KR850006171A - 피롤리디논 유도체의 제조방법 - Google Patents

피롤리디논 유도체의 제조방법 Download PDF

Info

Publication number
KR850006171A
KR850006171A KR1019850001130A KR850001130A KR850006171A KR 850006171 A KR850006171 A KR 850006171A KR 1019850001130 A KR1019850001130 A KR 1019850001130A KR 850001130 A KR850001130 A KR 850001130A KR 850006171 A KR850006171 A KR 850006171A
Authority
KR
South Korea
Prior art keywords
compound
formula
hydrogen
carbon atoms
alkyl
Prior art date
Application number
KR1019850001130A
Other languages
English (en)
Other versions
KR920002295B1 (ko
Inventor
푸훼이페르 유고 (외 1)
Original Assignee
마리노 레나
아이·에스·에프·에스·피·에이
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 마리노 레나, 아이·에스·에프·에스·피·에이 filed Critical 마리노 레나
Publication of KR850006171A publication Critical patent/KR850006171A/ko
Application granted granted Critical
Publication of KR920002295B1 publication Critical patent/KR920002295B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음

Description

피롤리디논 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 하기 식(2)의 화합물을 N-탈보호시켜 하기 식(3)의 화합물을 생성하여 분자내에 고리화 반응을 일으킴으로써 하기 식(1)의 피롤리디논 유도체를 제조하는 방법.
    상기 식(2)에서 R1은 수소이며 R2는 벤질 또는 치환된 벤질이며, 또는 R1과 R2는 둘다기를 형성할 수 있는데 여기서, R4와 R5는 각각 수소, 1 내지 4 탄소수의 알킬, 페닐 또는 임의적으로 치환된 알릴이거나 또는 둘 모두 1,4-부틸렌 또는 1,5-펜틸렌(-(CH2)5)-이다; R3는 수소 1 내지 4 탄소수의 직쇄알킬 또는 측쇄알킬이며; 임의적으로 R3가 수소일때 수소일때 생성물은 R이 아실 또는 알릴인 화합물로 전환될 수 있으며; X는 1 내지 10 탄소수의 직쇄알킬 또는 측쇄알킬이다.
  2. 제1항에 있어서 R1과 R2둘 모두는기를 형성할 수 있으며, 탈보호반응과 분자내 고리화 반응은 카르복실산 존재하에 90℃ 내지 160℃의 온도범위에서 가열하는 것을 특징으로 하는 방법.
  3. 제1항 또는 2항에 있어서 R1과 R2는 둘다 2-메틸-프리핀-1,1-디일기(CHCH(CH3)2)를 형성할 수 있으며 R3는 수소인 것을 특징으로 하는 방법.
  4. 제1항에 있어서 R2는 벤질 또는 치환된 벤질이며, 식(2)의 화합물을 목탄에 팔라듐이 입혀져 있는 촉매와의 촉매 수소화 반응에 의해 탈보호화시키는 것을 특징으로 하는 방법.
  5. 제1항 내지 4항중 어느 한 항에 있어서, 하기 식(4) 알킬 3,4-에폭시부타노에이트와 하기 식(5)의 글리신아미드 유도체를 반응시켜 R3가 수소인 식(2)의 화합물을 제조하는 방법.
    상기 식에서 X는 1 내지 10 탄소수의 알킬이며, R1과 R2는 제1항 내지 4항에서 정의된 것과 같으며 임의적으로 R3가 1 내지 4의 탄소수의 직쇄알킬 또는 측쇄알킬일때 생성물은 식(2)의 화합물로 전환될 수 있다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850001130A 1984-02-27 1985-02-22 프롤리디논 유도체의 제조방법 KR920002295B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8419802A IT1206699B (it) 1984-02-27 1984-02-27 Procedimento per preparare derivati di pirrolidone.
IT19802A/84 1984-02-27

Publications (2)

Publication Number Publication Date
KR850006171A true KR850006171A (ko) 1985-10-02
KR920002295B1 KR920002295B1 (ko) 1992-03-21

Family

ID=11161351

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850001130A KR920002295B1 (ko) 1984-02-27 1985-02-22 프롤리디논 유도체의 제조방법

Country Status (20)

Country Link
US (1) US4797496A (ko)
EP (1) EP0154490B1 (ko)
JP (1) JPH0791266B2 (ko)
KR (1) KR920002295B1 (ko)
AT (1) ATE36319T1 (ko)
AU (2) AU584605B2 (ko)
CA (1) CA1241333A (ko)
DE (1) DE3564264D1 (ko)
DK (1) DK86185A (ko)
ES (2) ES8700656A1 (ko)
FI (1) FI81339C (ko)
GR (1) GR850485B (ko)
HU (2) HU193399B (ko)
IL (1) IL74448A (ko)
IT (1) IT1206699B (ko)
NO (1) NO166712C (ko)
NZ (1) NZ211226A (ko)
PH (1) PH22518A (ko)
PT (1) PT80021B (ko)
ZA (1) ZA851401B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4686296A (en) * 1985-07-26 1987-08-11 Denki Kagaku Kogyo Kabushiki Kaisha Process for producing oxiracetam
CH668423A5 (de) * 1986-06-19 1988-12-30 Lonza Ag Verfahren zur herstellung von 4-alkoxy-3-pyrrolin-2-onen.
CH666891A5 (de) * 1985-11-26 1988-08-31 Lonza Ag 4-alkoxy-2-oxo-pyrrolidin-1-yl-essigsaeure-c(1)-c(4)-alkylester, deren herstellung und verwendung.
DE3602254A1 (de) * 1986-01-25 1987-07-30 Basf Ag Verfahren zur herstellung von oxiranylcarbonsaeureestern
CH680293A5 (ko) * 1990-06-26 1992-07-31 Lonza Ag
KR100424393B1 (ko) * 2001-11-26 2004-03-24 한국화학연구원 옥시라세탐의 제조방법
CN101704778B (zh) * 2009-09-30 2012-10-17 厦门市华兴化工有限公司 一种制备4-羟基吡咯烷酮-2-乙酰胺的方法
CN102249977B (zh) * 2011-08-11 2013-06-12 重庆润泽医药有限公司 4-羟基-2-氧代-1-吡咯烷乙酰胺外消旋体晶型ⅰ及其制备方法
CN102432516B (zh) * 2011-12-14 2013-10-09 山东阿如拉药物研究开发有限公司 奥拉西坦的精制方法
CN110615744B (zh) * 2018-06-20 2023-01-06 上海朴颐化学科技有限公司 一种布瓦西坦中间体及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI51098C (fi) * 1975-03-27 1976-10-11 Medipolar Oy Menetelmä terapeuttisesti arvokkaan 2-okso-1-pyrrolidinyyliasetamidin valmistamiseksi.
IT1045043B (it) * 1975-08-13 1980-04-21 Isf Spa Derivati pirrolidinici
IT1075280B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici
IT1075564B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici
JPS5812272B2 (ja) * 1981-04-28 1983-03-07 電気化学工業株式会社 ４−ヒドロキシ−２−ピロリドンの製造法
FR2515179A1 (fr) * 1981-07-24 1983-04-29 Hoffmann La Roche Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
IT1173768B (it) * 1984-04-02 1987-06-24 Isf Spa Procedimento di preparazione di derivati 1-carbamoilmetilici di 4-idrossi-2-osso-pirrolidina nonche' di intermedi per ottenere tali composti

Also Published As

Publication number Publication date
FI81339B (fi) 1990-06-29
US4797496A (en) 1989-01-10
EP0154490B1 (en) 1988-08-10
DK86185A (da) 1985-08-28
GR850485B (ko) 1985-06-26
JPH0791266B2 (ja) 1995-10-04
PH22518A (en) 1988-09-12
AU3918085A (en) 1985-09-05
HUT38614A (en) 1986-06-30
NO166712B (no) 1991-05-21
DK86185D0 (da) 1985-02-26
FI850505A0 (fi) 1985-02-07
NO166712C (no) 1991-08-28
NO850778L (no) 1985-08-28
ES8700656A1 (es) 1986-10-16
NZ211226A (en) 1990-06-26
KR920002295B1 (ko) 1992-03-21
EP0154490A3 (en) 1986-02-12
CA1241333A (en) 1988-08-30
FI81339C (fi) 1990-10-10
AU612000B2 (en) 1991-06-27
ZA851401B (en) 1985-11-27
ES540601A0 (es) 1986-10-16
IT1206699B (it) 1989-04-27
ATE36319T1 (de) 1988-08-15
HU195957B (en) 1988-08-29
AU584605B2 (en) 1989-06-01
ES8800135A1 (es) 1987-10-16
EP0154490A2 (en) 1985-09-11
FI850505L (fi) 1985-08-28
HU193399B (en) 1987-10-28
IT8419802A0 (it) 1984-02-27
IL74448A0 (en) 1985-05-31
IL74448A (en) 1989-01-31
DE3564264D1 (en) 1988-09-15
JPS60208957A (ja) 1985-10-21
CA1256883C (ko) 1989-07-04
AU3024789A (en) 1989-06-22
ES552957A0 (es) 1987-10-16
PT80021B (pt) 1987-06-17
HUT41391A (en) 1987-04-28

Similar Documents

Publication Publication Date Title
KR860001104A (ko) 테트라히드로프탈이미드의 제조방법
KR850006171A (ko) 피롤리디논 유도체의 제조방법
KR830006198A (ko) 시클로헥산 유도체의 제조방법
KR860008144A (ko) 1,3- 디알킬 -2- 이미다졸리디논의 제조방법
KR880009010A (ko) 신규한 테트라히드로 푸란의 5-옥시 유도체의 제조방법
KR850001724A (ko) 4-페닐-4-옥소-부텐-2-오인산유도체의 제조방법
KR840001968A (ko) 4-페닐퀴나졸린 유도체의 제조방법
KR840000530A (ko) 신규 벤조트리아졸의 제조방법
KR830009077A (ko) 푸란 유도체의 제조방법
KR920008054A (ko) 4-에톡시페닐-3-아릴프로필(디메틸)실란의 제조방법
KR850001165A (ko) 중추 신경계 활성을 갖는 피롤리디논의 제조방법
KR840002821A (ko) N-(2,3-에폭시프로필렌)-n-아르알킬술폰아미드 유도체의 제조방법
KR870002110A (ko) 구아니디노티아졸 유도체의 제조방법
KR830004211A (ko) N-(2,2-디알콕시에틸)-n-치환된-2,2-디클로로 아세트아미드의 제조방법
KR850007069A (ko) N-아실화 1-알킬아미노-1-데옥시-케토오스 유도체의 제조방법
KR830006205A (ko) 인돌 및 인돌린 유도체의 방법
KR950700246A (ko) E형 프로스타글라딘류의 제조방법
KR830001890A (ko) 카바졸 유도체의 제조방법
KR880001635A (ko) 5-플루오로우라실 유도체, 그의 제조방법 및 용도
ES412047A1 (es) Un procedimiento para la preparacion de dihidrocumarina o una alcohil-dihidrocumarina.
BR7906138A (pt) Processo para isomerizacao de zm cis- ou trans-2-ciano-3-aza-biciclo-(3,1,0)-hexano
KR910016673A (ko) 히드록시페닐프로피오네이트의 제조방법
KR840006227A (ko) 5-티오-1,2,3-티아디아졸의 합성법
KR840004404A (ko) 3-페닐피롤 유도체의 제조방법
KR880002871A (ko) 피롤로디아제핀 화합물의 제조방법

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20040113

Year of fee payment: 13

EXPY Expiration of term