ES8202343A1 - Un procedimiento para preparar imidazo-piridinas - Google Patents
Un procedimiento para preparar imidazo-piridinasInfo
- Publication number
- ES8202343A1 ES8202343A1 ES500727A ES500727A ES8202343A1 ES 8202343 A1 ES8202343 A1 ES 8202343A1 ES 500727 A ES500727 A ES 500727A ES 500727 A ES500727 A ES 500727A ES 8202343 A1 ES8202343 A1 ES 8202343A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- hydrogen
- preparation
- pyridines
- imidazo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
- C07D213/77—Hydrazine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE IMIDAZOPIRIDINAS DE FORMULA (I) O (II), EN LAS QUE Q Y R2 SON HIDROGENO O ALQUILO INFERIOR; PY ES 4- O 3-PIRIDINILO SIN SUSTITUIR O SUSTITUIDO CON UNO O DOS RADICALES ALQUILO INFERIOR; Y R1 Y R3 UEDE SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UNA 2-R3NH-3-R1NH-5-PY-6-Q-PIRIDINA, EN LA QUE O BIEN R1 O R3 EW HIDROGENO, CON UBN ORTOALCANOATO INFERIOR DE TRIALQUILO INFERIOR, TENIENDO Q, PY Y, EN SU CASO, R1 O R3 LOS MISMOS SIGNIFICADOS QUE EN LAS FORMULAS (I) Y (II). LA REACCION SE LLEVA A CABO EN AUSENCIA O PRESENCIA DE UN DISOLVENTE INERTE A UNA TEMPERATURA COMPRENDIDA ENTRE 50 Y 150 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES CARDIOTONICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/135,211 US4276293A (en) | 1980-03-28 | 1980-03-28 | Compositions and their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8202343A1 true ES8202343A1 (es) | 1982-01-16 |
ES500727A0 ES500727A0 (es) | 1982-01-16 |
Family
ID=22467044
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES500727A Granted ES500727A0 (es) | 1980-03-28 | 1981-03-26 | Un procedimiento para preparar imidazo-piridinas |
Country Status (22)
Country | Link |
---|---|
US (1) | US4276293A (es) |
JP (1) | JPS56150090A (es) |
KR (1) | KR830005217A (es) |
AU (1) | AU6883781A (es) |
BE (1) | BE888088A (es) |
CA (1) | CA1159061A (es) |
DE (1) | DE3112197A1 (es) |
DK (1) | DK136881A (es) |
ES (1) | ES500727A0 (es) |
FI (1) | FI810921L (es) |
FR (1) | FR2479225A1 (es) |
GB (1) | GB2072673B (es) |
IL (1) | IL62403A0 (es) |
IT (1) | IT1136972B (es) |
LU (1) | LU83259A1 (es) |
NL (1) | NL8101455A (es) |
NO (1) | NO811041L (es) |
NZ (1) | NZ196573A (es) |
PH (1) | PH16999A (es) |
PT (1) | PT72744B (es) |
SE (1) | SE8101951L (es) |
ZA (1) | ZA811776B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4363911A (en) * | 1981-09-03 | 1982-12-14 | Sterling Drug Inc. | 1,2-Dihydro-6-[2-(dimethylamino)ethenyl]-2-oxo-5-(pyridinyl) nicotinonitriles |
US4465686A (en) * | 1981-09-08 | 1984-08-14 | Sterling Drug Inc. | 5-(Hydroxy- and/or amino-phenyl)-6-(lower-alkyl)-2-(1H)-pyridinones, their cardiotonic use and preparation |
US4347363A (en) * | 1981-09-17 | 1982-08-31 | Sterling Drug Inc. | Process for preparing 1,2-dihydro-6-methyl-2-oxo-5-(pyridinyl)nicotinonitriles |
US4599423A (en) * | 1982-04-26 | 1986-07-08 | Sterling Drug Inc. | Preparation of 5-(hydroxy- and/or aminophenyl-6-lower-alkyl)-2(1H)-pyridinones |
US4417054A (en) * | 1982-05-24 | 1983-11-22 | Sterling Drug Inc. | 2-(Lower-alkoxy)-1-(pyridinyl)ethenyl lower-alkyl ketones |
US4469871A (en) * | 1982-05-24 | 1984-09-04 | Sterling Drug Inc. | Process for preparing 2-(lower-alkoxy)-1-(pyridinyl) ethenyl lower-alkyl ketones |
NO163008C (no) * | 1982-05-24 | 1990-03-21 | Sterling Drug Inc | 2-(laverealkoksy)-1-(pyridinyl)etenyl-lavere-alkylketon og fremgangsmaate for fremstilling av pyridinylnikotinderivater. |
US4413127A (en) * | 1982-05-24 | 1983-11-01 | Sterling Drug Inc. | Preparation of 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(pyridinyl)nicotinonitriles |
US4595762A (en) * | 1982-08-25 | 1986-06-17 | Sterling Drug Inc. | 5-α-bromoalkanoyl-2-oxo-3-pyridinecarbonitriles |
US4469699A (en) * | 1982-08-25 | 1984-09-04 | Sterling Drug Inc. | 5-(4-Thiazolyl)-6-alkyl-2(1H)-pyridinones and their cardiotonic use |
US4539327A (en) * | 1982-08-25 | 1985-09-03 | Sterling Drug Inc. | 5-(2-Substituted-4-thiazolyl)-6-alkyl-2(1H)-pyridinones and cardiotonic use thereof |
US4448780A (en) * | 1982-09-03 | 1984-05-15 | Sterling Drug Inc. | N-(Lower-alkyl)-N'-[5-(pyridinyl)-2-pyridinyl]ureas and cardiotonic use thereof |
US4517192A (en) * | 1983-01-31 | 1985-05-14 | Sterling Drug Inc. | 6-Alkyl-5-[4-(alkylsulfinyl or alkylsulfonyl)phenyl]-2(1H)-pyridinones and their use as cardiatonics |
US4977144A (en) * | 1988-08-02 | 1990-12-11 | Ciba-Geigy Corporation | Imidazo[4,5-b]pyridine derivatives as cardiovascular agents |
AU3820989A (en) * | 1988-08-02 | 1990-02-08 | Ciba-Geigy Ag | 7-amino-3-beta-d-ribofuranosyl-3h-imidazo(4,5-b) pyridin-5-amine derivatives |
US4963561A (en) * | 1990-02-28 | 1990-10-16 | Sterling Drug Inc. | Imidazopyridines, their preparation and use |
US5010086A (en) * | 1990-02-28 | 1991-04-23 | Sterling Drug Inc. | Imidazopyridines, compositions and use |
US6465484B1 (en) * | 1997-09-26 | 2002-10-15 | Merck & Co., Inc. | Angiogenesis inhibitors |
EP1362894B1 (en) | 2002-02-14 | 2007-12-19 | FUJIFILM Corporation | Method for optical measurement of multi-stranded nucleic acid using cyanine dyes |
-
1980
- 1980-03-28 US US06/135,211 patent/US4276293A/en not_active Expired - Lifetime
- 1980-03-28 NZ NZ196573A patent/NZ196573A/en unknown
-
1981
- 1981-03-17 IL IL62403A patent/IL62403A0/xx unknown
- 1981-03-18 ZA ZA00811776A patent/ZA811776B/xx unknown
- 1981-03-20 PH PH25393A patent/PH16999A/en unknown
- 1981-03-24 GB GB8109259A patent/GB2072673B/en not_active Expired
- 1981-03-24 BE BE1/10186A patent/BE888088A/fr not_active IP Right Cessation
- 1981-03-24 NL NL8101455A patent/NL8101455A/nl not_active Application Discontinuation
- 1981-03-25 FI FI810921A patent/FI810921L/fi not_active Application Discontinuation
- 1981-03-26 PT PT72744A patent/PT72744B/pt unknown
- 1981-03-26 DK DK136881A patent/DK136881A/da not_active IP Right Cessation
- 1981-03-26 ES ES500727A patent/ES500727A0/es active Granted
- 1981-03-26 NO NO811041A patent/NO811041L/no unknown
- 1981-03-26 SE SE8101951A patent/SE8101951L/xx not_active Application Discontinuation
- 1981-03-26 FR FR8106072A patent/FR2479225A1/fr active Granted
- 1981-03-27 JP JP4533681A patent/JPS56150090A/ja active Pending
- 1981-03-27 DE DE19813112197 patent/DE3112197A1/de not_active Withdrawn
- 1981-03-27 CA CA000374059A patent/CA1159061A/en not_active Expired
- 1981-03-27 IT IT20784/81A patent/IT1136972B/it active
- 1981-03-27 AU AU68837/81A patent/AU6883781A/en not_active Abandoned
- 1981-03-27 KR KR1019810001015A patent/KR830005217A/ko unknown
- 1981-03-27 LU LU83259A patent/LU83259A1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
AU6883781A (en) | 1981-10-08 |
CA1159061A (en) | 1983-12-20 |
NO811041L (no) | 1981-09-28 |
LU83259A1 (fr) | 1981-10-29 |
PT72744B (en) | 1982-03-24 |
DE3112197A1 (de) | 1982-02-25 |
IT1136972B (it) | 1986-09-03 |
GB2072673A (en) | 1981-10-07 |
BE888088A (fr) | 1981-09-24 |
JPS56150090A (en) | 1981-11-20 |
FR2479225A1 (fr) | 1981-10-02 |
ZA811776B (en) | 1982-04-28 |
NZ196573A (en) | 1984-03-16 |
GB2072673B (en) | 1983-11-02 |
DK136881A (da) | 1981-09-29 |
PH16999A (en) | 1984-05-04 |
IL62403A0 (en) | 1981-05-20 |
NL8101455A (nl) | 1981-10-16 |
PT72744A (en) | 1981-04-01 |
SE8101951L (sv) | 1981-09-29 |
KR830005217A (ko) | 1983-08-03 |
US4276293A (en) | 1981-06-30 |
ES500727A0 (es) | 1982-01-16 |
FR2479225B1 (es) | 1984-05-18 |
FI810921L (fi) | 1981-09-29 |
IT8120784A0 (it) | 1981-03-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8202343A1 (es) | Un procedimiento para preparar imidazo-piridinas | |
ES8202816A1 (es) | Un procedimiento para preparar diaminopiridinas | |
MD1761B2 (ro) | Eteri de 2,6-dihidroxipiridină, procedeu de preparare a lor, compoziţie erbicidă şi metodă de combatere a creşterii plantelor indezirabile | |
ES8203845A1 (es) | Procedimiento para preparar derivados de piridoxina | |
ES8107215A1 (es) | Un procedimiento para preparar una 2-r-6-py-3(2h)-piridaci- nona | |
ES8704492A1 (es) | Metodo de preparar derivados de b-carbolin-3-oxadiazolilo | |
ES8201947A1 (es) | Un procedimiento para preparar 9-aminoalquilfluorenos | |
SE8101591L (sv) | Pyrazolopyridinderivat och forfarande for framstellning derav | |
ES8606233A1 (es) | Un procedimiento para la preparacion de fosfatidos de eter de glicol | |
ES8307799A1 (es) | Procedimiento para la obtencion de 2-imidazolilmetil-2-fenil-1,3-dioxolanos. | |
ES8100283A1 (es) | Un procedimiento para la preparacion de derivados del acido 4,5-dihidro-4-oxofuran-2-carboxilico | |
ES8601138A1 (es) | Un procedimiento para preparar derivados de 5-(piridinil o fenil)-2(1h)-piridinona | |
ES8202006A1 (es) | Un procedimiento para preparar derivados de imidazo (4,5-b) piridina | |
ES8306733A1 (es) | Derivados de anilina y sus sales. | |
GB1474896A (en) | Salts of phenylpyridazines and the preparation thereof | |
FR2529891B1 (es) | ||
ES8702399A1 (es) | Un procedimiento para preparar derivdos de 1,5-benzoxatiepina | |
ES468486A1 (es) | Procedimiento para la preparacion de nuevos derivados de 1-(3-(3,4,5-trimetoxifenoxi)-2-hidroxi - propil)-4-aril pi- perazina | |
ES8603458A1 (es) | Un procedimiento para preparar una 3-r1-4-r2-5-q-6-r-2(1h)-piridinona | |
IE780982L (en) | 4-hydroxythiazoline-2-thiones. | |
ES8400435A1 (es) | Procedimiento para preparar 1,2-dihidropirido (3,4 6) pirazinas. | |
ES8506301A1 (es) | Un procedimiento para preparar 2-alcoxi-5-(piridinil) piridinas | |
US4198500A (en) | Trans-4,5-didehydro-PGI1 amides | |
ES481486A1 (es) | Procedimientos para preparar derivados de acidos 1-pirrol- carboxilixos | |
GB1426666A (en) | Pyridine derivatives their preparation and pharmaceutical composi ions containing them |