ES8401078A1 - Procedimiento para la obtencion de esteres del acido 7b-2-(2-amino-4-tiazolil)-2-sin)-metoxiiminoacetamido-3-cefem-4-carboxilico. - Google Patents

Procedimiento para la obtencion de esteres del acido 7b-2-(2-amino-4-tiazolil)-2-sin)-metoxiiminoacetamido-3-cefem-4-carboxilico.

Info

Publication number
ES8401078A1
ES8401078A1 ES516591A ES516591A ES8401078A1 ES 8401078 A1 ES8401078 A1 ES 8401078A1 ES 516591 A ES516591 A ES 516591A ES 516591 A ES516591 A ES 516591A ES 8401078 A1 ES8401078 A1 ES 8401078A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
esters
cephalosporin esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES516591A
Other languages
English (en)
Other versions
ES516591A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8401078A1 publication Critical patent/ES8401078A1/es
Publication of ES516591A0 publication Critical patent/ES516591A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ESTERES DEL ACIDO 7B-1-(2-AMINO-4-TIAZOLIL)-2-(SIN)-METOXIIMINOAC ETAMIDO-3-CEFEM-4-CARBOXILICO Y DE SUS SALES DE ADICION DE ACIDO, DE FORMULA (I), EN LA QUE R1 ES HIDROGENO O ALQUILO INFERIOR; R2 ES ALQUILO INFERIOR; Y AM ES AMINO.CONSISTE EN LA REACCION DE DISOCIACION DE UN COMPUESTO DE FORMULA (II), EN LA QUE RO ES HIDROXI, HIDROXI ESTERIFICADO O AMINO Y R1, R2 Y AM TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), TRANSFORMANDO EL GRUPO RO EN HRO. LA DISOCIACION SE EFECTUA POR TRATAMIENTO CON UN ACIDO EN UN DISOLVENTE INERTE.ESTOS COMPUESTOSTIENEN APLICACIONES FARMACOLOGICAS COMO ANTIBIOTICOS ANTIBACTERIALES.
ES516591A 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2-amino-4-tiazolil)-2-sin)-metoxiiminoacetamido-3-cefem-4-carboxilico. Granted ES516591A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH919680 1980-12-12

Publications (2)

Publication Number Publication Date
ES8401078A1 true ES8401078A1 (es) 1983-11-16
ES516591A0 ES516591A0 (es) 1983-11-16

Family

ID=4349398

Family Applications (6)

Application Number Title Priority Date Filing Date
ES507907A Granted ES507907A0 (es) 1980-12-12 1981-12-11 Procedimiento para la obtencion de esteres del acido 7b-(2-(2-animo-4-tiazolil)-2-(sin)-metoxiimino-acetamido)-3-cefem-4-caboxilico.
ES516590A Granted ES516590A0 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7 2(2-amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido)-3-cefem-4-carboxilico.
ES516593A Granted ES516593A0 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2-amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido)-3-cefem-4-carboxilico.
ES516592A Expired ES8307820A1 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido-3-cefem-4-carboxilico.
ES516594A Expired ES8401080A1 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7 -2-(2amino-4-tiazolil)-2-(sin)-metoxiimionoacetamido)-3-cefem-4-carboxilico.
ES516591A Granted ES516591A0 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2-amino-4-tiazolil)-2-sin)-metoxiiminoacetamido-3-cefem-4-carboxilico.

Family Applications Before (5)

Application Number Title Priority Date Filing Date
ES507907A Granted ES507907A0 (es) 1980-12-12 1981-12-11 Procedimiento para la obtencion de esteres del acido 7b-(2-(2-animo-4-tiazolil)-2-(sin)-metoxiimino-acetamido)-3-cefem-4-caboxilico.
ES516590A Granted ES516590A0 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7 2(2-amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido)-3-cefem-4-carboxilico.
ES516593A Granted ES516593A0 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2-amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido)-3-cefem-4-carboxilico.
ES516592A Expired ES8307820A1 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7b-2-(2amino-4-tiazolil)-2-(sin)-metoxiiminoacetamido-3-cefem-4-carboxilico.
ES516594A Expired ES8401080A1 (es) 1980-12-12 1982-10-16 Procedimiento para la obtencion de esteres del acido 7 -2-(2amino-4-tiazolil)-2-(sin)-metoxiimionoacetamido)-3-cefem-4-carboxilico.

Country Status (18)

Country Link
EP (1) EP0054512A3 (es)
JP (1) JPS57123190A (es)
KR (1) KR830007683A (es)
AR (1) AR231984A1 (es)
AU (1) AU7846681A (es)
DD (1) DD208155A5 (es)
DK (1) DK550081A (es)
ES (6) ES507907A0 (es)
FI (1) FI813946L (es)
GB (1) GB2111043B (es)
GR (1) GR76967B (es)
HU (1) HU185985B (es)
IE (1) IE52008B1 (es)
IL (1) IL64506A (es)
NO (1) NO814232L (es)
NZ (1) NZ199255A (es)
PT (1) PT74119B (es)
ZA (1) ZA818622B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK554481A (da) * 1980-12-15 1982-06-16 Fujisawa Pharmaceutical Co Fremgangsmaade til fremstilling af cephalosporansyrederivater
JPS57156495A (en) * 1981-03-23 1982-09-27 Kyoto Yakuhin Kogyo Kk Cephalosporin derivative and remedy for microbism used in oral administration
IT1190897B (it) * 1982-06-29 1988-02-24 Opos Biochimica Srl Procedimento per la preparazione dell'estere 1-etossicarbonilossietilico dell'acido 6-(d(-)-alfa aminoalfa fenilacetamido)-penicillanico
US4606865A (en) * 1982-09-20 1986-08-19 Astra Lakemedel Aktiebolag Methods for the preparation of α-bromodiethylcarbonate
JPS59116291A (ja) * 1982-12-06 1984-07-05 Fujisawa Pharmaceut Co Ltd ７−置換−３−セフエム−４−カルボン酸エステルおよびその製法
US5202454A (en) * 1986-07-11 1993-04-13 Societe Nationale Des Poudres Et Explosifs Process for the manufacture of 1-bromoalkyl hydrocarbyl carbonates
KR0173796B1 (ko) * 1989-10-28 1999-02-01 기까미 기즈히꼬 세팔로스포린 화합물 및 그의 제조방법
NZ333687A (en) * 1996-07-26 2000-08-25 Gilead Sciences Inc Phosphonomethoxy nucleotide analogs
US20040224916A1 (en) 2003-01-14 2004-11-11 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3965099A (en) * 1974-06-26 1976-06-22 Smithkline Corporation Cephalosporin esters with antibacterial activity
JPS5321192A (en) * 1976-08-10 1978-02-27 Takeda Chem Ind Ltd Cephalosporin derivatives and their preparation
US4370326A (en) * 1977-09-13 1983-01-25 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and composition
ZA793391B (en) * 1978-07-07 1980-06-25 Ciba Geigy Ag Aminothiazole compounds
MA18686A1 (fr) * 1978-07-07 1980-10-01 Ciba Geigy Ag Composes aminothiazoliques
JPS5543011A (en) * 1978-09-20 1980-03-26 Shionogi & Co Ltd 7-halothiazolylalkoxyiminoacetamido-3-cephem compound
GR78221B (es) * 1980-02-01 1984-09-26 Ciba Geigy Ag

Also Published As

Publication number Publication date
GR76967B (es) 1984-09-04
NZ199255A (en) 1985-08-30
PT74119A (de) 1982-01-01
ES516594A0 (es) 1983-11-16
GB2111043B (en) 1985-02-06
AU7846681A (en) 1982-06-17
HU185985B (en) 1985-04-28
DD208155A5 (de) 1984-03-28
PT74119B (de) 1983-12-19
ES8303424A1 (es) 1983-02-01
IE812915L (en) 1982-06-12
DK550081A (da) 1982-06-13
ES516592A0 (es) 1983-08-01
ES8401077A1 (es) 1983-11-16
NO814232L (no) 1982-06-14
JPS57123190A (en) 1982-07-31
ES516591A0 (es) 1983-11-16
ES8401079A1 (es) 1983-11-16
ES8307820A1 (es) 1983-08-01
FI813946L (fi) 1982-06-13
AR231984A1 (es) 1985-04-30
ES516590A0 (es) 1983-11-16
EP0054512A2 (de) 1982-06-23
EP0054512A3 (de) 1983-08-03
GB2111043A (en) 1983-06-29
ZA818622B (en) 1982-10-27
IL64506A (en) 1985-05-31
ES516593A0 (es) 1983-11-16
ES8401080A1 (es) 1983-11-16
JPH0314038B2 (es) 1991-02-25
ES507907A0 (es) 1983-02-01
IE52008B1 (en) 1987-05-13
IL64506A0 (en) 1982-03-31
KR830007683A (ko) 1983-11-04

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