GB201506894D0 - Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders - Google Patents

Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders

Info

Publication number
GB201506894D0
GB201506894D0 GBGB1506894.3A GB201506894A GB201506894D0 GB 201506894 D0 GB201506894 D0 GB 201506894D0 GB 201506894 A GB201506894 A GB 201506894A GB 201506894 D0 GB201506894 D0 GB 201506894D0
Authority
GB
United Kingdom
Prior art keywords
dihydropyridoisoquinolinones
novel
treatment
pharmaceutical compositions
inflammatory disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1506894.3A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galapagos NV
Original Assignee
Galapagos NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galapagos NV filed Critical Galapagos NV
Priority to GBGB1506894.3A priority Critical patent/GB201506894D0/en
Publication of GB201506894D0 publication Critical patent/GB201506894D0/en
Priority to PCT/EP2016/058607 priority patent/WO2016169911A1/en
Priority to US15/568,275 priority patent/US10568879B2/en
Priority to CA2983342A priority patent/CA2983342A1/en
Priority to SG11201708671RA priority patent/SG11201708671RA/en
Priority to RU2017134551A priority patent/RU2017134551A/en
Priority to CN201680023369.1A priority patent/CN107531703B/en
Priority to JP2017555303A priority patent/JP6777652B2/en
Priority to KR1020177033832A priority patent/KR20170139142A/en
Priority to EP16720370.2A priority patent/EP3286191B1/en
Priority to AU2016251517A priority patent/AU2016251517A1/en
Priority to BR112017022008-3A priority patent/BR112017022008A2/en
Priority to MX2017013382A priority patent/MX2017013382A/en
Priority to TW105112490A priority patent/TW201702243A/en
Priority to ARP160101128A priority patent/AR104362A1/en
Priority to ZA2017/06674A priority patent/ZA201706674B/en
Priority to IL255109A priority patent/IL255109A0/en
Priority to PH12017501911A priority patent/PH12017501911A1/en
Priority to CONC2017/0011093A priority patent/CO2017011093A2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
GBGB1506894.3A 2015-04-23 2015-04-23 Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders Ceased GB201506894D0 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
GBGB1506894.3A GB201506894D0 (en) 2015-04-23 2015-04-23 Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
MX2017013382A MX2017013382A (en) 2015-04-23 2016-04-19 Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders.
KR1020177033832A KR20170139142A (en) 2015-04-23 2016-04-19 Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
AU2016251517A AU2016251517A1 (en) 2015-04-23 2016-04-19 Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
CA2983342A CA2983342A1 (en) 2015-04-23 2016-04-19 Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
SG11201708671RA SG11201708671RA (en) 2015-04-23 2016-04-19 Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
RU2017134551A RU2017134551A (en) 2015-04-23 2016-04-19 NEW DIHYDROPYRIDOISOCHINOLINONES AND THEIR PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF INFLAMMATORY DISORDERS
CN201680023369.1A CN107531703B (en) 2015-04-23 2016-04-19 Dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory diseases
JP2017555303A JP6777652B2 (en) 2015-04-23 2016-04-19 Novel dihydropyridoisoquinolinone and pharmaceutical compositions thereof for the treatment of inflammatory disorders
PCT/EP2016/058607 WO2016169911A1 (en) 2015-04-23 2016-04-19 Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
EP16720370.2A EP3286191B1 (en) 2015-04-23 2016-04-19 Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
US15/568,275 US10568879B2 (en) 2015-04-23 2016-04-19 Dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
BR112017022008-3A BR112017022008A2 (en) 2015-04-23 2016-04-19 dihydropyridoisoquinolinone compositions and pharmaceutical compositions thereof for the treatment of inflammatory disorders
TW105112490A TW201702243A (en) 2015-04-23 2016-04-21 Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
ARP160101128A AR104362A1 (en) 2015-04-23 2016-04-22 DIHYDROPIRIDOISOQUINOLINONES AND PHARMACEUTICAL COMPOSITIONS OF THE SAME FOR THE TREATMENT OF INFLAMMATORY DISORDERS
ZA2017/06674A ZA201706674B (en) 2015-04-23 2017-10-04 Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
IL255109A IL255109A0 (en) 2015-04-23 2017-10-18 Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
PH12017501911A PH12017501911A1 (en) 2015-04-23 2017-10-19 Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
CONC2017/0011093A CO2017011093A2 (en) 2015-04-23 2017-10-30 6,7-Dihydropyrid [2,1-a] isoquinolin-2-one derivatives as gpr84 receptor antagonists, and compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1506894.3A GB201506894D0 (en) 2015-04-23 2015-04-23 Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders

Publications (1)

Publication Number Publication Date
GB201506894D0 true GB201506894D0 (en) 2015-06-10

Family

ID=53488521

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1506894.3A Ceased GB201506894D0 (en) 2015-04-23 2015-04-23 Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders

Country Status (19)

Country Link
US (1) US10568879B2 (en)
EP (1) EP3286191B1 (en)
JP (1) JP6777652B2 (en)
KR (1) KR20170139142A (en)
CN (1) CN107531703B (en)
AR (1) AR104362A1 (en)
AU (1) AU2016251517A1 (en)
BR (1) BR112017022008A2 (en)
CA (1) CA2983342A1 (en)
CO (1) CO2017011093A2 (en)
GB (1) GB201506894D0 (en)
IL (1) IL255109A0 (en)
MX (1) MX2017013382A (en)
PH (1) PH12017501911A1 (en)
RU (1) RU2017134551A (en)
SG (1) SG11201708671RA (en)
TW (1) TW201702243A (en)
WO (1) WO2016169911A1 (en)
ZA (1) ZA201706674B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3403649A1 (en) * 2017-05-16 2018-11-21 Bayer Pharma Aktiengesellschaft Inhibitors and antagonists of gpr84 for the treatment of endometriosis
CN106977483A (en) * 2017-06-02 2017-07-25 遵义医学院 A kind of synthetic method of the flavonols of fluoroalkyl substitution, isoflavones alcohol and coumarin kind compound
EP3665156A4 (en) 2017-08-09 2021-04-28 Denali Therapeutics Inc. Compounds, compositions and methods
BR112020008425A2 (en) * 2017-11-15 2020-11-17 Galapagos N.V. compounds and pharmaceutical compositions thereof for use in the treatment of fibrotic diseases
WO2020007342A1 (en) * 2018-07-06 2020-01-09 中国科学院上海药物研究所 Application of biphenyl phosphate compound as gpr84 antagonist
EP3924341A4 (en) * 2019-02-13 2022-11-02 Denali Therapeutics Inc. Compounds, compositions and methods
CN113518618A (en) * 2019-02-13 2021-10-19 戴纳立制药公司 Compounds, compositions and methods
CN115135656A (en) * 2019-12-19 2022-09-30 拜耳公司 Furanoinindazole derivatives
WO2021123394A1 (en) 2019-12-20 2021-06-24 University Of Copenhagen G protein-coupled receptor modulators and a pharmaceutical composition
CA3211437A1 (en) 2021-02-23 2022-09-01 Bayer Aktiengesellschaft Furoindazole derivatives as gpr84 antagonists
WO2022218372A1 (en) * 2021-04-14 2022-10-20 武汉人福创新药物研发中心有限公司 Dihydropyrimidoisoquinolinone derivative and use thereof
EP4330260A1 (en) 2021-04-29 2024-03-06 Bayer Aktiengesellschaft Furoindazole derivatives as antagonists or inhibitors of gpr84
WO2022263676A1 (en) 2021-06-18 2022-12-22 University Of Copenhagen Polysubstituted 4-hydroxypyridine and 4-hydroxyquinoline derivatives as gpr84 antagonists
CN115611944A (en) 2021-07-15 2023-01-17 中国科学院上海药物研究所 Asymmetric GPR84 antagonists and uses thereof
WO2024083705A1 (en) 2022-10-18 2024-04-25 Bayer Aktiengesellschaft Furoindazole derivatives for the treatment of pain

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0926148A1 (en) * 1997-12-23 1999-06-30 Applied Research Systems Ars Holding N.V. Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors
WO2005050225A2 (en) * 2003-10-31 2005-06-02 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 84 (gpr84)
US8691498B2 (en) 2005-09-02 2014-04-08 Arena Pharmaceuticals, Inc. Methods of screening for a compound that reduces atherogenesis
JP2013537203A (en) 2010-09-20 2013-09-30 グラクソ グループ リミテッド Tricyclic compounds, production methods, and uses thereof
AR089284A1 (en) * 2011-12-22 2014-08-13 Galapagos Nv DIHYDROPIRIMIDINOISOQUINOLINONES AND PHARMACEUTICAL COMPOSITIONS OF THE SAME FOR THE TREATMENT OF INFLAMMATORY DISORDERS
CN104870445B (en) 2012-12-20 2017-09-15 加拉帕戈斯股份有限公司 New dihydro-pyrimidin and isobioquin group and its pharmaceutical composition (GPR84 antagonists) for treating inflammatory disease
GB201411241D0 (en) * 2014-06-25 2014-08-06 Galapagos Nv Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders

Also Published As

Publication number Publication date
JP2018513180A (en) 2018-05-24
CN107531703B (en) 2020-09-01
SG11201708671RA (en) 2017-11-29
MX2017013382A (en) 2017-12-07
CA2983342A1 (en) 2016-10-27
AU2016251517A1 (en) 2017-10-26
PH12017501911A1 (en) 2018-03-05
IL255109A0 (en) 2017-12-31
RU2017134551A (en) 2019-04-04
US20190062325A1 (en) 2019-02-28
CN107531703A (en) 2018-01-02
US10568879B2 (en) 2020-02-25
ZA201706674B (en) 2019-07-31
EP3286191B1 (en) 2020-07-29
WO2016169911A1 (en) 2016-10-27
BR112017022008A2 (en) 2018-07-03
KR20170139142A (en) 2017-12-18
JP6777652B2 (en) 2020-10-28
TW201702243A (en) 2017-01-16
CO2017011093A2 (en) 2018-01-31
AR104362A1 (en) 2017-07-12
EP3286191A1 (en) 2018-02-28

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Legal Events

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AT Applications terminated before publication under section 16(1)