ES8303424A1 - Procedimiento para la obtencion de esteres del acido 7b-(2-(2-animo-4-tiazolil)-2-(sin)-metoxiimino-acetamido)-3-cefem-4-caboxilico. - Google Patents

Procedimiento para la obtencion de esteres del acido 7b-(2-(2-animo-4-tiazolil)-2-(sin)-metoxiimino-acetamido)-3-cefem-4-caboxilico.

Info

Publication number
ES8303424A1
ES8303424A1 ES507907A ES507907A ES8303424A1 ES 8303424 A1 ES8303424 A1 ES 8303424A1 ES 507907 A ES507907 A ES 507907A ES 507907 A ES507907 A ES 507907A ES 8303424 A1 ES8303424 A1 ES 8303424A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
esters
cephalosporin esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES507907A
Other languages
English (en)
Other versions
ES507907A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8303424A1 publication Critical patent/ES8303424A1/es
Publication of ES507907A0 publication Critical patent/ES507907A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ESTERES DE ACIDO 7~J- 2-(2-AMINO-4-TIAZOLIL)-2-(SIN)-METOXIIMINO-ACETAMIDO -3-CEFEM -4-CARBOXILICO Y DE SUS SALES DE ADICION DE ACIDO, DE FORMULA (I), EN LA QUE R ES HIDROGENO O ALQUILO INFERIOR; R ES ALQUILO INFERIOR; Y AM ES AMINO. CONSISTE EN LA REACCION DE ACILACION DEL GRUPO 7~J-AMINO DE UN COMPUESTO DE FORMULA (II), POR TRATAMIENTO CON UN AGENTE DE ACILACION INTRODUCTOR DEL RESTO ACILO DE UN ACIDO DE FORMULA (III), EN LAS QUE R , R Y AM TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN UN DISOLVENTE INERTE, EN PRESENCIA DE UN AGENTE ACEPTOR DE ACIDO, A UNA TEMPERATURA ENTRE -40 C Y 100 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTIBIOTICOS ANTIBACTERIALES.
ES507907A 1980-12-12 1981-12-11 Procedimiento para la obtencion de esteres del acido 7b-(2-(2-animo-4-tiazolil)-2-(sin)-metoxiimino-acetamido)-3-cefem-4-caboxilico. Granted ES507907A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH919680 1980-12-12

Publications (2)

Publication Number Publication Date
ES8303424A1 true ES8303424A1 (es) 1983-02-01
ES507907A0 ES507907A0 (es) 1983-02-01

Family

ID=4349398

Family Applications (6)

Application Number Title Priority Date Filing Date
ES507907A Granted ES507907A0 (es) 1980-12-12 1981-12-11 Procedimiento para la obtencion de esteres del acido 7b-(2-(2-animo-4-tiazolil)-2-(sin)-metoxiimino-acetamido)-3-cefem-4-caboxilico.
ES516593A Granted ES516593A0 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2-amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido)-3-cefem-4-carboxilico.
ES516592A Expired ES8307820A1 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido-3-cefem-4-carboxilico.
ES516591A Granted ES516591A0 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2-amino-4-tiazolil)-2-sin)-metoxiiminoacetamido-3-cefem-4-carboxilico.
ES516590A Granted ES516590A0 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7 2(2-amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido)-3-cefem-4-carboxilico.
ES516594A Granted ES516594A0 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7 -2-(2amino-4-tiazolil)-2-(sin)-metoxiimionoacetamido)-3-cefem-4-carboxilico.

Family Applications After (5)

Application Number Title Priority Date Filing Date
ES516593A Granted ES516593A0 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2-amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido)-3-cefem-4-carboxilico.
ES516592A Expired ES8307820A1 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido-3-cefem-4-carboxilico.
ES516591A Granted ES516591A0 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2-amino-4-tiazolil)-2-sin)-metoxiiminoacetamido-3-cefem-4-carboxilico.
ES516590A Granted ES516590A0 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7 2(2-amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido)-3-cefem-4-carboxilico.
ES516594A Granted ES516594A0 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7 -2-(2amino-4-tiazolil)-2-(sin)-metoxiimionoacetamido)-3-cefem-4-carboxilico.

Country Status (18)

Country Link
EP (1) EP0054512A3 (es)
JP (1) JPS57123190A (es)
KR (1) KR830007683A (es)
AR (1) AR231984A1 (es)
AU (1) AU7846681A (es)
DD (1) DD208155A5 (es)
DK (1) DK550081A (es)
ES (6) ES507907A0 (es)
FI (1) FI813946L (es)
GB (1) GB2111043B (es)
GR (1) GR76967B (es)
HU (1) HU185985B (es)
IE (1) IE52008B1 (es)
IL (1) IL64506A (es)
NO (1) NO814232L (es)
NZ (1) NZ199255A (es)
PT (1) PT74119B (es)
ZA (1) ZA818622B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8303422A1 (es) * 1980-12-15 1983-02-01 Fujisawa Pharmaceutical Co Un procedimiento para preparar derivados del acido 7-acilaminocefalosporanico .
JPS57156495A (en) * 1981-03-23 1982-09-27 Kyoto Yakuhin Kogyo Kk Cephalosporin derivative and remedy for microbism used in oral administration
IT1190897B (it) * 1982-06-29 1988-02-24 Opos Biochimica Srl Procedimento per la preparazione dell'estere 1-etossicarbonilossietilico dell'acido 6-(d(-)-alfa aminoalfa fenilacetamido)-penicillanico
US4606865A (en) * 1982-09-20 1986-08-19 Astra Lakemedel Aktiebolag Methods for the preparation of α-bromodiethylcarbonate
JPS59116291A (ja) * 1982-12-06 1984-07-05 Fujisawa Pharmaceut Co Ltd ７−置換−３−セフエム−４−カルボン酸エステルおよびその製法
US5202454A (en) * 1986-07-11 1993-04-13 Societe Nationale Des Poudres Et Explosifs Process for the manufacture of 1-bromoalkyl hydrocarbyl carbonates
CA2072106C (en) * 1989-10-28 2001-04-17 Hiroyuki Muro Cephalosporin compounds and method for producing them
AU713374B2 (en) * 1996-07-26 1999-12-02 Gilead Sciences, Inc. Nucleotide analogs
NZ540728A (en) 2003-01-14 2008-08-29 Gilead Sciences Inc Compositions and methods for combination antiviral therapy
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3965099A (en) * 1974-06-26 1976-06-22 Smithkline Corporation Cephalosporin esters with antibacterial activity
JPS5321192A (en) * 1976-08-10 1978-02-27 Takeda Chem Ind Ltd Cephalosporin derivatives and their preparation
US4370326A (en) * 1977-09-13 1983-01-25 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and composition
MA18686A1 (fr) * 1978-07-07 1980-10-01 Ciba Geigy Ag Composes aminothiazoliques
ZA793391B (en) * 1978-07-07 1980-06-25 Ciba Geigy Ag Aminothiazole compounds
JPS5543011A (en) * 1978-09-20 1980-03-26 Shionogi & Co Ltd 7-halothiazolylalkoxyiminoacetamido-3-cephem compound
GR78221B (es) * 1980-02-01 1984-09-26 Ciba Geigy Ag

Also Published As

Publication number Publication date
IL64506A (en) 1985-05-31
IE52008B1 (en) 1987-05-13
AU7846681A (en) 1982-06-17
GB2111043A (en) 1983-06-29
IE812915L (en) 1982-06-12
EP0054512A2 (de) 1982-06-23
ES8401080A1 (es) 1983-11-16
GB2111043B (en) 1985-02-06
ES8401079A1 (es) 1983-11-16
ES8401078A1 (es) 1983-11-16
AR231984A1 (es) 1985-04-30
JPS57123190A (en) 1982-07-31
IL64506A0 (en) 1982-03-31
ES516594A0 (es) 1983-11-16
EP0054512A3 (de) 1983-08-03
PT74119A (de) 1982-01-01
KR830007683A (ko) 1983-11-04
HU185985B (en) 1985-04-28
ES516592A0 (es) 1983-08-01
PT74119B (de) 1983-12-19
ES8401077A1 (es) 1983-11-16
GR76967B (es) 1984-09-04
JPH0314038B2 (es) 1991-02-25
ES516590A0 (es) 1983-11-16
ES507907A0 (es) 1983-02-01
NZ199255A (en) 1985-08-30
NO814232L (no) 1982-06-14
FI813946L (fi) 1982-06-13
ES8307820A1 (es) 1983-08-01
DD208155A5 (de) 1984-03-28
DK550081A (da) 1982-06-13
ES516591A0 (es) 1983-11-16
ZA818622B (en) 1982-10-27
ES516593A0 (es) 1983-11-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010402