ES8401062A1 - Procedimiento para la preparacion de nuevas 1-furil-3,4-dihidroisoquinoleinas. - Google Patents

Procedimiento para la preparacion de nuevas 1-furil-3,4-dihidroisoquinoleinas.

Info

Publication number
ES8401062A1
ES8401062A1 ES517108A ES517108A ES8401062A1 ES 8401062 A1 ES8401062 A1 ES 8401062A1 ES 517108 A ES517108 A ES 517108A ES 517108 A ES517108 A ES 517108A ES 8401062 A1 ES8401062 A1 ES 8401062A1
Authority
ES
Spain
Prior art keywords
dihydroisoquinolines
furyl
preparation
hydroxyl
medicines containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES517108A
Other languages
English (en)
Other versions
ES517108A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim GmbH
Original Assignee
Boehringer Ingelheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim GmbH filed Critical Boehringer Ingelheim GmbH
Publication of ES8401062A1 publication Critical patent/ES8401062A1/es
Publication of ES517108A0 publication Critical patent/ES517108A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 1-FURIL-3,4-DIHIDROIXOQUINOLEINAS DE FORMULA GENERAL (I), EN LA QUE R1 Y R2, QUE PUEDEN SER IGUALES O DIFERENTES, SIGNIFICAN UN GRUPO HIDROXILO O ALCOXILO; Y R3 SIGNIFICA UN GRUPO CIANO, Y SUS SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN CICLIZAR UNA AMIDA DE ACIDO FURANO-3,4-DICARBOXILICO, DE FORMULA GENERAL (II), EN LA QUE R1, R2 Y R3 TIENEN LOS SIGNIFICADOS YA INDICADOS, CON ACIDOS DE LEWIS. EL COMPUESTO OBTENIDO SE TRANSFORMA EVENTUALMENTE EN UNA SAL POR ADICION DE ACIDOS.DE APLICACION ENEL TRATAMIENTO DE TRASTORNOS DE LA CIRCULACION SANGUINEA Y CORONARIOS.
ES517108A 1981-11-05 1982-11-04 Procedimiento para la preparacion de nuevas 1-furil-3,4-dihidroisoquinoleinas. Granted ES517108A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813143876 DE3143876A1 (de) 1981-11-05 1981-11-05 Neue1-furyl-3,4-dihydroisochinoline diese enthaltende arzneimittel sowie verfahren zu deren herstellung und deren verwendung

Publications (2)

Publication Number Publication Date
ES8401062A1 true ES8401062A1 (es) 1983-11-16
ES517108A0 ES517108A0 (es) 1983-11-16

Family

ID=6145648

Family Applications (1)

Application Number Title Priority Date Filing Date
ES517108A Granted ES517108A0 (es) 1981-11-05 1982-11-04 Procedimiento para la preparacion de nuevas 1-furil-3,4-dihidroisoquinoleinas.

Country Status (26)

Country Link
US (1) US4452789A (es)
EP (1) EP0078949B1 (es)
JP (1) JPS5885883A (es)
KR (1) KR880001715B1 (es)
AT (1) ATE13887T1 (es)
AU (1) AU557772B2 (es)
CA (1) CA1190545A (es)
CS (1) CS228942B2 (es)
DD (1) DD208616A5 (es)
DE (2) DE3143876A1 (es)
DK (1) DK490282A (es)
ES (1) ES517108A0 (es)
FI (1) FI74960C (es)
GB (1) GB2110671B (es)
GR (1) GR77057B (es)
HU (1) HU190995B (es)
IE (1) IE54085B1 (es)
IL (1) IL67168A0 (es)
NO (1) NO158676C (es)
NZ (1) NZ202391A (es)
PH (1) PH18875A (es)
PL (1) PL134673B1 (es)
PT (1) PT75793B (es)
SU (1) SU1149877A3 (es)
YU (1) YU42057B (es)
ZA (1) ZA828068B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3603194A1 (de) * 1986-02-03 1987-08-06 Boehringer Ingelheim Kg Neue 2-amino-3-formyl-furane, verfahren zu ihrer herstellung und die enthaltenden pharmazeutischen zusammensetzungen
KR100544521B1 (ko) * 2001-11-15 2006-01-23 박주섭 무우 써는 기계
US6973298B2 (en) * 2003-03-27 2005-12-06 Kyocera Wireless Corp. Location capable mobile handset
JP2013515740A (ja) 2009-12-23 2013-05-09 バイオクライスト ファーマシューティカルズ， インコーポレイテッド Ｊａｎｕｓキナーゼインヒビターとしての複素環式化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1620496A1 (de) * 1965-03-24 1970-01-02 Thomae Gmbh Dr K Verfahren zur Herstellung von neuen 1-Pyridyl-3,4-dihydroisochinolinen
FR2351656A1 (fr) * 1976-05-21 1977-12-16 Rhone Poulenc Ind Nouveaux derives de la dibenzo(de, h) quinoleine, leur preparation et les compositions qui les contiennent
US4190660A (en) * 1978-08-11 1980-02-26 Siu Patrick M Anti-drug withdrawal syndrome composition and method of use
DE3013906A1 (de) * 1980-04-11 1981-10-15 C.H. Boehringer Sohn, 6507 Ingelheim Substituierte (alpha) -aminocarbonyl-l-benzyl-3,4-dihydro-isochinoline, verfahren zu deren herstellung und deren verwendung

Also Published As

Publication number Publication date
NO823676L (no) 1983-05-06
JPS5885883A (ja) 1983-05-23
PT75793A (de) 1982-12-01
CS228942B2 (en) 1984-05-14
IE54085B1 (en) 1989-06-07
DE3264303D1 (en) 1985-07-25
NO158676B (no) 1988-07-11
FI74960C (fi) 1988-04-11
PL134673B1 (en) 1985-09-30
KR840002375A (ko) 1984-06-25
GB2110671A (en) 1983-06-22
DD208616A5 (de) 1984-04-04
ZA828068B (en) 1984-07-25
DE3143876A1 (de) 1983-05-11
PH18875A (en) 1985-10-21
ATE13887T1 (de) 1985-07-15
US4452789A (en) 1984-06-05
SU1149877A3 (ru) 1985-04-07
PL238869A1 (en) 1984-03-12
NO158676C (no) 1988-10-19
IL67168A0 (en) 1983-03-31
YU42057B (en) 1988-04-30
GR77057B (es) 1984-09-05
HU190995B (en) 1986-12-28
IE822637L (en) 1983-05-05
FI74960B (fi) 1987-12-31
NZ202391A (en) 1985-01-31
AU557772B2 (en) 1987-01-08
PT75793B (de) 1986-01-21
GB2110671B (en) 1985-04-17
YU246482A (en) 1984-12-31
AU9021882A (en) 1983-05-12
ES517108A0 (es) 1983-11-16
FI823732A0 (fi) 1982-11-02
KR880001715B1 (ko) 1988-09-08
CA1190545A (en) 1985-07-16
EP0078949A1 (de) 1983-05-18
EP0078949B1 (de) 1985-06-19
FI823732L (fi) 1983-05-06
DK490282A (da) 1983-05-06

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