ATE146186T1 - Trifluormethylketon peptid derivate mit hle- inhibierende aktivität, deren herstellung und pharmazeutischen zusammensetzungen - Google Patents

Trifluormethylketon peptid derivate mit hle- inhibierende aktivität, deren herstellung und pharmazeutischen zusammensetzungen

Info

Publication number
ATE146186T1
ATE146186T1 AT93401937T AT93401937T ATE146186T1 AT E146186 T1 ATE146186 T1 AT E146186T1 AT 93401937 T AT93401937 T AT 93401937T AT 93401937 T AT93401937 T AT 93401937T AT E146186 T1 ATE146186 T1 AT E146186T1
Authority
AT
Austria
Prior art keywords
hle
preparation
pharmaceutical compositions
inhibiting activity
peptide derivatives
Prior art date
Application number
AT93401937T
Other languages
English (en)
Inventor
Michel Vincent
Nanteuil Guillaume De
Georges Remond
Bernard Portevin
Yolande Herve
Michel Lonchampt
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Application granted granted Critical
Publication of ATE146186T1 publication Critical patent/ATE146186T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT93401937T 1992-07-28 1993-07-27 Trifluormethylketon peptid derivate mit hle- inhibierende aktivität, deren herstellung und pharmazeutischen zusammensetzungen ATE146186T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9209254A FR2694295B1 (fr) 1992-07-28 1992-07-28 Nouveaux peptides dérivés de trifluoromethylcetones, leur procéde de préparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ATE146186T1 true ATE146186T1 (de) 1996-12-15

Family

ID=9432302

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93401937T ATE146186T1 (de) 1992-07-28 1993-07-27 Trifluormethylketon peptid derivate mit hle- inhibierende aktivität, deren herstellung und pharmazeutischen zusammensetzungen

Country Status (12)

Country Link
US (1) US5565429A (de)
EP (1) EP0585155B1 (de)
JP (1) JPH0826066B2 (de)
AT (1) ATE146186T1 (de)
AU (1) AU662232B2 (de)
CA (1) CA2101350A1 (de)
DE (1) DE69306505T2 (de)
DK (1) DK0585155T3 (de)
ES (1) ES2098004T3 (de)
FR (1) FR2694295B1 (de)
GR (1) GR3022631T3 (de)
NZ (1) NZ248263A (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2701951B1 (fr) * 1993-02-24 1995-06-09 Adir Nouveaux derives peptidiques de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
CA2118985A1 (en) * 1993-04-02 1994-10-03 Dinesh V. Patel Heterocyclic inhibitors of farnesyl protein transferase
CA2183428A1 (en) * 1994-03-11 1995-09-14 John J. Baldwin Sulfonamide derivatives and their use
FR2719589B1 (fr) * 1994-05-05 1996-06-14 Adir Nouveaux peptides dérivés de trifluorométhylcétones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US6100238A (en) * 1994-11-21 2000-08-08 Cortech Inc. Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors
US5998379A (en) * 1994-11-21 1999-12-07 Cortech Inc. Serine protease inhibitors-proline analogs
US5618792A (en) * 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
US6001811A (en) * 1994-11-21 1999-12-14 Cortech Inc. Serine protease inhibitors--N-substituted derivatives
US6015791A (en) * 1994-11-21 2000-01-18 Cortech Inc. Serine protease inhibitors-cycloheptane derivatives
US6150334A (en) * 1994-11-21 2000-11-21 Cortech, Inc. Serine protease inhibitors-tripeptoid analogs
US6159938A (en) * 1994-11-21 2000-12-12 Cortech, Inc. Serine protease inhibitors comprising α-keto heterocycles
US6001813A (en) * 1994-11-21 1999-12-14 Cortech Inc. Val-pro containing α-keto oxadiazoles as serine protease inhibitors
US20020119985A1 (en) 1994-11-21 2002-08-29 Albert Gyorkos Serine protease inhibitors
US6001814A (en) * 1994-11-21 1999-12-14 Cortech Inc. Serine protease inhibitors
RU2217436C2 (ru) * 1996-12-06 2003-11-27 Кортеч, Инк. Производные оксадиазола, тиадиазола или триазола, являющиеся ингибиторами сериновых протеаз, и содержащие их фармацевтические композиции
US6004933A (en) * 1997-04-25 1999-12-21 Cortech Inc. Cysteine protease inhibitors
US6656910B2 (en) 1997-12-04 2003-12-02 Cortech, Inc. Serine protease inhibitors
JP4320791B2 (ja) * 1998-02-24 2009-08-26 アステラス製薬株式会社 皮ふの老化の予防、治療剤
JP2003520185A (ja) 1998-06-03 2003-07-02 コーテック インコーポレーテッド セリンプロテアーゼ阻害剤としてのα−ケトオキサジアゾール類
EP1135406A1 (de) 1998-12-02 2001-09-26 Merck Frosst Canada & Co. Gamma-ketosäure-tetrapeptide als kaspase-3-inhibitoren
CA2430978C (en) * 2000-12-28 2012-05-15 Daiichi Pharmaceutical Co., Ltd. Vla-4 inhibitors
AR037097A1 (es) * 2001-10-05 2004-10-20 Novartis Ag Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento
TWI340134B (en) 2003-07-24 2011-04-11 Daiichi Seiyaku Co Cyclohexanecarboxylic acids
FR2942797B1 (fr) * 2009-03-03 2011-04-29 Pf Medicament Derives de benzothiazines, leur preparation et leur application a titre de medicaments
JP5830534B2 (ja) 2010-07-09 2015-12-09 ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ 化合物
US8772343B2 (en) 2010-07-12 2014-07-08 Pfizer Limited Chemical compounds
EP2593431B1 (de) 2010-07-12 2014-11-19 Pfizer Limited N-sulfonylbenzamide als inhibitoren von spannungsabhängigen natriumkanälen
EP2593432B1 (de) 2010-07-12 2014-10-22 Pfizer Limited N-sulfonylbenzamidderivate als spannungsgesteuerte natriumkanalhemmer
ES2532357T3 (es) 2010-07-12 2015-03-26 Pfizer Limited Derivados de sulfonamida como inhibidores de Nav1.7 para el tratamiento del dolor
CA2804716A1 (en) 2010-07-12 2012-01-19 Pfizer Limited Chemical compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
FR2585709B1 (fr) * 1985-08-05 1987-10-02 Adir Nouveaux derives peptidiques a structure lactonique ou cycloamidique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP0276101A3 (de) * 1987-01-19 1989-11-23 Ici Americas Inc. Substituierte Peptid-Derivate
EP0369391A3 (de) * 1988-11-15 1991-09-25 Boehringer Ingelheim Pharmaceuticals Inc. N-substituierte Amide
FR2649110B1 (fr) * 1989-06-29 1994-10-21 Adir Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5221665A (en) * 1989-10-27 1993-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. N-substituted amides
FR2663336B1 (fr) * 1990-06-18 1992-09-04 Adir Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof

Also Published As

Publication number Publication date
NZ248263A (en) 1994-12-22
JPH0826066B2 (ja) 1996-03-13
US5565429A (en) 1996-10-15
ES2098004T3 (es) 1997-04-16
GR3022631T3 (en) 1997-05-31
DE69306505T2 (de) 1997-06-19
DK0585155T3 (da) 1997-06-09
DE69306505D1 (de) 1997-01-23
AU662232B2 (en) 1995-08-24
FR2694295B1 (fr) 1994-09-02
JPH06184192A (ja) 1994-07-05
CA2101350A1 (fr) 1994-01-29
AU4218093A (en) 1994-02-03
EP0585155A1 (de) 1994-03-02
EP0585155B1 (de) 1996-12-11
FR2694295A1 (fr) 1994-02-04

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee