BE891936A - Quinazolines antitumorales - Google Patents

Quinazolines antitumorales

Info

Publication number
BE891936A
BE891936A BE0/207169A BE207169A BE891936A BE 891936 A BE891936 A BE 891936A BE 0/207169 A BE0/207169 A BE 0/207169A BE 207169 A BE207169 A BE 207169A BE 891936 A BE891936 A BE 891936A
Authority
BE
Belgium
Prior art keywords
quinazolines
antitumor
antitumor quinazolines
Prior art date
Application number
BE0/207169A
Other languages
English (en)
Inventor
W Kreighbaum
W Comer
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of BE891936A publication Critical patent/BE891936A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE0/207169A 1981-03-06 1982-01-28 Quinazolines antitumorales BE891936A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/241,317 US4343940A (en) 1979-02-13 1981-03-06 Anti-tumor quinazoline compounds

Publications (1)

Publication Number Publication Date
BE891936A true BE891936A (fr) 1982-07-28

Family

ID=22910195

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/207169A BE891936A (fr) 1981-03-06 1982-01-28 Quinazolines antitumorales

Country Status (31)

Country Link
US (1) US4343940A (fr)
JP (1) JPS57158780A (fr)
KR (1) KR880001852B1 (fr)
AR (1) AR231138A1 (fr)
AT (1) AT380476B (fr)
AU (1) AU556099B2 (fr)
BE (1) BE891936A (fr)
CA (1) CA1163995A (fr)
CH (1) CH647776A5 (fr)
CY (1) CY1371A (fr)
DE (1) DE3203770C2 (fr)
DK (1) DK159442C (fr)
ES (1) ES509434A0 (fr)
FI (1) FI71559C (fr)
FR (1) FR2501207B1 (fr)
GB (1) GB2094295B (fr)
GR (1) GR75903B (fr)
HK (1) HK4588A (fr)
HU (1) HU189997B (fr)
IE (1) IE52385B1 (fr)
IL (1) IL64875A0 (fr)
IT (1) IT1154272B (fr)
KE (1) KE3715A (fr)
LU (1) LU83903A1 (fr)
NL (1) NL8200473A (fr)
NZ (1) NZ199576A (fr)
PH (1) PH18529A (fr)
PT (1) PT74394B (fr)
SE (1) SE461732B (fr)
SG (1) SG30787G (fr)
YU (1) YU42031B (fr)

Families Citing this family (63)

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DE3131365A1 (de) * 1981-08-07 1983-02-24 Henkel KGaA, 4000 Düsseldorf Neue diglycidyl-substituierte heterocyclische verbindungen, verfahren zu ihrer herstellung und ihre verwendung in arzneimittelzubereitungen mit cytostatischer wirksamkeit
US4963554A (en) * 1990-02-14 1990-10-16 Ortho Pharmaceutical Corporation 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
US5030635A (en) * 1990-02-14 1991-07-09 Ortho Pharmaceutical Corporation 6-7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
US5710158A (en) * 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5714493A (en) * 1991-05-10 1998-02-03 Rhone-Poulenc Rorer Pharmaceuticals, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5480883A (en) * 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US6645969B1 (en) 1991-05-10 2003-11-11 Aventis Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
USRE37650E1 (en) 1991-05-10 2002-04-09 Aventis Pharmacetical Products, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
DE69422450T2 (de) * 1993-06-29 2000-06-08 Takeda Chemical Industries Ltd Chinoline oder Chinazolin-Derivate und deren Verwendung zur Herstellung eines Medikaments für die Behandlung von Osteoporose
US5804396A (en) * 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
TW321649B (fr) * 1994-11-12 1997-12-01 Zeneca Ltd
GB9424233D0 (en) * 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
US5837815A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polypeptide products
US5837524A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polynucleotide products
GB9508535D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivative
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9508565D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9508537D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US5932574A (en) * 1995-04-27 1999-08-03 Zeneca Limited Quinazoline derivatives
EP0832073B1 (fr) * 1995-06-07 2002-01-16 Sugen, Inc. Quinazolines et compositions pharmaceutiques
JP4009681B2 (ja) * 1995-11-07 2007-11-21 キリンファーマ株式会社 血小板由来成長因子受容体自己リン酸化を阻害するキノリン誘導体ならびにキナゾリン誘導体およびそれらを含有する薬学的組成物
US6716575B2 (en) 1995-12-18 2004-04-06 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
US7119174B2 (en) * 1995-12-18 2006-10-10 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
BR9707495A (pt) 1996-02-13 1999-07-27 Zeneca Ltd Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
GB9603097D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
KR100489174B1 (ko) 1996-03-05 2005-09-30 제네카-파마 소시에떼아노님 4-아닐리노퀴나졸린유도체
GB9607729D0 (en) * 1996-04-13 1996-06-19 Zeneca Ltd Quinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
JP2001505779A (ja) * 1996-12-11 2001-05-08 スージェン・インコーポレーテッド Ｐｙｋ２関連産物および方法
US6818440B2 (en) * 1997-04-28 2004-11-16 Sugen, Inc. Diagnosis and treatment of alk-7 related disorders
US6228641B1 (en) 1997-05-20 2001-05-08 Sugen, Inc. Diagnosis and treatment of PTP04 related disorders
US7115710B2 (en) * 1997-06-11 2006-10-03 Sugen, Inc. Diagnosis and treatment of PTP related disorders
US6342593B1 (en) 1997-06-11 2002-01-29 Sugen, Inc. Diagnosis and treatment of ALP related disorders
US6388063B1 (en) 1997-06-18 2002-05-14 Sugen, Inc. Diagnosis and treatment of SAD related disorders
US6495353B1 (en) 1998-01-21 2002-12-17 Sugen, Inc. Human orthologues of wart
AU3642499A (en) * 1998-04-14 1999-11-01 Sugen, Inc. Ste20-related protein kinases
WO1999061428A1 (fr) 1998-05-28 1999-12-02 Parker Hughes Institute Utilisation des quinazolines pour le traitement de tumeurs cerebrales
US6800649B1 (en) 1998-06-30 2004-10-05 Parker Hughes Institute Method for inhibiting c-jun expression using JAK-3 inhibitors
US6313129B1 (en) 1998-08-21 2001-11-06 Hughes Institute Therapeutic compounds
US6861442B1 (en) 1998-12-30 2005-03-01 Sugen, Inc. PYK2 and inflammation
US6080747A (en) 1999-03-05 2000-06-27 Hughes Institute JAK-3 inhibitors for treating allergic disorders
US6258820B1 (en) * 1999-03-19 2001-07-10 Parker Hughes Institute Synthesis and anti-tumor activity of 6,7-dialkoxy-4-phenylamino-quinazolines
US7364866B2 (en) * 1999-10-22 2008-04-29 Pharmacia & Upjohn Company Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
EP1222273A2 (fr) 1999-10-22 2002-07-17 PHARMACIA & UPJOHN COMPANY Recepteurs couples a la proteine de drosophila g, acides nucleiques et procedes apparentes
US20030162223A1 (en) * 1999-10-22 2003-08-28 Lowery David E. Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
EP1676845B1 (fr) 1999-11-05 2008-06-11 AstraZeneca AB Nouveaux dérivés de type quinazoline
US20030082534A1 (en) * 1999-11-16 2003-05-01 Peter Lind Novel G protein-coupled receptors
AU784543B2 (en) * 1999-11-16 2006-04-27 Pharmacia & Upjohn Company Novel G protein-coupled receptors
EP1265925A2 (fr) * 2000-02-23 2002-12-18 PHARMACIA & UPJOHN COMPANY Nouveaux recepteurs couples a la proteine g
MXPA02009891A (es) * 2000-04-07 2003-03-27 Astrazeneca Ab Compuestos de quinazolina.
US20050069976A1 (en) * 2001-02-14 2005-03-31 Peter Lind Protein-coupled receptor
BRPI0313165B8 (pt) 2002-08-02 2021-05-25 Ab Science 2-(3-aminoaril)amino-4-aril-tiazóis e sua utilização como inibidores de c-kit
US8450302B2 (en) * 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
CN1950347B (zh) * 2003-10-23 2012-04-04 Ab科学公司 作为酪氨酸激酶抑制剂的2-氨基芳基噁唑化合物
MX2007012392A (es) 2005-04-04 2007-12-05 Ab Science Derivados de oxazol sustituidos y su uso como inhibidores de tirosina cinasa.
US8246966B2 (en) * 2006-08-07 2012-08-21 University Of Georgia Research Foundation, Inc. Trypanosome microsome system and uses thereof
CN101547922B (zh) 2006-10-04 2012-06-20 辉瑞产品公司 作为钙受体拮抗剂的吡啶并[4,3-d]嘧啶-4(3H)-酮衍生物
WO2008066755A2 (fr) 2006-11-22 2008-06-05 University Of Georgia Research Foundation, Inc. Inhibiteurs de tyrosine kinase en tant qu'agents anti-kinétolastides et anti-apicomplexes
US20110008347A1 (en) * 2006-12-01 2011-01-13 Agency For Science ,Technology And Research Cancer-related protein kinases
BR112013022552B1 (pt) 2011-03-04 2021-11-23 Newgen Therapeutics, Inc Compostos de quinazolina substituídos com alcino, seu uso, composição farmacêutica, e kit

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3298291A (en) * 1965-12-28 1967-01-17 Jack D Layton Paver screed assembly
US3455920A (en) * 1967-01-13 1969-07-15 Squibb & Sons Inc 2,3-dihydro-5 and 6-substituted-2-phenyl-4(1h)-quinazolinones
US3637693A (en) * 1968-07-12 1972-01-25 Du Pont Hydroxyarylquinazolines and their use as uv-absorbers
DE2050092C3 (de) 1970-10-13 1980-04-24 Bayer Ag, 5090 Leverkusen Chinazolondiurethane, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten
AU438472B2 (en) * 1970-12-23 1973-08-09 Sumitomo Chemical Company, Limited Quinazolinone derivatives anda process for production thereof
JPS6011032B2 (ja) 1975-12-16 1985-03-22 大鵬薬品工業株式会社 ２―置換―５―フルオルピリミジン―４―オン誘導体の製造法
US4080455A (en) * 1975-12-16 1978-03-21 Taisho Pharmaceutical Company Limited 5-Fluoropyrimidin-4-one compositions

Also Published As

Publication number Publication date
ES8304095A1 (es) 1983-02-16
IL64875A0 (en) 1982-03-31
FI820399L (fi) 1982-09-07
IE820163L (en) 1982-09-06
KE3715A (en) 1987-04-16
AU7998182A (en) 1982-09-09
PT74394A (en) 1982-03-01
JPS57158780A (en) 1982-09-30
IE52385B1 (en) 1987-10-14
US4343940A (en) 1982-08-10
IT8247713A0 (it) 1982-02-03
ATA39582A (de) 1985-10-15
IT1154272B (it) 1987-01-21
PT74394B (en) 1984-10-22
PH18529A (en) 1985-08-02
DK159442C (da) 1991-03-18
GB2094295A (en) 1982-09-15
CY1371A (en) 1987-08-07
SE461732B (sv) 1990-03-19
DE3203770C2 (de) 1993-11-04
FR2501207A1 (fr) 1982-09-10
JPH0337552B2 (fr) 1991-06-05
SG30787G (en) 1988-09-16
FI71559C (fi) 1987-01-19
HU189997B (en) 1986-08-28
NZ199576A (en) 1986-05-09
AR231138A1 (es) 1984-09-28
AU556099B2 (en) 1986-10-23
SE8200526L (sv) 1982-09-07
YU25682A (en) 1985-03-20
DE3203770A1 (de) 1982-11-11
FR2501207B1 (fr) 1985-12-06
AT380476B (de) 1986-05-26
CA1163995A (fr) 1984-03-20
KR880001852B1 (ko) 1988-09-22
KR830009050A (ko) 1983-12-17
CH647776A5 (de) 1985-02-15
ES509434A0 (es) 1983-02-16
HK4588A (en) 1988-01-29
FI71559B (fi) 1986-10-10
GB2094295B (en) 1984-09-12
GR75903B (fr) 1984-08-02
DK50482A (da) 1982-09-07
DK159442B (da) 1990-10-15
YU42031B (en) 1988-04-30
NL8200473A (nl) 1982-10-01
LU83903A1 (fr) 1982-09-13

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: BRISTOL-MYERS CY

Effective date: 19940131