KR950700246A - E형 프로스타글라딘류의 제조방법 - Google Patents
E형 프로스타글라딘류의 제조방법Info
- Publication number
- KR950700246A KR950700246A KR1019940702557A KR19940702557A KR950700246A KR 950700246 A KR950700246 A KR 950700246A KR 1019940702557 A KR1019940702557 A KR 1019940702557A KR 19940702557 A KR19940702557 A KR 19940702557A KR 950700246 A KR950700246 A KR 950700246A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- lower alkyl
- prostaglandin
- different
- same
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 3
- 229940094443 oxytocics prostaglandins Drugs 0.000 title claims description 3
- 150000003180 prostaglandins Chemical class 0.000 title claims description 3
- 125000000217 alkyl group Chemical group 0.000 claims abstract 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims abstract 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical group [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims abstract 3
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 2
- -1 allyl ester Chemical class 0.000 claims abstract 2
- 125000003118 aryl group Chemical group 0.000 claims abstract 2
- 125000005677 ethinylene group Chemical group [*:2]C#C[*:1] 0.000 claims abstract 2
- 235000019253 formic acid Nutrition 0.000 claims abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 2
- 125000006239 protecting group Chemical group 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 1
- 150000007860 aryl ester derivatives Chemical group 0.000 claims 1
- 229910052763 palladium Inorganic materials 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0235—Nitrogen containing compounds
- B01J31/0237—Amines
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0255—Phosphorus containing compounds
- B01J31/0267—Phosphines or phosphonium compounds, i.e. phosphorus bonded to at least one carbon atom, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, the other atoms bonded to phosphorus being either carbon or hydrogen
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/04—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing carboxylic acids or their salts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
- B01J31/2204—Organic complexes the ligands containing oxygen or sulfur as complexing atoms
- B01J31/2208—Oxygen, e.g. acetylacetonates
- B01J31/2226—Anionic ligands, i.e. the overall ligand carries at least one formal negative charge
- B01J31/223—At least two oxygen atoms present in one at least bidentate or bridging ligand
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
- B01J31/2282—Unsaturated compounds used as ligands
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
- B01J31/2282—Unsaturated compounds used as ligands
- B01J31/2291—Olefins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B61/00—Other general methods
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/80—Complexes comprising metals of Group VIII as the central metal
- B01J2531/82—Metals of the platinum group
- B01J2531/824—Palladium
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Abstract
[목적] : 단시간에 효율 좋게, 또한 이성체의 생성을 극히 적도록 억제하여 E형 프로스타글란딘류를 제조한다.
[구성] : 식
[식중, R1및 R2는 동일 또는 상이한 것으로서 수소원자 또는 저급 알킬기를 나타내고, R3는 수소원자, 저급알킬기, 알케일기 또는 아릴기를 나타내고, R4및 R5는 동일 또는 상이한 것으로서 수소원자 또는 히드록시기의 보호기를 나타내고, A, R6및 R7는 반응에 관여하지 않은 임의의 기를 나타내고, B는 비닐렌기 또는 에티닐렌기를 나타낸다]로 표시되는 E형 프로스타글란딘류의 아릴에스테르를, 0가 또는 2가의 착체 또는 착염의 존재하에 염기 및 포름산으로 된 군에서 선택된 1종 또는 2종과 반응시킴을 특징으로 하는 식
(식중, A,B,R4,R5,R6및 R7는 전술한 바와 같다)로 표시되는 E형 프로스 타글란딘류의 제조방법.
Description
[발명의 목적]
E형 프로스타글라딘류의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- (1) 식[식중, R1및 R2는 동일 또는 상이한 것으로서 수소원자 또는 저급 알킬기를 나타내고, R3는 수소원자, 저급알킬기, 알케닐기 또는 아릴기를 나타내고, R4및 R5는 동일 또는 상이한 것으로서 수소원자 또는 히드록시기의 보호기를 나타내고, A, R6및 R7는 반응에 관여하지 않은 임의의 기를 나타내고, B는 비닐렌기 또는 에티닐렌기를 나타낸다]로 표시되는 E형 프로스타글란딘류의 아릴에스테르를, 0가 또는 2가의 팔라듐 착체 또는 착염의 존재하에 염기 및 포름산으로 된 군에서 선택된 1종 또는 2종과 반응시킴을 특징으로 하는 식(식중, A,B,R4,R5,R6및 R7는 전술한 바와 같다)로 표시되는 E형 프로스 타글란딘류의 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2026492 | 1992-02-05 | ||
| JP20151/1992 | 1992-02-05 | ||
| JP2015192 | 1992-02-05 | ||
| JP20264/1992 | 1992-02-05 | ||
| PCT/JP1993/000115 WO1993016041A1 (en) | 1992-02-05 | 1993-02-02 | Process for producing prostaglandin e |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR950700246A true KR950700246A (ko) | 1995-01-16 |
| KR100255355B1 KR100255355B1 (ko) | 2000-05-01 |
Family
ID=26357058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019940702557A KR100255355B1 (ko) | 1992-02-05 | 1993-02-02 | E형 프로스타글란딘류의 제조방법 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5648526A (ko) |
| EP (1) | EP0627416B1 (ko) |
| JP (1) | JP3153241B2 (ko) |
| KR (1) | KR100255355B1 (ko) |
| AT (1) | ATE166048T1 (ko) |
| AU (1) | AU665980B2 (ko) |
| CA (1) | CA2129537C (ko) |
| DE (1) | DE69318546T2 (ko) |
| WO (1) | WO1993016041A1 (ko) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2099822T3 (es) * | 1991-04-22 | 1997-06-01 | Taisho Pharmaceutical Co Ltd | Analogo de prostaglandina e1. |
| JP3316018B2 (ja) | 1992-03-13 | 2002-08-19 | 大正製薬株式会社 | Ｅ型プロスタグランジン類またはそのエステルの製造方法 |
| AU770343B2 (en) * | 1999-09-06 | 2004-02-19 | Fumie Sato | Prostaglandin E analogues |
| EP2143712A1 (en) * | 2008-07-10 | 2010-01-13 | Sandoz AG | Improved Process for the Production of Prostaglandins and Prostaglandin Analogs |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5221392A (en) * | 1975-08-13 | 1977-02-17 | Teijin Ltd | Process for preparing prostaglandin derivatives |
| JPS5874661A (ja) * | 1981-10-30 | 1983-05-06 | Teijin Ltd | Ｅ型プロスタン酸誘導体の新規製造法 |
| ES2099822T3 (es) * | 1991-04-22 | 1997-06-01 | Taisho Pharmaceutical Co Ltd | Analogo de prostaglandina e1. |
-
1993
- 1993-02-02 DE DE69318546T patent/DE69318546T2/de not_active Expired - Lifetime
- 1993-02-02 US US08/256,924 patent/US5648526A/en not_active Expired - Lifetime
- 1993-02-02 EP EP93902553A patent/EP0627416B1/en not_active Expired - Lifetime
- 1993-02-02 JP JP51394093A patent/JP3153241B2/ja not_active Expired - Lifetime
- 1993-02-02 KR KR1019940702557A patent/KR100255355B1/ko not_active IP Right Cessation
- 1993-02-02 WO PCT/JP1993/000115 patent/WO1993016041A1/ja active IP Right Grant
- 1993-02-02 AU AU33680/93A patent/AU665980B2/en not_active Ceased
- 1993-02-02 CA CA002129537A patent/CA2129537C/en not_active Expired - Fee Related
- 1993-02-02 AT AT93902553T patent/ATE166048T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69318546D1 (de) | 1998-06-18 |
| EP0627416A1 (en) | 1994-12-07 |
| JP3153241B2 (ja) | 2001-04-03 |
| CA2129537A1 (en) | 1993-08-06 |
| EP0627416B1 (en) | 1998-05-13 |
| AU665980B2 (en) | 1996-01-25 |
| WO1993016041A1 (en) | 1993-08-19 |
| EP0627416A4 (en) | 1995-05-03 |
| ATE166048T1 (de) | 1998-05-15 |
| US5648526A (en) | 1997-07-15 |
| DE69318546T2 (de) | 1998-09-10 |
| CA2129537C (en) | 2002-05-07 |
| KR100255355B1 (ko) | 2000-05-01 |
| AU3368093A (en) | 1993-09-03 |
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