ES8305336A1 - "un metodo de preparar una 4-ariloxi-1,2,3,4-tetrahidroisoquinoleina". - Google Patents
"un metodo de preparar una 4-ariloxi-1,2,3,4-tetrahidroisoquinoleina".Info
- Publication number
- ES8305336A1 ES8305336A1 ES509535A ES509535A ES8305336A1 ES 8305336 A1 ES8305336 A1 ES 8305336A1 ES 509535 A ES509535 A ES 509535A ES 509535 A ES509535 A ES 509535A ES 8305336 A1 ES8305336 A1 ES 8305336A1
- Authority
- ES
- Spain
- Prior art keywords
- same
- hydrogen
- alkyl
- tetrahydroisoquinolines
- aryloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
UN METODO DE PREPARAR UNA 4-ARILOXI-1,2,3,4-TETRAHIDROISOQUINOLEINA. SE HACE REACCIONAR UN 1,2,3,4-TETRAHIDRO-4-ISOQUINOLEINOL SUSTITUIDO DE FORMULA GENERAL (II), EN QUE R ES HIDROGENO Y R , ES HIDROGENO, ALCOHILO O ARALCOHILO, CON UN COMPUESTO FENILO SUSTITUIDO (III), EN QUE Z ES HALOGENO. SE OBTIENE EL COMPUESTO (I). TIPICAMENTE SE FORMA EN PRIMER LUGAR UNA SAL DEL COMPUESTO (II), HACIENDO REACCIONAR DICHO COMPUESTO CON HIDRURO DE SODIO, A UNA TEMPERATURA DE 50 Y 80 C DURANTE UN TIEMPO DE 1 A 5 HORAS. LA SAL SE HACE REACCIONAR DESPUES CON EL COMPUESTO (III) A TEMPERATURAS DE 10 A 35 C DURANTE 2 A 5 HORAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/235,801 US4375471A (en) | 1981-02-19 | 1981-02-19 | 4-Aryloxy-1,2,3,4-tetrahydroisoquinolines |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8305336A1 true ES8305336A1 (es) | 1983-04-01 |
ES509535A0 ES509535A0 (es) | 1983-04-01 |
Family
ID=22886966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES509535A Granted ES509535A0 (es) | 1981-02-19 | 1982-02-12 | "un metodo de preparar una 4-ariloxi-1,2,3,4-tetrahidroisoquinoleina". |
Country Status (7)
Country | Link |
---|---|
US (1) | US4375471A (es) |
EP (1) | EP0058932B1 (es) |
JP (1) | JPS57163368A (es) |
AT (1) | ATE14308T1 (es) |
CA (1) | CA1173833A (es) |
DE (1) | DE3264708D1 (es) |
ES (1) | ES509535A0 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2564461B1 (fr) * | 1984-05-15 | 1986-09-19 | Synthelabo | Derives d'isoquinoleine, leur preparation et leurs applications |
DE3640641A1 (de) * | 1986-11-28 | 1988-07-14 | Thomae Gmbh Dr K | Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
CZ290661B6 (cs) * | 1993-06-22 | 2002-09-11 | Knoll Aktiengesellschaft | Tetrahydroisochinolinová sloučenina, způsob její přípravy, farmaceutický prostředek s jejím obsahem a použití |
CA2424292A1 (en) | 2000-10-10 | 2002-04-18 | Calyx Therapeutics, Inc. | Tricyclic compounds and uses thereof |
WO2004050630A1 (en) * | 2002-12-02 | 2004-06-17 | Pharmacia & Upjohn Company Llc | The use of aryl- and heteroaryl-substituted tetrahydroisoquinolines in the treatment of chronic and neuropathic pain, migraine headaches, and urge, stress and mixed urinary incontinence |
CA2505783A1 (en) * | 2002-12-02 | 2004-06-17 | Pharmacia & Upjohn Company Llc | The use of 4-phenyl-substituted tetrahydroisoquinolines in the treatment of pain, migraine headaches and urinary incontinence |
AU2003280192A1 (en) * | 2002-12-02 | 2004-06-23 | Pharmacia & Upjohn Company Llc | The use of 4-phenyl substituted tetrahydroisoquinolines in the treatment of pain, migraine and urinary incontinence |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1035777A (en) * | 1963-08-20 | 1966-07-13 | Bellon Labor Sa Roger | Isoquinoline derivatives |
NL6504208A (es) * | 1964-04-03 | 1965-10-04 | ||
DE1670694B2 (de) * | 1966-05-05 | 1976-07-22 | Hoechst Ag, 6000 Frankfurt | Verfahren zur herstellung von tetrahydroisochinolinen |
US3629265A (en) * | 1969-10-30 | 1971-12-21 | Hoffmann La Roche | 7-halo-4-isoquinolones |
US4059586A (en) * | 1974-03-28 | 1977-11-22 | Marion Laboratories, Inc. | 5-Alkoxy-2-alkyl-1,2,3,4-tetrahydroisoquinolene-8-carboxaldehyde and derivatives |
GB1504424A (en) * | 1975-08-09 | 1978-03-22 | Beecham Group Ltd | Isoquinoline-derived aminoethers |
JPS54138572A (en) * | 1978-04-17 | 1979-10-27 | Kyowa Hakko Kogyo Co Ltd | Novel isoquinoline derivative |
-
1981
- 1981-02-19 US US06/235,801 patent/US4375471A/en not_active Expired - Fee Related
-
1982
- 1982-02-12 ES ES509535A patent/ES509535A0/es active Granted
- 1982-02-17 DE DE8282101170T patent/DE3264708D1/de not_active Expired
- 1982-02-17 AT AT82101170T patent/ATE14308T1/de not_active IP Right Cessation
- 1982-02-17 EP EP82101170A patent/EP0058932B1/en not_active Expired
- 1982-02-18 CA CA000396564A patent/CA1173833A/en not_active Expired
- 1982-02-18 JP JP57023690A patent/JPS57163368A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0058932B1 (en) | 1985-07-17 |
EP0058932A2 (en) | 1982-09-01 |
US4375471A (en) | 1983-03-01 |
ATE14308T1 (de) | 1985-08-15 |
JPS57163368A (en) | 1982-10-07 |
ES509535A0 (es) | 1983-04-01 |
EP0058932A3 (en) | 1982-10-27 |
DE3264708D1 (en) | 1985-08-22 |
CA1173833A (en) | 1984-09-04 |
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