JPS57185273A - Aniline derivative - Google Patents
Aniline derivativeInfo
- Publication number
- JPS57185273A JPS57185273A JP56069690A JP6969081A JPS57185273A JP S57185273 A JPS57185273 A JP S57185273A JP 56069690 A JP56069690 A JP 56069690A JP 6969081 A JP6969081 A JP 6969081A JP S57185273 A JPS57185273 A JP S57185273A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- formulai
- cardiac
- aniline derivative
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:An aniline derivative of formulaI(R1 is H, lower alkoxycarbonyl; R2 is lower alkoxy; A is lower alkylene; n is 1, 2) and its salt.
EXAMPLE: o-Methoxycarbonyl-α-[4-(3, 4-dimethoxybenzoyl)-1-piperazinyl]acetoanilide.
USE: Cardiac: it has activity of strengthening the contraction of cardiac muscles and increasing the amount of coronary blood flow without causing increase in pulse count. It is low-toxic. The dose is preferably 0.1W10mg/kg day based on the active ingredient.
PREPARATION: For example, the reaction of an anilide derivative of formula II (X is halogen) with a piperazine derivative of formula III is carried out in an inert solvent, preferably by use of a basic compound as an acid acceptor at room temperature to 80°C for 1W24hr to give the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56069690A JPS57185273A (en) | 1981-05-08 | 1981-05-08 | Aniline derivative |
US06/432,902 US4585774A (en) | 1981-05-08 | 1982-05-04 | Aniline derivatives and cardiotonic composition |
PCT/JP1982/000152 WO1982003861A1 (en) | 1981-05-08 | 1982-05-04 | Aniline derivatives,process for their preparation,and cardiotonics |
AU84000/82A AU535498B2 (en) | 1981-05-08 | 1982-05-04 | Aniline derivatives, process for their preparation, and cardiotonics |
CA000402347A CA1201121A (en) | 1981-05-08 | 1982-05-05 | Aniline derivatives, process for preparing the same and cardiotonic compositions containing the same |
PH27242A PH18071A (en) | 1981-05-08 | 1982-05-05 | Novel aniline derivatives and cardiotonic compositions containing the same |
ZA823085A ZA823085B (en) | 1981-05-08 | 1982-05-05 | Aniline derivatives,process for preparing the same and cardiotonic compositions containing the same |
ES512024A ES512024A0 (en) | 1981-05-08 | 1982-05-07 | DERIVATIVES OF ANILINE AND ITS SALTS. |
PT74858A PT74858B (en) | 1981-05-08 | 1982-05-07 | Novel aniline derivatives process for preparing the same and cardiotonic compositions containing the same |
MX778182A MX155083A (en) | 1981-05-08 | 1982-05-07 | PROCEDURE FOR PREPARING ANILINE DERIVATIVES |
KR8202007A KR860000062B1 (en) | 1981-05-08 | 1982-05-08 | Process for preparing aniline derivatives |
DE8282302381T DE3264889D1 (en) | 1981-05-08 | 1982-05-10 | Novel aniline derivatives, process for preparing the same and cardiotonic compositions containing the same |
EP82302381A EP0064878B1 (en) | 1981-05-08 | 1982-05-10 | Novel aniline derivatives, process for preparing the same and cardiotonic compositions containing the same |
SU823511152A SU1316560A3 (en) | 1981-05-08 | 1982-10-19 | Method for producing aniline derivatives or pharmaceutically acceptable salt thereof |
FI823575A FI74704C (en) | 1981-05-08 | 1982-10-19 | Process for the preparation of therapeutically useful aniline derivatives. |
DK465282A DK159971C (en) | 1981-05-08 | 1982-10-20 | ANALOGY PROCEDURE FOR PREPARING BENZOYL-1-PIPERAZINYL ACYLANILIDES OR SALTS THEREOF |
NO824124A NO159270C (en) | 1981-05-08 | 1982-12-08 | ANALOGY PROCEDURE FOR PREPARING THERAPEUTIC ACTIVE ANILIN DERIVATIVES. |
ES519853A ES8403469A1 (en) | 1981-05-08 | 1983-02-16 | Novel aniline derivatives, process for preparing the same and cardiotonic compositions containing the same. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56069690A JPS57185273A (en) | 1981-05-08 | 1981-05-08 | Aniline derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57185273A true JPS57185273A (en) | 1982-11-15 |
JPS643195B2 JPS643195B2 (en) | 1989-01-19 |
Family
ID=13410110
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56069690A Granted JPS57185273A (en) | 1981-05-08 | 1981-05-08 | Aniline derivative |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPS57185273A (en) |
ZA (1) | ZA823085B (en) |
-
1981
- 1981-05-08 JP JP56069690A patent/JPS57185273A/en active Granted
-
1982
- 1982-05-05 ZA ZA823085A patent/ZA823085B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA823085B (en) | 1983-03-30 |
JPS643195B2 (en) | 1989-01-19 |
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