ES8306733A1 - Derivados de anilina y sus sales. - Google Patents
Derivados de anilina y sus sales.Info
- Publication number
- ES8306733A1 ES8306733A1 ES512024A ES512024A ES8306733A1 ES 8306733 A1 ES8306733 A1 ES 8306733A1 ES 512024 A ES512024 A ES 512024A ES 512024 A ES512024 A ES 512024A ES 8306733 A1 ES8306733 A1 ES 8306733A1
- Authority
- ES
- Spain
- Prior art keywords
- same
- hydrogen
- lower alkyl
- aniline derivatives
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE ANILINA DE FORMULA (I). SE HACE REACCIONAR UN COMPUESTO DE FORMULA (II) EN DONDE R , R Y R SON IGUALES O DIFERENTES Y CADA UNO DE ELLOS ES UN ATOMO DE HIDROGENO O HALOGENO O UN GRUPO NITRO, AMINO, CARBOXI, CIANO, HIDROXI, SULFONAMIDA O ALQUILO INFERIOR, R ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO INFERIOR, A ES UN GRUPO ALQUILENO INFERIOR Y X ES UN ATOMO DE HALOGENO, CON UN COMPUESTO DE FORMULA (III) DONDE R ES UN GRUPO CIANO, NITRO, ALQUILO INFERIOR O ALCOXI INFERIOR O HALOGENO Y M ES UN NUMERO ENTERO DE 1 A 3, LLEVANDOSE A CABO LA REACCION A UNA TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y 80 C Y DURANTE UN TIEMPO DE 1 A 24 HORAS. SE UTILIZAN COMO CARDIOTONICOS PARA CURAR ENFERMEDADES CARDIACAS, TALES COMO FALLO CARDIACO AGUDO VENTRICULAR IZQUIERDO, SHOCK CARDIOGENICO Y SIMILARES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56069690A JPS57185273A (en) | 1981-05-08 | 1981-05-08 | Aniline derivative |
JP56178722A JPS5879986A (ja) | 1981-11-06 | 1981-11-06 | アニリン誘導体 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES512024A0 ES512024A0 (es) | 1983-06-01 |
ES8306733A1 true ES8306733A1 (es) | 1983-06-01 |
Family
ID=26410858
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES512024A Expired ES8306733A1 (es) | 1981-05-08 | 1982-05-07 | Derivados de anilina y sus sales. |
ES519853A Granted ES519853A0 (es) | 1981-05-08 | 1983-02-16 | Un procedimiento para la preparacion de derivados de anilinay sus sales. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES519853A Granted ES519853A0 (es) | 1981-05-08 | 1983-02-16 | Un procedimiento para la preparacion de derivados de anilinay sus sales. |
Country Status (13)
Country | Link |
---|---|
US (1) | US4585774A (es) |
EP (1) | EP0064878B1 (es) |
KR (1) | KR860000062B1 (es) |
AU (1) | AU535498B2 (es) |
CA (1) | CA1201121A (es) |
DE (1) | DE3264889D1 (es) |
DK (1) | DK159971C (es) |
ES (2) | ES8306733A1 (es) |
FI (1) | FI74704C (es) |
PH (1) | PH18071A (es) |
PT (1) | PT74858B (es) |
SU (1) | SU1316560A3 (es) |
WO (1) | WO1982003861A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3315424A1 (de) * | 1983-04-28 | 1984-12-20 | Cassella Ag, 6000 Frankfurt | Substituierte piperazin-1-yl-essigsaeure-amide, verfahren zu ihrer herstellung und ihre verwendung |
IL92011A0 (en) * | 1988-10-19 | 1990-07-12 | Abbott Lab | Heterocyclic peptide renin inhibitors |
US5164388A (en) * | 1988-10-19 | 1992-11-17 | Abbott Laboratories | Heterocyclic peptide renin inhibitors |
GB2244704B (en) * | 1990-05-04 | 1995-05-17 | Consultants Suppliers Limited | Substituted benzene compounds |
US5719151A (en) * | 1990-05-04 | 1998-02-17 | Shall; Sydney | Substituted benzene compounds |
DE4410822A1 (de) * | 1994-03-24 | 1995-09-28 | Schering Ag | Neue Piperidin-Derivate |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1143882A (es) * | 1966-06-21 | |||
FR2209560A1 (en) * | 1972-12-07 | 1974-07-05 | Degussa | N-(Trialkoxyaroyl)-ethylenediamine derivs - useful as cardioactive medicaments, exhibit anti-ischaemic activity comparable to nitroglycerin |
DE2304155A1 (de) * | 1973-01-29 | 1974-08-01 | Ichthyol Ges Cordes Hermanni & | N-acylierte substituierte piperazinbzw. homopiperazinderivate, sowie verfahren zu ihrer herstellung |
GB1561023A (en) * | 1977-04-22 | 1980-02-13 | Beecham Group Ltd | 2-methoxy - 5 - chloro aniline derivatives |
-
1982
- 1982-05-04 US US06/432,902 patent/US4585774A/en not_active Expired - Fee Related
- 1982-05-04 AU AU84000/82A patent/AU535498B2/en not_active Ceased
- 1982-05-04 WO PCT/JP1982/000152 patent/WO1982003861A1/ja active IP Right Grant
- 1982-05-05 CA CA000402347A patent/CA1201121A/en not_active Expired
- 1982-05-05 PH PH27242A patent/PH18071A/en unknown
- 1982-05-07 ES ES512024A patent/ES8306733A1/es not_active Expired
- 1982-05-07 PT PT74858A patent/PT74858B/pt not_active IP Right Cessation
- 1982-05-08 KR KR8202007A patent/KR860000062B1/ko active
- 1982-05-10 DE DE8282302381T patent/DE3264889D1/de not_active Expired
- 1982-05-10 EP EP82302381A patent/EP0064878B1/en not_active Expired
- 1982-10-19 SU SU823511152A patent/SU1316560A3/ru active
- 1982-10-19 FI FI823575A patent/FI74704C/fi not_active IP Right Cessation
- 1982-10-20 DK DK465282A patent/DK159971C/da not_active IP Right Cessation
-
1983
- 1983-02-16 ES ES519853A patent/ES519853A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
PT74858A (en) | 1982-06-01 |
US4585774A (en) | 1986-04-29 |
AU535498B2 (en) | 1984-03-22 |
DK465282A (da) | 1982-11-09 |
CA1201121A (en) | 1986-02-25 |
EP0064878A1 (en) | 1982-11-17 |
ES512024A0 (es) | 1983-06-01 |
EP0064878B1 (en) | 1985-07-24 |
WO1982003861A1 (en) | 1982-11-11 |
KR860000062B1 (ko) | 1986-02-06 |
DK159971C (da) | 1991-05-27 |
PT74858B (en) | 1983-12-07 |
FI74704B (fi) | 1987-11-30 |
FI74704C (fi) | 1988-03-10 |
ES8403469A1 (es) | 1984-03-16 |
FI823575L (fi) | 1982-11-09 |
AU8400082A (en) | 1982-12-07 |
DK159971B (da) | 1991-01-07 |
KR830010090A (ko) | 1983-12-26 |
FI823575A0 (fi) | 1982-10-19 |
ES519853A0 (es) | 1984-03-16 |
PH18071A (en) | 1985-03-18 |
DE3264889D1 (en) | 1985-08-29 |
SU1316560A3 (ru) | 1987-06-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970203 |