KR840001968A - 4-페닐퀴나졸린 유도체의 제조방법 - Google Patents
4-페닐퀴나졸린 유도체의 제조방법 Download PDFInfo
- Publication number
- KR840001968A KR840001968A KR1019820004715A KR820004715A KR840001968A KR 840001968 A KR840001968 A KR 840001968A KR 1019820004715 A KR1019820004715 A KR 1019820004715A KR 820004715 A KR820004715 A KR 820004715A KR 840001968 A KR840001968 A KR 840001968A
- Authority
- KR
- South Korea
- Prior art keywords
- derivative
- group
- phenylquinazoline
- phosphorus
- phenyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 3
- VEFDQCSIVBIYFQ-UHFFFAOYSA-N 4-phenylquinazoline Chemical class C1=CC=CC=C1C1=NC=NC2=CC=CC=C12 VEFDQCSIVBIYFQ-UHFFFAOYSA-N 0.000 title claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 150000003017 phosphorus Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000007858 starting material Substances 0.000 claims 2
- CRVSRCOECJCBAJ-UHFFFAOYSA-N 2,6-dichloro-4-phenylquinazoline Chemical compound C12=CC(Cl)=CC=C2N=C(Cl)N=C1C1=CC=CC=C1 CRVSRCOECJCBAJ-UHFFFAOYSA-N 0.000 claims 1
- DBKIXSRJBMRMMF-UHFFFAOYSA-N 6-chloro-4-phenyl-1h-quinazolin-2-one Chemical class C12=CC(Cl)=CC=C2NC(=O)N=C1C1=CC=CC=C1 DBKIXSRJBMRMMF-UHFFFAOYSA-N 0.000 claims 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 238000009835 boiling Methods 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 230000000536 complexating effect Effects 0.000 claims 1
- RCJVRSBWZCNNQT-UHFFFAOYSA-N dichloridooxygen Chemical group ClOCl RCJVRSBWZCNNQT-UHFFFAOYSA-N 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 239000012442 inert solvent Substances 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 235000005985 organic acids Nutrition 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Luminescent Compositions (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- 적절히 치환된 6-클로로 4-페닐 2-퀴나졸론을 출발물지로서 사용하여 약 60~120℃의 온도에서 인의 염소화 유도체를 착화시킴으로써 이 출발물질을 상응하는 2,6-디클로로 4-페닐퀴나졸린으로 전환시키고, 그리고 수득된 생성물을 불활성 용매중에서 식 H1H를 같는 과량의 아민과 반응시키는 단계로 이루어짐을 특징으로 하는 하기 일반식(Ⅰ) 4-의페닐퀴나졸린 유도체 및 이들 신규 유도체와 약학적으로 무독한 무기 또는 유기산과의 염의 제조방법상기 식에서, R1은 a) 기[식중, R3는 기-(CH2)nOH를 기타내고, R4는 n이 2,3 또는 4의 정수를 나타내는 기 (CH2)nOH를 나타냄]; b) 기[식중, R5는 메타 또는 파라 위에 위치한 -(CH2)m-OH(m은 0~2의 정수임)를 나타냄];c) 기로부터 선택되며, R2는 할로겐원자, 바람직하게는 염소 또는플루오르원자를 나타내거나, 또는 R1이인 경우 수소이어도 무방하다.
- 제1항에 있어서, 인의 염소하 유도체가 옥시염화인 염을 특징으로 하는 방법.
- 제1 및 2항중의 하나에 있어서, 아민과의 반응이 에탄올중 이 용매의 비점온도에서 수행됨을 특징으로 하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8119767A FR2514765A1 (fr) | 1981-10-21 | 1981-10-21 | Nouveaux derives de la phenyl-4 quinazoline actifs sur le systeme nerveux central |
| FR81/19767 | 1981-10-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR840001968A true KR840001968A (ko) | 1984-06-07 |
| KR880001077B1 KR880001077B1 (ko) | 1988-06-22 |
Family
ID=9263248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR8204715A KR880001077B1 (ko) | 1981-10-21 | 1982-10-20 | 4-페닐 퀴나졸린 유도체의 제조방법 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4499092A (ko) |
| EP (1) | EP0079810B1 (ko) |
| JP (1) | JPS5888369A (ko) |
| KR (1) | KR880001077B1 (ko) |
| AT (1) | ATE17576T1 (ko) |
| AU (1) | AU551938B2 (ko) |
| CA (1) | CA1236102A (ko) |
| CS (1) | CS229692B2 (ko) |
| DD (1) | DD210040A5 (ko) |
| DE (1) | DE3268699D1 (ko) |
| DK (1) | DK156063C (ko) |
| ES (1) | ES8307226A1 (ko) |
| FI (1) | FI73982C (ko) |
| FR (1) | FR2514765A1 (ko) |
| GR (1) | GR76535B (ko) |
| HU (1) | HU187579B (ko) |
| IE (1) | IE53653B1 (ko) |
| IL (1) | IL66960A0 (ko) |
| NO (1) | NO164167C (ko) |
| NZ (1) | NZ202237A (ko) |
| PT (1) | PT75667B (ko) |
| SU (1) | SU1299511A3 (ko) |
| YU (1) | YU43528B (ko) |
| ZA (1) | ZA827516B (ko) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2521144A1 (fr) * | 1982-02-08 | 1983-08-12 | Sanofi Sa | Nouveaux derives de la piperazinyl-2 phenyl-4 quinazoline possedant des proprietes antidepressives, methode de preparation desdits composes et medicaments en contenant |
| WO1994007498A1 (en) * | 1992-10-07 | 1994-04-14 | Sumitomo Pharmaceuticals Company, Limited | Pharmaceutical composition for inhibiting tumor necrosis factor production |
| JPH11209350A (ja) | 1998-01-26 | 1999-08-03 | Eisai Co Ltd | 含窒素複素環誘導体およびその医薬 |
| US20050009817A1 (en) * | 2003-04-30 | 2005-01-13 | Jennifer Savoy | Substituted heteroaryls |
| WO2005042501A1 (en) * | 2003-11-03 | 2005-05-12 | Warner-Lambert Company Llc | Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders |
| WO2007000392A2 (en) * | 2005-06-27 | 2007-01-04 | F. Hoffmann-La Roche Ag | Chloro-substituted guanidines |
| US7855194B2 (en) | 2006-03-27 | 2010-12-21 | Hoffmann-La Roche Inc. | Pyrimidine, quinazoline, pteridine and triazine derivatives |
| CA2669275C (en) * | 2006-11-22 | 2015-02-24 | Sumitomo Chemical Company, Limited | Agent for inhibiting cytokinin signaling |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA894239A (en) * | 1972-02-29 | Pfizer Inc. | Nitrogen heterocycles | |
| US3305553A (en) * | 1965-10-18 | 1967-02-21 | Parke Davis & Co | 2-aminoquinazoline derivatives |
| US3509141A (en) * | 1966-09-15 | 1970-04-28 | Ciba Geigy Corp | 2-amino-quinazolines |
| GB1347493A (en) * | 1971-02-11 | 1974-02-27 | Aspro Nicholas Ltd | Benzazine derivatives |
| JPS5398997A (en) * | 1977-02-09 | 1978-08-29 | Sumitomo Chem Co Ltd | Fused pyridine derivertives and process for their preparation |
-
1981
- 1981-10-21 FR FR8119767A patent/FR2514765A1/fr active Granted
-
1982
- 1982-09-29 GR GR69402A patent/GR76535B/el unknown
- 1982-10-05 YU YU2233/82A patent/YU43528B/xx unknown
- 1982-10-08 IE IE2447/82A patent/IE53653B1/en not_active IP Right Cessation
- 1982-10-11 IL IL66960A patent/IL66960A0/xx not_active IP Right Cessation
- 1982-10-12 PT PT75667A patent/PT75667B/pt not_active IP Right Cessation
- 1982-10-14 ZA ZA827516A patent/ZA827516B/xx unknown
- 1982-10-18 DE DE8282401905T patent/DE3268699D1/de not_active Expired
- 1982-10-18 EP EP82401905A patent/EP0079810B1/fr not_active Expired
- 1982-10-18 AT AT82401905T patent/ATE17576T1/de not_active IP Right Cessation
- 1982-10-19 US US06/435,230 patent/US4499092A/en not_active Expired - Fee Related
- 1982-10-19 CS CS827411A patent/CS229692B2/cs unknown
- 1982-10-20 NO NO823491A patent/NO164167C/no unknown
- 1982-10-20 KR KR8204715A patent/KR880001077B1/ko active
- 1982-10-20 FI FI823580A patent/FI73982C/fi not_active IP Right Cessation
- 1982-10-20 DK DK465182A patent/DK156063C/da not_active IP Right Cessation
- 1982-10-20 HU HU823354A patent/HU187579B/hu not_active IP Right Cessation
- 1982-10-20 NZ NZ202237A patent/NZ202237A/en unknown
- 1982-10-20 DD DD82244148A patent/DD210040A5/de unknown
- 1982-10-20 SU SU823502049A patent/SU1299511A3/ru active
- 1982-10-20 AU AU89628/82A patent/AU551938B2/en not_active Ceased
- 1982-10-20 CA CA000413787A patent/CA1236102A/en not_active Expired
- 1982-10-20 ES ES516694A patent/ES8307226A1/es not_active Expired
- 1982-10-21 JP JP57183801A patent/JPS5888369A/ja active Pending
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