EA200000697A1 - ПРОИЗВОДНЫЕ БЕНЗО[C]ХИНОЛИЗИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ 5α-РЕДУКТАЗ - Google Patents

ПРОИЗВОДНЫЕ БЕНЗО[C]ХИНОЛИЗИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ 5α-РЕДУКТАЗ

Info

Publication number
EA200000697A1
EA200000697A1 EA200000697A EA200000697A EA200000697A1 EA 200000697 A1 EA200000697 A1 EA 200000697A1 EA 200000697 A EA200000697 A EA 200000697A EA 200000697 A EA200000697 A EA 200000697A EA 200000697 A1 EA200000697 A1 EA 200000697A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitors
quinolysin
benzo
derivatives
application
Prior art date
Application number
EA200000697A
Other languages
English (en)
Other versions
EA002831B1 (ru
Inventor
Антонио Гуарна
Марио Серио
Original Assignee
Апплайд Резеч Системз Арс Холдинг Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Апплайд Резеч Системз Арс Холдинг Н.В. filed Critical Апплайд Резеч Системз Арс Холдинг Н.В.
Publication of EA200000697A1 publication Critical patent/EA200000697A1/ru
Publication of EA002831B1 publication Critical patent/EA002831B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Steroid Compounds (AREA)

Abstract

(57) Данное изобретение относится к производным бензо[с]хинолизинов, полностью и частично насыщенным, имеющим формулу (I), и их фармацевтически приемлемым солям, которые, как оказывается, полезны для фармацевтического и сельскохозяйственного использования, поскольку способны ингибировать фермент 5α-редуктазу, либо селективно в отношении 5αR-I или 5αR-II, либо в отношении обоих изоферментов.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000697A 1997-12-23 1998-12-21 ПРОИЗВОДНЫЕ БЕНЗО[C]ХИНОЛИЗИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ 5α-РЕДУКТАЗ EA002831B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97122733A EP0926148A1 (en) 1997-12-23 1997-12-23 Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors
PCT/EP1998/008582 WO1999033828A1 (en) 1997-12-23 1998-12-21 Benzo[c]quinolizine derivatives and their use as 5 alpha-reductases inhibitors

Publications (2)

Publication Number Publication Date
EA200000697A1 true EA200000697A1 (ru) 2000-12-25
EA002831B1 EA002831B1 (ru) 2002-10-31

Family

ID=8227866

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000697A EA002831B1 (ru) 1997-12-23 1998-12-21 ПРОИЗВОДНЫЕ БЕНЗО[C]ХИНОЛИЗИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ 5α-РЕДУКТАЗ

Country Status (22)

Country Link
US (1) US6962925B1 (ru)
EP (2) EP0926148A1 (ru)
JP (1) JP2001527074A (ru)
KR (1) KR100580742B1 (ru)
CN (1) CN1144804C (ru)
AR (1) AR017964A1 (ru)
AT (1) ATE303382T1 (ru)
AU (1) AU744105B2 (ru)
BR (1) BR9813836A (ru)
CA (1) CA2315055A1 (ru)
DE (1) DE69831427T2 (ru)
EA (1) EA002831B1 (ru)
EE (1) EE04615B1 (ru)
ES (1) ES2245053T3 (ru)
HK (1) HK1033128A1 (ru)
IL (1) IL136919A0 (ru)
NO (1) NO326034B1 (ru)
PT (1) PT1066284E (ru)
SI (1) SI1066284T1 (ru)
UA (1) UA66371C2 (ru)
WO (1) WO1999033828A1 (ru)
ZA (1) ZA9811762B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0926148A1 (en) * 1997-12-23 1999-06-30 Applied Research Systems Ars Holding N.V. Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors
CA2338298A1 (en) * 1998-07-29 2000-02-10 Merck & Co., Inc. Tricyclic compounds
KR100785088B1 (ko) 2006-05-23 2007-12-12 한국과학기술연구원 두 개의 엑소 메틸렌을 가지는 고리가 접합된 락탐화합물과이의 제조방법
WO2008007778A1 (fr) * 2006-07-13 2008-01-17 Nihon Nohyaku Co., Ltd. agent de RÉGULATION de plante parasite et son emploi
GB201506894D0 (en) * 2015-04-23 2015-06-10 Galapagos Nv Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
CN106008423B (zh) * 2016-06-24 2018-02-02 云南民族大学 一种苯丙素类化合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0591583B1 (en) * 1991-08-21 2001-12-19 Eli Lilly And Company Benzo (f) quinolinones as 5-alpha-reductase inhibitors
US5239075A (en) * 1991-08-21 1993-08-24 Eli Lilly And Company Process for the preparation of benzo (f) quinolinones
US5250539A (en) * 1991-08-21 1993-10-05 Eli Lilly And Company Hexahydrobenzo[f]quinolinones
ES2125884T3 (es) * 1991-08-21 1999-03-16 Lilly Co Eli Hexahidrobenzo(f)quinolinonas como inhibidores de la 5-alfa-reductasa.
WO1994021614A1 (en) * 1993-03-24 1994-09-29 Merck & Co., Inc. SUBSTITUTED 3-PHENANTHRIDINONE DERIVATIVES AS 5α-REDUCTASE INHIBITORS
US5578724A (en) * 1994-09-20 1996-11-26 Eli Lilly And Company Process for preparation of benzo[f]quinolinones
IT1286545B1 (it) * 1996-02-09 1998-07-15 Antonio Guarna Derivati benzo(c) chinolizinici,loro preparazione ed uso come inibitori delle 5-alfa-riduttasi
ITFI970193A1 (it) * 1997-08-01 1999-02-01 Applied Research Systems Uso di derivati benzo(c) chinolizinici come regolatori della crescita delle piante e composizioni ad uso agricolo che contengono tali
EP0926148A1 (en) * 1997-12-23 1999-06-30 Applied Research Systems Ars Holding N.V. Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors

Also Published As

Publication number Publication date
CN1284954A (zh) 2001-02-21
JP2001527074A (ja) 2001-12-25
IL136919A0 (en) 2001-06-14
ATE303382T1 (de) 2005-09-15
CA2315055A1 (en) 1999-07-08
KR100580742B1 (ko) 2006-05-15
US6962925B1 (en) 2005-11-08
ES2245053T3 (es) 2005-12-16
EP0926148A1 (en) 1999-06-30
DE69831427T2 (de) 2006-06-08
EP1066284B1 (en) 2005-08-31
AU2419499A (en) 1999-07-19
PT1066284E (pt) 2005-11-30
EE200000387A (et) 2001-12-17
KR20010033432A (ko) 2001-04-25
BR9813836A (pt) 2000-10-10
EP1066284A1 (en) 2001-01-10
SI1066284T1 (sl) 2005-12-31
WO1999033828A1 (en) 1999-07-08
EA002831B1 (ru) 2002-10-31
AR017964A1 (es) 2001-10-24
ZA9811762B (en) 1999-06-23
EE04615B1 (et) 2006-04-17
HK1033128A1 (en) 2001-08-17
AU744105B2 (en) 2002-02-14
DE69831427D1 (de) 2005-10-06
NO20003199D0 (no) 2000-06-20
CN1144804C (zh) 2004-04-07
NO326034B1 (no) 2008-09-01
NO20003199L (no) 2000-08-23
UA66371C2 (en) 2004-05-17

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Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU