ES8203917A1 - Un procedimiento para la preparacion de un derivado de nu- cleosido de adenina - Google Patents

Un procedimiento para la preparacion de un derivado de nu- cleosido de adenina

Info

Publication number
ES8203917A1
ES8203917A1 ES503221A ES503221A ES8203917A1 ES 8203917 A1 ES8203917 A1 ES 8203917A1 ES 503221 A ES503221 A ES 503221A ES 503221 A ES503221 A ES 503221A ES 8203917 A1 ES8203917 A1 ES 8203917A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
nucleoside derivatives
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES503221A
Other languages
English (en)
Other versions
ES503221A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Minnesota
Original Assignee
University of Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/162,097 external-priority patent/US4362729A/en
Priority claimed from US06/225,567 external-priority patent/US4338310A/en
Application filed by University of Minnesota filed Critical University of Minnesota
Publication of ES8203917A1 publication Critical patent/ES8203917A1/es
Publication of ES503221A0 publication Critical patent/ES503221A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE NUCLEOSIDO DE ADENINA. CONSISTE EN ESTERIFICAR VIDARABINA O CICLARADINA O UNO DE SUS DERIVADOS REACTIVOS CON UN ACIDO ALCOXIALCANOICO (R1-O-R2-COOH). SI SE DESEA, SE HIDROLIZA SELECTIVAMENTE EL DIESTER O TRIESTER OBTENIDO Y SE AISLA EL ESTER OBTENIDO DE LA FORMA LIBRE. LA ESTERIFICACION SE EFECTUA DE LA FORMA LIBRE. LA ESTERIFICACION SE EFECTUA MEDIANTE UN HALURO DE ALCOXIALCANOILO, PREFERENTEMENTE EL CLORURO. EL GRUPO ALCOXIALCANOILO ES UN GRUPO METOXIACETILO. SE OBTIENEN COMPUESTOS DE FORMULA GENERAL (I).
ES503221A 1980-06-23 1981-06-19 Un procedimiento para la preparacion de un derivado de nu- cleosido de adenina Granted ES503221A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/162,097 US4362729A (en) 1980-06-23 1980-06-23 Alkoxyalkanoate esters of cyclaradine
US06/225,567 US4338310A (en) 1981-01-16 1981-01-16 Alkoxyalkanoate esters of arabinofuranosyladenine

Publications (2)

Publication Number Publication Date
ES8203917A1 true ES8203917A1 (es) 1982-04-01
ES503221A0 ES503221A0 (es) 1982-04-01

Family

ID=26858449

Family Applications (1)

Application Number Title Priority Date Filing Date
ES503221A Granted ES503221A0 (es) 1980-06-23 1981-06-19 Un procedimiento para la preparacion de un derivado de nu- cleosido de adenina

Country Status (14)

Country Link
EP (1) EP0042596B1 (es)
AR (1) AR230448A1 (es)
AU (1) AU542271B2 (es)
CA (1) CA1157854A (es)
DE (1) DE3162644D1 (es)
DK (1) DK149026C (es)
ES (1) ES503221A0 (es)
FI (1) FI70903C (es)
HU (1) HU183493B (es)
IE (1) IE51332B1 (es)
IL (1) IL63132A (es)
NZ (1) NZ197458A (es)
PH (1) PH17109A (es)
PT (1) PT73237B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4594350A (en) * 1984-07-30 1986-06-10 Reagents Of University Of Minnesota (3-ethoxypropionate) esters of cyclaradine
EP0219838A3 (en) * 1985-10-22 1988-04-06 Takeda Chemical Industries, Ltd. Carbocyclic purine nucleosides, their production and use
GB9007569D0 (en) * 1990-04-04 1990-05-30 Nycomed As Carbo-nucleoside derivatives
EP0523110A1 (en) * 1990-04-04 1993-01-20 Nycomed Imaging As Nucleoside derivatives
FR2759091B1 (fr) * 1997-02-06 1999-03-19 Expertises Ind Et Procede biologique d'obtention de nouveaux derives de l'adenosine et les compositions pharmaceutiques qui les contiennent
CN104297402B (zh) * 2014-07-22 2016-01-20 吉林大学 车前子中腺嘌呤核苷的hplc含量测定方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069382A (en) * 1976-05-17 1978-01-17 Parke, Davis & Company 9-(5-O-Acyl-β-D-arabinofuranosyl)adenine compounds
US4055718A (en) * 1976-05-17 1977-10-25 Parke, Davis & Company 9-(2-O-Acyl-β-D-arabinofuranosyl)-adenine compounds and method for their production
US4055717A (en) * 1976-05-17 1977-10-25 Parke, Davis & Company 9-(3-O-Acyl-β-D-arabinofuranosyl)adenine compounds, 9-(2,3-di-O-acyl-β-D-arabinofuranosyl)-adenine compounds, and method for their production
US4138562A (en) 1977-02-09 1979-02-06 The Regents Of The University Of Minnesota Adenosine deaminase resistant antiviral purine nucleosides and method of preparation

Also Published As

Publication number Publication date
DK268981A (da) 1981-12-24
DK149026C (da) 1986-07-07
PT73237A (en) 1981-07-01
PT73237B (en) 1983-04-29
HU183493B (en) 1984-05-28
NZ197458A (en) 1983-11-30
CA1157854A (en) 1983-11-29
AU7195681A (en) 1982-01-07
FI811928L (fi) 1981-12-24
EP0042596B1 (en) 1984-03-14
DE3162644D1 (en) 1984-04-19
FI70903C (fi) 1986-10-27
EP0042596A1 (en) 1981-12-30
IL63132A0 (en) 1981-09-13
AR230448A1 (es) 1984-04-30
DK149026B (da) 1985-12-23
ES503221A0 (es) 1982-04-01
FI70903B (fi) 1986-07-18
IE51332B1 (en) 1986-12-10
AU542271B2 (en) 1985-02-14
PH17109A (en) 1984-06-01
IL63132A (en) 1984-06-29
IE811349L (en) 1981-12-23

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