JPS57185273A - Aniline derivative - Google Patents

Aniline derivative

Info

Publication number
JPS57185273A
JPS57185273A JP56069690A JP6969081A JPS57185273A JP S57185273 A JPS57185273 A JP S57185273A JP 56069690 A JP56069690 A JP 56069690A JP 6969081 A JP6969081 A JP 6969081A JP S57185273 A JPS57185273 A JP S57185273A
Authority
JP
Japan
Prior art keywords
derivative
formulai
cardiac
aniline derivative
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56069690A
Other languages
Japanese (ja)
Other versions
JPS643195B2 (en
Inventor
Michiaki Tominaga
Nagao Yo
Hidenori Ogawa
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP56069690A priority Critical patent/JPS57185273A/en
Priority to US06/432,902 priority patent/US4585774A/en
Priority to PCT/JP1982/000152 priority patent/WO1982003861A1/en
Priority to AU84000/82A priority patent/AU535498B2/en
Priority to CA000402347A priority patent/CA1201121A/en
Priority to PH27242A priority patent/PH18071A/en
Priority to ZA823085A priority patent/ZA823085B/en
Priority to MX778182A priority patent/MX155083A/en
Priority to PT74858A priority patent/PT74858B/en
Priority to ES512024A priority patent/ES512024A0/en
Priority to KR8202007A priority patent/KR860000062B1/en
Priority to DE8282302381T priority patent/DE3264889D1/en
Priority to EP82302381A priority patent/EP0064878B1/en
Priority to FI823575A priority patent/FI74704C/en
Priority to SU823511152A priority patent/SU1316560A3/en
Priority to DK465282A priority patent/DK159971C/en
Publication of JPS57185273A publication Critical patent/JPS57185273A/en
Priority to NO824124A priority patent/NO159270C/en
Priority to ES519853A priority patent/ES8403469A1/en
Publication of JPS643195B2 publication Critical patent/JPS643195B2/ja
Granted legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An aniline derivative of formulaI(R1 is H, lower alkoxycarbonyl; R2 is lower alkoxy; A is lower alkylene; n is 1, 2) and its salt.
EXAMPLE: o-Methoxycarbonyl-α-[4-(3, 4-dimethoxybenzoyl)-1-piperazinyl]acetoanilide.
USE: Cardiac: it has activity of strengthening the contraction of cardiac muscles and increasing the amount of coronary blood flow without causing increase in pulse count. It is low-toxic. The dose is preferably 0.1W10mg/kg day based on the active ingredient.
PREPARATION: For example, the reaction of an anilide derivative of formula II (X is halogen) with a piperazine derivative of formula III is carried out in an inert solvent, preferably by use of a basic compound as an acid acceptor at room temperature to 80°C for 1W24hr to give the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP56069690A 1981-05-08 1981-05-08 Aniline derivative Granted JPS57185273A (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
JP56069690A JPS57185273A (en) 1981-05-08 1981-05-08 Aniline derivative
US06/432,902 US4585774A (en) 1981-05-08 1982-05-04 Aniline derivatives and cardiotonic composition
PCT/JP1982/000152 WO1982003861A1 (en) 1981-05-08 1982-05-04 Aniline derivatives,process for their preparation,and cardiotonics
AU84000/82A AU535498B2 (en) 1981-05-08 1982-05-04 Aniline derivatives, process for their preparation, and cardiotonics
CA000402347A CA1201121A (en) 1981-05-08 1982-05-05 Aniline derivatives, process for preparing the same and cardiotonic compositions containing the same
PH27242A PH18071A (en) 1981-05-08 1982-05-05 Novel aniline derivatives and cardiotonic compositions containing the same
ZA823085A ZA823085B (en) 1981-05-08 1982-05-05 Aniline derivatives,process for preparing the same and cardiotonic compositions containing the same
ES512024A ES512024A0 (en) 1981-05-08 1982-05-07 DERIVATIVES OF ANILINE AND ITS SALTS.
PT74858A PT74858B (en) 1981-05-08 1982-05-07 Novel aniline derivatives process for preparing the same and cardiotonic compositions containing the same
MX778182A MX155083A (en) 1981-05-08 1982-05-07 PROCEDURE FOR PREPARING ANILINE DERIVATIVES
KR8202007A KR860000062B1 (en) 1981-05-08 1982-05-08 Process for preparing aniline derivatives
DE8282302381T DE3264889D1 (en) 1981-05-08 1982-05-10 Novel aniline derivatives, process for preparing the same and cardiotonic compositions containing the same
EP82302381A EP0064878B1 (en) 1981-05-08 1982-05-10 Novel aniline derivatives, process for preparing the same and cardiotonic compositions containing the same
SU823511152A SU1316560A3 (en) 1981-05-08 1982-10-19 Method for producing aniline derivatives or pharmaceutically acceptable salt thereof
FI823575A FI74704C (en) 1981-05-08 1982-10-19 Process for the preparation of therapeutically useful aniline derivatives.
DK465282A DK159971C (en) 1981-05-08 1982-10-20 ANALOGY PROCEDURE FOR PREPARING BENZOYL-1-PIPERAZINYL ACYLANILIDES OR SALTS THEREOF
NO824124A NO159270C (en) 1981-05-08 1982-12-08 ANALOGY PROCEDURE FOR PREPARING THERAPEUTIC ACTIVE ANILIN DERIVATIVES.
ES519853A ES8403469A1 (en) 1981-05-08 1983-02-16 Novel aniline derivatives, process for preparing the same and cardiotonic compositions containing the same.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56069690A JPS57185273A (en) 1981-05-08 1981-05-08 Aniline derivative

Publications (2)

Publication Number Publication Date
JPS57185273A true JPS57185273A (en) 1982-11-15
JPS643195B2 JPS643195B2 (en) 1989-01-19

Family

ID=13410110

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56069690A Granted JPS57185273A (en) 1981-05-08 1981-05-08 Aniline derivative

Country Status (2)

Country Link
JP (1) JPS57185273A (en)
ZA (1) ZA823085B (en)

Also Published As

Publication number Publication date
ZA823085B (en) 1983-03-30
JPS643195B2 (en) 1989-01-19

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