BE891493A - Derives de 1,2-dihydro-5(pyridinyl) nicotinamide, leur preparation et leur utilisation comme agents cardiotoniques et intermediaires - Google Patents
Derives de 1,2-dihydro-5(pyridinyl) nicotinamide, leur preparation et leur utilisation comme agents cardiotoniques et intermediairesInfo
- Publication number
- BE891493A BE891493A BE1/10374A BE1010374A BE891493A BE 891493 A BE891493 A BE 891493A BE 1/10374 A BE1/10374 A BE 1/10374A BE 1010374 A BE1010374 A BE 1010374A BE 891493 A BE891493 A BE 891493A
- Authority
- BE
- Belgium
- Prior art keywords
- cardiotonic
- pyridinyl
- dihydro
- preparation
- nicotinamide derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/218,616 US4305948A (en) | 1980-12-22 | 1980-12-22 | N-Hydroxy-1,2-dihydro-2-oxo-5-(pyridinyl)-nicotinimidamide and their cardiotonic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE891493A true BE891493A (fr) | 1982-06-16 |
Family
ID=22815795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE1/10374A BE891493A (fr) | 1980-12-22 | 1981-12-16 | Derives de 1,2-dihydro-5(pyridinyl) nicotinamide, leur preparation et leur utilisation comme agents cardiotoniques et intermediaires |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4305948A (fr) |
| JP (1) | JPS57140767A (fr) |
| AU (1) | AU7793981A (fr) |
| BE (1) | BE891493A (fr) |
| CA (1) | CA1175838A (fr) |
| DE (1) | DE3150062A1 (fr) |
| DK (1) | DK557681A (fr) |
| ES (1) | ES8502434A1 (fr) |
| FI (1) | FI813913L (fr) |
| FR (1) | FR2496659A1 (fr) |
| GB (1) | GB2089791B (fr) |
| GR (1) | GR76987B (fr) |
| IL (1) | IL64439A0 (fr) |
| IT (1) | IT1142099B (fr) |
| LU (1) | LU83840A1 (fr) |
| NL (1) | NL8105667A (fr) |
| NO (1) | NO814294L (fr) |
| PT (1) | PT74114B (fr) |
| SE (1) | SE8107551L (fr) |
| ZA (1) | ZA818277B (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4361569A (en) * | 1981-08-26 | 1982-11-30 | Sterling Drug Inc. | 3-(Hydroxy or hydroxymethyl)-6-methyl-5-(4-pyridinyl)-2(1H)-pyridinone and cardiotonic use thereof |
| ZA848428B (en) * | 1983-11-03 | 1985-06-26 | Merrell Pharma Inc | Novel alkoxyimino ether derivatives of 5-acyl-2(1h)-pyridiones |
| US4849522A (en) * | 1983-11-03 | 1989-07-18 | Merrell Dow Pharmaceuticals | Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones |
| US5212314A (en) * | 1983-11-03 | 1993-05-18 | Merrell Dow Pharmaceuticals Inc. | Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones |
| CN104326975A (zh) * | 2014-10-20 | 2015-02-04 | 郑州四环医药用品有限公司 | 一种高纯度米力农的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4004012A (en) * | 1975-10-14 | 1977-01-18 | Sterling Drug Inc. | 3-Cyano-5-(pyridinyl)-2(1H)-pyridinones |
| US4072746A (en) * | 1975-10-14 | 1978-02-07 | Sterling Drug Inc. | 3-Amino-5-(pyridinyl)-2(1H)-pyridinones |
| NZ195564A (en) * | 1979-11-26 | 1983-09-30 | Sterling Drug Inc | 5-pyridinyl-2(1h)-pyridinones pharmaceutical compositions intermediate pyridine compounds |
-
1980
- 1980-12-22 US US06/218,616 patent/US4305948A/en not_active Expired - Lifetime
-
1981
- 1981-11-23 CA CA000390670A patent/CA1175838A/fr not_active Expired
- 1981-11-27 AU AU77939/81A patent/AU7793981A/en not_active Abandoned
- 1981-11-30 ZA ZA818277A patent/ZA818277B/xx unknown
- 1981-12-02 IL IL64439A patent/IL64439A0/xx unknown
- 1981-12-02 GB GB8136374A patent/GB2089791B/en not_active Expired
- 1981-12-04 GR GR66684A patent/GR76987B/el unknown
- 1981-12-07 FI FI813913A patent/FI813913L/fi not_active Application Discontinuation
- 1981-12-11 PT PT74114A patent/PT74114B/pt unknown
- 1981-12-14 IT IT25585/81A patent/IT1142099B/it active
- 1981-12-15 FR FR8123458A patent/FR2496659A1/fr not_active Withdrawn
- 1981-12-16 NO NO814294A patent/NO814294L/no unknown
- 1981-12-16 ES ES508020A patent/ES8502434A1/es not_active Expired
- 1981-12-16 SE SE8107551A patent/SE8107551L/xx not_active Application Discontinuation
- 1981-12-16 BE BE1/10374A patent/BE891493A/fr not_active IP Right Cessation
- 1981-12-16 NL NL8105667A patent/NL8105667A/nl not_active Application Discontinuation
- 1981-12-16 DK DK557681A patent/DK557681A/da not_active Application Discontinuation
- 1981-12-17 DE DE19813150062 patent/DE3150062A1/de not_active Withdrawn
- 1981-12-17 JP JP56204485A patent/JPS57140767A/ja active Pending
- 1981-12-17 LU LU83840A patent/LU83840A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT74114A (en) | 1982-01-01 |
| SE8107551L (sv) | 1982-06-23 |
| ZA818277B (en) | 1982-10-27 |
| ES508020A0 (es) | 1985-01-01 |
| LU83840A1 (fr) | 1982-07-07 |
| FR2496659A1 (fr) | 1982-06-25 |
| CA1175838A (fr) | 1984-10-09 |
| JPS57140767A (en) | 1982-08-31 |
| GB2089791B (en) | 1984-08-30 |
| IL64439A0 (en) | 1982-03-31 |
| DK557681A (da) | 1982-06-23 |
| IT1142099B (it) | 1986-10-08 |
| NL8105667A (nl) | 1982-07-16 |
| US4305948A (en) | 1981-12-15 |
| PT74114B (en) | 1983-06-06 |
| DE3150062A1 (de) | 1982-07-22 |
| GB2089791A (en) | 1982-06-30 |
| FI813913L (fi) | 1982-06-23 |
| IT8125585A0 (it) | 1981-12-14 |
| NO814294L (no) | 1982-06-23 |
| GR76987B (fr) | 1984-09-04 |
| ES8502434A1 (es) | 1985-01-01 |
| AU7793981A (en) | 1982-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: STERLING DRUG INC. Effective date: 19841216 |