ATE161836T1 - 4-substituierte-2-deoxy-2,3-didehydro alpha-d- neuraminsäure antivirale derivate - Google Patents

4-substituierte-2-deoxy-2,3-didehydro alpha-d- neuraminsäure antivirale derivate

Info

Publication number
ATE161836T1
ATE161836T1 AT92309684T AT92309684T ATE161836T1 AT E161836 T1 ATE161836 T1 AT E161836T1 AT 92309684 T AT92309684 T AT 92309684T AT 92309684 T AT92309684 T AT 92309684T AT E161836 T1 ATE161836 T1 AT E161836T1
Authority
AT
Austria
Prior art keywords
didehydro
deoxy
alpha
substituted
neuramic acid
Prior art date
Application number
AT92309684T
Other languages
English (en)
Inventor
Itzstein Von
Wen-Yang Wu
Tho Van Phan
Betty Jin
Original Assignee
Biota Scient Management
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biota Scient Management filed Critical Biota Scient Management
Application granted granted Critical
Publication of ATE161836T1 publication Critical patent/ATE161836T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT92309684T 1991-10-23 1992-10-22 4-substituierte-2-deoxy-2,3-didehydro alpha-d- neuraminsäure antivirale derivate ATE161836T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPK905191 1991-10-23

Publications (1)

Publication Number Publication Date
ATE161836T1 true ATE161836T1 (de) 1998-01-15

Family

ID=3775765

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92309684T ATE161836T1 (de) 1991-10-23 1992-10-22 4-substituierte-2-deoxy-2,3-didehydro alpha-d- neuraminsäure antivirale derivate

Country Status (11)

Country Link
EP (1) EP0539204B1 (de)
JP (1) JP2925863B2 (de)
AT (1) ATE161836T1 (de)
AU (1) AU659501B2 (de)
CA (1) CA2081068C (de)
DE (1) DE69223914T2 (de)
DK (1) DK0539204T3 (de)
ES (1) ES2113413T3 (de)
GR (1) GR3026218T3 (de)
HK (1) HK1015137A1 (de)
ZA (1) ZA928170B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9220241D0 (en) * 1992-09-25 1992-11-11 Glaxo Group Ltd Process
GB9220327D0 (en) * 1992-09-25 1992-11-11 Glaxo Group Ltd Process
GB9325841D0 (en) * 1993-12-17 1994-02-23 Glaxo Group Ltd Chemical compounds
AUPM354694A0 (en) * 1994-01-27 1994-02-17 Biota Scientific Management Pty Ltd Chemical compounds
GB9410817D0 (en) * 1994-05-28 1994-07-20 Glaxo Group Ltd Medicaments
US5561146A (en) * 1994-06-10 1996-10-01 Bristol-Myers Squibb Company Modified guanidino and amidino thrombin inhibitors
US5512596A (en) * 1994-09-02 1996-04-30 Gilead Sciences, Inc. Aromatic compounds
US5866601A (en) * 1995-02-27 1999-02-02 Gilead Sciences, Inc. Carbocyclic compounds
SI9620042A (sl) * 1995-02-27 1998-12-31 Gilead Sciences, Inc. Novi selektivni inhibitorji virusnih ali bakterijskih neuraminidaz
CA2546660C (en) * 1995-02-27 2009-08-11 Gilead Sciences Inc. Selective inhibitors of viral or bacterial neuraminidase
US5602277A (en) * 1995-03-30 1997-02-11 Biocryst Pharmaceuticals, Inc. Substituted benzene derivatives useful as neuraminidase inhibitors
WO1996036628A1 (en) * 1995-05-19 1996-11-21 Biota Scientific Management Pty. Ltd. 6-carboxamido dihydropyran derivatives
GB9516276D0 (en) * 1995-08-08 1995-10-11 Biota Scient Management Chemical compounds
US5763483A (en) * 1995-12-29 1998-06-09 Gilead Sciences, Inc. Carbocyclic compounds
US6340702B1 (en) 1996-07-22 2002-01-22 Sankyo Company, Limited Neuraminic acid derivatives, their preparation and their medical use
US6451766B1 (en) 1996-07-22 2002-09-17 Sankyo Company, Limited Neuraminic acid derivatives, their preparation and their medical use
PT823428E (pt) * 1996-07-22 2002-04-29 Sankyo Co Derivados do acido neuraminico sua preparacao e sua utilizacao em medicina
PT934939E (pt) * 1996-08-13 2003-07-31 Sankyo Co Compostos de acido neuraminico
US6518438B2 (en) 1996-08-23 2003-02-11 Gilead Sciences, Inc. Preparation of cyclohexene carboxylate derivatives
US5859284A (en) * 1996-08-23 1999-01-12 Gilead Sciences, Inc. Preparation of carbocyclic compounds
AU711845B2 (en) * 1996-09-10 1999-10-21 Daikin Industries, Ltd. 4-substituted-2,7-dideoxy-7-fluoro-2,3-didehydro-sialic acid compounds
US5994377A (en) 1996-10-21 1999-11-30 Gilead Sciences, Inc. Piperidine compounds
AU743333B2 (en) * 1996-10-21 2002-01-24 Gilead Sciences, Inc. Piperidine compounds
BR9714299A (pt) * 1996-11-14 2000-04-25 Biota Scient Mangent Pty Ltd Composto macromolecular, processos para detecção de virus da influenza e tratamento de infeção da influenza, composição farmacêutica para esse tratamento e utilização de composto
US5886213A (en) * 1997-08-22 1999-03-23 Gilead Sciences, Inc. Preparation of carbocyclic compounds
TW480247B (en) * 1997-12-12 2002-03-21 Gilead Sciences Inc Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
US6608081B2 (en) 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6593314B1 (en) 1999-10-19 2003-07-15 Abbott Laboratories Neuraminidase inhibitors
WO2002092555A1 (fr) * 2001-05-11 2002-11-21 Sankyo Company, Limited Derives d'acides sialiques
PL215419B1 (pl) 2003-02-10 2013-12-31 Nippon Catalytic Chem Ind Srodek pochlaniajacy wode
WO2008090151A1 (en) 2007-01-23 2008-07-31 Therapicon Srl Antiviral compounds
WO2009004899A1 (ja) * 2007-06-15 2009-01-08 National University Corporation Hokkaido University シアリダーゼ阻害剤
JP2012510456A (ja) 2008-11-28 2012-05-10 シプラ・リミテッド ザナミビルの製造方法及び該方法に使用するための中間体
KR20120025519A (ko) 2009-05-15 2012-03-15 레드엑스 파마 리미티드 산화환원 약물 유도체
IT1396620B1 (it) 2009-11-25 2012-12-14 Therapicon Srl Analoghi chimerici
US20140073804A1 (en) 2011-02-24 2014-03-13 Ganpat Dan Shimbhu CHARAN Process for the preparation of zanamivir
DE102011117128A1 (de) * 2011-10-28 2013-05-02 Christian-Albrechts-Universität Zu Kiel Verbindungen zur Therapie der Influenza

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP249A (en) * 1990-04-24 1993-03-17 Biota Scient Management Pty Ltd Anti-viral compounds.
GB9220241D0 (en) * 1992-09-25 1992-11-11 Glaxo Group Ltd Process

Also Published As

Publication number Publication date
EP0539204B1 (de) 1998-01-07
GR3026218T3 (en) 1998-05-29
CA2081068A1 (en) 1993-04-24
CA2081068C (en) 2005-11-29
HK1015137A1 (en) 1999-10-08
DE69223914T2 (de) 1998-04-30
EP0539204A1 (de) 1993-04-28
ZA928170B (en) 1993-11-15
AU2724292A (en) 1993-04-29
JPH0625209A (ja) 1994-02-01
JP2925863B2 (ja) 1999-07-28
AU659501B2 (en) 1995-05-18
DE69223914D1 (de) 1998-02-12
ES2113413T3 (es) 1998-05-01
DK0539204T3 (da) 1998-09-07

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee