MX9301544A - Compuestos de acido n-2-amino-4-sustutuido-(pirrolo o pirido) 2,3-d pirimidinil/alquil/benzoil-l- glutamico, procedimiento para su preparacion y formulado farmaceutico que los comprende. - Google Patents

Compuestos de acido n-2-amino-4-sustutuido-(pirrolo o pirido) 2,3-d pirimidinil/alquil/benzoil-l- glutamico, procedimiento para su preparacion y formulado farmaceutico que los comprende.

Info

Publication number
MX9301544A
MX9301544A MX9301544A MX9301544A MX9301544A MX 9301544 A MX9301544 A MX 9301544A MX 9301544 A MX9301544 A MX 9301544A MX 9301544 A MX9301544 A MX 9301544A MX 9301544 A MX9301544 A MX 9301544A
Authority
MX
Mexico
Prior art keywords
amino
substituted
alkyl
acid compounds
glutamic
Prior art date
Application number
MX9301544A
Other languages
English (en)
Inventor
Lynn Stacy Gossett
Chuan Shih
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX9301544A publication Critical patent/MX9301544A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Esta invención se refiere a compuestos de ácido N-(2-amino-4-sustituído-((pirrolo o pirido)(2,3-d) pirimidinil/alquil/benzoil/-L-glutámico, a algunas de sus formas reducidas, a intermedios para su síntesis, a formulados farmacéuticos que contienen estos compuestos y su uso como agentes antineoplásicos.
MX9301544A 1992-03-24 1993-03-19 Compuestos de acido n-2-amino-4-sustutuido-(pirrolo o pirido) 2,3-d pirimidinil/alquil/benzoil-l- glutamico, procedimiento para su preparacion y formulado farmaceutico que los comprende. MX9301544A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/856,611 US5196424A (en) 1992-03-24 1992-03-24 N-[2-amino-4-substituted[[(pyrrollo or pyrido)[2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acids

Publications (1)

Publication Number Publication Date
MX9301544A true MX9301544A (es) 1994-07-29

Family

ID=25324069

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9301544A MX9301544A (es) 1992-03-24 1993-03-19 Compuestos de acido n-2-amino-4-sustutuido-(pirrolo o pirido) 2,3-d pirimidinil/alquil/benzoil-l- glutamico, procedimiento para su preparacion y formulado farmaceutico que los comprende.

Country Status (18)

Country Link
US (1) US5196424A (es)
EP (1) EP0567223A1 (es)
JP (1) JPH0625246A (es)
KR (1) KR930019676A (es)
CN (1) CN1078235A (es)
AU (1) AU3542993A (es)
BR (1) BR9301273A (es)
CA (1) CA2091978A1 (es)
CZ (1) CZ44093A3 (es)
FI (1) FI931251A (es)
HU (1) HUT70036A (es)
IL (1) IL105100A0 (es)
MX (1) MX9301544A (es)
MY (1) MY131322A (es)
NO (1) NO931008L (es)
NZ (1) NZ247193A (es)
TW (1) TW224098B (es)
ZA (1) ZA931944B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457056A (en) * 1993-07-06 1995-10-10 Fiberchem, Inc. Halohydrocarbon sensing chemistry with base modifier
US6537999B2 (en) * 1996-06-06 2003-03-25 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
CA2263907A1 (en) * 1996-08-30 1998-03-05 Christopher Leighon Jordan Nonclassical pyrrolo[2,3-d]pyrimidine antifolates
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
US8030319B2 (en) * 2005-02-10 2011-10-04 Duquesne University Of The Holy Ghost Methods for treating cancer and other pathological proliferating disorders by inhibiting mitosis using pyrrolo[2 3-d]pyrimidines
EP2392258B1 (en) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-informatics system
CN1962658B (zh) * 2005-11-10 2010-05-12 北京大学 一种四氢吡啶并[3,2-d]嘧啶类化合物及制备抗肿瘤药物的用途
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
AU2010216512B2 (en) 2009-02-20 2016-06-30 2-Bbb Medicines B.V. Glutathione-based drug delivery system
WO2010129819A2 (en) 2009-05-06 2010-11-11 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
JP2013510163A (ja) * 2009-11-06 2013-03-21 チェルシー・セラピューティクス，インコーポレイテッド 酵素阻害化合物
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN102977107B (zh) * 2012-12-25 2015-04-22 山西普德药业股份有限公司 一种培美曲塞二钠化合物及其组合物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0119591B1 (en) * 1983-03-17 1988-06-22 Takeda Chemical Industries, Ltd. Thiodeazapurine derivatives
JPS59170091A (ja) * 1983-03-17 1984-09-26 Takeda Chem Ind Ltd ６−チオ−７−デアザプリン誘導体およびその製造法
JPS61500845A (ja) * 1983-12-27 1986-05-01 エス・ア−ル・アイ・インタ−ナシヨナル ８，１０―ジデアザミノプテリン及び抗白血病剤組成物
US5026851A (en) * 1985-03-08 1991-06-25 The Trustees Of Princeton University Pyrido[2,3-]pyrimidine derivatives
US4684653A (en) * 1985-03-08 1987-08-04 The Trustees Of Princeton University Pyrido(2,3-d)pyrimidine derivatives
ZA861235B (en) * 1985-03-08 1986-10-29 Univ Princeton Pyrido(2,3-d)pyrimidine derivatives
US4927828A (en) * 1985-03-08 1990-05-22 The Trustees Of Princeton University Diastereoisomeric tetrahydropyrido-(2,3,d) pyrimidine derivatives
US4923872A (en) * 1986-08-26 1990-05-08 Warner-Lambert Co. Analogues of pyrrolo[3,2d]pyrimidin-4-ones
US4988702A (en) * 1986-08-26 1991-01-29 Warner-Lambert Company Novel 9-deazaguanines
US4988813A (en) * 1986-10-20 1991-01-29 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
US4902796A (en) * 1986-10-20 1990-02-20 The Trustees Of Princeton University 6-alkenyl and ethynyl derivatives of 2-amino-4-hydroxypyrido[2,3-d]pyrimidines
US4921858A (en) * 1986-10-24 1990-05-01 Warner-Lambert Company 7-deazaguanines as immunomodulators
JP2830008B2 (ja) * 1988-04-01 1998-12-02 武田薬品工業株式会社 縮合ピリミジン誘導体
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
US4882333A (en) * 1988-05-25 1989-11-21 The Trustess Of Princeton University N-(5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives
CH677140A5 (es) * 1988-10-11 1991-04-15 W & E Umwelttechnik Ag
WO1991004254A1 (fr) * 1989-09-19 1991-04-04 Teijin Limited DERIVE DE PYRROLO[2,3-d]PYRIMIDINE, SON PROCEDE DE PREPARATION, ET PREPARATION PHARMACEUTIQUE COMPRENANT LE DERIVE COMME INGREDIENT ACTIF
CA2032695A1 (en) * 1989-12-20 1991-06-21 Hiroshi Akimoto Condensed heterocyclic compounds, their production and use

Also Published As

Publication number Publication date
CN1078235A (zh) 1993-11-10
HUT70036A (en) 1995-09-28
ZA931944B (en) 1994-09-18
BR9301273A (pt) 1993-09-28
JPH0625246A (ja) 1994-02-01
CZ44093A3 (en) 1994-02-16
HU9300804D0 (en) 1993-06-28
EP0567223A1 (en) 1993-10-27
US5196424A (en) 1993-03-23
CA2091978A1 (en) 1993-09-25
KR930019676A (ko) 1993-10-18
NO931008L (no) 1993-09-27
TW224098B (es) 1994-05-21
FI931251A0 (fi) 1993-03-22
MY131322A (en) 2007-08-30
FI931251A (fi) 1993-09-25
IL105100A0 (en) 1993-12-28
NZ247193A (en) 1995-05-26
NO931008D0 (no) 1993-03-19
AU3542993A (en) 1993-09-30

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