EA199700209A1 - ПРОИЗВОДНЫЕ ИМИДАЗО[1,2-a]ПИРИДИНА - Google Patents

ПРОИЗВОДНЫЕ ИМИДАЗО[1,2-a]ПИРИДИНА

Info

Publication number
EA199700209A1
EA199700209A1 EA199700209A EA199700209A EA199700209A1 EA 199700209 A1 EA199700209 A1 EA 199700209A1 EA 199700209 A EA199700209 A EA 199700209A EA 199700209 A EA199700209 A EA 199700209A EA 199700209 A1 EA199700209 A1 EA 199700209A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
halogen
formula
imidazo
pyridine derivatives
Prior art date
Application number
EA199700209A
Other languages
English (en)
Inventor
Пол Джон Бесвик
Айан Бэкстер Кэмпбелл
Элан Нейлор
Original Assignee
Глаксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9506965.4A external-priority patent/GB9506965D0/en
Priority claimed from GBGB9512099.4A external-priority patent/GB9512099D0/en
Priority claimed from GBGB9516117.0A external-priority patent/GB9516117D0/en
Application filed by Глаксо Груп Лимитед filed Critical Глаксо Груп Лимитед
Publication of EA199700209A1 publication Critical patent/EA199700209A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

В изобретении предлагаются соединения формулы (I) и их фармацевтически приемлемые производные, в которых Rобозначает галоген; Rи Rнезависимо выбраны из H, галогена, Cалкила, Cалкила, замещенного одним или большим числом атомов фтора, Cалкоксила, Cгидроксиалкила, SCалкила, C(O)H или C(O)Cалкила; Rобозначает Cалкил. Соединения формулы (I) являются сильными и селективными ингибиторами COX-2 и применяются для лечения боли, лихорадки, воспаления при ряде состояний и заболеваний.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199700209A 1995-04-04 1996-04-02 ПРОИЗВОДНЫЕ ИМИДАЗО[1,2-a]ПИРИДИНА EA199700209A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9506965.4A GB9506965D0 (en) 1995-04-04 1995-04-04 Chemical compounds
GBGB9512099.4A GB9512099D0 (en) 1995-06-14 1995-06-14 Chemical compounds
GBGB9516117.0A GB9516117D0 (en) 1995-08-05 1995-08-05 Chemical compounds
PCT/EP1996/001438 WO1996031509A1 (en) 1995-04-04 1996-04-02 IMIDAZO[1,2-a]PYRIDINE DERIVATIVES

Publications (1)

Publication Number Publication Date
EA199700209A1 true EA199700209A1 (ru) 1998-04-30

Family

ID=27267657

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700209A EA199700209A1 (ru) 1995-04-04 1996-04-02 ПРОИЗВОДНЫЕ ИМИДАЗО[1,2-a]ПИРИДИНА

Country Status (17)

Country Link
EP (1) EP0819127A1 (ru)
JP (1) JPH11501049A (ru)
KR (1) KR19980703559A (ru)
CN (1) CN1186492A (ru)
AU (1) AU5276696A (ru)
BG (1) BG101934A (ru)
CA (1) CA2216809A1 (ru)
CZ (1) CZ313397A3 (ru)
EA (1) EA199700209A1 (ru)
HU (1) HUP9801602A3 (ru)
IS (1) IS4570A (ru)
NO (1) NO974595L (ru)
NZ (1) NZ304886A (ru)
PL (1) PL322623A1 (ru)
SK (1) SK133297A3 (ru)
TR (1) TR199701105T1 (ru)
WO (1) WO1996031509A1 (ru)

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FR2771005B1 (fr) * 1997-11-18 2002-06-07 Union Pharma Scient Appl Nouvelle association pharmaceutique a activite analgesique
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ES2140354B1 (es) * 1998-08-03 2000-11-01 S A L V A T Lab Sa Imidazo (1,2a) azinas sustituidas como inhibidores selectivos de la cox-2.
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DE69919887T2 (de) * 1998-11-03 2005-09-15 Glaxo Group Ltd., Greenford Pyrazolopyridin derivative als selektive cox-2 inhibitoren
ATE261444T1 (de) * 1999-02-27 2004-03-15 Glaxo Group Ltd Pyrazolopyridine
GB9930358D0 (en) 1999-12-22 2000-02-09 Glaxo Group Ltd Process for the preparation of chemical compounds
NZ519781A (en) 1999-12-23 2004-04-30 Nitromed Inc Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
GB0002312D0 (en) * 2000-02-01 2000-03-22 Glaxo Group Ltd Medicaments
PE20011333A1 (es) 2000-03-16 2002-01-16 Almirall Prodesfarma Ag Derivados de 2-fenilpiran-4-ona como inhibidores de ciclooxigenasa 2
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
DK1303265T3 (da) 2000-07-20 2007-11-12 Lauras As Anvendelse af COX-2-inhibitorer, som immunostimulerende midler ved behandling af HIV eller AIDS
PE20020506A1 (es) * 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
GB0025449D0 (en) * 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
US6919352B2 (en) 2000-12-15 2005-07-19 Smithkline Beecham Corporation Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds
DE60112330T2 (de) 2000-12-15 2006-04-13 Glaxo Group Ltd., Greenford Pyrazolopyridinderivate
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CN1518550A (zh) 2001-06-21 2004-08-04 ʷ��˿�������ȳ�ķ���޹�˾ 用于预防和治疗疱疹病毒感染的咪唑并[1,2-a]吡啶衍生物
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
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GB0124936D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124938D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124939D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124934D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124933D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124941D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124931D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
JP2005516916A (ja) 2001-12-11 2005-06-09 スミスクライン ビーチャム コーポレーション 抗ヘルペス薬としてのピラゾロ−ピリジン誘導体
ATE485275T1 (de) 2002-02-12 2010-11-15 Glaxosmithkline Llc Nicotinamide und deren verwendung als p38 inhibitoren
AU2003279622A1 (en) 2002-06-28 2004-01-19 Nitromed, Inc. Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use
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Also Published As

Publication number Publication date
WO1996031509A1 (en) 1996-10-10
JPH11501049A (ja) 1999-01-26
PL322623A1 (en) 1998-02-02
SK133297A3 (en) 1998-07-08
AU5276696A (en) 1996-10-23
NZ304886A (en) 1998-11-25
NO974595L (no) 1997-12-03
KR19980703559A (ko) 1998-11-05
HUP9801602A3 (en) 1999-01-28
BG101934A (en) 1999-04-30
EP0819127A1 (en) 1998-01-21
IS4570A (is) 1997-09-25
CZ313397A3 (cs) 1998-03-18
TR199701105T1 (xx) 1998-02-21
HUP9801602A2 (hu) 1998-11-30
CN1186492A (zh) 1998-07-01
NO974595D0 (no) 1997-10-03
MX9707379A (es) 1997-11-29
CA2216809A1 (en) 1996-10-10

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