KR840000551A - 이미다조[1, 2-a]피리미딘의 제조방법 - Google Patents
이미다조[1, 2-a]피리미딘의 제조방법 Download PDFInfo
- Publication number
- KR840000551A KR840000551A KR1019820002812A KR820002812A KR840000551A KR 840000551 A KR840000551 A KR 840000551A KR 1019820002812 A KR1019820002812 A KR 1019820002812A KR 820002812 A KR820002812 A KR 820002812A KR 840000551 A KR840000551 A KR 840000551A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- pyrimidine
- compound
- acid addition
- temperature
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (2)
- 일반식 (Ⅱ)의 화합물을 60 내지 180℃의 온도에서 폐환시키거나, 일반식 (Ⅲ)의 이미다조 [12-a]-피리미딘을 강염기의 존재하에서 40 내지 60℃의 온도에서 이성질화시키고, 필요시 수득한 염기를 그의 산부가염으로 전환시킴을 특징으로 하여 일반식 (Ⅰ)의 화합물 및 그의 산부가염을 제조하는 방법.상기식에서 R은 수소, 불소, 염소 또는 브롬원자나 메틸 또는 트리플루오로 메틸 그룹으로 모노-내지 트리치환된 페닐 그룹이며, 여기에서 치환체는 동일하거나 다르다.
- 제 1 항에 있어서, 극성 또는 비극성 유기용매의 존재하에서 반응시킴의 특징인 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813124718 DE3124718A1 (de) | 1981-06-24 | 1981-06-24 | Neue imidazo (1,2-a)pyramidine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung |
| DEP3,124,718.0 | 1981-06-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR840000551A true KR840000551A (ko) | 1984-02-25 |
Family
ID=6135235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019820002812A KR840000551A (ko) | 1981-06-24 | 1982-06-23 | 이미다조[1, 2-a]피리미딘의 제조방법 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4438118A (ko) |
| EP (1) | EP0068302A1 (ko) |
| JP (1) | JPS584784A (ko) |
| KR (1) | KR840000551A (ko) |
| AU (1) | AU8531482A (ko) |
| CS (1) | CS226449B2 (ko) |
| DE (1) | DE3124718A1 (ko) |
| DK (1) | DK281882A (ko) |
| ES (2) | ES8307811A1 (ko) |
| FI (1) | FI822236L (ko) |
| GR (1) | GR76833B (ko) |
| HU (1) | HU185108B (ko) |
| IL (1) | IL66111A0 (ko) |
| NO (1) | NO822076L (ko) |
| PL (1) | PL237052A1 (ko) |
| PT (1) | PT75107B (ko) |
| YU (1) | YU135182A (ko) |
| ZA (1) | ZA824437B (ko) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4636502A (en) * | 1982-12-27 | 1987-01-13 | Eli Lilly And Company | Methods of producing a positive inotropic effect or vasodilation by administration of 2-phenyl imidazo pyrimidines and pyrazines |
| JPS60193990A (ja) * | 1984-03-12 | 1985-10-02 | Yoshitomi Pharmaceut Ind Ltd | 新規なポリアザ複素環誘導体 |
| JPS6152118A (ja) * | 1984-08-21 | 1986-03-14 | 三菱電機株式会社 | 電源装置 |
| US5252563A (en) * | 1991-12-19 | 1993-10-12 | G. D. Searle & Company | 5,6,7,8-tetrahydro-imidazo[1,2-a]pyrimidine compounds for treatment of neurotoxic injury |
| JP4209165B2 (ja) | 2002-09-30 | 2009-01-14 | 本田技研工業株式会社 | 車両用情報表示装置 |
| GB2456961A (en) * | 2006-10-19 | 2009-08-05 | Blaise Harrison Llc | Exothermic personal lubricant |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2118261A1 (de) | 1971-04-15 | 1972-11-02 | C.H. Boehringer Sohn, 6507 Ingelheim | Neue N-haltige Bicyclen, deren Säureadditionssalze sowie Verfahren zu deren Herstellung |
| BE786028A (fr) | 1971-07-08 | 1973-01-08 | Boehringer Sohn Ingelheim | 2,3-dihydro-oxo-imidazo(1,2-a)-pyrimidines, leurs sels d'addition avec des acides et procedes pour les fabriquer |
| DE2523103C3 (de) | 1975-05-24 | 1979-11-29 | C.H. Boehringer Sohn, 6507 Ingelheim | Substituierte 2-[N-Progargyl-N-(2-chlorphenyl)amino] -imidazoline-^), deren Säureadditionssalze, Verfahren zu ihrer Herstellung und deren Verwendung |
-
1981
- 1981-06-24 DE DE19813124718 patent/DE3124718A1/de not_active Withdrawn
-
1982
- 1982-06-16 EP EP82105264A patent/EP0068302A1/de not_active Withdrawn
- 1982-06-17 US US06/389,284 patent/US4438118A/en not_active Expired - Fee Related
- 1982-06-21 YU YU01351/82A patent/YU135182A/xx unknown
- 1982-06-22 NO NO822076A patent/NO822076L/no unknown
- 1982-06-22 PL PL23705282A patent/PL237052A1/xx unknown
- 1982-06-22 FI FI822236A patent/FI822236L/fi not_active Application Discontinuation
- 1982-06-23 ES ES513377A patent/ES8307811A1/es not_active Expired
- 1982-06-23 IL IL66111A patent/IL66111A0/xx unknown
- 1982-06-23 CS CS824664A patent/CS226449B2/cs unknown
- 1982-06-23 GR GR68539A patent/GR76833B/el unknown
- 1982-06-23 ZA ZA824437A patent/ZA824437B/xx unknown
- 1982-06-23 JP JP57108262A patent/JPS584784A/ja active Pending
- 1982-06-23 PT PT75107A patent/PT75107B/pt unknown
- 1982-06-23 DK DK281882A patent/DK281882A/da not_active Application Discontinuation
- 1982-06-23 KR KR1019820002812A patent/KR840000551A/ko unknown
- 1982-06-23 HU HU822032A patent/HU185108B/hu unknown
- 1982-06-24 AU AU85314/82A patent/AU8531482A/en not_active Abandoned
- 1982-12-23 ES ES518499A patent/ES8308884A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FI822236L (fi) | 1982-12-25 |
| ES513377A0 (es) | 1983-07-01 |
| PT75107B (de) | 1985-05-31 |
| US4438118A (en) | 1984-03-20 |
| YU135182A (en) | 1986-04-30 |
| ES518499A0 (es) | 1983-10-01 |
| DK281882A (da) | 1982-12-25 |
| ES8308884A1 (es) | 1983-10-01 |
| AU8531482A (en) | 1983-01-06 |
| NO822076L (no) | 1982-12-27 |
| IL66111A0 (en) | 1982-09-30 |
| PL237052A1 (en) | 1983-06-20 |
| FI822236A0 (fi) | 1982-06-22 |
| ES8307811A1 (es) | 1983-07-01 |
| PT75107A (de) | 1982-07-01 |
| DE3124718A1 (de) | 1983-01-13 |
| JPS584784A (ja) | 1983-01-11 |
| EP0068302A1 (de) | 1983-01-05 |
| HU185108B (en) | 1984-12-28 |
| GR76833B (ko) | 1984-09-04 |
| CS226449B2 (en) | 1984-03-19 |
| ZA824437B (en) | 1984-02-29 |
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