ES8401080A1 - Procedimiento para la obtencion de esteres del acido 7 -2-(2amino-4-tiazolil)-2-(sin)-metoxiimionoacetamido)-3-cefem-4-carboxilico. - Google Patents

Procedimiento para la obtencion de esteres del acido 7 -2-(2amino-4-tiazolil)-2-(sin)-metoxiimionoacetamido)-3-cefem-4-carboxilico.

Info

Publication number
ES8401080A1
ES8401080A1 ES516594A ES516594A ES8401080A1 ES 8401080 A1 ES8401080 A1 ES 8401080A1 ES 516594 A ES516594 A ES 516594A ES 516594 A ES516594 A ES 516594A ES 8401080 A1 ES8401080 A1 ES 8401080A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
esters
cephalosporin esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES516594A
Other languages
English (en)
Other versions
ES516594A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES516594A0 publication Critical patent/ES516594A0/es
Publication of ES8401080A1 publication Critical patent/ES8401080A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ESTERES DEL ACIDO 7B-2-AMINO-4-TIAZOLIL-2-(SIN)-METOXIIMINOACETAM IDO-3-CEFEM-CARBOXILICO, Y DE SUS SALES DE ADICION DE ACIDO, DE FORMULA (I), EN LA QUE R2 ES HIDROGENO O ALQUILO INFERIOR, R2 ES ALQUILO INFERIOR Y AM ES AMINO.CONSISTE EN LA REACCION DE DISOCIACION DEL GRUPO PROTECTOR DE AMINO, SUSTITUYENDOLO POR HIDROGENO, EN EL COMPUESTO DE FORMULA (II), EN LA QUE AM ES UN GRUPO AMINO PROTEGIDO Y R1 Y R2 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, CON ACIDO TRIFLUOROACETICO, A UNA TEMPERATURAENTRE -20JC Y 50JC.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTIBIOTICOS ANTIBACTERIALES.
ES516594A 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7 -2-(2amino-4-tiazolil)-2-(sin)-metoxiimionoacetamido)-3-cefem-4-carboxilico. Expired ES8401080A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH919680 1980-12-12

Publications (2)

Publication Number Publication Date
ES516594A0 ES516594A0 (es) 1983-11-16
ES8401080A1 true ES8401080A1 (es) 1983-11-16

Family

ID=4349398

Family Applications (6)

Application Number Title Priority Date Filing Date
ES507907A Granted ES507907A0 (es) 1980-12-12 1981-12-11 Procedimiento para la obtencion de esteres del acido 7b-(2-(2-animo-4-tiazolil)-2-(sin)-metoxiimino-acetamido)-3-cefem-4-caboxilico.
ES516593A Expired ES8401079A1 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2-amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido)-3-cefem-4-carboxilico.
ES516592A Expired ES8307820A1 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido-3-cefem-4-carboxilico.
ES516594A Expired ES8401080A1 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7 -2-(2amino-4-tiazolil)-2-(sin)-metoxiimionoacetamido)-3-cefem-4-carboxilico.
ES516591A Granted ES516591A0 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2-amino-4-tiazolil)-2-sin)-metoxiiminoacetamido-3-cefem-4-carboxilico.
ES516590A Expired ES8401077A1 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7 2(2-amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido)-3-cefem-4-carboxilico.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES507907A Granted ES507907A0 (es) 1980-12-12 1981-12-11 Procedimiento para la obtencion de esteres del acido 7b-(2-(2-animo-4-tiazolil)-2-(sin)-metoxiimino-acetamido)-3-cefem-4-caboxilico.
ES516593A Expired ES8401079A1 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2-amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido)-3-cefem-4-carboxilico.
ES516592A Expired ES8307820A1 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido-3-cefem-4-carboxilico.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES516591A Granted ES516591A0 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2-amino-4-tiazolil)-2-sin)-metoxiiminoacetamido-3-cefem-4-carboxilico.
ES516590A Expired ES8401077A1 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7 2(2-amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido)-3-cefem-4-carboxilico.

Country Status (18)

Country Link
EP (1) EP0054512A3 (es)
JP (1) JPS57123190A (es)
KR (1) KR830007683A (es)
AR (1) AR231984A1 (es)
AU (1) AU7846681A (es)
DD (1) DD208155A5 (es)
DK (1) DK550081A (es)
ES (6) ES507907A0 (es)
FI (1) FI813946L (es)
GB (1) GB2111043B (es)
GR (1) GR76967B (es)
HU (1) HU185985B (es)
IE (1) IE52008B1 (es)
IL (1) IL64506A (es)
NO (1) NO814232L (es)
NZ (1) NZ199255A (es)
PT (1) PT74119B (es)
ZA (1) ZA818622B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES507942A0 (es) * 1980-12-15 1983-02-01 Fujisawa Pharmaceutical Co Un procedimiento para preparar derivados del acido 7-acilaminocefalosporanico .
JPS57156495A (en) * 1981-03-23 1982-09-27 Kyoto Yakuhin Kogyo Kk Cephalosporin derivative and remedy for microbism used in oral administration
IT1190897B (it) * 1982-06-29 1988-02-24 Opos Biochimica Srl Procedimento per la preparazione dell'estere 1-etossicarbonilossietilico dell'acido 6-(d(-)-alfa aminoalfa fenilacetamido)-penicillanico
US4606865A (en) * 1982-09-20 1986-08-19 Astra Lakemedel Aktiebolag Methods for the preparation of α-bromodiethylcarbonate
JPS59116291A (ja) * 1982-12-06 1984-07-05 Fujisawa Pharmaceut Co Ltd ７−置換−３−セフエム−４−カルボン酸エステルおよびその製法
US5202454A (en) * 1986-07-11 1993-04-13 Societe Nationale Des Poudres Et Explosifs Process for the manufacture of 1-bromoalkyl hydrocarbyl carbonates
DK0497978T3 (da) * 1989-10-28 1997-10-20 Kyoto Pharma Ind Cephalosporinforbindelser og fremstilling heraf.
NZ333687A (en) * 1996-07-26 2000-08-25 Gilead Sciences Inc Phosphonomethoxy nucleotide analogs
SI1583542T1 (sl) 2003-01-14 2008-12-31 Gilead Sciences Inc Sestavki in postopki za kombinacijsko antivirusnoterapijo
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3965099A (en) * 1974-06-26 1976-06-22 Smithkline Corporation Cephalosporin esters with antibacterial activity
JPS5321192A (en) * 1976-08-10 1978-02-27 Takeda Chem Ind Ltd Cephalosporin derivatives and their preparation
US4370326A (en) * 1977-09-13 1983-01-25 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and composition
ZA793391B (en) * 1978-07-07 1980-06-25 Ciba Geigy Ag Aminothiazole compounds
MA18686A1 (fr) * 1978-07-07 1980-10-01 Ciba Geigy Ag Composes aminothiazoliques
JPS5543011A (en) * 1978-09-20 1980-03-26 Shionogi & Co Ltd 7-halothiazolylalkoxyiminoacetamido-3-cephem compound
GR78221B (es) * 1980-02-01 1984-09-26 Ciba Geigy Ag

Also Published As

Publication number Publication date
ES516592A0 (es) 1983-08-01
ES8303424A1 (es) 1983-02-01
ES516593A0 (es) 1983-11-16
IE52008B1 (en) 1987-05-13
EP0054512A3 (de) 1983-08-03
ES8401079A1 (es) 1983-11-16
FI813946L (fi) 1982-06-13
ES8307820A1 (es) 1983-08-01
JPH0314038B2 (es) 1991-02-25
JPS57123190A (en) 1982-07-31
NO814232L (no) 1982-06-14
ES8401078A1 (es) 1983-11-16
HU185985B (en) 1985-04-28
AU7846681A (en) 1982-06-17
GB2111043B (en) 1985-02-06
IL64506A0 (en) 1982-03-31
AR231984A1 (es) 1985-04-30
IL64506A (en) 1985-05-31
IE812915L (en) 1982-06-12
NZ199255A (en) 1985-08-30
KR830007683A (ko) 1983-11-04
GB2111043A (en) 1983-06-29
PT74119A (de) 1982-01-01
ES516591A0 (es) 1983-11-16
ZA818622B (en) 1982-10-27
EP0054512A2 (de) 1982-06-23
ES507907A0 (es) 1983-02-01
ES516594A0 (es) 1983-11-16
GR76967B (es) 1984-09-04
PT74119B (de) 1983-12-19
ES516590A0 (es) 1983-11-16
ES8401077A1 (es) 1983-11-16
DD208155A5 (de) 1984-03-28
DK550081A (da) 1982-06-13

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