ES8403469A1 - Un procedimiento para la preparacion de derivados de anilinay sus sales. - Google Patents

Un procedimiento para la preparacion de derivados de anilinay sus sales.

Info

Publication number
ES8403469A1
ES8403469A1 ES519853A ES519853A ES8403469A1 ES 8403469 A1 ES8403469 A1 ES 8403469A1 ES 519853 A ES519853 A ES 519853A ES 519853 A ES519853 A ES 519853A ES 8403469 A1 ES8403469 A1 ES 8403469A1
Authority
ES
Spain
Prior art keywords
same
hydrogen
lower alkyl
aniline derivatives
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES519853A
Other languages
English (en)
Other versions
ES519853A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP56069690A external-priority patent/JPS57185273A/ja
Priority claimed from JP56178722A external-priority patent/JPS5879986A/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of ES519853A0 publication Critical patent/ES519853A0/es
Publication of ES8403469A1 publication Critical patent/ES8403469A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ANILINA Y DE SUS SALES DE FORMULA (I), EN LA QUE A, R0, R1, R2, R3 Y R4 PUEDEN SER VARIOS TIPOS DE RADICALES Y N VALE 1-3.CONSISTE EN LA REACCION DE UN DERIVADO DE ANILINA DE FORMULA (II), CON UN DERIVADO DE PIPERAZINA, DE FORMULA (III), EN LAS QUE X ES UN ATOMO DE HALOGENO Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE COMO ACEPTOR DE ACIDOS, A UNA TEMPERATURA ENTRE LA AMBIENTE Y 100JC.ESTOSCOMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES CARDIOTONICOS.
ES519853A 1981-05-08 1983-02-16 Un procedimiento para la preparacion de derivados de anilinay sus sales. Expired ES8403469A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56069690A JPS57185273A (en) 1981-05-08 1981-05-08 Aniline derivative
JP56178722A JPS5879986A (ja) 1981-11-06 1981-11-06 アニリン誘導体

Publications (2)

Publication Number Publication Date
ES519853A0 ES519853A0 (es) 1984-03-16
ES8403469A1 true ES8403469A1 (es) 1984-03-16

Family

ID=26410858

Family Applications (2)

Application Number Title Priority Date Filing Date
ES512024A Granted ES512024A0 (es) 1981-05-08 1982-05-07 Derivados de anilina y sus sales.
ES519853A Expired ES8403469A1 (es) 1981-05-08 1983-02-16 Un procedimiento para la preparacion de derivados de anilinay sus sales.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES512024A Granted ES512024A0 (es) 1981-05-08 1982-05-07 Derivados de anilina y sus sales.

Country Status (13)

Country Link
US (1) US4585774A (es)
EP (1) EP0064878B1 (es)
KR (1) KR860000062B1 (es)
AU (1) AU535498B2 (es)
CA (1) CA1201121A (es)
DE (1) DE3264889D1 (es)
DK (1) DK159971C (es)
ES (2) ES512024A0 (es)
FI (1) FI74704C (es)
PH (1) PH18071A (es)
PT (1) PT74858B (es)
SU (1) SU1316560A3 (es)
WO (1) WO1982003861A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3315424A1 (de) * 1983-04-28 1984-12-20 Cassella Ag, 6000 Frankfurt Substituierte piperazin-1-yl-essigsaeure-amide, verfahren zu ihrer herstellung und ihre verwendung
US5164388A (en) * 1988-10-19 1992-11-17 Abbott Laboratories Heterocyclic peptide renin inhibitors
IL92011A0 (en) * 1988-10-19 1990-07-12 Abbott Lab Heterocyclic peptide renin inhibitors
US5719151A (en) * 1990-05-04 1998-02-17 Shall; Sydney Substituted benzene compounds
GB2244704B (en) * 1990-05-04 1995-05-17 Consultants Suppliers Limited Substituted benzene compounds
DE4410822A1 (de) * 1994-03-24 1995-09-28 Schering Ag Neue Piperidin-Derivate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143882A (es) * 1966-06-21
FR2209560A1 (en) * 1972-12-07 1974-07-05 Degussa N-(Trialkoxyaroyl)-ethylenediamine derivs - useful as cardioactive medicaments, exhibit anti-ischaemic activity comparable to nitroglycerin
DE2304155A1 (de) * 1973-01-29 1974-08-01 Ichthyol Ges Cordes Hermanni & N-acylierte substituierte piperazinbzw. homopiperazinderivate, sowie verfahren zu ihrer herstellung
GB1561023A (en) * 1977-04-22 1980-02-13 Beecham Group Ltd 2-methoxy - 5 - chloro aniline derivatives

Also Published As

Publication number Publication date
DK159971B (da) 1991-01-07
ES8306733A1 (es) 1983-06-01
EP0064878A1 (en) 1982-11-17
ES512024A0 (es) 1983-06-01
FI823575A0 (fi) 1982-10-19
SU1316560A3 (ru) 1987-06-07
DE3264889D1 (en) 1985-08-29
FI74704B (fi) 1987-11-30
WO1982003861A1 (en) 1982-11-11
CA1201121A (en) 1986-02-25
DK465282A (da) 1982-11-09
FI823575L (fi) 1982-11-09
FI74704C (fi) 1988-03-10
EP0064878B1 (en) 1985-07-24
PT74858A (en) 1982-06-01
ES519853A0 (es) 1984-03-16
KR830010090A (ko) 1983-12-26
AU535498B2 (en) 1984-03-22
DK159971C (da) 1991-05-27
US4585774A (en) 1986-04-29
PH18071A (en) 1985-03-18
PT74858B (en) 1983-12-07
KR860000062B1 (ko) 1986-02-06
AU8400082A (en) 1982-12-07

Similar Documents

Publication Publication Date Title
SU1538893A3 (ru) Способ получени гидрохлорида N-деформил-N [N,N -бис(2-хлорэтил)]дистамицина А
ES8104286A1 (es) Un procedimiento para la produccion de un derivado 4-amino- 3-carboxi o ciano-1,2-dihidro-2-oxo-1,8-naftiridina
ES8706627A1 (es) Procedimiento para preparar nuevos derivados de pirrol
EG15674A (en) Novel substituted oxonicotinates,their use as plant growth regulators and plant growth regulating compositions containing them
ES8403444A1 (es) Procedimiento para la obtencion de derivados de fenilsulfonil-urea sustituidas.
ES8403469A1 (es) Un procedimiento para la preparacion de derivados de anilinay sus sales.
DK0563798T3 (da) Butadienderivater og fremgangsmåder til fremstilling deraf
ATE31414T1 (de) 8-substituierte pyrrolizidin-derivate und deren verwendung.
ES8801545A1 (es) Un procedimiento para la preparacion de compuestos aminoheterociclicos
ES8307708A1 (es) Procedimiento para la obtencion de fenoxipropionatos sustituidos.
ES8203917A1 (es) Un procedimiento para la preparacion de un derivado de nu- cleosido de adenina
ES8608500A1 (es) Un procedimiento para preparar nuevas 1,2,4-tiadiazinas
ES8301888A1 (es) "procedimiento para la preparacion de derivados de fenoxi-aminopropanol substituidos" como divisional de la patente de invencion n 502.649 del 1 junio 1981.
DE68928127D1 (de) 2'-Methylidenpyrimidinnukleosidverbindungen, ihre Verwendung und Verfahren zu ihrer Herstellung
HK127993A (en) Mitomycin analogs,a process for preparing them and pharmaceutical compositions
ES8704947A1 (es) Un procedimiento para preparar un derivado de imidazopirida-zina
ES8300826A1 (es) Procedimiento para la obtencion de colorantes de azufre
KR790000068B1 (en) Process for preparation of guanidine derivatives
ES8702877A1 (es) Un metodo para producir un derivado de acido benzoico.
ES8606287A1 (es) Un procedimiento para la preparacion de heterociclilfenil- formamidinas

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401