DE69306505D1 - Trifluormethylketon Peptid Derivate mit HLE-inhibierende Aktivität, deren Herstellung und pharmazeutischen Zusammensetzungen - Google Patents

Trifluormethylketon Peptid Derivate mit HLE-inhibierende Aktivität, deren Herstellung und pharmazeutischen Zusammensetzungen

Info

Publication number
DE69306505D1
DE69306505D1 DE69306505T DE69306505T DE69306505D1 DE 69306505 D1 DE69306505 D1 DE 69306505D1 DE 69306505 T DE69306505 T DE 69306505T DE 69306505 T DE69306505 T DE 69306505T DE 69306505 D1 DE69306505 D1 DE 69306505D1
Authority
DE
Germany
Prior art keywords
preparation
pharmaceutical compositions
inhibitory activity
peptide derivatives
trifluoromethyl ketone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69306505T
Other languages
English (en)
Other versions
DE69306505T2 (de
Inventor
Michel Vincent
Nanteuil Guillaume De
Georges Remond
Bernard Portevin
Yolande Herve
Michel Lonchampt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of DE69306505D1 publication Critical patent/DE69306505D1/de
Publication of DE69306505T2 publication Critical patent/DE69306505T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69306505T 1992-07-28 1993-07-27 Trifluormethylketon Peptid Derivate mit HLE-inhibierende Aktivität, deren Herstellung und pharmazeutischen Zusammensetzungen Expired - Fee Related DE69306505T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9209254A FR2694295B1 (fr) 1992-07-28 1992-07-28 Nouveaux peptides dérivés de trifluoromethylcetones, leur procéde de préparation et les compositions pharmaceutiques qui les contiennent.

Publications (2)

Publication Number Publication Date
DE69306505D1 true DE69306505D1 (de) 1997-01-23
DE69306505T2 DE69306505T2 (de) 1997-06-19

Family

ID=9432302

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69306505T Expired - Fee Related DE69306505T2 (de) 1992-07-28 1993-07-27 Trifluormethylketon Peptid Derivate mit HLE-inhibierende Aktivität, deren Herstellung und pharmazeutischen Zusammensetzungen

Country Status (12)

Country Link
US (1) US5565429A (de)
EP (1) EP0585155B1 (de)
JP (1) JPH0826066B2 (de)
AT (1) ATE146186T1 (de)
AU (1) AU662232B2 (de)
CA (1) CA2101350A1 (de)
DE (1) DE69306505T2 (de)
DK (1) DK0585155T3 (de)
ES (1) ES2098004T3 (de)
FR (1) FR2694295B1 (de)
GR (1) GR3022631T3 (de)
NZ (1) NZ248263A (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2701951B1 (fr) * 1993-02-24 1995-06-09 Adir Nouveaux derives peptidiques de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
CA2118985A1 (en) * 1993-04-02 1994-10-03 Dinesh V. Patel Heterocyclic inhibitors of farnesyl protein transferase
US5756810A (en) * 1994-03-11 1998-05-26 Pharmacopeia, Inc. Process of preparing 3-nitro benzoate compounds in lower alkanol
FR2719589B1 (fr) * 1994-05-05 1996-06-14 Adir Nouveaux peptides dérivés de trifluorométhylcétones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US6001813A (en) * 1994-11-21 1999-12-14 Cortech Inc. Val-pro containing α-keto oxadiazoles as serine protease inhibitors
US6001811A (en) * 1994-11-21 1999-12-14 Cortech Inc. Serine protease inhibitors--N-substituted derivatives
US5998379A (en) * 1994-11-21 1999-12-07 Cortech Inc. Serine protease inhibitors-proline analogs
US20020119985A1 (en) 1994-11-21 2002-08-29 Albert Gyorkos Serine protease inhibitors
US6015791A (en) * 1994-11-21 2000-01-18 Cortech Inc. Serine protease inhibitors-cycloheptane derivatives
US6001814A (en) * 1994-11-21 1999-12-14 Cortech Inc. Serine protease inhibitors
US6159938A (en) * 1994-11-21 2000-12-12 Cortech, Inc. Serine protease inhibitors comprising α-keto heterocycles
US6150334A (en) * 1994-11-21 2000-11-21 Cortech, Inc. Serine protease inhibitors-tripeptoid analogs
US6100238A (en) * 1994-11-21 2000-08-08 Cortech Inc. Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors
US5618792A (en) * 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
HUP0100669A3 (en) * 1996-12-06 2001-12-28 Cortech Inc Denver Peptide derivatives as serine protease inhibitors, their use and pharmaceutical compositions comprising thereof
US6004933A (en) * 1997-04-25 1999-12-21 Cortech Inc. Cysteine protease inhibitors
US6656910B2 (en) 1997-12-04 2003-12-02 Cortech, Inc. Serine protease inhibitors
US6610748B1 (en) * 1998-02-24 2003-08-26 Fujisawa Pharmaceutical Co., Ltd. Preventives/remedies for skin aging
EP1135151A4 (de) 1998-06-03 2002-01-02 Cortech Inc Alpha-keto oxadiazole enthaltende peptoide und nichtpeptoide als serinprotease hemmstoffe
JP2002531464A (ja) 1998-12-02 2002-09-24 メルク フロスト カナダ アンド カンパニー カスパーゼ−３阻害薬としてのγ−ケト酸テトラペプチド類
JP4212358B2 (ja) 2000-12-28 2009-01-21 第一三共株式会社 Ｖｌａ−４阻害薬
AR037097A1 (es) * 2001-10-05 2004-10-20 Novartis Ag Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento
JP4676884B2 (ja) 2003-07-24 2011-04-27 第一三共株式会社 シクロヘキサンカルボン酸類
FR2942797B1 (fr) * 2009-03-03 2011-04-29 Pf Medicament Derives de benzothiazines, leur preparation et leur application a titre de medicaments
EP2590951B1 (de) 2010-07-09 2015-01-07 Pfizer Limited Benzolsulfonamide als kaliumkanalhemmer
US8772343B2 (en) 2010-07-12 2014-07-08 Pfizer Limited Chemical compounds
JP2013532185A (ja) 2010-07-12 2013-08-15 ファイザー・リミテッド 化合物
ES2525581T3 (es) 2010-07-12 2014-12-26 Pfizer Limited Derivados de N-sulfonilbenzamida útiles como inhibidores del canal de sodio dependiente de voltaje
US9102621B2 (en) 2010-07-12 2015-08-11 Pfizer Limited Acyl sulfonamide compounds
WO2012007883A1 (en) 2010-07-12 2012-01-19 Pfizer Limited Sulfonamide derivatives as nav1.7 inhibitors for the treatment of pain

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
FR2585709B1 (fr) * 1985-08-05 1987-10-02 Adir Nouveaux derives peptidiques a structure lactonique ou cycloamidique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP0276101A3 (de) * 1987-01-19 1989-11-23 Ici Americas Inc. Substituierte Peptid-Derivate
EP0369391A3 (de) * 1988-11-15 1991-09-25 Boehringer Ingelheim Pharmaceuticals Inc. N-substituierte Amide
FR2649110B1 (fr) * 1989-06-29 1994-10-21 Adir Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5221665A (en) * 1989-10-27 1993-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. N-substituted amides
FR2663336B1 (fr) * 1990-06-18 1992-09-04 Adir Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof

Also Published As

Publication number Publication date
JPH06184192A (ja) 1994-07-05
FR2694295A1 (fr) 1994-02-04
ATE146186T1 (de) 1996-12-15
ES2098004T3 (es) 1997-04-16
AU4218093A (en) 1994-02-03
JPH0826066B2 (ja) 1996-03-13
EP0585155A1 (de) 1994-03-02
DE69306505T2 (de) 1997-06-19
EP0585155B1 (de) 1996-12-11
US5565429A (en) 1996-10-15
DK0585155T3 (da) 1997-06-09
AU662232B2 (en) 1995-08-24
FR2694295B1 (fr) 1994-09-02
NZ248263A (en) 1994-12-22
CA2101350A1 (fr) 1994-01-29
GR3022631T3 (en) 1997-05-31

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee