ES2032482T3 - Derivados del bencilidenamino-, bencilamino- y benzoilamino-imidazol y su empleo como medicamentos. (reserva del art. 167.2 cpe). - Google Patents

Derivados del bencilidenamino-, bencilamino- y benzoilamino-imidazol y su empleo como medicamentos. (reserva del art. 167.2 cpe).

Info

Publication number
ES2032482T3
ES2032482T3 ES198888103746T ES88103746T ES2032482T3 ES 2032482 T3 ES2032482 T3 ES 2032482T3 ES 198888103746 T ES198888103746 T ES 198888103746T ES 88103746 T ES88103746 T ES 88103746T ES 2032482 T3 ES2032482 T3 ES 2032482T3
Authority
ES
Spain
Prior art keywords
lower alkyl
hydrogen
formula
derivatives
bencilidenamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888103746T
Other languages
English (en)
Inventor
Wilhelm Prof. Dr. Klotzer
Marc Dr. Montavon
Renate Dr. Mussner
Nicolas Singewald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2032482T3 publication Critical patent/ES2032482T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Epoxy Resins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

DERIVADOS DE IMIDAZOL DE FORMULA (I) Y SUS SALES DE ADICION DE ACIDOS FARMACOLOGICAMENTE ACEPTABLES. SIENDO R1 Y R2 UN ALQUILO BAJO; R3 HIDROGENO; R4 HIDROGENO O ALQUILO BAJO R3 Y R4 CONJUNTAMENTE UNA UNION CARBONO NITROGENO; R5 HIDROGENO O ALQUILO BAJO; R6 HIDROGENO, ALQUILO BAJO, ALQUENILO BAJO O UN RESTO DE FORMULA - NR7R8; R7 Y R8 ALQUILOS BAJOS O CONJUNTAMENTE CON EL NITROGENO UN HETEROCICLO SATURADO DE 5 A 6 MIEMBROS Y X UN RESTO - (CH)R3 - O CO -. POSEE PROPIEDADES FARMACODINAMICAS VALIOSAS (PROPIEDADES ANTIFLEMATICAS Y ANTIENDEMICAS) Y SE UTILIZA PARA EL TRATAMIENTO O PRESENCIA DE AGENTES PATOGENOS (TRATAMIENTO O PREVENCION DE INFLAMACIONES Y EDEMAS).
ES198888103746T 1987-03-20 1988-03-09 Derivados del bencilidenamino-, bencilamino- y benzoilamino-imidazol y su empleo como medicamentos. (reserva del art. 167.2 cpe). Expired - Lifetime ES2032482T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH107387 1987-03-20

Publications (1)

Publication Number Publication Date
ES2032482T3 true ES2032482T3 (es) 1993-02-16

Family

ID=4201822

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888103746T Expired - Lifetime ES2032482T3 (es) 1987-03-20 1988-03-09 Derivados del bencilidenamino-, bencilamino- y benzoilamino-imidazol y su empleo como medicamentos. (reserva del art. 167.2 cpe).

Country Status (23)

Country Link
US (1) US4908363A (es)
EP (1) EP0283857B1 (es)
JP (1) JPS63253070A (es)
KR (1) KR880011117A (es)
CN (1) CN1016169B (es)
AT (1) ATE73777T1 (es)
AU (1) AU613349B2 (es)
CS (1) CS276093B6 (es)
DE (1) DE3869163D1 (es)
DK (1) DK59888A (es)
ES (1) ES2032482T3 (es)
FI (1) FI880813A (es)
GR (1) GR3004729T3 (es)
HU (1) HU201312B (es)
IL (1) IL85725A (es)
MC (1) MC1919A1 (es)
MX (1) MX10721A (es)
NO (1) NO170215C (es)
NZ (1) NZ223862A (es)
PT (1) PT87025B (es)
SU (1) SU1657057A3 (es)
YU (1) YU46444B (es)
ZA (1) ZA881810B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5073566A (en) * 1989-11-30 1991-12-17 Eli Lilly And Company Angiotensin ii antagonist 1,3-imidazoles and use thereas
US5401851A (en) * 1992-06-03 1995-03-28 Eli Lilly And Company Angiotensin II antagonists
US5612360A (en) * 1992-06-03 1997-03-18 Eli Lilly And Company Angiotensin II antagonists
US5574057A (en) * 1993-02-03 1996-11-12 University Of Utah Research Foundation Naamidine A extracted from sea sponges and methods for its use as an anti-tumor agent
US5523310A (en) * 1994-12-05 1996-06-04 Hoffmann-La Roche Inc. 1,2,3-triazole derivatives
AU1383200A (en) 1998-11-23 2000-06-13 F. Hoffmann-La Roche Ag Synthesis of anti-inflammatory (1,2,3)triazoles
DE10132896A1 (de) * 2001-07-06 2003-01-16 Bayer Cropscience Ag Heterocyclische Amidderivate
WO2003010143A1 (en) 2001-07-26 2003-02-06 Samsung Electronics Co., Ltd. Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses
US6737433B1 (en) * 2002-12-16 2004-05-18 Laboratoire Theramex 1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors and pharmaceutical compositions containing them

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4457859A (en) * 1980-07-31 1984-07-03 Ivaschenko Alexandr V Mesomorphic material containing 2,2'-azoimidazole compounds containing 1,1'-benzylideneamino substituents
EP0200947B1 (de) * 1985-04-26 1990-09-12 F. Hoffmann-La Roche Ag 1,3-Disubstituierte Imidazoliumsalze
ZW6687A1 (en) * 1986-05-13 1987-12-02 Hoffmann La Roche 1,3-disubstituted imidazolium salts
MW7087A1 (en) * 1986-10-03 1988-05-11 Hoffmann La Roche 1,3-disubstituted imidazolium salts
KR890700582A (ko) * 1987-03-20 1989-04-25 사무엘 에스. 블라이트 살진균성 아미노트리아졸 및 아미노이미다졸

Also Published As

Publication number Publication date
PT87025A (pt) 1988-04-01
AU1353288A (en) 1988-09-22
NO881199D0 (no) 1988-03-18
ZA881810B (en) 1988-09-20
NO170215C (no) 1992-09-23
DE3869163D1 (de) 1992-04-23
CN1016169B (zh) 1992-04-08
AU613349B2 (en) 1991-08-01
NO881199L (no) 1988-09-21
FI880813A0 (fi) 1988-02-22
FI880813A (fi) 1988-09-21
NZ223862A (en) 1990-08-28
SU1657057A3 (ru) 1991-06-15
NO170215B (no) 1992-06-15
IL85725A (en) 1991-12-12
EP0283857A1 (de) 1988-09-28
DK59888A (da) 1988-09-21
HU201312B (en) 1990-10-28
JPS63253070A (ja) 1988-10-20
MC1919A1 (fr) 1989-04-06
ATE73777T1 (de) 1992-04-15
US4908363A (en) 1990-03-13
CS276093B6 (en) 1992-04-15
KR880011117A (ko) 1988-10-26
CS8800891A2 (en) 1990-09-12
CN88101452A (zh) 1988-10-05
MX10721A (es) 1993-09-01
YU40388A (en) 1990-02-28
PT87025B (pt) 1992-06-30
GR3004729T3 (es) 1993-04-28
IL85725A0 (en) 1988-08-31
HUT49581A (en) 1989-10-30
YU46444B (sh) 1993-10-20
EP0283857B1 (de) 1992-03-18
DK59888D0 (da) 1988-02-05

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