DE69223914D1 - 4-substituierte-2-Deoxy-2,3-Didehydro Alpha-D-Neuraminsäure antivirale Derivate - Google Patents

4-substituierte-2-Deoxy-2,3-Didehydro Alpha-D-Neuraminsäure antivirale Derivate

Info

Publication number
DE69223914D1
DE69223914D1 DE69223914T DE69223914T DE69223914D1 DE 69223914 D1 DE69223914 D1 DE 69223914D1 DE 69223914 T DE69223914 T DE 69223914T DE 69223914 T DE69223914 T DE 69223914T DE 69223914 D1 DE69223914 D1 DE 69223914D1
Authority
DE
Germany
Prior art keywords
didehydro
deoxy
alpha
substituted
neuraminic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69223914T
Other languages
English (en)
Other versions
DE69223914T2 (de
Inventor
Itzstein Von Itzstein Von
Wen-Yang Wu
Tho Van Phan
Betty Jin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biota Scientific Management Pty Ltd
Original Assignee
Biota Scientific Management Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biota Scientific Management Pty Ltd filed Critical Biota Scientific Management Pty Ltd
Application granted granted Critical
Publication of DE69223914D1 publication Critical patent/DE69223914D1/de
Publication of DE69223914T2 publication Critical patent/DE69223914T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
DE69223914T 1991-10-23 1992-10-22 4-substituierte-2-Deoxy-2,3-Didehydro Alpha-D-Neuraminsäure antivirale Derivate Expired - Lifetime DE69223914T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPK905191 1991-10-23

Publications (2)

Publication Number Publication Date
DE69223914D1 true DE69223914D1 (de) 1998-02-12
DE69223914T2 DE69223914T2 (de) 1998-04-30

Family

ID=3775765

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69223914T Expired - Lifetime DE69223914T2 (de) 1991-10-23 1992-10-22 4-substituierte-2-Deoxy-2,3-Didehydro Alpha-D-Neuraminsäure antivirale Derivate

Country Status (11)

Country Link
EP (1) EP0539204B1 (de)
JP (1) JP2925863B2 (de)
AT (1) ATE161836T1 (de)
AU (1) AU659501B2 (de)
CA (1) CA2081068C (de)
DE (1) DE69223914T2 (de)
DK (1) DK0539204T3 (de)
ES (1) ES2113413T3 (de)
GR (1) GR3026218T3 (de)
HK (1) HK1015137A1 (de)
ZA (1) ZA928170B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9220327D0 (en) * 1992-09-25 1992-11-11 Glaxo Group Ltd Process
GB9220241D0 (en) * 1992-09-25 1992-11-11 Glaxo Group Ltd Process
GB9325841D0 (en) * 1993-12-17 1994-02-23 Glaxo Group Ltd Chemical compounds
AUPM354694A0 (en) * 1994-01-27 1994-02-17 Biota Scientific Management Pty Ltd Chemical compounds
GB9410817D0 (en) * 1994-05-28 1994-07-20 Glaxo Group Ltd Medicaments
US5561146A (en) * 1994-06-10 1996-10-01 Bristol-Myers Squibb Company Modified guanidino and amidino thrombin inhibitors
US5512596A (en) * 1994-09-02 1996-04-30 Gilead Sciences, Inc. Aromatic compounds
US5866601A (en) * 1995-02-27 1999-02-02 Gilead Sciences, Inc. Carbocyclic compounds
CN101172957B (zh) * 1995-02-27 2012-11-14 吉里德科学公司 新颖化合物,其合成方法及治疗用途
HU228450B1 (en) * 1995-02-27 2013-03-28 Gilead Sciences Inc Novel selective inhibitors of viral or bacterial neuraminidases
US5602277A (en) * 1995-03-30 1997-02-11 Biocryst Pharmaceuticals, Inc. Substituted benzene derivatives useful as neuraminidase inhibitors
HUP9801766A3 (en) * 1995-05-19 2000-09-28 Biota Scient Managemant Pty Lt 6-carboxamido dihydropyran derivatives, process for producing them and medicaments containing the same
GB9516276D0 (en) * 1995-08-08 1995-10-11 Biota Scient Management Chemical compounds
US5763483A (en) * 1995-12-29 1998-06-09 Gilead Sciences, Inc. Carbocyclic compounds
US6451766B1 (en) 1996-07-22 2002-09-17 Sankyo Company, Limited Neuraminic acid derivatives, their preparation and their medical use
EP0823428B1 (de) * 1996-07-22 2002-01-02 Sankyo Company Limited Neuraminsäuredervate, ihre Herstellung und medizinische Verwendung
US6340702B1 (en) 1996-07-22 2002-01-22 Sankyo Company, Limited Neuraminic acid derivatives, their preparation and their medical use
DK0934939T3 (da) * 1996-08-13 2003-07-21 Sankyo Co Neuraminsyreforbinelser
US5859284A (en) * 1996-08-23 1999-01-12 Gilead Sciences, Inc. Preparation of carbocyclic compounds
US6518438B2 (en) 1996-08-23 2003-02-11 Gilead Sciences, Inc. Preparation of cyclohexene carboxylate derivatives
AU711845B2 (en) * 1996-09-10 1999-10-21 Daikin Industries, Ltd. 4-substituted-2,7-dideoxy-7-fluoro-2,3-didehydro-sialic acid compounds
US5994377A (en) * 1996-10-21 1999-11-30 Gilead Sciences, Inc. Piperidine compounds
KR20000052702A (ko) * 1996-10-21 2000-08-25 헨슬레이 맥스 디. 피페리딘 화합물
CA2271249C (en) * 1996-11-14 2010-07-20 Biota Scientific Management Pty. Ltd. Macromolecular neuraminidase-binding compounds
US5886213A (en) * 1997-08-22 1999-03-23 Gilead Sciences, Inc. Preparation of carbocyclic compounds
TW477783B (en) * 1997-12-12 2002-03-01 Gilead Sciences Inc Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
US6608081B2 (en) 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6593314B1 (en) 1999-10-19 2003-07-15 Abbott Laboratories Neuraminidase inhibitors
WO2002092555A1 (fr) * 2001-05-11 2002-11-21 Sankyo Company, Limited Derives d'acides sialiques
KR100697944B1 (ko) 2003-02-10 2007-03-20 니폰 쇼쿠바이 컴파니 리미티드 수분-흡수제
WO2008090151A1 (en) 2007-01-23 2008-07-31 Therapicon Srl Antiviral compounds
JPWO2009004899A1 (ja) * 2007-06-15 2010-08-26 国立大学法人北海道大学 シアリダーゼ阻害剤
KR20110098760A (ko) 2008-11-28 2011-09-01 시플라 리미티드 자나미비르의 제조방법 및 상기 제조방법에 사용되는 중간체
EP2429991B1 (de) 2009-05-15 2014-09-10 Redx Pharma Limited Redox-wirkstoffderivate
IT1396620B1 (it) 2009-11-25 2012-12-14 Therapicon Srl Analoghi chimerici
EP2678324A1 (de) 2011-02-24 2014-01-01 Cadila Healthcare Limited Verfahren zur herstellung von zanamivir
DE102011117128A1 (de) * 2011-10-28 2013-05-02 Christian-Albrechts-Universität Zu Kiel Verbindungen zur Therapie der Influenza

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP249A (en) * 1990-04-24 1993-03-17 Biota Scient Management Pty Ltd Anti-viral compounds.
GB9220241D0 (en) * 1992-09-25 1992-11-11 Glaxo Group Ltd Process

Also Published As

Publication number Publication date
DK0539204T3 (da) 1998-09-07
EP0539204B1 (de) 1998-01-07
CA2081068C (en) 2005-11-29
ZA928170B (en) 1993-11-15
JPH0625209A (ja) 1994-02-01
AU659501B2 (en) 1995-05-18
ATE161836T1 (de) 1998-01-15
HK1015137A1 (en) 1999-10-08
AU2724292A (en) 1993-04-29
ES2113413T3 (es) 1998-05-01
DE69223914T2 (de) 1998-04-30
EP0539204A1 (de) 1993-04-28
GR3026218T3 (en) 1998-05-29
CA2081068A1 (en) 1993-04-24
JP2925863B2 (ja) 1999-07-28

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