ES8304095A1 - Un procedimiento para la preparacion de derivados de quinazolina. - Google Patents

Un procedimiento para la preparacion de derivados de quinazolina.

Info

Publication number
ES8304095A1
ES8304095A1 ES509434A ES509434A ES8304095A1 ES 8304095 A1 ES8304095 A1 ES 8304095A1 ES 509434 A ES509434 A ES 509434A ES 509434 A ES509434 A ES 509434A ES 8304095 A1 ES8304095 A1 ES 8304095A1
Authority
ES
Spain
Prior art keywords
methyl
formula
tumor
oxyranyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES509434A
Other languages
English (en)
Other versions
ES509434A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES8304095A1 publication Critical patent/ES8304095A1/es
Publication of ES509434A0 publication Critical patent/ES509434A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE QUINAZOLINA, DE FORMULA (I), EN LA QUE UNO DE R Y R ES OXIRANILMETILO Y EL OTRO ES METILO U OXIRANILMETILO; Y R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); Y UNO DE R<A Y R<B ES HIDROGENO Y EL OTRO ES HIDROGENO O METILO, CON HEPICLORHIDRINA O HEPIBROMHIDRINA. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE UNA BASE, A UNA TEMPERATURA PROXIMA A LA AMBIENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTITUMORAL.
ES509434A 1981-03-06 1982-02-08 Un procedimiento para la preparacion de derivados de quinazolina. Granted ES509434A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/241,317 US4343940A (en) 1979-02-13 1981-03-06 Anti-tumor quinazoline compounds

Publications (2)

Publication Number Publication Date
ES8304095A1 true ES8304095A1 (es) 1983-02-16
ES509434A0 ES509434A0 (es) 1983-02-16

Family

ID=22910195

Family Applications (1)

Application Number Title Priority Date Filing Date
ES509434A Granted ES509434A0 (es) 1981-03-06 1982-02-08 Un procedimiento para la preparacion de derivados de quinazolina.

Country Status (31)

Country Link
US (1) US4343940A (es)
JP (1) JPS57158780A (es)
KR (1) KR880001852B1 (es)
AR (1) AR231138A1 (es)
AT (1) AT380476B (es)
AU (1) AU556099B2 (es)
BE (1) BE891936A (es)
CA (1) CA1163995A (es)
CH (1) CH647776A5 (es)
CY (1) CY1371A (es)
DE (1) DE3203770C2 (es)
DK (1) DK159442C (es)
ES (1) ES509434A0 (es)
FI (1) FI71559C (es)
FR (1) FR2501207B1 (es)
GB (1) GB2094295B (es)
GR (1) GR75903B (es)
HK (1) HK4588A (es)
HU (1) HU189997B (es)
IE (1) IE52385B1 (es)
IL (1) IL64875A0 (es)
IT (1) IT1154272B (es)
KE (1) KE3715A (es)
LU (1) LU83903A1 (es)
NL (1) NL8200473A (es)
NZ (1) NZ199576A (es)
PH (1) PH18529A (es)
PT (1) PT74394B (es)
SE (1) SE461732B (es)
SG (1) SG30787G (es)
YU (1) YU42031B (es)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3131365A1 (de) * 1981-08-07 1983-02-24 Henkel KGaA, 4000 Düsseldorf Neue diglycidyl-substituierte heterocyclische verbindungen, verfahren zu ihrer herstellung und ihre verwendung in arzneimittelzubereitungen mit cytostatischer wirksamkeit
US5030635A (en) * 1990-02-14 1991-07-09 Ortho Pharmaceutical Corporation 6-7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
US4963554A (en) * 1990-02-14 1990-10-16 Ortho Pharmaceutical Corporation 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
US6645969B1 (en) * 1991-05-10 2003-11-11 Aventis Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
USRE37650E1 (en) 1991-05-10 2002-04-09 Aventis Pharmacetical Products, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5480883A (en) * 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5714493A (en) * 1991-05-10 1998-02-03 Rhone-Poulenc Rorer Pharmaceuticals, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5710158A (en) * 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
EP0634169B1 (en) * 1993-06-29 2000-01-05 Takeda Chemical Industries, Ltd. Quinoline or quinazoline derivatives and their use in the manufacture of a medicament for the treatment of osteoporosis
KR100225721B1 (ko) * 1994-02-23 1999-10-15 디. 제이. 우드, 스피겔 알렌 제이 4-헤테로사이클릴-치환된 퀴나졸린 유도체, 이들의 제조 방법 및항암제로서의 용도
US5804396A (en) * 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
TW321649B (es) * 1994-11-12 1997-12-01 Zeneca Ltd
GB9424233D0 (en) * 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
US5837524A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polynucleotide products
US5837815A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polypeptide products
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
DE69613367T2 (de) * 1995-04-27 2002-04-18 Astrazeneca Ab, Soedertaelje Chinazolin derivate
GB9508535D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivative
GB9508537D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9508565D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
JPH11507052A (ja) * 1995-06-07 1999-06-22 スージェン・インコーポレーテッド キナゾリンおよび医薬組成物
EP0860433B1 (en) * 1995-11-07 2002-07-03 Kirin Beer Kabushiki Kaisha Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of growth factor receptor originating in platelet and pharmaceutical compositions containing the same
US6716575B2 (en) 1995-12-18 2004-04-06 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
US7119174B2 (en) * 1995-12-18 2006-10-10 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
GB9624482D0 (en) * 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
BR9707495A (pt) 1996-02-13 1999-07-27 Zeneca Ltd Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente
GB9603097D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
JP4464466B2 (ja) 1996-03-05 2010-05-19 アストラゼネカ・ユーケイ・リミテッド ４―アニリノキナゾリン誘導体
GB9607729D0 (en) * 1996-04-13 1996-06-19 Zeneca Ltd Quinazoline derivatives
GB9718972D0 (en) * 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
PT948604E (pt) * 1996-12-11 2004-10-29 Univ New York Medical Ct Produtos e metodos relacionados com pyk2
US6818440B2 (en) * 1997-04-28 2004-11-16 Sugen, Inc. Diagnosis and treatment of alk-7 related disorders
US6228641B1 (en) 1997-05-20 2001-05-08 Sugen, Inc. Diagnosis and treatment of PTP04 related disorders
US6342593B1 (en) 1997-06-11 2002-01-29 Sugen, Inc. Diagnosis and treatment of ALP related disorders
US7115710B2 (en) * 1997-06-11 2006-10-03 Sugen, Inc. Diagnosis and treatment of PTP related disorders
US6388063B1 (en) 1997-06-18 2002-05-14 Sugen, Inc. Diagnosis and treatment of SAD related disorders
WO1999037787A2 (en) * 1998-01-21 1999-07-29 Sugen, Inc. Human orthologues of wart
CA2369172A1 (en) * 1998-04-14 1999-10-21 Sugen, Inc. Ste20-related protein kinases
CA2333392A1 (en) 1998-05-28 1999-12-02 Parker Hughes Institute Quinazolines for treating brain tumor
US6800649B1 (en) * 1998-06-30 2004-10-05 Parker Hughes Institute Method for inhibiting c-jun expression using JAK-3 inhibitors
IL141434A0 (en) * 1998-08-21 2002-03-10 Parker Hughes Inst Quinazoline derivatives
US6861442B1 (en) 1998-12-30 2005-03-01 Sugen, Inc. PYK2 and inflammation
US6080747A (en) 1999-03-05 2000-06-27 Hughes Institute JAK-3 inhibitors for treating allergic disorders
US6258820B1 (en) 1999-03-19 2001-07-10 Parker Hughes Institute Synthesis and anti-tumor activity of 6,7-dialkoxy-4-phenylamino-quinazolines
US20030162223A1 (en) * 1999-10-22 2003-08-28 Lowery David E. Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
JP2003512838A (ja) * 1999-10-22 2003-04-08 ファルマシア・アンド・アップジョン・カンパニー ショウジョウバエｇタンパク質結合レセプター、核酸、およびそれに関連する方法。
US7364866B2 (en) * 1999-10-22 2008-04-29 Pharmacia & Upjohn Company Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
EP1676845B1 (en) 1999-11-05 2008-06-11 AstraZeneca AB New quinazoline derivatives
US20030082534A1 (en) * 1999-11-16 2003-05-01 Peter Lind Novel G protein-coupled receptors
WO2001036473A2 (en) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Human g protein-coupled receptors
US20030003451A1 (en) * 2000-02-23 2003-01-02 Gabriel Vogeli Novel G protein-coupled receptors
EP1274692B1 (en) * 2000-04-07 2006-08-02 AstraZeneca AB Quinazoline compounds
US20050069976A1 (en) * 2001-02-14 2005-03-31 Peter Lind Protein-coupled receptor
US8450302B2 (en) * 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
MXPA05001277A (es) 2002-08-02 2005-10-06 Ab Science 2-(3-aminoaril)amino-4-aril-tiazoles y su uso como inhibidores del c-kit.
CA2542909C (en) * 2003-10-23 2012-07-10 Ab Science 2-aminoaryloxazole compounds as tyrosine kinase inhibitors
CA2603826C (en) 2005-04-04 2013-03-12 Ab Science Substituted oxazole derivatives and their use as tyrosine kinase inhibitors
US8246966B2 (en) * 2006-08-07 2012-08-21 University Of Georgia Research Foundation, Inc. Trypanosome microsome system and uses thereof
EP2079739A2 (en) 2006-10-04 2009-07-22 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
WO2008066755A2 (en) * 2006-11-22 2008-06-05 University Of Georgia Research Foundation, Inc. Tyrosine kinase inhibitors as anti-kinetolastid and anti-apicomplexan agents
JP2010511382A (ja) * 2006-12-01 2010-04-15 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 癌関連タンパク質キナーゼ
SG193291A1 (en) 2011-03-04 2013-10-30 Newgen Therapeutics Inc Alkyne substituted quinazoline compound and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3298291A (en) * 1965-12-28 1967-01-17 Jack D Layton Paver screed assembly
US3455920A (en) * 1967-01-13 1969-07-15 Squibb & Sons Inc 2,3-dihydro-5 and 6-substituted-2-phenyl-4(1h)-quinazolinones
US3637693A (en) * 1968-07-12 1972-01-25 Du Pont Hydroxyarylquinazolines and their use as uv-absorbers
DE2050092C3 (de) 1970-10-13 1980-04-24 Bayer Ag, 5090 Leverkusen Chinazolondiurethane, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten
DE2162327C3 (de) * 1970-12-23 1975-09-18 Sumitomo Chemical Co., Ltd., Osaka (Japan) Verfahren zur Herstellung von 3,4-Oihydro-2(1 H)-chinazolinonen
US4080455A (en) * 1975-12-16 1978-03-21 Taisho Pharmaceutical Company Limited 5-Fluoropyrimidin-4-one compositions
JPS6011032B2 (ja) 1975-12-16 1985-03-22 大鵬薬品工業株式会社 ２―置換―５―フルオルピリミジン―４―オン誘導体の製造法

Also Published As

Publication number Publication date
PH18529A (en) 1985-08-02
LU83903A1 (fr) 1982-09-13
FI71559C (fi) 1987-01-19
IE52385B1 (en) 1987-10-14
SE8200526L (sv) 1982-09-07
YU25682A (en) 1985-03-20
AT380476B (de) 1986-05-26
DK159442B (da) 1990-10-15
DK159442C (da) 1991-03-18
CY1371A (en) 1987-08-07
GR75903B (es) 1984-08-02
BE891936A (fr) 1982-07-28
FI820399L (fi) 1982-09-07
FI71559B (fi) 1986-10-10
GB2094295B (en) 1984-09-12
JPH0337552B2 (es) 1991-06-05
AU556099B2 (en) 1986-10-23
FR2501207A1 (fr) 1982-09-10
DE3203770A1 (de) 1982-11-11
YU42031B (en) 1988-04-30
IT8247713A1 (it) 1983-08-03
CH647776A5 (de) 1985-02-15
AR231138A1 (es) 1984-09-28
GB2094295A (en) 1982-09-15
HU189997B (en) 1986-08-28
KR880001852B1 (ko) 1988-09-22
DK50482A (da) 1982-09-07
PT74394B (en) 1984-10-22
IT8247713A0 (it) 1982-02-03
KE3715A (en) 1987-04-16
HK4588A (en) 1988-01-29
NZ199576A (en) 1986-05-09
FR2501207B1 (fr) 1985-12-06
KR830009050A (ko) 1983-12-17
SG30787G (en) 1988-09-16
US4343940A (en) 1982-08-10
IT1154272B (it) 1987-01-21
ES509434A0 (es) 1983-02-16
ATA39582A (de) 1985-10-15
IE820163L (en) 1982-09-06
DE3203770C2 (de) 1993-11-04
PT74394A (en) 1982-03-01
NL8200473A (nl) 1982-10-01
IL64875A0 (en) 1982-03-31
AU7998182A (en) 1982-09-09
CA1163995A (en) 1984-03-20
SE461732B (sv) 1990-03-19
JPS57158780A (en) 1982-09-30

Similar Documents

Publication Publication Date Title
ES8304095A1 (es) Un procedimiento para la preparacion de derivados de quinazolina.
ES8204428A1 (es) Procedimiento para preparar alfa-aril-1h-1,2,4-triazol-1- etanoles
ES8205789A1 (es) Un procedimiento para la preparacion de derivados del indol
AR241247A1 (es) Procedimiento para la preparacion de nuevos derivados de imidazo ¡4,5-c¿ piridina.
ES8303383A1 (es) Un procedimiento para la preparacion de derivados del 1,2,5-tiadiazol
ES8306133A1 (es) Un procedimiento para la preparacion de oxazolidin-2,4-dionas 5-fenil y 5-naftil sustituidas.
ES8704926A1 (es) Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofeno
ES8601992A1 (es) Procedimiento para preparar 2-fenil-imidazoles
ES8801618A1 (es) Un procedimiento para preparar derivados de arilciclobutilalquilamina
ES8306750A1 (es) Un procedimiento para la preparacion de 2-guanidino-4-heteroariltiazoles.
ES8603497A1 (es) Procedimiento para preparar derivados de cefalosporina
ES8706654A1 (es) Un procedimiento para la preparacion de nuevos derivados de benzotiazina
ES8202343A1 (es) Un procedimiento para preparar imidazo-piridinas
ES8301972A1 (es) Procedimiento para la obtencion de n-oxidos de compuestos den-oxaciclil-alquil-piperidil-diaza
ES8201116A1 (es) Procedimiento para preparar derivados de 2-nitro-5-(fenoxi sustituido)-benzoilo
ES8801666A1 (es) Un procedimiento para la prepracion de derivados de acidos griseolicos.
ES8405000A1 (es) Un procedimiento para la preparacion de un derivado de carbostirilo.
ES8609323A1 (es) Un procedimiento para la preparacion de hexahidro-arilquinolizinas sustituidas.
ES8704503A1 (es) Procedimiento para preparar sales de ciclimonio
ES8606321A1 (es) Un procedimiento para preparar un derivado de 2-hidroxi-3- (4-fenilpiperazimil)propoxi-benzofurano
ES8800193A1 (es) Procedimiento para preparar 2,4-difenil-1,3-dioxanos
ES8607960A1 (es) Procedimiento para preparar acidos aroil-benzofuran y benzo-tiofen-aceticos y-propionicos
ES8301216A1 (es) Un procedimiento para la preparacion de derivados de enantolactama.
ES8303424A1 (es) Procedimiento para la obtencion de esteres del acido 7b-(2-(2-animo-4-tiazolil)-2-(sin)-metoxiimino-acetamido)-3-cefem-4-caboxilico.
ES8601211A1 (es) Procedimiento para la preparacion de nuevos derivados de sinergistinas

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519