EE04615B1 - Täielikult ja osaliselt küllastatud benso[c]kinolisiini derivaadid, nende valmistamine ja kasutamine 5a-reduktaasi inhibiitoritena ning neid sisaldavad ravimkoostised - Google Patents
Täielikult ja osaliselt küllastatud benso[c]kinolisiini derivaadid, nende valmistamine ja kasutamine 5a-reduktaasi inhibiitoritena ning neid sisaldavad ravimkoostisedInfo
- Publication number
- EE04615B1 EE04615B1 EEP200000387A EEP200000387A EE04615B1 EE 04615 B1 EE04615 B1 EE 04615B1 EE P200000387 A EEP200000387 A EE P200000387A EE P200000387 A EEP200000387 A EE P200000387A EE 04615 B1 EE04615 B1 EE 04615B1
- Authority
- EE
- Estonia
- Prior art keywords
- fully
- preparation
- pharmaceutical compositions
- compositions containing
- partially saturated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Wood Science & Technology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97122733A EP0926148A1 (en) | 1997-12-23 | 1997-12-23 | Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors |
| PCT/EP1998/008582 WO1999033828A1 (en) | 1997-12-23 | 1998-12-21 | Benzo[c]quinolizine derivatives and their use as 5 alpha-reductases inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE200000387A EE200000387A (et) | 2001-12-17 |
| EE04615B1 true EE04615B1 (et) | 2006-04-17 |
Family
ID=8227866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200000387A EE04615B1 (et) | 1997-12-23 | 1998-12-21 | Täielikult ja osaliselt küllastatud benso[c]kinolisiini derivaadid, nende valmistamine ja kasutamine 5a-reduktaasi inhibiitoritena ning neid sisaldavad ravimkoostised |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6962925B1 (et) |
| EP (2) | EP0926148A1 (et) |
| JP (1) | JP2001527074A (et) |
| KR (1) | KR100580742B1 (et) |
| CN (1) | CN1144804C (et) |
| AR (1) | AR017964A1 (et) |
| AT (1) | ATE303382T1 (et) |
| AU (1) | AU744105B2 (et) |
| BR (1) | BR9813836A (et) |
| CA (1) | CA2315055A1 (et) |
| DE (1) | DE69831427T2 (et) |
| EA (1) | EA002831B1 (et) |
| EE (1) | EE04615B1 (et) |
| ES (1) | ES2245053T3 (et) |
| HK (1) | HK1033128A1 (et) |
| IL (1) | IL136919A0 (et) |
| NO (1) | NO326034B1 (et) |
| PT (1) | PT1066284E (et) |
| SI (1) | SI1066284T1 (et) |
| UA (1) | UA66371C2 (et) |
| WO (1) | WO1999033828A1 (et) |
| ZA (1) | ZA9811762B (et) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0926148A1 (en) * | 1997-12-23 | 1999-06-30 | Applied Research Systems Ars Holding N.V. | Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors |
| JP2002521449A (ja) * | 1998-07-29 | 2002-07-16 | メルク エンド カムパニー インコーポレーテッド | 三環式化合物 |
| KR100785088B1 (ko) | 2006-05-23 | 2007-12-12 | 한국과학기술연구원 | 두 개의 엑소 메틸렌을 가지는 고리가 접합된 락탐화합물과이의 제조방법 |
| US20100009853A1 (en) * | 2006-07-13 | 2010-01-14 | Nihon Nohyaku Co., Ltd | Parasitic plant control agent and use thereof |
| GB201506894D0 (en) * | 2015-04-23 | 2015-06-10 | Galapagos Nv | Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| CN106008423B (zh) * | 2016-06-24 | 2018-02-02 | 云南民族大学 | 一种苯丙素类化合物及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5239075A (en) * | 1991-08-21 | 1993-08-24 | Eli Lilly And Company | Process for the preparation of benzo (f) quinolinones |
| EP0591582B1 (en) * | 1991-08-21 | 1999-01-20 | Eli Lilly And Company | Hexahydrobenzo (f) quinolinones as 5-alpha-reductase inhibitors |
| EP0591583B1 (en) * | 1991-08-21 | 2001-12-19 | Eli Lilly And Company | Benzo (f) quinolinones as 5-alpha-reductase inhibitors |
| US5250539A (en) * | 1991-08-21 | 1993-10-05 | Eli Lilly And Company | Hexahydrobenzo[f]quinolinones |
| AU6413594A (en) * | 1993-03-24 | 1994-10-11 | Merck & Co., Inc. | Substituted 3-phenanthridinone derivatives as 5alpha-reductase inhibitors |
| US5578724A (en) * | 1994-09-20 | 1996-11-26 | Eli Lilly And Company | Process for preparation of benzo[f]quinolinones |
| IT1286545B1 (it) * | 1996-02-09 | 1998-07-15 | Antonio Guarna | Derivati benzo(c) chinolizinici,loro preparazione ed uso come inibitori delle 5-alfa-riduttasi |
| ITFI970193A1 (it) * | 1997-08-01 | 1999-02-01 | Applied Research Systems | Uso di derivati benzo(c) chinolizinici come regolatori della crescita delle piante e composizioni ad uso agricolo che contengono tali |
| EP0926148A1 (en) * | 1997-12-23 | 1999-06-30 | Applied Research Systems Ars Holding N.V. | Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors |
-
1997
- 1997-12-23 EP EP97122733A patent/EP0926148A1/en not_active Withdrawn
-
1998
- 1998-12-21 KR KR1020007006912A patent/KR100580742B1/ko not_active IP Right Cessation
- 1998-12-21 IL IL13691998A patent/IL136919A0/xx unknown
- 1998-12-21 AT AT98966711T patent/ATE303382T1/de not_active IP Right Cessation
- 1998-12-21 CN CNB98813702XA patent/CN1144804C/zh not_active Expired - Fee Related
- 1998-12-21 UA UA2000063687A patent/UA66371C2/uk unknown
- 1998-12-21 EE EEP200000387A patent/EE04615B1/et not_active IP Right Cessation
- 1998-12-21 EA EA200000697A patent/EA002831B1/ru not_active IP Right Cessation
- 1998-12-21 EP EP98966711A patent/EP1066284B1/en not_active Expired - Lifetime
- 1998-12-21 BR BR9813836-7A patent/BR9813836A/pt not_active Application Discontinuation
- 1998-12-21 AU AU24194/99A patent/AU744105B2/en not_active Ceased
- 1998-12-21 JP JP2000526509A patent/JP2001527074A/ja active Pending
- 1998-12-21 DE DE69831427T patent/DE69831427T2/de not_active Expired - Fee Related
- 1998-12-21 CA CA002315055A patent/CA2315055A1/en not_active Abandoned
- 1998-12-21 PT PT98966711T patent/PT1066284E/pt unknown
- 1998-12-21 WO PCT/EP1998/008582 patent/WO1999033828A1/en not_active Application Discontinuation
- 1998-12-21 SI SI9830791T patent/SI1066284T1/sl unknown
- 1998-12-21 ES ES98966711T patent/ES2245053T3/es not_active Expired - Lifetime
- 1998-12-22 ZA ZA9811762A patent/ZA9811762B/xx unknown
- 1998-12-23 AR ARP980106662A patent/AR017964A1/es active IP Right Grant
-
2000
- 2000-06-12 US US09/593,173 patent/US6962925B1/en not_active Expired - Fee Related
- 2000-06-20 NO NO20003199A patent/NO326034B1/no not_active IP Right Cessation
-
2001
- 2001-05-29 HK HK01103695A patent/HK1033128A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR100580742B1 (ko) | 2006-05-15 |
| US6962925B1 (en) | 2005-11-08 |
| BR9813836A (pt) | 2000-10-10 |
| ATE303382T1 (de) | 2005-09-15 |
| JP2001527074A (ja) | 2001-12-25 |
| EA200000697A1 (ru) | 2000-12-25 |
| EP1066284A1 (en) | 2001-01-10 |
| SI1066284T1 (sl) | 2005-12-31 |
| IL136919A0 (en) | 2001-06-14 |
| UA66371C2 (en) | 2004-05-17 |
| CN1284954A (zh) | 2001-02-21 |
| WO1999033828A1 (en) | 1999-07-08 |
| DE69831427T2 (de) | 2006-06-08 |
| AU744105B2 (en) | 2002-02-14 |
| HK1033128A1 (en) | 2001-08-17 |
| PT1066284E (pt) | 2005-11-30 |
| EP1066284B1 (en) | 2005-08-31 |
| NO20003199L (no) | 2000-08-23 |
| EP0926148A1 (en) | 1999-06-30 |
| EA002831B1 (ru) | 2002-10-31 |
| NO20003199D0 (no) | 2000-06-20 |
| AR017964A1 (es) | 2001-10-24 |
| ES2245053T3 (es) | 2005-12-16 |
| ZA9811762B (en) | 1999-06-23 |
| EE200000387A (et) | 2001-12-17 |
| CA2315055A1 (en) | 1999-07-08 |
| DE69831427D1 (de) | 2005-10-06 |
| CN1144804C (zh) | 2004-04-07 |
| AU2419499A (en) | 1999-07-19 |
| NO326034B1 (no) | 2008-09-01 |
| KR20010033432A (ko) | 2001-04-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB4A | Valid patent at the end of a year |
Effective date: 20061231 |
|
| GB1A | Change in the ownership or in the address of the owner | ||
| KB4A | Valid patent at the end of a year |
Effective date: 20071231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20081231 |
|
| MM4A | Lapsed by not paying the annual fees |
Effective date: 20091221 |