ZA9811762B - Fully and partially saturated benzo¬c¾quinolizine derivatives their preparations and use as 5alpha-reductases inhibitors - Google Patents

Fully and partially saturated benzo¬c¾quinolizine derivatives their preparations and use as 5alpha-reductases inhibitors

Info

Publication number
ZA9811762B
ZA9811762B ZA9811762A ZA9811762A ZA9811762B ZA 9811762 B ZA9811762 B ZA 9811762B ZA 9811762 A ZA9811762 A ZA 9811762A ZA 9811762 A ZA9811762 A ZA 9811762A ZA 9811762 B ZA9811762 B ZA 9811762B
Authority
ZA
South Africa
Prior art keywords
5alpha
preparations
derivatives
fully
partially saturated
Prior art date
Application number
ZA9811762A
Other languages
English (en)
Inventor
Antonio Guarna
Mario Serio
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of ZA9811762B publication Critical patent/ZA9811762B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
ZA9811762A 1997-12-23 1998-12-22 Fully and partially saturated benzo¬c¾quinolizine derivatives their preparations and use as 5alpha-reductases inhibitors ZA9811762B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97122733A EP0926148A1 (en) 1997-12-23 1997-12-23 Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors

Publications (1)

Publication Number Publication Date
ZA9811762B true ZA9811762B (en) 1999-06-23

Family

ID=8227866

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9811762A ZA9811762B (en) 1997-12-23 1998-12-22 Fully and partially saturated benzo¬c¾quinolizine derivatives their preparations and use as 5alpha-reductases inhibitors

Country Status (22)

Country Link
US (1) US6962925B1 (et)
EP (2) EP0926148A1 (et)
JP (1) JP2001527074A (et)
KR (1) KR100580742B1 (et)
CN (1) CN1144804C (et)
AR (1) AR017964A1 (et)
AT (1) ATE303382T1 (et)
AU (1) AU744105B2 (et)
BR (1) BR9813836A (et)
CA (1) CA2315055A1 (et)
DE (1) DE69831427T2 (et)
EA (1) EA002831B1 (et)
EE (1) EE04615B1 (et)
ES (1) ES2245053T3 (et)
HK (1) HK1033128A1 (et)
IL (1) IL136919A0 (et)
NO (1) NO326034B1 (et)
PT (1) PT1066284E (et)
SI (1) SI1066284T1 (et)
UA (1) UA66371C2 (et)
WO (1) WO1999033828A1 (et)
ZA (1) ZA9811762B (et)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0926148A1 (en) * 1997-12-23 1999-06-30 Applied Research Systems Ars Holding N.V. Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors
JP2002521449A (ja) * 1998-07-29 2002-07-16 メルク エンド カムパニー インコーポレーテッド 三環式化合物
KR100785088B1 (ko) 2006-05-23 2007-12-12 한국과학기술연구원 두 개의 엑소 메틸렌을 가지는 고리가 접합된 락탐화합물과이의 제조방법
US20100009853A1 (en) * 2006-07-13 2010-01-14 Nihon Nohyaku Co., Ltd Parasitic plant control agent and use thereof
GB201506894D0 (en) * 2015-04-23 2015-06-10 Galapagos Nv Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
CN106008423B (zh) * 2016-06-24 2018-02-02 云南民族大学 一种苯丙素类化合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5239075A (en) * 1991-08-21 1993-08-24 Eli Lilly And Company Process for the preparation of benzo (f) quinolinones
EP0591582B1 (en) * 1991-08-21 1999-01-20 Eli Lilly And Company Hexahydrobenzo (f) quinolinones as 5-alpha-reductase inhibitors
EP0591583B1 (en) * 1991-08-21 2001-12-19 Eli Lilly And Company Benzo (f) quinolinones as 5-alpha-reductase inhibitors
US5250539A (en) * 1991-08-21 1993-10-05 Eli Lilly And Company Hexahydrobenzo[f]quinolinones
AU6413594A (en) * 1993-03-24 1994-10-11 Merck & Co., Inc. Substituted 3-phenanthridinone derivatives as 5alpha-reductase inhibitors
US5578724A (en) * 1994-09-20 1996-11-26 Eli Lilly And Company Process for preparation of benzo[f]quinolinones
IT1286545B1 (it) * 1996-02-09 1998-07-15 Antonio Guarna Derivati benzo(c) chinolizinici,loro preparazione ed uso come inibitori delle 5-alfa-riduttasi
ITFI970193A1 (it) * 1997-08-01 1999-02-01 Applied Research Systems Uso di derivati benzo(c) chinolizinici come regolatori della crescita delle piante e composizioni ad uso agricolo che contengono tali
EP0926148A1 (en) * 1997-12-23 1999-06-30 Applied Research Systems Ars Holding N.V. Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors

Also Published As

Publication number Publication date
KR100580742B1 (ko) 2006-05-15
US6962925B1 (en) 2005-11-08
BR9813836A (pt) 2000-10-10
ATE303382T1 (de) 2005-09-15
JP2001527074A (ja) 2001-12-25
EA200000697A1 (ru) 2000-12-25
EP1066284A1 (en) 2001-01-10
SI1066284T1 (sl) 2005-12-31
IL136919A0 (en) 2001-06-14
UA66371C2 (en) 2004-05-17
CN1284954A (zh) 2001-02-21
WO1999033828A1 (en) 1999-07-08
DE69831427T2 (de) 2006-06-08
AU744105B2 (en) 2002-02-14
HK1033128A1 (en) 2001-08-17
EE04615B1 (et) 2006-04-17
PT1066284E (pt) 2005-11-30
EP1066284B1 (en) 2005-08-31
NO20003199L (no) 2000-08-23
EP0926148A1 (en) 1999-06-30
EA002831B1 (ru) 2002-10-31
NO20003199D0 (no) 2000-06-20
AR017964A1 (es) 2001-10-24
ES2245053T3 (es) 2005-12-16
EE200000387A (et) 2001-12-17
CA2315055A1 (en) 1999-07-08
DE69831427D1 (de) 2005-10-06
CN1144804C (zh) 2004-04-07
AU2419499A (en) 1999-07-19
NO326034B1 (no) 2008-09-01
KR20010033432A (ko) 2001-04-25

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