ES8202006A1 - Un procedimiento para preparar derivados de imidazo (4,5-b) piridina - Google Patents

Un procedimiento para preparar derivados de imidazo (4,5-b) piridina

Info

Publication number
ES8202006A1
ES8202006A1 ES500605A ES500605A ES8202006A1 ES 8202006 A1 ES8202006 A1 ES 8202006A1 ES 500605 A ES500605 A ES 500605A ES 500605 A ES500605 A ES 500605A ES 8202006 A1 ES8202006 A1 ES 8202006A1
Authority
ES
Spain
Prior art keywords
hydrogen
alkyl
imidazoä4
büpyridine
cardiotonics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500605A
Other languages
English (en)
Other versions
ES500605A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/132,907 external-priority patent/US4294836A/en
Priority claimed from US06/135,105 external-priority patent/US4294837A/en
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of ES500605A0 publication Critical patent/ES500605A0/es
Publication of ES8202006A1 publication Critical patent/ES8202006A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE IMIDAZO (4,5B) PIRIDINA, DE FORMULA (I), DONDE Z ES OXIGENO O AZUFRE; R1 Y R3 SON HIDROGENO, ALQUILO, HIDROXI-ALQUILO U OTROS, Y Q ES HIDROGENO DE FORMULA (II) Y Q'' ES HIDROGENO. SE BASA EN LA REACCION DE 2R3NH-3-R1NH-5-Q''-6-Q''-PIRIDINA CON UREA MEDIANTE CALENTAMIENTO DE AMBOS REACTIVOS EN DIMETILFORMAMIDA A REFLUJO DURANTE TRES HORAS A 35 C. Y POSTERIORMENTE DURANTE DOS A DIECISEIS HORAS A 70-80 C. SE ENFRIA LA MEZCLA DE REACCION. EL SOLIDO RESULTANTE SE LAVA Y SE SECA. EL PRODUCTO FINAL SE PURIFICA POR RECRISTALIZACION. DE APLICACION COMO AGENTES CARDIOTONICOS PARA INCREMENTAR LA CONTRACTILIDAD CARDIACA.
ES500605A 1980-03-24 1981-03-23 Un procedimiento para preparar derivados de imidazo (4,5-b) piridina Expired ES8202006A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/132,907 US4294836A (en) 1980-03-24 1980-03-24 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]-pyridine-2-thiones and their cardiotonic use
US06/135,105 US4294837A (en) 1980-03-28 1980-03-28 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use

Publications (2)

Publication Number Publication Date
ES500605A0 ES500605A0 (es) 1982-01-01
ES8202006A1 true ES8202006A1 (es) 1982-01-01

Family

ID=26830852

Family Applications (1)

Application Number Title Priority Date Filing Date
ES500605A Expired ES8202006A1 (es) 1980-03-24 1981-03-23 Un procedimiento para preparar derivados de imidazo (4,5-b) piridina

Country Status (14)

Country Link
AU (1) AU6868381A (es)
DE (1) DE3111563A1 (es)
DK (1) DK130381A (es)
ES (1) ES8202006A1 (es)
FI (1) FI810878L (es)
FR (1) FR2478637A1 (es)
GB (1) GB2072187A (es)
IL (1) IL62402A0 (es)
IT (1) IT1167724B (es)
LU (1) LU83251A1 (es)
NL (1) NL8101454A (es)
NO (1) NO810989L (es)
PT (1) PT72710B (es)
SE (1) SE8101841L (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103848783A (zh) * 2014-01-14 2014-06-11 红太阳集团有限公司 一种一步氧化合成2-氯烟酸的方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1979000206A1 (fr) * 1977-10-13 1979-04-19 Roussel Uclaf Nouveaux derives substitues de la 1,3-dihydro imadazo (4, 5-b) pyridin-2-one, procede, application, compositions et intermediaires obtenus

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103848783A (zh) * 2014-01-14 2014-06-11 红太阳集团有限公司 一种一步氧化合成2-氯烟酸的方法

Also Published As

Publication number Publication date
IL62402A0 (en) 1981-05-20
FI810878L (fi) 1981-09-25
NL8101454A (nl) 1981-10-16
DE3111563A1 (de) 1982-06-16
LU83251A1 (fr) 1981-10-29
DK130381A (da) 1981-09-25
IT8120658A0 (it) 1981-03-23
IT1167724B (it) 1987-05-13
FR2478637A1 (fr) 1981-09-25
AU6868381A (en) 1981-10-01
SE8101841L (sv) 1981-09-25
ES500605A0 (es) 1982-01-01
NO810989L (no) 1981-09-25
GB2072187A (en) 1981-09-30
PT72710B (en) 1982-03-24
PT72710A (en) 1981-04-01

Similar Documents

Publication Publication Date Title
ES8202343A1 (es) Un procedimiento para preparar imidazo-piridinas
ES8401044A1 (es) Procedimiento para preparar derivados de piridona.
KR830005216A (ko) 이미다조[4,5-b] 피리딘 유도체의 제조방법
GB1521092A (en) 3-phenyl-5-substituted-4 (1h)-pyridones-(thiones)
PT75849B (en) Process for the preparation of tiadiazinone oxadiazinone or tr iazinone derivatives and pharmaceutical compositions therewith
ES8107215A1 (es) Un procedimiento para preparar una 2-r-6-py-3(2h)-piridaci- nona
ES8606233A1 (es) Un procedimiento para la preparacion de fosfatidos de eter de glicol
ES373698A1 (es) Un procedimiento para la preparacion de 5-nr1r2-6-cloro - 1h-imidazo (4,5-b) pirazin-2-onas.
ES350167A1 (es) Un procedimiento de epoxidacion de compuestos olefinicos.
JPS5724369A (en) Pyrimidine derivative and its preparation
SE7603051L (sv) Pyrimidinylkarbamider
ES8202006A1 (es) Un procedimiento para preparar derivados de imidazo (4,5-b) piridina
ES8404340A1 (es) Procedimientos para preparar derivados piridazinona.
ES422906A1 (es) Un procedimiento para preparar nuevos derivados de 2-amino-indano.
ES465176A1 (es) Un procedimiento para la preparacion de nuevos derivados de hidantoina
GB866843A (en) Sulphonamidopyrimidines
ES8502435A1 (es) Un metodo para preparar 2(1h)-piridinonas
EP0449195A3 (en) Aminobenzene compounds, their production and use
ES466794A1 (es) Un procedimiento para la preparacion de derivados de imida- zol.
ES8601138A1 (es) Un procedimiento para preparar derivados de 5-(piridinil o fenil)-2(1h)-piridinona
GB934935A (en) Guanidine compounds
ES8603458A1 (es) Un procedimiento para preparar una 3-r1-4-r2-5-q-6-r-2(1h)-piridinona
ES8502434A1 (es) Un procedimiento para preparar una 1-r1-3-amino-5-py-6-r-2-(1h) piridinona.
IE780982L (en) 4-hydroxythiazoline-2-thiones.
GB972962A (en) A process for the manufacture of benzodiazepine derivatives