ES8505962A1 - Un procedimiento para preparar nuevos derivados amidinicos de 4-fenilimidazol sustituido en la posicion 2 - Google Patents

Un procedimiento para preparar nuevos derivados amidinicos de 4-fenilimidazol sustituido en la posicion 2

Info

Publication number
ES8505962A1
ES8505962A1 ES534375A ES534375A ES8505962A1 ES 8505962 A1 ES8505962 A1 ES 8505962A1 ES 534375 A ES534375 A ES 534375A ES 534375 A ES534375 A ES 534375A ES 8505962 A1 ES8505962 A1 ES 8505962A1
Authority
ES
Spain
Prior art keywords
formula
substituted
phenilimidazole
compound
amidine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES534375A
Other languages
English (en)
Other versions
ES534375A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Instituto de Angeli SpA
Original Assignee
Instituto de Angeli SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instituto de Angeli SpA filed Critical Instituto de Angeli SpA
Publication of ES8505962A1 publication Critical patent/ES8505962A1/es
Publication of ES534375A0 publication Critical patent/ES534375A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS AMIDINICOS DE 4-FENILIMIDAZOL SUSTITUIDO EN LA POSICION 2, DE SUS FORMAS TAUTOMERAS Y DE SUS SALES DE ADICION DE ACIDO, DE FORMULA (I), EN LA QUE R Y R1-R4 PUEDEN SER VARIOS RADICALES.COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN LAS QUE XC REPRESENTA EL ANION DE UN ACIDO INORGANICO, A ES BENZOILOXI; CLORO O ETOXI, Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I).ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO INHIBIDORES DE LA SECRECION DE ACIDO GASTRICO Y AGENTES ANTIULCEROSOS.
ES534375A 1983-07-18 1984-07-17 Un procedimiento para preparar nuevos derivados amidinicos de 4-fenilimidazol sustituido en la posicion 2 Granted ES534375A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8322110A IT1206498B (it) 1983-07-18 1983-07-18 Derivati amidinici del4-fenilmidazolo 2-sostituto processi per la loro preparazione e loro uso farmaceutico.

Publications (2)

Publication Number Publication Date
ES8505962A1 true ES8505962A1 (es) 1985-06-16
ES534375A0 ES534375A0 (es) 1985-06-16

Family

ID=11191639

Family Applications (2)

Application Number Title Priority Date Filing Date
ES534376A Granted ES534376A0 (es) 1983-07-18 1984-07-17 Un procedimiento para preparar nuevos derivados amidinicos de 4-fenilimidazol sustituido en la posicion 2
ES534375A Granted ES534375A0 (es) 1983-07-18 1984-07-17 Un procedimiento para preparar nuevos derivados amidinicos de 4-fenilimidazol sustituido en la posicion 2

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES534376A Granted ES534376A0 (es) 1983-07-18 1984-07-17 Un procedimiento para preparar nuevos derivados amidinicos de 4-fenilimidazol sustituido en la posicion 2

Country Status (28)

Country Link
US (1) US4649150A (es)
EP (1) EP0131973B1 (es)
JP (1) JPS6038367A (es)
KR (1) KR910000661B1 (es)
AT (1) ATE45149T1 (es)
AU (1) AU565292B2 (es)
CA (1) CA1257274A (es)
CS (1) CS244141B2 (es)
DD (1) DD232696A5 (es)
DE (1) DE3479212D1 (es)
DK (1) DK350084A (es)
ES (2) ES534376A0 (es)
FI (1) FI842432A (es)
GB (1) GB2149395B (es)
GR (1) GR79981B (es)
HK (1) HK74287A (es)
HU (1) HU193292B (es)
IL (1) IL72417A (es)
IT (1) IT1206498B (es)
NO (1) NO162857C (es)
NZ (1) NZ208920A (es)
PH (1) PH21566A (es)
PL (2) PL143303B1 (es)
PT (1) PT78935B (es)
SG (1) SG48687G (es)
SU (2) SU1322979A3 (es)
YU (2) YU43367B (es)
ZA (1) ZA845490B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4888348A (en) * 1986-09-04 1989-12-19 Ciba-Geigy Corporation Substituted thioureas, isothioureas and carbodiimides
AU744297B2 (en) 1997-07-03 2002-02-21 Neurogen Corporation Certain diarylimidazole derivatives; a new class of NPY specific ligands
US6887870B1 (en) 1999-10-12 2005-05-03 Bristol-Myers Squibb Company Heterocyclic sodium/proton exchange inhibitors and method
TR200201568T2 (tr) 1999-12-16 2002-10-21 Schering Corporation İkame edilmiş imidazol nöropeptid Y Y5 reseptörü antagonistleri.
FR2917087B1 (fr) 2007-06-05 2012-09-21 Galderma Res & Dev Nouveaux 4-phenyl-imidazole-2-thiones comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique.
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1209431B (it) * 1980-11-28 1989-07-16 Angeli Inst Spa Imidazolilfenil amidine, processi per la loro preparazione e loro impiego farmaceutico, ed intermedi di preparazione.

Also Published As

Publication number Publication date
YU43701B (en) 1989-10-31
DK350084A (da) 1985-01-19
HU193292B (en) 1987-09-28
AU3080084A (en) 1985-01-24
IT8322110A0 (it) 1983-07-18
AU565292B2 (en) 1987-09-10
SU1322979A3 (ru) 1987-07-07
HUT34959A (en) 1985-05-28
SU1313345A3 (ru) 1987-05-23
IL72417A (en) 1988-03-31
NZ208920A (en) 1987-03-31
NO162857C (no) 1990-02-28
NO162857B (no) 1989-11-20
JPS6038367A (ja) 1985-02-27
EP0131973B1 (en) 1989-08-02
PL254625A1 (en) 1986-05-06
CS244141B2 (en) 1986-07-17
PT78935A (de) 1984-08-01
US4649150A (en) 1987-03-10
PT78935B (de) 1986-10-23
GR79981B (es) 1984-10-31
PH21566A (en) 1987-12-11
FI842432A0 (fi) 1984-06-15
DD232696A5 (de) 1986-02-05
GB2149395A (en) 1985-06-12
CA1257274A (en) 1989-07-11
YU43367B (en) 1989-06-30
GB8418149D0 (en) 1984-08-22
PL143732B1 (en) 1988-03-31
ATE45149T1 (de) 1989-08-15
DK350084D0 (da) 1984-07-17
NO842921L (no) 1985-01-21
SG48687G (en) 1987-07-24
KR850001173A (ko) 1985-03-16
IT1206498B (it) 1989-04-27
IL72417A0 (en) 1984-11-30
YU115484A (en) 1986-12-31
EP0131973A1 (en) 1985-01-23
FI842432A (fi) 1985-01-19
ES8601910A1 (es) 1985-11-01
HK74287A (en) 1987-10-23
ES534375A0 (es) 1985-06-16
PL143303B1 (en) 1988-02-29
CS554284A2 (en) 1985-08-15
PL248779A1 (en) 1985-12-03
ES534376A0 (es) 1985-11-01
KR910000661B1 (ko) 1991-01-31
ZA845490B (en) 1986-03-26
DE3479212D1 (en) 1989-09-07
GB2149395B (en) 1986-11-26
YU112686A (en) 1987-12-31

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