DK465282A - Fremgangsmaade til fremstilling af anilinderivater - Google Patents

Fremgangsmaade til fremstilling af anilinderivater Download PDF

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Publication number
DK465282A
DK465282A DK465282A DK465282A DK465282A DK 465282 A DK465282 A DK 465282A DK 465282 A DK465282 A DK 465282A DK 465282 A DK465282 A DK 465282A DK 465282 A DK465282 A DK 465282A
Authority
DK
Denmark
Prior art keywords
group
alkyl
halogen atom
alkoxy
atom
Prior art date
Application number
DK465282A
Other languages
English (en)
Other versions
DK159971B (da
DK159971C (da
Inventor
Michiaki Tominaga
Yung-Hsiung Yang
Hidenori Ogawa
Kazuyuki Nakagawa
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP56069690A external-priority patent/JPS57185273A/ja
Priority claimed from JP56178722A external-priority patent/JPS5879986A/ja
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of DK465282A publication Critical patent/DK465282A/da
Publication of DK159971B publication Critical patent/DK159971B/da
Application granted granted Critical
Publication of DK159971C publication Critical patent/DK159971C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182Radicals derived from carboxylic acids
    • C07D295/192Radicals derived from carboxylic acids from aromatic carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
DK465282A 1981-05-08 1982-10-20 Analogifremgangsmaade til fremstilling af benzoyl-1-piperazinyl-acylanilider eller salte deraf DK159971C (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP6969081 1981-05-08
JP56069690A JPS57185273A (en) 1981-05-08 1981-05-08 Aniline derivative
JP56178722A JPS5879986A (ja) 1981-11-06 1981-11-06 アニリン誘導体
JP17872281 1981-11-06
PCT/JP1982/000152 WO1982003861A1 (en) 1981-05-08 1982-05-04 Aniline derivatives,process for their preparation,and cardiotonics
JP8200152 1982-05-04

Publications (3)

Publication Number Publication Date
DK465282A true DK465282A (da) 1982-11-09
DK159971B DK159971B (da) 1991-01-07
DK159971C DK159971C (da) 1991-05-27

Family

ID=26410858

Family Applications (1)

Application Number Title Priority Date Filing Date
DK465282A DK159971C (da) 1981-05-08 1982-10-20 Analogifremgangsmaade til fremstilling af benzoyl-1-piperazinyl-acylanilider eller salte deraf

Country Status (13)

Country Link
US (1) US4585774A (da)
EP (1) EP0064878B1 (da)
KR (1) KR860000062B1 (da)
AU (1) AU535498B2 (da)
CA (1) CA1201121A (da)
DE (1) DE3264889D1 (da)
DK (1) DK159971C (da)
ES (2) ES512024A0 (da)
FI (1) FI74704C (da)
PH (1) PH18071A (da)
PT (1) PT74858B (da)
SU (1) SU1316560A3 (da)
WO (1) WO1982003861A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3315424A1 (de) * 1983-04-28 1984-12-20 Cassella Ag, 6000 Frankfurt Substituierte piperazin-1-yl-essigsaeure-amide, verfahren zu ihrer herstellung und ihre verwendung
US5164388A (en) * 1988-10-19 1992-11-17 Abbott Laboratories Heterocyclic peptide renin inhibitors
IL92011A0 (en) * 1988-10-19 1990-07-12 Abbott Lab Heterocyclic peptide renin inhibitors
US5719151A (en) * 1990-05-04 1998-02-17 Shall; Sydney Substituted benzene compounds
GB2244704B (en) * 1990-05-04 1995-05-17 Consultants Suppliers Limited Substituted benzene compounds
DE4410822A1 (de) * 1994-03-24 1995-09-28 Schering Ag Neue Piperidin-Derivate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143882A (da) * 1966-06-21
FR2209560A1 (en) * 1972-12-07 1974-07-05 Degussa N-(Trialkoxyaroyl)-ethylenediamine derivs - useful as cardioactive medicaments, exhibit anti-ischaemic activity comparable to nitroglycerin
DE2304155A1 (de) * 1973-01-29 1974-08-01 Ichthyol Ges Cordes Hermanni & N-acylierte substituierte piperazinbzw. homopiperazinderivate, sowie verfahren zu ihrer herstellung
GB1561023A (en) * 1977-04-22 1980-02-13 Beecham Group Ltd 2-methoxy - 5 - chloro aniline derivatives

Also Published As

Publication number Publication date
DK159971B (da) 1991-01-07
ES8306733A1 (es) 1983-06-01
EP0064878A1 (en) 1982-11-17
ES512024A0 (es) 1983-06-01
FI823575A0 (fi) 1982-10-19
SU1316560A3 (ru) 1987-06-07
DE3264889D1 (en) 1985-08-29
FI74704B (fi) 1987-11-30
WO1982003861A1 (en) 1982-11-11
CA1201121A (en) 1986-02-25
FI823575L (fi) 1982-11-09
FI74704C (fi) 1988-03-10
EP0064878B1 (en) 1985-07-24
PT74858A (en) 1982-06-01
ES519853A0 (es) 1984-03-16
ES8403469A1 (es) 1984-03-16
KR830010090A (ko) 1983-12-26
AU535498B2 (en) 1984-03-22
DK159971C (da) 1991-05-27
US4585774A (en) 1986-04-29
PH18071A (en) 1985-03-18
PT74858B (en) 1983-12-07
KR860000062B1 (ko) 1986-02-06
AU8400082A (en) 1982-12-07

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