YU46444B - Postupak za izradu derivata imidazola - Google Patents

Postupak za izradu derivata imidazola

Info

Publication number
YU46444B
YU46444B YU40388A YU40388A YU46444B YU 46444 B YU46444 B YU 46444B YU 40388 A YU40388 A YU 40388A YU 40388 A YU40388 A YU 40388A YU 46444 B YU46444 B YU 46444B
Authority
YU
Yugoslavia
Prior art keywords
lower alkyl
hydrogen
formula
imidazole derivatives
residue
Prior art date
Application number
YU40388A
Other languages
English (en)
Other versions
YU40388A (en
Inventor
W. Kloetzer
M. Montavon
R. Muessner
N. Singewald
Original Assignee
F. Hoffmann - La Roche And Co. Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann - La Roche And Co. Ag. filed Critical F. Hoffmann - La Roche And Co. Ag.
Publication of YU40388A publication Critical patent/YU40388A/xx
Publication of YU46444B publication Critical patent/YU46444B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Epoxy Resins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

POSTUPAK ZA IZRADU DERIVATA IMIDAZOLA, opšte formule u kojoj R(na prvi stepen) i R(na drugi stepen) označavaju alkil sa 1 do 4 C-atoma, R(na peti stepen) označava vodonik ili alkil sa 1 do 4 C-atoma, dok R(na šesti stepen) označava vodonik, alkil sa 1 do 4 C-atoma, alkiltio sa 1 do 4 C-atoma ili morfolinoi njihovih fermaceutski prihvatljivih kiselinskih adicionih soli, naznačen time, što se jedinjenje opšte formule u kojoj R(na prvi stepen), R(na drugi stepen), R(na peti stepen) i R(na šesti stepen) imaju gore navedeno značenje redukuje katalitičkom hidrogenizacijom u prisustvu katalizatora kao što je paladijm u inertnom organskom rastvaraču kao što je metanol na sobnoj temperaturi i pri normalnom pritisku uz celishodno dodavanje kiseline kao što je hlorovodonična kiselina ili pomoću kompleksnog hidrida kao što je natrijum cijanoborhidrid u pogodnom rastvaraču kao što je glacijalna sirćetna kiselina na sobnoj temperaturi i normalnom pritisku.
YU40388A 1987-03-20 1988-03-01 Postupak za izradu derivata imidazola YU46444B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH107387 1987-03-20

Publications (2)

Publication Number Publication Date
YU40388A YU40388A (en) 1990-02-28
YU46444B true YU46444B (sh) 1993-10-20

Family

ID=4201822

Family Applications (1)

Application Number Title Priority Date Filing Date
YU40388A YU46444B (sh) 1987-03-20 1988-03-01 Postupak za izradu derivata imidazola

Country Status (23)

Country Link
US (1) US4908363A (sh)
EP (1) EP0283857B1 (sh)
JP (1) JPS63253070A (sh)
KR (1) KR880011117A (sh)
CN (1) CN1016169B (sh)
AT (1) ATE73777T1 (sh)
AU (1) AU613349B2 (sh)
CS (1) CS276093B6 (sh)
DE (1) DE3869163D1 (sh)
DK (1) DK59888A (sh)
ES (1) ES2032482T3 (sh)
FI (1) FI880813A (sh)
GR (1) GR3004729T3 (sh)
HU (1) HU201312B (sh)
IL (1) IL85725A (sh)
MC (1) MC1919A1 (sh)
MX (1) MX10721A (sh)
NO (1) NO170215C (sh)
NZ (1) NZ223862A (sh)
PT (1) PT87025B (sh)
SU (1) SU1657057A3 (sh)
YU (1) YU46444B (sh)
ZA (1) ZA881810B (sh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5073566A (en) * 1989-11-30 1991-12-17 Eli Lilly And Company Angiotensin ii antagonist 1,3-imidazoles and use thereas
US5401851A (en) * 1992-06-03 1995-03-28 Eli Lilly And Company Angiotensin II antagonists
US5612360A (en) * 1992-06-03 1997-03-18 Eli Lilly And Company Angiotensin II antagonists
US5574057A (en) * 1993-02-03 1996-11-12 University Of Utah Research Foundation Naamidine A extracted from sea sponges and methods for its use as an anti-tumor agent
US5523310A (en) * 1994-12-05 1996-06-04 Hoffmann-La Roche Inc. 1,2,3-triazole derivatives
WO2000031052A1 (en) * 1998-11-23 2000-06-02 F. Hoffmann-La Roche Ag Synthesis of anti-inflammatory [1,2,3]triazoles
DE10132896A1 (de) * 2001-07-06 2003-01-16 Bayer Cropscience Ag Heterocyclische Amidderivate
WO2003010143A1 (en) * 2001-07-26 2003-02-06 Samsung Electronics Co., Ltd. Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses
EP1431292A1 (en) * 2002-12-16 2004-06-23 Laboratoire Theramex 1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3152228C1 (de) * 1980-07-31 1985-07-18 Vadim Michajlovič Frjazino Moskovskaja oblast' Šošin 2,2'-Azoimidazolderivate,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung eines fluessigkristallinen Materials
DE3674054D1 (de) * 1985-04-26 1990-10-18 Hoffmann La Roche 1,3-disubstituierte imidazoliumsalze.
ZW6687A1 (en) * 1986-05-13 1987-12-02 Hoffmann La Roche 1,3-disubstituted imidazolium salts
MW7087A1 (en) * 1986-10-03 1988-05-11 Hoffmann La Roche 1,3-disubstituted imidazolium salts
JPH02502721A (ja) * 1987-03-20 1990-08-30 イー・アイ・デユポン・デ・ニモアス・アンド・カンパニー 殺菌・殺カビ性アミノトリアゾール及びアミノイミダゾール

Also Published As

Publication number Publication date
NO170215C (no) 1992-09-23
AU613349B2 (en) 1991-08-01
HU201312B (en) 1990-10-28
HUT49581A (en) 1989-10-30
JPS63253070A (ja) 1988-10-20
GR3004729T3 (sh) 1993-04-28
ATE73777T1 (de) 1992-04-15
IL85725A (en) 1991-12-12
CN1016169B (zh) 1992-04-08
DE3869163D1 (de) 1992-04-23
NO881199D0 (no) 1988-03-18
ZA881810B (en) 1988-09-20
FI880813A0 (fi) 1988-02-22
FI880813A (fi) 1988-09-21
ES2032482T3 (es) 1993-02-16
KR880011117A (ko) 1988-10-26
NO881199L (no) 1988-09-21
DK59888D0 (da) 1988-02-05
EP0283857B1 (de) 1992-03-18
NZ223862A (en) 1990-08-28
CN88101452A (zh) 1988-10-05
NO170215B (no) 1992-06-15
PT87025B (pt) 1992-06-30
YU40388A (en) 1990-02-28
PT87025A (pt) 1988-04-01
AU1353288A (en) 1988-09-22
CS8800891A2 (en) 1990-09-12
IL85725A0 (en) 1988-08-31
DK59888A (da) 1988-09-21
EP0283857A1 (de) 1988-09-28
US4908363A (en) 1990-03-13
MC1919A1 (fr) 1989-04-06
CS276093B6 (en) 1992-04-15
SU1657057A3 (ru) 1991-06-15
MX10721A (es) 1993-09-01

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