WO1995013280A3 - 1,3,8,10 tetrasubstituted derivatives of 4,5,6,7-tetrathiocino-(1,2-b:3,4-b')-diimidazolyl-2,9-dithione, their preparation and their use as antitumor agent - Google Patents

1,3,8,10 tetrasubstituted derivatives of 4,5,6,7-tetrathiocino-(1,2-b:3,4-b')-diimidazolyl-2,9-dithione, their preparation and their use as antitumor agent Download PDF

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Publication number
WO1995013280A3
WO1995013280A3 PCT/EP1994/003665 EP9403665W WO9513280A3 WO 1995013280 A3 WO1995013280 A3 WO 1995013280A3 EP 9403665 W EP9403665 W EP 9403665W WO 9513280 A3 WO9513280 A3 WO 9513280A3
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WO
WIPO (PCT)
Prior art keywords
tetrathiocino
diimidazolyl
dithione
preparation
antitumor agent
Prior art date
Application number
PCT/EP1994/003665
Other languages
French (fr)
Other versions
WO1995013280A2 (en
Inventor
Colla Paolo La
Emanuele Trogu
Paola Deplano
Original Assignee
Univ Cagliari
Colla Paolo
Emanuele Trogu
Paola Deplano
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cagliari, Colla Paolo, Emanuele Trogu, Paola Deplano filed Critical Univ Cagliari
Priority to AU80613/94A priority Critical patent/AU8061394A/en
Publication of WO1995013280A2 publication Critical patent/WO1995013280A2/en
Publication of WO1995013280A3 publication Critical patent/WO1995013280A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,3,8,10 tetrasubstituted compounds of 4,5,6,7-tetrathiocino-(1,2-b:3,4-b')-diimidazolyl-2,9 dithione of formula (I), wherein R is selected from the class consisting of: C3-C5 linear or branched alkyl, benzyl, 2-thiophenyl-methyl. Therapeutical compositions having antitumor activity containing as the active principle at least one derivative of formula (I), wherein the R substituent is selected from the class consisting of C1-C5 linear or branched alkyl, phenyl, o-tolyl, benzyl, 2-thiophenylmethyl, in combination with suitable excipients and/or diluents.
PCT/EP1994/003665 1993-11-09 1994-11-08 1,3,8,10 TETRASUBSTITUTED DERIVATIVES OF 4,5,6,7-TETRATHIOCINO-(1,2-b:3,4-b')-DIIMIDAZOLYL-2,9-DITHIONE, THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENT WO1995013280A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU80613/94A AU8061394A (en) 1993-11-09 1994-11-08 1,3,8,10 tetrasubstituted derivatives of 4,5,6,7-tetrathiocino-(1,2-b:3,4-b')-diimidazolyl-2,9-dithio ne, their preparation and their use as antitumor agent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT93MI002377A IT1266787B1 (en) 1993-11-09 1993-11-09 THERAPEUTIC COMPOSITIONS WITH ANTI-CANCER ACTIVITY BASED ON 1,3,8,10 TETRASUSTITUTED DERIVATIVES OF 4,5,6,7-TETRATHIOCYNO-(1,2-B: 3,4-B')-
ITMI93A002377 1993-11-09

Publications (2)

Publication Number Publication Date
WO1995013280A2 WO1995013280A2 (en) 1995-05-18
WO1995013280A3 true WO1995013280A3 (en) 1995-06-15

Family

ID=11367172

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1994/003665 WO1995013280A2 (en) 1993-11-09 1994-11-08 1,3,8,10 TETRASUBSTITUTED DERIVATIVES OF 4,5,6,7-TETRATHIOCINO-(1,2-b:3,4-b')-DIIMIDAZOLYL-2,9-DITHIONE, THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENT

Country Status (3)

Country Link
AU (1) AU8061394A (en)
IT (1) IT1266787B1 (en)
WO (1) WO1995013280A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4210716A (en) * 1979-01-31 1980-07-01 E. I. Du Pont De Nemours And Company Silver halide emulsion containing tetrathiocino diisothiazoles as antifoggers

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4210716A (en) * 1979-01-31 1980-07-01 E. I. Du Pont De Nemours And Company Silver halide emulsion containing tetrathiocino diisothiazoles as antifoggers

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
ALLEN D.W. ET AL.: "Synthesis of novel macrocyclic compounds containing sulphur or oxygen in the ring: Thia- and oxa-cyclophanes. Mass spectral and other studies", JOURNAL OF THE CHEMICAL SOCIETY, SECTION C, no. 20, 1971, pages 3454 - 3466 *
ATZEI D. ET AL,: "Interaction of diiodine with Et4todit = 4,5,6,7-tetrathiocino[1,2-b:3,4-b']diimidazolyl-1,3,8,10-tetraethyl-2,9-dithione. Crystal and molecular structure of Et4todit.2I2", CANADIAN JOURNAL OF CHEMISTRY, vol. 67, no. 9, September 1989 (1989-09-01), pages 1416 - 1420 *
BIGOLI F. ET AL.: "Synthesis of some 4,5,6,7-tetrathiocino[1,2-b:3,4-b']diimidazolyl-1,3,8,10-tetrasubstituted-2,9-dithiones and crystal structure of the tetraethyl derivative", PHOSPHORUS AND SULFUR, vol. 37, no. 3-4, 1988, pages 189 - 194 *
CHEMICAL ABSTRACTS, vol. 96, no. 1, 4 January 1982, Columbus, Ohio, US; abstract no. 1976s, MONTANARI L. ET AL.: "Antifungal activity of 3,3'-diindolyl-2,2'-tetrasulfide" page 180; column 2; *
DODSON R.M. ET AL.: "Disulfur monoxide. Reaction with dienes", JOURNAL OF ORGANIC CHEMISTRY, vol. 37, no. 15, 28 July 1972 (1972-07-28), pages 2367 - 2372 *
HINO T. ET AL.: "Thiation of oxindoles: Formation of indole derivatives", CHEMISTRY AND INDUSTRY (LONDON), no. 7, 18 February 1967 (1967-02-18), pages 275 - 276 *
IL FARMACO, ED. SCI., vol. 36, no. 10, 1981, pages 856 - 861 *
NICOLAOU K.C. ET AL.: "Dithiatopazine and related systems. Synthesis, chemistry, X-ray crytallographic analysis and calculations", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 112, no. 8, 11 April 1990 (1990-04-11), pages 3029 - 3039 *
SCHROTH W. ET AL.: "Concerning the questionable existence of thioxoindigoid compounds", ANGEWANDTE CHEMIE INT. ED. ENGL., vol. 33, no. 7, 18 April 1994 (1994-04-18), pages 739 - 741 *
WILLIAMS C.R. & HARPP D.N.: "Reaction of chloro(triphenylmethyl)disulfide with 1,3-dienes: Synthesis of cyclic di- and tetrasulfides", TETRAHEDRON LETTERS, vol. 32, no. 52, 23 December 1991 (1991-12-23), pages 7651 - 7654 *

Also Published As

Publication number Publication date
ITMI932377A0 (en) 1993-11-09
ITMI932377A1 (en) 1995-05-09
AU8061394A (en) 1995-05-29
IT1266787B1 (en) 1997-01-21
WO1995013280A2 (en) 1995-05-18

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