PT87025A - Process for the preparation of imidazol derivatives and of pharmaceutical compositions containing the same - Google Patents

Process for the preparation of imidazol derivatives and of pharmaceutical compositions containing the same

Info

Publication number
PT87025A
PT87025A PT87025A PT8702588A PT87025A PT 87025 A PT87025 A PT 87025A PT 87025 A PT87025 A PT 87025A PT 8702588 A PT8702588 A PT 8702588A PT 87025 A PT87025 A PT 87025A
Authority
PT
Portugal
Prior art keywords
lower alkyl
hydrogen
formula
preparation
same
Prior art date
Application number
PT87025A
Other languages
English (en)
Other versions
PT87025B (pt
Inventor
Wilhelm Klotzer
Marc Montavon
Renate Mussner
Nicolas Singewald
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PT87025A publication Critical patent/PT87025A/pt
Publication of PT87025B publication Critical patent/PT87025B/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88Nitrogen atoms, e.g. allantoin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Resins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT87025A 1987-03-20 1988-03-18 Processo para a preparacao de derivados de imidazol e de composicoes farmaceuticas que os contem PT87025B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH107387 1987-03-20

Publications (2)

Publication Number Publication Date
PT87025A true PT87025A (pt) 1988-04-01
PT87025B PT87025B (pt) 1992-06-30

Family

ID=4201822

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87025A PT87025B (pt) 1987-03-20 1988-03-18 Processo para a preparacao de derivados de imidazol e de composicoes farmaceuticas que os contem

Country Status (23)

Country Link
US (1) US4908363A (pt)
EP (1) EP0283857B1 (pt)
JP (1) JPS63253070A (pt)
KR (1) KR880011117A (pt)
CN (1) CN1016169B (pt)
AT (1) ATE73777T1 (pt)
AU (1) AU613349B2 (pt)
CS (1) CS276093B6 (pt)
DE (1) DE3869163D1 (pt)
DK (1) DK59888A (pt)
ES (1) ES2032482T3 (pt)
FI (1) FI880813A (pt)
GR (1) GR3004729T3 (pt)
HU (1) HU201312B (pt)
IL (1) IL85725A (pt)
MC (1) MC1919A1 (pt)
MX (1) MX10721A (pt)
NO (1) NO170215C (pt)
NZ (1) NZ223862A (pt)
PT (1) PT87025B (pt)
SU (1) SU1657057A3 (pt)
YU (1) YU46444B (pt)
ZA (1) ZA881810B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5073566A (en) * 1989-11-30 1991-12-17 Eli Lilly And Company Angiotensin ii antagonist 1,3-imidazoles and use thereas
US5401851A (en) * 1992-06-03 1995-03-28 Eli Lilly And Company Angiotensin II antagonists
US5612360A (en) * 1992-06-03 1997-03-18 Eli Lilly And Company Angiotensin II antagonists
US5574057A (en) * 1993-02-03 1996-11-12 University Of Utah Research Foundation Naamidine A extracted from sea sponges and methods for its use as an anti-tumor agent
US5523310A (en) * 1994-12-05 1996-06-04 Hoffmann-La Roche Inc. 1,2,3-triazole derivatives
AU1383200A (en) 1998-11-23 2000-06-13 F. Hoffmann-La Roche Ag Synthesis of anti-inflammatory (1,2,3)triazoles
DE10132896A1 (de) * 2001-07-06 2003-01-16 Bayer Cropscience Ag Heterocyclische Amidderivate
WO2003010143A1 (en) 2001-07-26 2003-02-06 Samsung Electronics Co., Ltd. Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses
EP1431292A1 (en) * 2002-12-16 2004-06-23 Laboratoire Theramex 1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH651844A5 (de) * 1980-07-31 1985-10-15 Alexandr V Ivaschenko 2,2'-azoimidazolderivate, verfahren fuer ihre herstellung, fluessigkristallines material und eine elektrooptische vorrichtung.
EP0200947B1 (de) * 1985-04-26 1990-09-12 F. Hoffmann-La Roche Ag 1,3-Disubstituierte Imidazoliumsalze
ZW6687A1 (en) * 1986-05-13 1987-12-02 Hoffmann La Roche 1,3-disubstituted imidazolium salts
MW7087A1 (en) * 1986-10-03 1988-05-11 Hoffmann La Roche 1,3-disubstituted imidazolium salts
WO1988007040A1 (en) * 1987-03-20 1988-09-22 E.I. Du Pont De Nemours And Company Fungicidal aminotriazoles and aminoimidazoles

Also Published As

Publication number Publication date
ATE73777T1 (de) 1992-04-15
FI880813A0 (fi) 1988-02-22
MC1919A1 (fr) 1989-04-06
US4908363A (en) 1990-03-13
IL85725A0 (en) 1988-08-31
MX10721A (es) 1993-09-01
JPS63253070A (ja) 1988-10-20
FI880813A (fi) 1988-09-21
NO881199D0 (no) 1988-03-18
ZA881810B (en) 1988-09-20
YU40388A (en) 1990-02-28
NO170215C (no) 1992-09-23
AU613349B2 (en) 1991-08-01
DK59888A (da) 1988-09-21
NO170215B (no) 1992-06-15
KR880011117A (ko) 1988-10-26
GR3004729T3 (pt) 1993-04-28
DE3869163D1 (de) 1992-04-23
CS276093B6 (en) 1992-04-15
CN88101452A (zh) 1988-10-05
NO881199L (no) 1988-09-21
HU201312B (en) 1990-10-28
CN1016169B (zh) 1992-04-08
YU46444B (sh) 1993-10-20
HUT49581A (en) 1989-10-30
DK59888D0 (da) 1988-02-05
AU1353288A (en) 1988-09-22
IL85725A (en) 1991-12-12
EP0283857B1 (de) 1992-03-18
CS8800891A2 (en) 1990-09-12
PT87025B (pt) 1992-06-30
NZ223862A (en) 1990-08-28
EP0283857A1 (de) 1988-09-28
ES2032482T3 (es) 1993-02-16
SU1657057A3 (ru) 1991-06-15

Similar Documents

Publication Publication Date Title
SE7614539L (sv) Forfarande for framstellning av karbostyrilderivat med terapeutisk verkan
EP0269574A3 (en) Novel adenosine derivatives and pharmaceutical compositions containing them as an active ingredient
MX9306831A (es) Nuevos compuestos heterociclicos.
ES8203883A1 (es) Un procedimiento para la preparacion de derivados de imida- zol
GB8426076D0 (en) Pyrollidine derivatives
HU900636D0 (en) Process for preparation of new tetrahydro-benzimidazole derivatives and pharmaceutical compositions containing the above compounds
GR3021865T3 (en) Compositon containing rhodacyanine dyes for treating cancer
DK457286D0 (da) Fluorenforbindelse og farmaceutisk praeparat indeholdende en saadan forbindelse
PT87025A (pt) Process for the preparation of imidazol derivatives and of pharmaceutical compositions containing the same
ES8800142A1 (es) Un procedimiento para preparar un derivado de semicarbazida
ES8307792A1 (es) Un metodo de produccion de compuesto de dihidropiridina.
ES8403125A1 (es) Procedimiento para la preparacion de nuevas piridobenzodiazepinonas.
ES8407052A1 (es) Procedimiento para la preparacion de nuevas tienobenzodiazepinonas sustituidas
DE3569528D1 (en) Penem derivatives, methods of producing them, their use and pharmaceutical compositions
IL68204A (en) Guanidinoazolylphenylamidine derivatives,their preparation and pharmaceutical compositions containing them
CA2053705A1 (en) Piperazine derivatives
ZA899321B (en) Indole derivatives,process for preparing them and pharmaceutical compositions containing them
IL83216A (en) 1((5-(10->9)abeo-6-methylergolin-8beta-yl)methyl)-imidazolidine-(and hexahydropyrimidine)-2,4-dione derivatives,their preparation and pharmaceutical compositions containing them
ES8801652A1 (es) Un procedimiento para la preparacion de un derivado de tiazolidina.
HU895651D0 (en) Process for the preparation of substituted 3-amino-nonimine derivatives and pharmaceutical compositions containing said compounds
ES8305751A1 (es) Procedimiento para la obtencion de derivados del ditiol-1,2 ilideno-3 amonio.

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19911210

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19940630