BE888088A - Imidazopyridines, leur preparation et leur utilisation comme agents cardiotoniques - Google Patents
Imidazopyridines, leur preparation et leur utilisation comme agents cardiotoniquesInfo
- Publication number
- BE888088A BE888088A BE1/10186A BE1010186A BE888088A BE 888088 A BE888088 A BE 888088A BE 1/10186 A BE1/10186 A BE 1/10186A BE 1010186 A BE1010186 A BE 1010186A BE 888088 A BE888088 A BE 888088A
- Authority
- BE
- Belgium
- Prior art keywords
- imidazopyridines
- preparation
- cardiotonic agents
- cardiotonic
- agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
- C07D213/77—Hydrazine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/135,211 US4276293A (en) | 1980-03-28 | 1980-03-28 | Compositions and their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE888088A true BE888088A (fr) | 1981-09-24 |
Family
ID=22467044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE1/10186A BE888088A (fr) | 1980-03-28 | 1981-03-24 | Imidazopyridines, leur preparation et leur utilisation comme agents cardiotoniques |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4276293A (fr) |
| JP (1) | JPS56150090A (fr) |
| KR (1) | KR830005217A (fr) |
| AU (1) | AU6883781A (fr) |
| BE (1) | BE888088A (fr) |
| CA (1) | CA1159061A (fr) |
| DE (1) | DE3112197A1 (fr) |
| DK (1) | DK136881A (fr) |
| ES (1) | ES8202343A1 (fr) |
| FI (1) | FI810921L (fr) |
| FR (1) | FR2479225A1 (fr) |
| GB (1) | GB2072673B (fr) |
| IL (1) | IL62403A0 (fr) |
| IT (1) | IT1136972B (fr) |
| LU (1) | LU83259A1 (fr) |
| NL (1) | NL8101455A (fr) |
| NO (1) | NO811041L (fr) |
| NZ (1) | NZ196573A (fr) |
| PH (1) | PH16999A (fr) |
| PT (1) | PT72744B (fr) |
| SE (1) | SE8101951L (fr) |
| ZA (1) | ZA811776B (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4363911A (en) * | 1981-09-03 | 1982-12-14 | Sterling Drug Inc. | 1,2-Dihydro-6-[2-(dimethylamino)ethenyl]-2-oxo-5-(pyridinyl) nicotinonitriles |
| US4465686A (en) * | 1981-09-08 | 1984-08-14 | Sterling Drug Inc. | 5-(Hydroxy- and/or amino-phenyl)-6-(lower-alkyl)-2-(1H)-pyridinones, their cardiotonic use and preparation |
| US4347363A (en) * | 1981-09-17 | 1982-08-31 | Sterling Drug Inc. | Process for preparing 1,2-dihydro-6-methyl-2-oxo-5-(pyridinyl)nicotinonitriles |
| US4599423A (en) * | 1982-04-26 | 1986-07-08 | Sterling Drug Inc. | Preparation of 5-(hydroxy- and/or aminophenyl-6-lower-alkyl)-2(1H)-pyridinones |
| US4417054A (en) * | 1982-05-24 | 1983-11-22 | Sterling Drug Inc. | 2-(Lower-alkoxy)-1-(pyridinyl)ethenyl lower-alkyl ketones |
| NZ204175A (en) * | 1982-05-24 | 1985-12-13 | Sterling Drug Inc | Preparation of 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(pyridinyl)-nicotinonitriles and nicotinamides;and pyridine intermediates therefor |
| US4469871A (en) * | 1982-05-24 | 1984-09-04 | Sterling Drug Inc. | Process for preparing 2-(lower-alkoxy)-1-(pyridinyl) ethenyl lower-alkyl ketones |
| US4413127A (en) * | 1982-05-24 | 1983-11-01 | Sterling Drug Inc. | Preparation of 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(pyridinyl)nicotinonitriles |
| US4595762A (en) * | 1982-08-25 | 1986-06-17 | Sterling Drug Inc. | 5-α-bromoalkanoyl-2-oxo-3-pyridinecarbonitriles |
| US4539327A (en) * | 1982-08-25 | 1985-09-03 | Sterling Drug Inc. | 5-(2-Substituted-4-thiazolyl)-6-alkyl-2(1H)-pyridinones and cardiotonic use thereof |
| US4469699A (en) * | 1982-08-25 | 1984-09-04 | Sterling Drug Inc. | 5-(4-Thiazolyl)-6-alkyl-2(1H)-pyridinones and their cardiotonic use |
| US4448780A (en) * | 1982-09-03 | 1984-05-15 | Sterling Drug Inc. | N-(Lower-alkyl)-N'-[5-(pyridinyl)-2-pyridinyl]ureas and cardiotonic use thereof |
| US4517192A (en) * | 1983-01-31 | 1985-05-14 | Sterling Drug Inc. | 6-Alkyl-5-[4-(alkylsulfinyl or alkylsulfonyl)phenyl]-2(1H)-pyridinones and their use as cardiatonics |
| AU3820989A (en) * | 1988-08-02 | 1990-02-08 | Ciba-Geigy Ag | 7-amino-3-beta-d-ribofuranosyl-3h-imidazo(4,5-b) pyridin-5-amine derivatives |
| US4977144A (en) * | 1988-08-02 | 1990-12-11 | Ciba-Geigy Corporation | Imidazo[4,5-b]pyridine derivatives as cardiovascular agents |
| US5010086A (en) * | 1990-02-28 | 1991-04-23 | Sterling Drug Inc. | Imidazopyridines, compositions and use |
| US4963561A (en) * | 1990-02-28 | 1990-10-16 | Sterling Drug Inc. | Imidazopyridines, their preparation and use |
| US6465484B1 (en) * | 1997-09-26 | 2002-10-15 | Merck & Co., Inc. | Angiogenesis inhibitors |
| EP1889880A3 (fr) | 2002-02-14 | 2008-06-18 | FUJIFILM Corporation | Procédé de mesure optique d'acide nucléique multibrins |
-
1980
- 1980-03-28 NZ NZ196573A patent/NZ196573A/en unknown
- 1980-03-28 US US06/135,211 patent/US4276293A/en not_active Expired - Lifetime
-
1981
- 1981-03-17 IL IL62403A patent/IL62403A0/xx unknown
- 1981-03-18 ZA ZA00811776A patent/ZA811776B/xx unknown
- 1981-03-20 PH PH25393A patent/PH16999A/en unknown
- 1981-03-24 BE BE1/10186A patent/BE888088A/fr not_active IP Right Cessation
- 1981-03-24 NL NL8101455A patent/NL8101455A/nl not_active Application Discontinuation
- 1981-03-24 GB GB8109259A patent/GB2072673B/en not_active Expired
- 1981-03-25 FI FI810921A patent/FI810921L/fi not_active Application Discontinuation
- 1981-03-26 SE SE8101951A patent/SE8101951L/xx not_active Application Discontinuation
- 1981-03-26 ES ES500727A patent/ES8202343A1/es not_active Expired
- 1981-03-26 PT PT72744A patent/PT72744B/pt unknown
- 1981-03-26 NO NO811041A patent/NO811041L/no unknown
- 1981-03-26 DK DK136881A patent/DK136881A/da not_active IP Right Cessation
- 1981-03-26 FR FR8106072A patent/FR2479225A1/fr active Granted
- 1981-03-27 KR KR1019810001015A patent/KR830005217A/ko unknown
- 1981-03-27 LU LU83259A patent/LU83259A1/fr unknown
- 1981-03-27 JP JP4533681A patent/JPS56150090A/ja active Pending
- 1981-03-27 DE DE19813112197 patent/DE3112197A1/de not_active Withdrawn
- 1981-03-27 AU AU68837/81A patent/AU6883781A/en not_active Abandoned
- 1981-03-27 CA CA000374059A patent/CA1159061A/fr not_active Expired
- 1981-03-27 IT IT20784/81A patent/IT1136972B/it active
Also Published As
| Publication number | Publication date |
|---|---|
| GB2072673B (en) | 1983-11-02 |
| PH16999A (en) | 1984-05-04 |
| FI810921L (fi) | 1981-09-29 |
| PT72744B (en) | 1982-03-24 |
| ES500727A0 (es) | 1982-01-16 |
| ZA811776B (en) | 1982-04-28 |
| IL62403A0 (en) | 1981-05-20 |
| FR2479225A1 (fr) | 1981-10-02 |
| LU83259A1 (fr) | 1981-10-29 |
| ES8202343A1 (es) | 1982-01-16 |
| JPS56150090A (en) | 1981-11-20 |
| NO811041L (no) | 1981-09-28 |
| AU6883781A (en) | 1981-10-08 |
| IT8120784A0 (it) | 1981-03-27 |
| IT1136972B (it) | 1986-09-03 |
| CA1159061A (fr) | 1983-12-20 |
| US4276293A (en) | 1981-06-30 |
| GB2072673A (en) | 1981-10-07 |
| DK136881A (da) | 1981-09-29 |
| DE3112197A1 (de) | 1982-02-25 |
| FR2479225B1 (fr) | 1984-05-18 |
| KR830005217A (ko) | 1983-08-03 |
| SE8101951L (sv) | 1981-09-29 |
| NZ196573A (en) | 1984-03-16 |
| NL8101455A (nl) | 1981-10-16 |
| PT72744A (en) | 1981-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: STERLING DRUG INC. Effective date: 19850324 |