SE8200526L - Antitumorforeningar av kinazolintyp - Google Patents

Antitumorforeningar av kinazolintyp

Info

Publication number
SE8200526L
SE8200526L SE8200526A SE8200526A SE8200526L SE 8200526 L SE8200526 L SE 8200526L SE 8200526 A SE8200526 A SE 8200526A SE 8200526 A SE8200526 A SE 8200526A SE 8200526 L SE8200526 L SE 8200526L
Authority
SE
Sweden
Prior art keywords
chinazoline
type
antitumor compounds
oxiranylmethoxy
quinazoline
Prior art date
Application number
SE8200526A
Other languages
English (en)
Other versions
SE461732B (sv
Inventor
W E Kreighbaum
W T Comer
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE8200526L publication Critical patent/SE8200526L/sv
Publication of SE461732B publication Critical patent/SE461732B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SE8200526A 1981-03-06 1982-01-29 Antitumoerfoereningar av kinazolintyp SE461732B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/241,317 US4343940A (en) 1979-02-13 1981-03-06 Anti-tumor quinazoline compounds

Publications (2)

Publication Number Publication Date
SE8200526L true SE8200526L (sv) 1982-09-07
SE461732B SE461732B (sv) 1990-03-19

Family

ID=22910195

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8200526A SE461732B (sv) 1981-03-06 1982-01-29 Antitumoerfoereningar av kinazolintyp

Country Status (31)

Country Link
US (1) US4343940A (sv)
JP (1) JPS57158780A (sv)
KR (1) KR880001852B1 (sv)
AR (1) AR231138A1 (sv)
AT (1) AT380476B (sv)
AU (1) AU556099B2 (sv)
BE (1) BE891936A (sv)
CA (1) CA1163995A (sv)
CH (1) CH647776A5 (sv)
CY (1) CY1371A (sv)
DE (1) DE3203770C2 (sv)
DK (1) DK159442C (sv)
ES (1) ES509434A0 (sv)
FI (1) FI71559C (sv)
FR (1) FR2501207B1 (sv)
GB (1) GB2094295B (sv)
GR (1) GR75903B (sv)
HK (1) HK4588A (sv)
HU (1) HU189997B (sv)
IE (1) IE52385B1 (sv)
IL (1) IL64875A0 (sv)
IT (1) IT1154272B (sv)
KE (1) KE3715A (sv)
LU (1) LU83903A1 (sv)
NL (1) NL8200473A (sv)
NZ (1) NZ199576A (sv)
PH (1) PH18529A (sv)
PT (1) PT74394B (sv)
SE (1) SE461732B (sv)
SG (1) SG30787G (sv)
YU (1) YU42031B (sv)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3131365A1 (de) * 1981-08-07 1983-02-24 Henkel KGaA, 4000 Düsseldorf Neue diglycidyl-substituierte heterocyclische verbindungen, verfahren zu ihrer herstellung und ihre verwendung in arzneimittelzubereitungen mit cytostatischer wirksamkeit
US4963554A (en) * 1990-02-14 1990-10-16 Ortho Pharmaceutical Corporation 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
US5030635A (en) * 1990-02-14 1991-07-09 Ortho Pharmaceutical Corporation 6-7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
USRE37650E1 (en) 1991-05-10 2002-04-09 Aventis Pharmacetical Products, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5480883A (en) * 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5710158A (en) * 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US6645969B1 (en) * 1991-05-10 2003-11-11 Aventis Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5714493A (en) * 1991-05-10 1998-02-03 Rhone-Poulenc Rorer Pharmaceuticals, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
DE69422450T2 (de) * 1993-06-29 2000-06-08 Takeda Chemical Industries, Ltd. Chinoline oder Chinazolin-Derivate und deren Verwendung zur Herstellung eines Medikaments für die Behandlung von Osteoporose
US5804396A (en) * 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
TW321649B (sv) * 1994-11-12 1997-12-01 Zeneca Ltd
GB9424233D0 (en) * 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
US5837815A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polypeptide products
US5837524A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polynucleotide products
GB9508535D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivative
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
EP0824525B1 (en) * 1995-04-27 2001-06-13 AstraZeneca AB Quinazoline derivatives
GB9508565D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9508537D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
EP0832073B1 (en) * 1995-06-07 2002-01-16 Sugen, Inc. Quinazolines and pharmaceutical compositions
DE69622183D1 (de) * 1995-11-07 2002-08-08 Kirin Brewery Chinolinderivate und chinazolinderivate welche die autophosphorylierung des von blutplättchen abstammenden wachstumsfaktorrezeptors inhibiren und sie enthaltende pharmazeutische zusammensetzungen
US6716575B2 (en) 1995-12-18 2004-04-06 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
GB9624482D0 (en) * 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
US7119174B2 (en) * 1995-12-18 2006-10-10 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
KR19990082463A (ko) 1996-02-13 1999-11-25 돈 리사 로얄 혈관 내피 성장 인자 억제제로서의 퀴나졸린유도체
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
GB9603097D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
CN1116286C (zh) 1996-03-05 2003-07-30 曾尼卡有限公司 4－苯胺基喹唑啉衍生物
GB9607729D0 (en) * 1996-04-13 1996-06-19 Zeneca Ltd Quinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
DE69729954T2 (de) * 1996-12-11 2005-09-08 Sugen, Inc., San Francisco Identifizierungsverfahren für Substanzen die an das Pyk2 Polypeptid binden
US6818440B2 (en) 1997-04-28 2004-11-16 Sugen, Inc. Diagnosis and treatment of alk-7 related disorders
US6228641B1 (en) 1997-05-20 2001-05-08 Sugen, Inc. Diagnosis and treatment of PTP04 related disorders
US6342593B1 (en) 1997-06-11 2002-01-29 Sugen, Inc. Diagnosis and treatment of ALP related disorders
US7115710B2 (en) * 1997-06-11 2006-10-03 Sugen, Inc. Diagnosis and treatment of PTP related disorders
US6388063B1 (en) * 1997-06-18 2002-05-14 Sugen, Inc. Diagnosis and treatment of SAD related disorders
US6495353B1 (en) 1998-01-21 2002-12-17 Sugen, Inc. Human orthologues of wart
JP2002522009A (ja) 1998-04-14 2002-07-23 スージェン・インコーポレーテッド Ｓｔｅ−２０関連蛋白質キナーゼ
MXPA00011773A (es) 1998-05-28 2002-06-04 Parker Hughes Inst Quinazolinas para tratar tumores en el cerebro.
US6800649B1 (en) 1998-06-30 2004-10-05 Parker Hughes Institute Method for inhibiting c-jun expression using JAK-3 inhibitors
MXPA01001893A (es) 1998-08-21 2002-04-24 Parker Hughes Inst Derivados de quinazolina.
US6861442B1 (en) * 1998-12-30 2005-03-01 Sugen, Inc. PYK2 and inflammation
US6080747A (en) * 1999-03-05 2000-06-27 Hughes Institute JAK-3 inhibitors for treating allergic disorders
US6258820B1 (en) * 1999-03-19 2001-07-10 Parker Hughes Institute Synthesis and anti-tumor activity of 6,7-dialkoxy-4-phenylamino-quinazolines
US20030162223A1 (en) * 1999-10-22 2003-08-28 Lowery David E. Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
US7364866B2 (en) * 1999-10-22 2008-04-29 Pharmacia & Upjohn Company Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
EP1222273A2 (en) 1999-10-22 2002-07-17 PHARMACIA & UPJOHN COMPANY Drosophila g protein coupled receptors, nucleic acids, and methods related to the same
PT1244647E (pt) 1999-11-05 2006-10-31 Astrazeneca Ab Derivados de quinazolina como inibidores de vegf
EP1237909A2 (en) * 1999-11-16 2002-09-11 PHARMACIA & UPJOHN COMPANY Human g protein-coupled receptors
US20030082534A1 (en) * 1999-11-16 2003-05-01 Peter Lind Novel G protein-coupled receptors
US20030003451A1 (en) * 2000-02-23 2003-01-02 Gabriel Vogeli Novel G protein-coupled receptors
EP1274692B1 (en) * 2000-04-07 2006-08-02 AstraZeneca AB Quinazoline compounds
US20050069976A1 (en) * 2001-02-14 2005-03-31 Peter Lind Protein-coupled receptor
PT1525200E (pt) * 2002-08-02 2008-01-10 Ab Science 2-(3-aminoaril)amino-4-aril-tiazóis para o tratamento de doenças
US8450302B2 (en) * 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
DK1684750T3 (da) * 2003-10-23 2010-08-09 Ab Science 2-aminoaryloxazol-forbindelser som tyrosinkinase-inhibitorer
CN101217954B (zh) 2005-04-04 2013-07-10 Ab科学公司 经取代的噁唑衍生物及其作为酪氨酸激酶抑制剂的用途
US8246966B2 (en) * 2006-08-07 2012-08-21 University Of Georgia Research Foundation, Inc. Trypanosome microsome system and uses thereof
EP2079739A2 (en) 2006-10-04 2009-07-22 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
EP2088863A2 (en) * 2006-11-22 2009-08-19 University Of Georgia Research Foundation, Inc. Tyrosine kinase inhibitors as anti-kinetolastid and anti-apicomplexan agents
US20110008347A1 (en) * 2006-12-01 2011-01-13 Agency For Science ,Technology And Research Cancer-related protein kinases
KR20200003933A (ko) 2011-03-04 2020-01-10 뉴젠 세러퓨틱스 인코포레이티드 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3298291A (en) * 1965-12-28 1967-01-17 Jack D Layton Paver screed assembly
US3455920A (en) * 1967-01-13 1969-07-15 Squibb & Sons Inc 2,3-dihydro-5 and 6-substituted-2-phenyl-4(1h)-quinazolinones
US3637693A (en) * 1968-07-12 1972-01-25 Du Pont Hydroxyarylquinazolines and their use as uv-absorbers
DE2050092C3 (de) 1970-10-13 1980-04-24 Bayer Ag, 5090 Leverkusen Chinazolondiurethane, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten
DE2162327C3 (de) * 1970-12-23 1975-09-18 Sumitomo Chemical Co., Ltd., Osaka (Japan) Verfahren zur Herstellung von 3,4-Oihydro-2(1 H)-chinazolinonen
US4080455A (en) * 1975-12-16 1978-03-21 Taisho Pharmaceutical Company Limited 5-Fluoropyrimidin-4-one compositions
JPS6011032B2 (ja) 1975-12-16 1985-03-22 大鵬薬品工業株式会社 ２―置換―５―フルオルピリミジン―４―オン誘導体の製造法

Also Published As

Publication number Publication date
YU25682A (en) 1985-03-20
ES8304095A1 (es) 1983-02-16
GB2094295B (en) 1984-09-12
JPS57158780A (en) 1982-09-30
IE52385B1 (en) 1987-10-14
DE3203770A1 (de) 1982-11-11
KR830009050A (ko) 1983-12-17
DK159442B (da) 1990-10-15
JPH0337552B2 (sv) 1991-06-05
DE3203770C2 (de) 1993-11-04
FR2501207B1 (fr) 1985-12-06
IE820163L (en) 1982-09-06
SE461732B (sv) 1990-03-19
FR2501207A1 (fr) 1982-09-10
HU189997B (en) 1986-08-28
LU83903A1 (fr) 1982-09-13
AU7998182A (en) 1982-09-09
AR231138A1 (es) 1984-09-28
FI820399L (fi) 1982-09-07
DK50482A (da) 1982-09-07
IT1154272B (it) 1987-01-21
KE3715A (en) 1987-04-16
GR75903B (sv) 1984-08-02
PT74394B (en) 1984-10-22
SG30787G (en) 1988-09-16
US4343940A (en) 1982-08-10
YU42031B (en) 1988-04-30
CA1163995A (en) 1984-03-20
AT380476B (de) 1986-05-26
PT74394A (en) 1982-03-01
BE891936A (fr) 1982-07-28
PH18529A (en) 1985-08-02
CH647776A5 (de) 1985-02-15
HK4588A (en) 1988-01-29
NL8200473A (nl) 1982-10-01
NZ199576A (en) 1986-05-09
ATA39582A (de) 1985-10-15
FI71559C (sv) 1987-01-19
DK159442C (da) 1991-03-18
IT8247713A0 (it) 1982-02-03
IL64875A0 (en) 1982-03-31
FI71559B (fi) 1986-10-10
AU556099B2 (en) 1986-10-23
CY1371A (en) 1987-08-07
ES509434A0 (es) 1983-02-16
KR880001852B1 (ko) 1988-09-22
GB2094295A (en) 1982-09-15

Similar Documents

Publication Publication Date Title
SE8200526L (sv) Antitumorforeningar av kinazolintyp
NL970024I2 (nl) Anti-tumor middelen.
DK210185A (da) Antitumormidler
FI834498A (fi) Foerfarande foer diffusionssvetsning.
NO166494C (no) Fremgangsmaate for fremstilling av human lymfoblastoid interferon.
IT1146749B (it) Nuovo complesso organico del platino procedimento di preparazione ed attivita antitumorale dello stesso
DE3480763D1 (de) Bicyclische benzenoid-aminoalkylen-aether- und thioaether.
DE3885448D1 (de) Logarithmischer temperaturkompensierter verstärker.
FI851680L (fi) Dekoration av behaollare.
NO870829L (no) Immortalisering av primŸrceller.
ES517942A0 (es) Procedimiento de obtener alcaloides bisindolicos.
DK399487D0 (da) Antitumormiddel
DK239784A (da) Antitumor-middel
NO161959C (no) Tverrstroems diffusjonskolonne.
IT1157058B (it) Procedimento per la preparazione di acril e metaacrilamidi n.sostituite
FI841889A0 (fi) Hoegupploesningsmetod foer bestaemning av atp och koncentrering och bestaemning av encelliga organismer.
DK121682A (da) Bicykliske derivater
DK348784D0 (da) Antitumormiddel
OA07256A (fr) Halaolkyl-8-4H-(1)-benzopyran-4-ones,et procédés de préparation.
SE8101539L (sv) Kombinerat beslag for rygginstellning och hopfellning av tredgardsfatolj
FI813030L (fi) Reglerbar faestanordning
FI865002A (fi) Foerfarande och anordning foer utfoering av immunobestaemningar.
ES534608A0 (es) Agente anti-tumoral
NO830614L (no) Fremgangsmaate for behandling av glaukom.
FI824032A0 (fi) Bicykliska imidazol- och imidazolinderivat foer bekaempning av ektoparasiter och mask

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 8200526-5

Effective date: 19940810

Format of ref document f/p: F