ES8308884A1 - Procedimiento para la preparacion de nuevas imidazo(1,2-a)pirimidinas. - Google Patents
Procedimiento para la preparacion de nuevas imidazo(1,2-a)pirimidinas.Info
- Publication number
- ES8308884A1 ES8308884A1 ES518499A ES518499A ES8308884A1 ES 8308884 A1 ES8308884 A1 ES 8308884A1 ES 518499 A ES518499 A ES 518499A ES 518499 A ES518499 A ES 518499A ES 8308884 A1 ES8308884 A1 ES 8308884A1
- Authority
- ES
- Spain
- Prior art keywords
- pyrimidines
- addition salts
- imidazo
- preparation
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE IMIDAZOL _[1,2-A PIRIMIDINAS Y DE SUS SALES DE ADICION DE ACIDO, DE FORMULA (I), EN LA QUE R PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE ISOMERIZACION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R TIENE EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO POR TRATAMIENTO A TEMPERATURAS ENTRE 40 C Y 60 C EN UN DISOLVENTE ORGANICO, POLAR O NO POLAR, EN PRESENCIA DE UNA BASE FUERTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS EFECTOS ANALGESICOS, HIPOTENSORES Y REDUCTORES DEL RITMO CARDIACO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813124718 DE3124718A1 (de) | 1981-06-24 | 1981-06-24 | Neue imidazo (1,2-a)pyramidine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES518499A0 ES518499A0 (es) | 1983-10-01 |
| ES8308884A1 true ES8308884A1 (es) | 1983-10-01 |
Family
ID=6135235
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES513377A Expired ES8307811A1 (es) | 1981-06-24 | 1982-06-23 | "procedimiento para la preparacion de nuevas imidazo 1,2-a pirimidinas". |
| ES518499A Expired ES8308884A1 (es) | 1981-06-24 | 1982-12-23 | Procedimiento para la preparacion de nuevas imidazo(1,2-a)pirimidinas. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES513377A Expired ES8307811A1 (es) | 1981-06-24 | 1982-06-23 | "procedimiento para la preparacion de nuevas imidazo 1,2-a pirimidinas". |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4438118A (es) |
| EP (1) | EP0068302A1 (es) |
| JP (1) | JPS584784A (es) |
| KR (1) | KR840000551A (es) |
| AU (1) | AU8531482A (es) |
| CS (1) | CS226449B2 (es) |
| DE (1) | DE3124718A1 (es) |
| DK (1) | DK281882A (es) |
| ES (2) | ES8307811A1 (es) |
| FI (1) | FI822236L (es) |
| GR (1) | GR76833B (es) |
| HU (1) | HU185108B (es) |
| IL (1) | IL66111A0 (es) |
| NO (1) | NO822076L (es) |
| PL (1) | PL237052A1 (es) |
| PT (1) | PT75107B (es) |
| YU (1) | YU135182A (es) |
| ZA (1) | ZA824437B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4636502A (en) * | 1982-12-27 | 1987-01-13 | Eli Lilly And Company | Methods of producing a positive inotropic effect or vasodilation by administration of 2-phenyl imidazo pyrimidines and pyrazines |
| JPS60193990A (ja) * | 1984-03-12 | 1985-10-02 | Yoshitomi Pharmaceut Ind Ltd | 新規なポリアザ複素環誘導体 |
| JPS6152118A (ja) * | 1984-08-21 | 1986-03-14 | 三菱電機株式会社 | 電源装置 |
| US5252563A (en) * | 1991-12-19 | 1993-10-12 | G. D. Searle & Company | 5,6,7,8-tetrahydro-imidazo[1,2-a]pyrimidine compounds for treatment of neurotoxic injury |
| JP4209165B2 (ja) | 2002-09-30 | 2009-01-14 | 本田技研工業株式会社 | 車両用情報表示装置 |
| WO2008060817A2 (en) * | 2006-10-19 | 2008-05-22 | Blaise Harrison Llc | Exothermic personal lubricant |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2118261A1 (de) * | 1971-04-15 | 1972-11-02 | C.H. Boehringer Sohn, 6507 Ingelheim | Neue N-haltige Bicyclen, deren Säureadditionssalze sowie Verfahren zu deren Herstellung |
| BE786028A (fr) | 1971-07-08 | 1973-01-08 | Boehringer Sohn Ingelheim | 2,3-dihydro-oxo-imidazo(1,2-a)-pyrimidines, leurs sels d'addition avec des acides et procedes pour les fabriquer |
| DE2523103C3 (de) | 1975-05-24 | 1979-11-29 | C.H. Boehringer Sohn, 6507 Ingelheim | Substituierte 2-[N-Progargyl-N-(2-chlorphenyl)amino] -imidazoline-^), deren Säureadditionssalze, Verfahren zu ihrer Herstellung und deren Verwendung |
-
1981
- 1981-06-24 DE DE19813124718 patent/DE3124718A1/de not_active Withdrawn
-
1982
- 1982-06-16 EP EP82105264A patent/EP0068302A1/de not_active Withdrawn
- 1982-06-17 US US06/389,284 patent/US4438118A/en not_active Expired - Fee Related
- 1982-06-21 YU YU01351/82A patent/YU135182A/xx unknown
- 1982-06-22 NO NO822076A patent/NO822076L/no unknown
- 1982-06-22 PL PL23705282A patent/PL237052A1/xx unknown
- 1982-06-22 FI FI822236A patent/FI822236L/fi not_active Application Discontinuation
- 1982-06-23 KR KR1019820002812A patent/KR840000551A/ko not_active Withdrawn
- 1982-06-23 ES ES513377A patent/ES8307811A1/es not_active Expired
- 1982-06-23 HU HU822032A patent/HU185108B/hu unknown
- 1982-06-23 PT PT75107A patent/PT75107B/pt unknown
- 1982-06-23 DK DK281882A patent/DK281882A/da not_active Application Discontinuation
- 1982-06-23 ZA ZA824437A patent/ZA824437B/xx unknown
- 1982-06-23 IL IL66111A patent/IL66111A0/xx unknown
- 1982-06-23 GR GR68539A patent/GR76833B/el unknown
- 1982-06-23 CS CS824664A patent/CS226449B2/cs unknown
- 1982-06-23 JP JP57108262A patent/JPS584784A/ja active Pending
- 1982-06-24 AU AU85314/82A patent/AU8531482A/en not_active Abandoned
- 1982-12-23 ES ES518499A patent/ES8308884A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0068302A1 (de) | 1983-01-05 |
| HU185108B (en) | 1984-12-28 |
| ES513377A0 (es) | 1983-07-01 |
| PT75107A (de) | 1982-07-01 |
| CS226449B2 (en) | 1984-03-19 |
| NO822076L (no) | 1982-12-27 |
| ES518499A0 (es) | 1983-10-01 |
| DK281882A (da) | 1982-12-25 |
| YU135182A (en) | 1986-04-30 |
| FI822236A0 (fi) | 1982-06-22 |
| IL66111A0 (en) | 1982-09-30 |
| PL237052A1 (en) | 1983-06-20 |
| JPS584784A (ja) | 1983-01-11 |
| AU8531482A (en) | 1983-01-06 |
| DE3124718A1 (de) | 1983-01-13 |
| ZA824437B (en) | 1984-02-29 |
| FI822236A7 (fi) | 1982-12-25 |
| GR76833B (es) | 1984-09-04 |
| KR840000551A (ko) | 1984-02-25 |
| ES8307811A1 (es) | 1983-07-01 |
| PT75107B (de) | 1985-05-31 |
| FI822236L (fi) | 1982-12-25 |
| US4438118A (en) | 1984-03-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8304095A1 (es) | Un procedimiento para la preparacion de derivados de quinazolina. | |
| ES8306124A1 (es) | Procedimiento para la obtencion de derivados de imidazol trisustituidos. | |
| ES8303293A1 (es) | "procedimiento de preparar derivados carboxamidicos". | |
| ES8301980A1 (es) | Procedimiento para la preparacion de 8-arilalcohil-3-fenil-3-nortropanoles . | |
| ES8601992A1 (es) | Procedimiento para preparar 2-fenil-imidazoles | |
| ES8306750A1 (es) | Un procedimiento para la preparacion de 2-guanidino-4-heteroariltiazoles. | |
| ES8506616A1 (es) | Un procedimiento para la preparacion de carboxamidas | |
| ES8801222A1 (es) | Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina | |
| ES8206527A1 (es) | Procedimiento para la 5-aroilacion de esteres de acidos 1,2-dihidro-3h-pirrolo(1,2-a)pirrol-1-carboxilicos. | |
| ES8707243A1 (es) | Un procedimiento para preparar derivados de tienopiridona | |
| FI854926A0 (fi) | Foerfarande foer framstaellning av farmakologiskt aktiva pyrrolobensimidazoler. | |
| ES8609193A1 (es) | Procedimiento para preparar analogos de mevalonolactona y derivados de los mismos | |
| ES8308884A1 (es) | Procedimiento para la preparacion de nuevas imidazo(1,2-a)pirimidinas. | |
| ES2044901T3 (es) | Procedimiento para la preparacion de un derivado de imidazol y su utilizacion. | |
| ES8609327A1 (es) | Procedimiento para preparar derivados de imidazo (1,5-a)pi- rimidina | |
| ES8301883A1 (es) | Procedimiento para la preparacion de derivados de ciclohexe-no | |
| ES8800193A1 (es) | Procedimiento para preparar 2,4-difenil-1,3-dioxanos | |
| ES8303424A1 (es) | Procedimiento para la obtencion de esteres del acido 7b-(2-(2-animo-4-tiazolil)-2-(sin)-metoxiimino-acetamido)-3-cefem-4-caboxilico. | |
| ES8600730A1 (es) | Procedimiento para la preparacion de agentes anti-psoriaticos del tipo naftalenico | |
| ES8307827A1 (es) | "procedimiento para la preparacion de tiazolo(3,2-a)pirimidinas sustituidas". | |
| ES8601209A1 (es) | Procedimiento para preparar derivados de 5h-(1)-benzopirano-(2,3-d)pirimidina | |
| ES8201954A1 (es) | Un metodo para la preparacion de derivados del acido prope- noico. | |
| ES8601210A1 (es) | Procedimiento para la preparacion de nuevos derivados de sinergistinas | |
| ES8505993A1 (es) | Un metodo para preparar un derivado de 3-indolcarboxamida | |
| ES8300681A1 (es) | Procedimiento para preparar amidas. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19980401 |