EE04058B1 - Benso[c]kinolisiini derivaadid, nende valmistamine ja kasutamine 5a-reduktaasi inhibiitoritena - Google Patents

Benso[c]kinolisiini derivaadid, nende valmistamine ja kasutamine 5a-reduktaasi inhibiitoritena

Info

Publication number
EE04058B1
EE04058B1 EE9800233A EE9800233A EE04058B1 EE 04058 B1 EE04058 B1 EE 04058B1 EE 9800233 A EE9800233 A EE 9800233A EE 9800233 A EE9800233 A EE 9800233A EE 04058 B1 EE04058 B1 EE 04058B1
Authority
EE
Estonia
Prior art keywords
benzo
preparation
reductase inhibitors
quinolizine derivatives
quinolizine
Prior art date
Application number
EE9800233A
Other languages
English (en)
Other versions
EE9800233A (et
Inventor
Guarna Antonio
Serio Mario
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Publication of EE9800233A publication Critical patent/EE9800233A/et
Publication of EE04058B1 publication Critical patent/EE04058B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
EE9800233A 1996-02-09 1997-02-07 Benso[c]kinolisiini derivaadid, nende valmistamine ja kasutamine 5a-reduktaasi inhibiitoritena EE04058B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96FI000019A IT1286545B1 (it) 1996-02-09 1996-02-09 Derivati benzo(c) chinolizinici,loro preparazione ed uso come inibitori delle 5-alfa-riduttasi
PCT/EP1997/000552 WO1997029107A1 (en) 1996-02-09 1997-02-07 BENZO[C]QUINOLIZINE DERIVATIVES, THEIR PREPARATION AND USE AS 5α-REDUCTASES INHIBITORS

Publications (2)

Publication Number Publication Date
EE9800233A EE9800233A (et) 1998-12-15
EE04058B1 true EE04058B1 (et) 2003-06-16

Family

ID=11351478

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9800233A EE04058B1 (et) 1996-02-09 1997-02-07 Benso[c]kinolisiini derivaadid, nende valmistamine ja kasutamine 5a-reduktaasi inhibiitoritena

Country Status (26)

Country Link
US (3) US6303622B1 (et)
EP (1) EP0880520B1 (et)
JP (1) JP2000504680A (et)
KR (1) KR100480448B1 (et)
CN (1) CN1116296C (et)
AT (1) ATE237614T1 (et)
AU (1) AU711886C (et)
BG (1) BG64596B1 (et)
CZ (1) CZ298061B6 (et)
DE (1) DE69720966T2 (et)
DK (1) DK0880520T3 (et)
EA (1) EA000975B1 (et)
EE (1) EE04058B1 (et)
ES (1) ES2192263T3 (et)
HK (1) HK1018783A1 (et)
HU (1) HUP9900509A3 (et)
IL (2) IL125628A0 (et)
IT (1) IT1286545B1 (et)
MX (1) MX9806229A (et)
NO (2) NO320155B1 (et)
NZ (1) NZ331256A (et)
PL (1) PL187618B1 (et)
PT (1) PT880520E (et)
SK (1) SK283299B6 (et)
UA (1) UA67724C2 (et)
WO (1) WO1997029107A1 (et)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITFI970193A1 (it) * 1997-08-01 1999-02-01 Applied Research Systems Uso di derivati benzo(c) chinolizinici come regolatori della crescita delle piante e composizioni ad uso agricolo che contengono tali
EP0926148A1 (en) * 1997-12-23 1999-06-30 Applied Research Systems Ars Holding N.V. Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors
JP2002522435A (ja) 1998-08-03 2002-07-23 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ （１ｈ）−ベンゾ［ｃ］キノリン−３−オン誘導体の合成方法
KR20080023680A (ko) 2005-05-10 2008-03-14 인터뮨, 인크. 스트레스-활성화 단백질 키나제 시스템을 조절하기 위한피리돈 유도체
KR20080087070A (ko) * 2005-05-20 2008-09-30 알란토스 파마슈티컬즈 홀딩, 인코포레이티드 피리미딘 또는 트리아진 융합된 비시클릭 메탈로프로테아제억제제
US20070155738A1 (en) 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
MX2010012848A (es) 2008-06-03 2011-03-01 Intermune Inc Compuestos y metodos para tratar trastornos inflamatorios y fibroticos.
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
CN106459042B (zh) 2014-04-02 2019-06-28 英特穆恩公司 抗纤维化吡啶酮类
CN105001216B (zh) * 2015-07-08 2017-03-01 中国科学院兰州化学物理研究所 一种喹嗪酮的制备方法
CN107089980B (zh) * 2017-05-11 2019-08-30 合肥工业大学 一种手性苯并[a]喹嗪-2-酮类化合物及其不对称催化合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3455929A (en) * 1966-08-15 1969-07-15 Bristol Myers Co Esters of 1,4-dihydroquinoline-n-carboxylic acids and thione acids
FR1534278A (fr) 1966-08-15 1968-07-26 Bristol Myers Co Procédé de fabrication de 1, 4-dihydroquinoléine-n-carboxylates d'alcoyle
US3625877A (en) * 1968-01-08 1971-12-07 Eastman Kodak Co High-modulus polycarbonate compositions
SU1027166A1 (ru) 1981-09-11 1983-07-07 Киевский Ордена Ленина Государственный Университет Им.Т.Г.Шевченко Способ получени 1,2-полиметиленкетоцианоазагетероциклов
IE57014B1 (en) 1983-03-25 1992-03-11 Wyeth John & Brother Ltd Benzoquinolizines

Also Published As

Publication number Publication date
ITFI960019A0 (et) 1996-02-09
EP0880520A1 (en) 1998-12-02
EE9800233A (et) 1998-12-15
HUP9900509A2 (hu) 1999-06-28
US6303622B1 (en) 2001-10-16
DE69720966T2 (de) 2004-05-19
KR19990082126A (ko) 1999-11-15
AU1767297A (en) 1997-08-28
NZ331256A (en) 1999-06-29
UA67724C2 (en) 2004-07-15
ES2192263T3 (es) 2003-10-01
CZ298061B6 (cs) 2007-06-06
ATE237614T1 (de) 2003-05-15
DK0880520T3 (da) 2003-08-11
NO983444D0 (no) 1998-07-24
EA000975B1 (ru) 2000-08-28
HK1018783A1 (en) 2000-01-07
AU711886C (en) 2002-10-17
IL125628A (en) 2006-10-31
HUP9900509A3 (en) 1999-11-29
IL125628A0 (en) 1999-04-11
AU711886B2 (en) 1999-10-21
NO20045132L (no) 1998-07-24
MX9806229A (es) 1998-11-30
EP0880520B1 (en) 2003-04-16
JP2000504680A (ja) 2000-04-18
NO983444L (no) 1998-07-24
BG102661A (en) 1999-04-30
IT1286545B1 (it) 1998-07-15
PT880520E (pt) 2003-07-31
SK283299B6 (sk) 2003-05-02
PL187618B1 (pl) 2004-08-31
ITFI960019A1 (it) 1997-08-09
EA199800701A1 (ru) 1999-02-25
KR100480448B1 (ko) 2005-08-31
SK104498A3 (en) 1998-12-02
WO1997029107A1 (en) 1997-08-14
US6555549B2 (en) 2003-04-29
DE69720966D1 (de) 2003-05-22
US20010047098A1 (en) 2001-11-29
US20010044542A1 (en) 2001-11-22
BG64596B1 (bg) 2005-08-31
CN1116296C (zh) 2003-07-30
PL328123A1 (en) 1999-01-18
US6552034B2 (en) 2003-04-22
CZ228998A3 (cs) 1998-10-14
NO320155B1 (no) 2005-11-07
CN1210536A (zh) 1999-03-10

Similar Documents

Publication Publication Date Title
HUP0100156A2 (hu) Foszfolipáz-A2 inhibitor hatású indolszármazékok és alkalmazásuk gyógyászati készítmények előállítására
DK0889877T3 (da) Meta-substituerede phenylenderivater og deres anvendelse som alfav-beta3-integrin-antagonister eller -inhibitorer
ES2178037T3 (es) Derivados de ciclosporina, su preparacion y las composiciones farmaceuticas que los contienen.
UY26258A1 (es) Derivados de 8-fenil-6,9-dihidro-[1,2,4] triazolo [3,4-i] purin-5-ona.
DE69705300D1 (de) Cyclopropylalkansäurederivate
AU5699399A (en) Pyridyl-bridgehead derivatives and their analogues, pharmaceutical compositions and their use as inhibitors of nicotinic cholinergic receptors
FI102475B1 (fi) Menetelmä farmaseuttisesti aktiivisten oktahydro- ja heksahydrobentso[f]kinolinonijohdannaisten valmistamiseksi
EE04058B1 (et) Benso[c]kinolisiini derivaadid, nende valmistamine ja kasutamine 5a-reduktaasi inhibiitoritena
HUP0004282A2 (hu) 2-Halogén-6-0-szubsztituált ketolidszármazékok
NZ516100A (en) Streptogramin derivatives, preparation and compositions containing them
DE69819539D1 (de) Antithrombotische mittel
TW200718423A (en) Heteroatom-interrupted analogs of 15-hydroxyeicosatetraenoic acid and pharmaceutical composition thereof
ATE241624T1 (de) Benzo(f)naphthyridinderivate, ihre herstellung und sie enthaltende pharmazeutische zusammenstzungen
BR0208655A (pt) Composição farmacêuticas
DE69828522D1 (de) Antithrombotische mittel
EE04615B1 (et) Täielikult ja osaliselt küllastatud benso[c]kinolisiini derivaadid, nende valmistamine ja kasutamine 5a-reduktaasi inhibiitoritena ning neid sisaldavad ravimkoostised
CA2245758A1 (en) Benzo[c]quinolizine derivatives, their preparation and use as 5.alpha.-reductases inhibitors
NO20001846L (no) Nye farmasøytisk aktive forbindelser, deres fremstilling og anvendelse som ECE-inhibitorer
AU1434201A (en) Antithrombotic agents
DE69824410D1 (en) Antithrombosemittel

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

GB1A Change in the ownership or in the address of the owner
KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20091231

MM4A Lapsed by not paying the annual fees

Effective date: 20100207