ES8502434A1 - Un procedimiento para preparar una 1-r1-3-amino-5-py-6-r-2-(1h) piridinona. - Google Patents

Un procedimiento para preparar una 1-r1-3-amino-5-py-6-r-2-(1h) piridinona.

Info

Publication number
ES8502434A1
ES8502434A1 ES508020A ES508020A ES8502434A1 ES 8502434 A1 ES8502434 A1 ES 8502434A1 ES 508020 A ES508020 A ES 508020A ES 508020 A ES508020 A ES 508020A ES 8502434 A1 ES8502434 A1 ES 8502434A1
Authority
ES
Spain
Prior art keywords
pyridinyl
dihydro
oxo
hydroxy
nicotinimidamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES508020A
Other languages
English (en)
Other versions
ES508020A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of ES8502434A1 publication Critical patent/ES8502434A1/es
Publication of ES508020A0 publication Critical patent/ES508020A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Abstract

PROCEDIMIENTO PARA PREPARAR UNA 1-R1-3-AMINO-5-PY-6-R-2-(1H) PIRIDINONA.CONSISTE EN HACER REACCIONAR UN 1-R1-1,2-DIHIDRO-2-OXO-5-PY-6-NICOTINONITRILO CON HIDROXILAMINA O UNA DE SUS SALES DE ADICION DE ACIDO Y HACER REACCIONAR EL COMPUESTO OBTENIDO CORRESPONDIENTE DE FORMULA (I) CON ACIDO POLIFOSFORICO, EN DONDE R ES H O ALQUILO INFERIOR; R1 ES H, ALQUILO INFERIOR O HIDROALQUILO INFERIOR Y PY ES 4- O 3-PIRIDINILO O 4- O 3-PIRIDINILO QUE TIENE UNO O DOS SUSTITUYENTES DE ALQUILO INFERIOR.
ES508020A 1980-12-22 1981-12-16 Un procedimiento para preparar una 1-r1-3-amino-5-py-6-r-2-(1h) piridinona. Granted ES508020A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/218,616 US4305948A (en) 1980-12-22 1980-12-22 N-Hydroxy-1,2-dihydro-2-oxo-5-(pyridinyl)-nicotinimidamide and their cardiotonic use

Publications (2)

Publication Number Publication Date
ES8502434A1 true ES8502434A1 (es) 1985-01-01
ES508020A0 ES508020A0 (es) 1985-01-01

Family

ID=22815795

Family Applications (1)

Application Number Title Priority Date Filing Date
ES508020A Granted ES508020A0 (es) 1980-12-22 1981-12-16 Un procedimiento para preparar una 1-r1-3-amino-5-py-6-r-2-(1h) piridinona.

Country Status (20)

Country Link
US (1) US4305948A (es)
JP (1) JPS57140767A (es)
AU (1) AU7793981A (es)
BE (1) BE891493A (es)
CA (1) CA1175838A (es)
DE (1) DE3150062A1 (es)
DK (1) DK557681A (es)
ES (1) ES508020A0 (es)
FI (1) FI813913L (es)
FR (1) FR2496659A1 (es)
GB (1) GB2089791B (es)
GR (1) GR76987B (es)
IL (1) IL64439A0 (es)
IT (1) IT1142099B (es)
LU (1) LU83840A1 (es)
NL (1) NL8105667A (es)
NO (1) NO814294L (es)
PT (1) PT74114B (es)
SE (1) SE8107551L (es)
ZA (1) ZA818277B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361569A (en) * 1981-08-26 1982-11-30 Sterling Drug Inc. 3-(Hydroxy or hydroxymethyl)-6-methyl-5-(4-pyridinyl)-2(1H)-pyridinone and cardiotonic use thereof
ZA848428B (en) * 1983-11-03 1985-06-26 Merrell Pharma Inc Novel alkoxyimino ether derivatives of 5-acyl-2(1h)-pyridiones
US4849522A (en) * 1983-11-03 1989-07-18 Merrell Dow Pharmaceuticals Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
US5212314A (en) * 1983-11-03 1993-05-18 Merrell Dow Pharmaceuticals Inc. Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
CN104326975A (zh) * 2014-10-20 2015-02-04 郑州四环医药用品有限公司 一种高纯度米力农的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4004012A (en) * 1975-10-14 1977-01-18 Sterling Drug Inc. 3-Cyano-5-(pyridinyl)-2(1H)-pyridinones
US4072746A (en) * 1975-10-14 1978-02-07 Sterling Drug Inc. 3-Amino-5-(pyridinyl)-2(1H)-pyridinones
NZ195564A (en) * 1979-11-26 1983-09-30 Sterling Drug Inc 5-pyridinyl-2(1h)-pyridinones pharmaceutical compositions intermediate pyridine compounds

Also Published As

Publication number Publication date
DE3150062A1 (de) 1982-07-22
AU7793981A (en) 1982-07-01
JPS57140767A (en) 1982-08-31
PT74114A (en) 1982-01-01
US4305948A (en) 1981-12-15
IL64439A0 (en) 1982-03-31
ZA818277B (en) 1982-10-27
IT1142099B (it) 1986-10-08
DK557681A (da) 1982-06-23
FR2496659A1 (fr) 1982-06-25
GB2089791A (en) 1982-06-30
CA1175838A (en) 1984-10-09
BE891493A (fr) 1982-06-16
GB2089791B (en) 1984-08-30
SE8107551L (sv) 1982-06-23
IT8125585A0 (it) 1981-12-14
NL8105667A (nl) 1982-07-16
ES508020A0 (es) 1985-01-01
FI813913L (fi) 1982-06-23
GR76987B (es) 1984-09-04
PT74114B (en) 1983-06-06
NO814294L (no) 1982-06-23
LU83840A1 (fr) 1982-07-07

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981103