EA199800701A1 - БЕНЗО[С]ХИНОЛИЗИНОВЫЕ ПРОИЗВОДНЫЕ, ИХ ПОЛУЧЕНИЕ И ИСПОЛЬЗОВАНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ 5a-РЕДУКТАЗ - Google Patents

БЕНЗО[С]ХИНОЛИЗИНОВЫЕ ПРОИЗВОДНЫЕ, ИХ ПОЛУЧЕНИЕ И ИСПОЛЬЗОВАНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ 5a-РЕДУКТАЗ

Info

Publication number
EA199800701A1
EA199800701A1 EA199800701A EA199800701A EA199800701A1 EA 199800701 A1 EA199800701 A1 EA 199800701A1 EA 199800701 A EA199800701 A EA 199800701A EA 199800701 A EA199800701 A EA 199800701A EA 199800701 A1 EA199800701 A1 EA 199800701A1
Authority
EA
Eurasian Patent Office
Prior art keywords
benzo
derivatives
reductaz
quinolysinum
inhibitors
Prior art date
Application number
EA199800701A
Other languages
English (en)
Other versions
EA000975B1 (ru
Inventor
Антонио Гуарна
Марио Серио
Original Assignee
Апплайд Резеч Системз Арс Холдинг Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Апплайд Резеч Системз Арс Холдинг Н.В. filed Critical Апплайд Резеч Системз Арс Холдинг Н.В.
Publication of EA199800701A1 publication Critical patent/EA199800701A1/ru
Publication of EA000975B1 publication Critical patent/EA000975B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Настоящее изобретение относится к бензо[с]хинолизиновым производным общей формулы (I), их фармацевтически приемлемым солям или эфирам, способам их получения и содержащим их фармацевтическим композициям.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800701A 1996-02-09 1997-02-07 БЕНЗО[С]ХИНОЛИЗИНОВЫЕ ПРОИЗВОДНЫЕ, ИХ ПОЛУЧЕНИЕ И ИСПОЛЬЗОВАНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ 5α-РЕДУКТАЗ EA000975B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96FI000019A IT1286545B1 (it) 1996-02-09 1996-02-09 Derivati benzo(c) chinolizinici,loro preparazione ed uso come inibitori delle 5-alfa-riduttasi
PCT/EP1997/000552 WO1997029107A1 (en) 1996-02-09 1997-02-07 BENZO[C]QUINOLIZINE DERIVATIVES, THEIR PREPARATION AND USE AS 5α-REDUCTASES INHIBITORS

Publications (2)

Publication Number Publication Date
EA199800701A1 true EA199800701A1 (ru) 1999-02-25
EA000975B1 EA000975B1 (ru) 2000-08-28

Family

ID=11351478

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800701A EA000975B1 (ru) 1996-02-09 1997-02-07 БЕНЗО[С]ХИНОЛИЗИНОВЫЕ ПРОИЗВОДНЫЕ, ИХ ПОЛУЧЕНИЕ И ИСПОЛЬЗОВАНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ 5α-РЕДУКТАЗ

Country Status (26)

Country Link
US (3) US6303622B1 (ru)
EP (1) EP0880520B1 (ru)
JP (1) JP2000504680A (ru)
KR (1) KR100480448B1 (ru)
CN (1) CN1116296C (ru)
AT (1) ATE237614T1 (ru)
AU (1) AU711886C (ru)
BG (1) BG64596B1 (ru)
CZ (1) CZ298061B6 (ru)
DE (1) DE69720966T2 (ru)
DK (1) DK0880520T3 (ru)
EA (1) EA000975B1 (ru)
EE (1) EE04058B1 (ru)
ES (1) ES2192263T3 (ru)
HK (1) HK1018783A1 (ru)
HU (1) HUP9900509A3 (ru)
IL (2) IL125628A0 (ru)
IT (1) IT1286545B1 (ru)
MX (1) MX9806229A (ru)
NO (2) NO320155B1 (ru)
NZ (1) NZ331256A (ru)
PL (1) PL187618B1 (ru)
PT (1) PT880520E (ru)
SK (1) SK283299B6 (ru)
UA (1) UA67724C2 (ru)
WO (1) WO1997029107A1 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITFI970193A1 (it) * 1997-08-01 1999-02-01 Applied Research Systems Uso di derivati benzo(c) chinolizinici come regolatori della crescita delle piante e composizioni ad uso agricolo che contengono tali
EP0926148A1 (en) * 1997-12-23 1999-06-30 Applied Research Systems Ars Holding N.V. Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors
SK285438B6 (sk) * 1998-08-03 2007-01-04 Applied Research Systems Ars Holding N. V. Spôsob prípravy (1H)-benzo[c]chinolizín-3-ových derivátov
RS53599B1 (en) 2005-05-10 2015-02-27 Intermune, Inc. PIRIDON DERIVATIVES FOR STRESS MODULATION OF ACTIVATED PROTEIN KINASE SYSTEMS
US20070155738A1 (en) 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
EP1910367A2 (en) * 2005-05-20 2008-04-16 Alantos Pharmaceuticals, Inc. Pyrimidine or triazine fused bicyclic metalloprotease inhibitors
CA2726588C (en) 2008-06-03 2019-04-16 Karl Kossen Compounds and methods for treating inflammatory and fibrotic disorders
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
KR102373700B1 (ko) 2014-04-02 2022-03-11 인터뮨, 인크. 항섬유성 피리디논
CN105001216B (zh) * 2015-07-08 2017-03-01 中国科学院兰州化学物理研究所 一种喹嗪酮的制备方法
CN107089980B (zh) * 2017-05-11 2019-08-30 合肥工业大学 一种手性苯并[a]喹嗪-2-酮类化合物及其不对称催化合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1534278A (fr) 1966-08-15 1968-07-26 Bristol Myers Co Procédé de fabrication de 1, 4-dihydroquinoléine-n-carboxylates d'alcoyle
US3455929A (en) * 1966-08-15 1969-07-15 Bristol Myers Co Esters of 1,4-dihydroquinoline-n-carboxylic acids and thione acids
US3625877A (en) * 1968-01-08 1971-12-07 Eastman Kodak Co High-modulus polycarbonate compositions
SU1027166A1 (ru) 1981-09-11 1983-07-07 Киевский Ордена Ленина Государственный Университет Им.Т.Г.Шевченко Способ получени 1,2-полиметиленкетоцианоазагетероциклов
IE57014B1 (en) 1983-03-25 1992-03-11 Wyeth John & Brother Ltd Benzoquinolizines

Also Published As

Publication number Publication date
KR19990082126A (ko) 1999-11-15
US6303622B1 (en) 2001-10-16
BG102661A (en) 1999-04-30
PL328123A1 (en) 1999-01-18
CZ228998A3 (cs) 1998-10-14
BG64596B1 (bg) 2005-08-31
ATE237614T1 (de) 2003-05-15
US6552034B2 (en) 2003-04-22
DE69720966D1 (de) 2003-05-22
SK104498A3 (en) 1998-12-02
DK0880520T3 (da) 2003-08-11
ES2192263T3 (es) 2003-10-01
PT880520E (pt) 2003-07-31
MX9806229A (es) 1998-11-30
EP0880520B1 (en) 2003-04-16
CN1116296C (zh) 2003-07-30
CZ298061B6 (cs) 2007-06-06
US6555549B2 (en) 2003-04-29
HUP9900509A3 (en) 1999-11-29
NO320155B1 (no) 2005-11-07
AU711886C (en) 2002-10-17
WO1997029107A1 (en) 1997-08-14
AU1767297A (en) 1997-08-28
IL125628A (en) 2006-10-31
ITFI960019A1 (it) 1997-08-09
AU711886B2 (en) 1999-10-21
JP2000504680A (ja) 2000-04-18
EA000975B1 (ru) 2000-08-28
DE69720966T2 (de) 2004-05-19
HUP9900509A2 (hu) 1999-06-28
PL187618B1 (pl) 2004-08-31
SK283299B6 (sk) 2003-05-02
HK1018783A1 (en) 2000-01-07
EE9800233A (et) 1998-12-15
US20010044542A1 (en) 2001-11-22
EE04058B1 (et) 2003-06-16
ITFI960019A0 (ru) 1996-02-09
IL125628A0 (en) 1999-04-11
KR100480448B1 (ko) 2005-08-31
NO983444D0 (no) 1998-07-24
CN1210536A (zh) 1999-03-10
EP0880520A1 (en) 1998-12-02
NO983444L (no) 1998-07-24
NO20045132L (no) 1998-07-24
NZ331256A (en) 1999-06-29
US20010047098A1 (en) 2001-11-29
IT1286545B1 (it) 1998-07-15
UA67724C2 (en) 2004-07-15

Similar Documents

Publication Publication Date Title
EA200200360A1 (ru) Производные пурина
EA200201179A1 (ru) Производные 2-аминокарбонил-9h-пурина
EA200101203A1 (ru) Производные пурина
ES2162676T3 (es) Derivados de fenileno sustituidos en meta y su uso como antagonistas o inhibidores de integrina alfav,beta3.
EA199900183A1 (ru) Производные индазола и их использование в качестве ингибиторов фосфодиэстеразы (фдэ) типа iv и продуцирования фактора некроза опухоли (фно)
EA200100972A1 (ru) Новые соединения и композиции как ингибиторы протеаз
EA200200770A1 (ru) Производные пурина
EA200000920A1 (ru) Производные бициклических гидроксамовых кислот
EA200300354A1 (ru) Хинолиноновые производные в качестве ингибиторов тирозинкиназы
ATE253545T1 (de) Biarylessigsäure-derivate und ihre verwendung als cox-2 inhibitoren
ES2179318T3 (es) Derivados de acido cinamico y su uso como antagonistas de integrina.
EA199900855A1 (ru) Соль производного нафтиридинкарбоновой кислоты
EA199800701A1 (ru) БЕНЗО[С]ХИНОЛИЗИНОВЫЕ ПРОИЗВОДНЫЕ, ИХ ПОЛУЧЕНИЕ И ИСПОЛЬЗОВАНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ 5a-РЕДУКТАЗ
AR010984A1 (es) Nuevos esteres de la pleuromutilina, y el acido 1-azabiciclo-4- carbanilcarbanico; procedimiento para su preparacion y composicionesfarmaceuticas que los contienen.
ATE204278T1 (de) Serotoninergische ergolin derivate
EA200100984A1 (ru) Новые кристаллические формы макролидного антибиотика
AU1998995A (en) Substituted fused and bridged bicyclic compounds as therapeutic agents
ES2086195T3 (es) Nuevos derivados pseudopeptidicos de actividad antagonista de la bradiquinina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ATE241624T1 (de) Benzo(f)naphthyridinderivate, ihre herstellung und sie enthaltende pharmazeutische zusammenstzungen
EA200000697A1 (ru) ПРОИЗВОДНЫЕ БЕНЗО[C]ХИНОЛИЗИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ 5α-РЕДУКТАЗ
CA2245758A1 (en) Benzo[c]quinolizine derivatives, their preparation and use as 5.alpha.-reductases inhibitors
EA200100953A1 (ru) L-арабино-дисахариды антрациклинов, способы их получения и фармацевтические композиции, содержащие их
ATE268768T1 (de) Antithrombosemittel
EA200301315A1 (ru) Новые соединения и композиции в качестве ингибиторов катепсиса

Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title