ATE45149T1 - Amidine derivate von 2-substituierten-4phenylimidazolen. - Google Patents

Amidine derivate von 2-substituierten-4phenylimidazolen.

Info

Publication number
ATE45149T1
ATE45149T1 AT84200659T AT84200659T ATE45149T1 AT E45149 T1 ATE45149 T1 AT E45149T1 AT 84200659 T AT84200659 T AT 84200659T AT 84200659 T AT84200659 T AT 84200659T AT E45149 T1 ATE45149 T1 AT E45149T1
Authority
AT
Austria
Prior art keywords
group
substituted
alkyl
cyano
linear
Prior art date
Application number
AT84200659T
Other languages
English (en)
Inventor
Giuseppe Bietti
Enzo Cereda
Arturo Donetti
Antonio Giachetti
Ferdinando Pagani
Original Assignee
Angeli Inst Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angeli Inst Spa filed Critical Angeli Inst Spa
Application granted granted Critical
Publication of ATE45149T1 publication Critical patent/ATE45149T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68Halogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70One oxygen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88Nitrogen atoms, e.g. allantoin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Treatment Of Sludge (AREA)
  • Processing Of Solid Wastes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT84200659T 1983-07-18 1984-05-08 Amidine derivate von 2-substituierten-4phenylimidazolen. ATE45149T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8322110A IT1206498B (it) 1983-07-18 1983-07-18 Derivati amidinici del4-fenilmidazolo 2-sostituto processi per la loro preparazione e loro uso farmaceutico.
EP84200659A EP0131973B1 (de) 1983-07-18 1984-05-08 Amidine Derivate von 2-substituierten-4-Phenylimidazolen

Publications (1)

Publication Number Publication Date
ATE45149T1 true ATE45149T1 (de) 1989-08-15

Family

ID=11191639

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84200659T ATE45149T1 (de) 1983-07-18 1984-05-08 Amidine derivate von 2-substituierten-4phenylimidazolen.

Country Status (28)

Country Link
US (1) US4649150A (de)
EP (1) EP0131973B1 (de)
JP (1) JPS6038367A (de)
KR (1) KR910000661B1 (de)
AT (1) ATE45149T1 (de)
AU (1) AU565292B2 (de)
CA (1) CA1257274A (de)
CS (1) CS244141B2 (de)
DD (1) DD232696A5 (de)
DE (1) DE3479212D1 (de)
DK (1) DK350084A (de)
ES (2) ES8601910A1 (de)
FI (1) FI842432A (de)
GB (1) GB2149395B (de)
GR (1) GR79981B (de)
HK (1) HK74287A (de)
HU (1) HU193292B (de)
IL (1) IL72417A (de)
IT (1) IT1206498B (de)
NO (1) NO162857C (de)
NZ (1) NZ208920A (de)
PH (1) PH21566A (de)
PL (2) PL143303B1 (de)
PT (1) PT78935B (de)
SG (1) SG48687G (de)
SU (2) SU1322979A3 (de)
YU (2) YU43367B (de)
ZA (1) ZA845490B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4888348A (en) * 1986-09-04 1989-12-19 Ciba-Geigy Corporation Substituted thioureas, isothioureas and carbodiimides
BR9810651A (pt) 1997-07-03 2000-10-03 Neurogen Corp Certos derivados de diarilimidazol; uma nova classe de ligantes npy especìficos
US6887870B1 (en) 1999-10-12 2005-05-03 Bristol-Myers Squibb Company Heterocyclic sodium/proton exchange inhibitors and method
NZ519272A (en) 1999-12-16 2004-02-27 Schering Corp Substituted imidazole neuropeptide Y Y5 receptor antagonists
FR2917087B1 (fr) 2007-06-05 2012-09-21 Galderma Res & Dev Nouveaux 4-phenyl-imidazole-2-thiones comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique.
US20230349922A1 (en) 2020-08-11 2023-11-02 Université De Strasbourg H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1209431B (it) * 1980-11-28 1989-07-16 Angeli Inst Spa Imidazolilfenil amidine, processi per la loro preparazione e loro impiego farmaceutico, ed intermedi di preparazione.

Also Published As

Publication number Publication date
HUT34959A (en) 1985-05-28
DD232696A5 (de) 1986-02-05
ZA845490B (en) 1986-03-26
IL72417A0 (en) 1984-11-30
IL72417A (en) 1988-03-31
ES8505962A1 (es) 1985-06-16
DE3479212D1 (en) 1989-09-07
YU112686A (en) 1987-12-31
JPS6038367A (ja) 1985-02-27
PT78935A (de) 1984-08-01
IT1206498B (it) 1989-04-27
DK350084D0 (da) 1984-07-17
PL143732B1 (en) 1988-03-31
KR850001173A (ko) 1985-03-16
PL248779A1 (en) 1985-12-03
AU3080084A (en) 1985-01-24
NZ208920A (en) 1987-03-31
NO162857B (no) 1989-11-20
US4649150A (en) 1987-03-10
ES534376A0 (es) 1985-11-01
GB2149395A (en) 1985-06-12
FI842432A0 (fi) 1984-06-15
YU43701B (en) 1989-10-31
AU565292B2 (en) 1987-09-10
CS244141B2 (en) 1986-07-17
SU1313345A3 (ru) 1987-05-23
SG48687G (en) 1987-07-24
EP0131973B1 (de) 1989-08-02
YU43367B (en) 1989-06-30
PL254625A1 (en) 1986-05-06
ES534375A0 (es) 1985-06-16
YU115484A (en) 1986-12-31
GR79981B (de) 1984-10-31
HK74287A (en) 1987-10-23
ES8601910A1 (es) 1985-11-01
PL143303B1 (en) 1988-02-29
CA1257274A (en) 1989-07-11
IT8322110A0 (it) 1983-07-18
CS554284A2 (en) 1985-08-15
NO162857C (no) 1990-02-28
EP0131973A1 (de) 1985-01-23
HU193292B (en) 1987-09-28
GB2149395B (en) 1986-11-26
PH21566A (en) 1987-12-11
KR910000661B1 (ko) 1991-01-31
DK350084A (da) 1985-01-19
FI842432A (fi) 1985-01-19
GB8418149D0 (en) 1984-08-22
SU1322979A3 (ru) 1987-07-07
PT78935B (de) 1986-10-23
NO842921L (no) 1985-01-21

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Publication Publication Date Title
ATE45149T1 (de) Amidine derivate von 2-substituierten-4phenylimidazolen.
AU562246B2 (en) Hetero substituted phenyl formamidines

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee