30 2011-07-26 Novellus Systems, Inc. Closed contact electroplating cup assembly
PL2519261T3 (pl) 2009-12-28 2014-04-30 Laboratorio Reig Jofre S A Płynna kompozycja farmaceutyczna doustna nifedypiny

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU432703A3 (es) * 1971-08-24 1974-06-15 Фридрих Боссерт, Вульф Фатер, Курт Бауер
US3920823A (en) * 1972-03-06 1975-11-18 Bayer Ag Use of unsymmetrical esters of n-substituted 1,4-dihydropyridine 3,5-dicarboxylic acid as cardio-vascular agents
DE2650013C3 (de) * 1976-10-30 1981-04-02 Bayer Ag, 5090 Leverkusen 1.4-Dihydro-2.6-dimethyl-4-(3-nitrophenyl)-3.5-pyridindicarbonsäureisopropyl-(2-propoxy-äthyl)-ester, Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel
GB1579818A (en) * 1977-06-07 1980-11-26 Yamanouchi Pharma Co Ltd Nifedipine-containing solid preparation composition
EP0001247A1 (en) * 1977-09-14 1979-04-04 Kanebo, Ltd. Pharmaceutical preparation containing nifedipine and a method for producing the same.
DE2815578C2 (de) * 1978-04-11 1986-01-16 Bayer Ag, 5090 Leverkusen Neue pharmazeutische Verwendung von Nimodipin
DE3021958A1 (de) * 1980-06-12 1981-12-24 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridine, verfahren zu deren herstellung sowie diese enthaltende arzneimittel
JPS57167911A (en) * 1981-04-09 1982-10-16 Kyoto Yakuhin Kogyo Kk Liquid pharmaceutical of nifedipine
JPS58105913A (ja) * 1981-12-18 1983-06-24 Nippon Chemiphar Co Ltd ニフエジピン軟カプセル剤
DE3212736A1 (de) * 1982-04-06 1983-10-13 Bayer Ag, 5090 Leverkusen Verwendung von dihydropyridinen in arzneimitteln mit salidiuretischer wirkung
DE3307422A1 (de) * 1983-03-03 1984-09-06 Bayer Ag, 5090 Leverkusen Fluessigzubereitungen von dihydropyridinen, ein verfahren zu ihrer herstellung, sowie ihre verwendung bei der bekaempfung von erkrankungen
US4607041A (en) * 1983-04-27 1986-08-19 Fisons Plc Antihypertensive 2-phenyl Hantzsch dihydropyridines
DE3316510A1 (de) * 1983-05-06 1984-11-08 Bayer Ag Parenterale formulierung von nimodipin, ein verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung von erkrankungen
DE3326089A1 (de) * 1983-07-20 1985-02-07 Gödecke AG, 1000 Berlin Zur inhalation bestimmte darreichungsform von calcium-antagonisten
DE3376198D1 (en) * 1983-11-30 1988-05-11 Siegfried Ag Therapeutic coronary composition in the form of soft gelatine capsules
DE3414801A1 (de) * 1984-04-19 1985-10-24 Bayer Ag, 5090 Leverkusen 4-(nitrophenyl)-tetrahydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP0175671A1 (de) * 1984-08-23 1986-03-26 Kuhlemann & Co. Pharmazeutische Zubereitung sowie Verfahren zum Darreichen dieser pharmazeutischen Zubereitung

Also Published As

Publication number Publication date
BE905954A (fr) 1987-06-17
FR2592378B1 (fr) 1991-07-05
CA1281654C (en) 1991-03-19
DE3544692C2 (es) 1992-06-17
GR862915B (en) 1987-04-16
GB8629874D0 (en) 1987-01-28
DE3544692A1 (de) 1987-06-19
US4857312A (en) 1989-08-15
JPS62155216A (ja) 1987-07-10
GB2184654B (en) 1990-01-24
FR2592378A1 (fr) 1987-07-03
GB2184654A (en) 1987-07-01
CH667203A5 (de) 1988-09-30
IT1199680B (it) 1988-12-30
IT8622482A0 (it) 1986-11-27
ZA869448B (en) 1987-09-30

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-12-12