TR200302313T4 - Antivirütik pirimidin nükleosid analogları - Google Patents

Antivirütik pirimidin nükleosid analogları

Info

Publication number
TR200302313T4
TR200302313T4 TR2003/02313T TR200302313T TR200302313T4 TR 200302313 T4 TR200302313 T4 TR 200302313T4 TR 2003/02313 T TR2003/02313 T TR 2003/02313T TR 200302313 T TR200302313 T TR 200302313T TR 200302313 T4 TR200302313 T4 TR 200302313T4
Authority
TR
Turkey
Prior art keywords
nucleoside analogues
pyrimidine nucleoside
antiviral pyrimidine
antiviral
compounds
Prior art date
Application number
TR2003/02313T
Other languages
English (en)
Inventor
Mcguigan Christopher
Balzarini Jan
De Clercq Erik
Original Assignee
University College Cardiff Consultants Limited
Rega Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University College Cardiff Consultants Limited, Rega Foundation filed Critical University College Cardiff Consultants Limited
Publication of TR200302313T4 publication Critical patent/TR200302313T4/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals

Abstract

Formül (I) Virüslere, örnegin sitomegalovirüse karsi güçlü antivirütik aktivite gösteren Formül (I) e sahip bir bilesik ve bunun farmakolojik açidan kabul edilebilir bir tuzu, bir türevi veya ön ilaci olup; burada R, R',R",X,Z,W,T,T',T" ve T"', tarifnamede tarif edilen gruplardan seçilir.
TR2003/02313T 2000-05-09 2001-05-08 Antivirütik pirimidin nükleosid analogları TR200302313T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0011203.7A GB0011203D0 (en) 2000-05-09 2000-05-09 Chemical compounds

Publications (1)

Publication Number Publication Date
TR200302313T4 true TR200302313T4 (tr) 2004-01-21

Family

ID=9891276

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2003/02313T TR200302313T4 (tr) 2000-05-09 2001-05-08 Antivirütik pirimidin nükleosid analogları

Country Status (14)

Country Link
US (1) US7019135B2 (tr)
EP (1) EP1280813B1 (tr)
JP (1) JP2003532735A (tr)
AT (1) ATE254132T1 (tr)
AU (1) AU780879B2 (tr)
CA (1) CA2406633A1 (tr)
DE (1) DE60101223T2 (tr)
DK (1) DK1280813T3 (tr)
ES (1) ES2210153T3 (tr)
GB (1) GB0011203D0 (tr)
NZ (1) NZ521877A (tr)
PT (1) PT1280813E (tr)
TR (1) TR200302313T4 (tr)
WO (1) WO2001085749A1 (tr)

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DK1045897T3 (da) 1998-01-23 2002-05-13 Newbiotics Inc Enzymatisk katalyserede, terapeutiske midler
US7462605B2 (en) 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
US6683061B1 (en) 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
WO2001007088A2 (en) 1999-07-22 2001-02-01 Newbiotics, Inc. Methods for treating therapy-resistant tumors
GB0009486D0 (en) * 2000-04-17 2000-06-07 Univ Cardiff Chemical compounds
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
EP1576138B1 (en) 2002-11-15 2017-02-01 Idenix Pharmaceuticals LLC. 2'-methyl nucleosides in combination with interferon and flaviviridae mutation
GB0609178D0 (en) * 2006-05-09 2006-06-21 Univ Cardiff Novel compounds
US20080261913A1 (en) 2006-12-28 2008-10-23 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of liver disorders
EP2691409B1 (en) 2011-03-31 2018-02-21 Idenix Pharmaceuticals LLC. Compounds and pharmaceutical compositions for the treatment of viral infections
GB201111779D0 (en) 2011-07-08 2011-08-24 Univ Cardiff Chemical compounds
EP2755983B1 (en) 2011-09-12 2017-03-15 Idenix Pharmaceuticals LLC. Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections
US8507460B2 (en) 2011-10-14 2013-08-13 Idenix Pharmaceuticals, Inc. Substituted 3′,5′-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections
AU2013266393B2 (en) 2012-05-22 2017-09-28 Idenix Pharmaceuticals Llc D-amino acid compounds for liver disease
EP2852604B1 (en) 2012-05-22 2017-04-12 Idenix Pharmaceuticals LLC 3',5'-cyclic phosphoramidate prodrugs for hcv infection
US9296778B2 (en) 2012-05-22 2016-03-29 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphate prodrugs for HCV infection
EA027929B1 (ru) 2012-05-25 2017-09-29 Янссен Сайенсиз Айрлэнд Юси Нуклеозиды на основе урацила и спирооксетана
WO2014052638A1 (en) 2012-09-27 2014-04-03 Idenix Pharmaceuticals, Inc. Esters and malonates of sate prodrugs
ES2674980T3 (es) 2012-10-08 2018-07-05 Idenix Pharmaceuticals Llc Análogos de 2'-cloro nucleósidos para infección por VHC
US10723754B2 (en) 2012-10-22 2020-07-28 Idenix Pharmaceuticals Llc 2′,4′-bridged nucleosides for HCV infection
EP2935304A1 (en) 2012-12-19 2015-10-28 IDENIX Pharmaceuticals, Inc. 4'-fluoro nucleosides for the treatment of hcv
US9339541B2 (en) 2013-03-04 2016-05-17 Merck Sharp & Dohme Corp. Thiophosphate nucleosides for the treatment of HCV
US9309275B2 (en) 2013-03-04 2016-04-12 Idenix Pharmaceuticals Llc 3′-deoxy nucleosides for the treatment of HCV
EP2970357A1 (en) 2013-03-13 2016-01-20 IDENIX Pharmaceuticals, Inc. Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv
WO2014165542A1 (en) 2013-04-01 2014-10-09 Idenix Pharmaceuticals, Inc. 2',4'-fluoro nucleosides for the treatment of hcv
US10005779B2 (en) 2013-06-05 2018-06-26 Idenix Pharmaceuticals Llc 1′,4′-thio nucleosides for the treatment of HCV
EP3027636B1 (en) 2013-08-01 2022-01-05 Idenix Pharmaceuticals LLC D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease
WO2015161137A1 (en) 2014-04-16 2015-10-22 Idenix Pharmaceuticals, Inc. 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62255499A (ja) * 1986-04-28 1987-11-07 Teijin Ltd 螢光性ヌクレオシド又はヌクレオチド
GB9708611D0 (en) * 1997-04-28 1997-06-18 Univ Cardiff Chemical compounds
GB9716231D0 (en) * 1997-07-31 1997-10-08 Amersham Int Ltd Base analogues

Also Published As

Publication number Publication date
EP1280813A1 (en) 2003-02-05
AU5494501A (en) 2001-11-20
ES2210153T3 (es) 2004-07-01
DK1280813T3 (da) 2004-03-22
NZ521877A (en) 2004-11-26
US20030176370A1 (en) 2003-09-18
AU780879B2 (en) 2005-04-21
CA2406633A1 (en) 2001-11-15
EP1280813B1 (en) 2003-11-12
WO2001085749A1 (en) 2001-11-15
JP2003532735A (ja) 2003-11-05
DE60101223T2 (de) 2004-09-02
PT1280813E (pt) 2004-03-31
ATE254132T1 (de) 2003-11-15
GB0011203D0 (en) 2000-06-28
DE60101223D1 (de) 2003-12-18
US7019135B2 (en) 2006-03-28

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