ES2048109A1 - Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol. - Google Patents

Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.

Info

Publication number
ES2048109A1
ES2048109A1 ES9201512A ES9201512A ES2048109A1 ES 2048109 A1 ES2048109 A1 ES 2048109A1 ES 9201512 A ES9201512 A ES 9201512A ES 9201512 A ES9201512 A ES 9201512A ES 2048109 A1 ES2048109 A1 ES 2048109A1
Authority
ES
Spain
Prior art keywords
benzimidazole
antihistanminic
piperidine derivatives
antiallergic agents
new piperidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9201512A
Other languages
English (en)
Other versions
ES2048109B1 (es
Inventor
Venero Orjales
Rubio-Royo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fabrica Espanola de Productos Quimicos y Farmaceuticos FAES SA
Original Assignee
Fabrica Espanola de Productos Quimicos y Farmaceuticos FAES SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fabrica Espanola de Productos Quimicos y Farmaceuticos FAES SA filed Critical Fabrica Espanola de Productos Quimicos y Farmaceuticos FAES SA
Priority to ES09201512A priority Critical patent/ES2048109B1/es
Priority to US08/064,424 priority patent/US5322850A/en
Priority to MX9304215A priority patent/MX9304215A/es
Priority to AU41946/93A priority patent/AU667920B2/en
Priority to CA002100503A priority patent/CA2100503C/en
Priority to FI933213A priority patent/FI933213A/fi
Priority to KR1019930013436A priority patent/KR940005609A/ko
Priority to DE69326650T priority patent/DE69326650T2/de
Priority to AT93500105T priority patent/ATE185344T1/de
Priority to EP93500105A priority patent/EP0580541B1/en
Priority to JP5178199A priority patent/JPH07291964A/ja
Priority to ZA935195A priority patent/ZA935195B/xx
Priority to NO932607A priority patent/NO303014B1/no
Priority to TW082106440A priority patent/TW225529B/zh
Publication of ES2048109A1 publication Critical patent/ES2048109A1/es
Application granted granted Critical
Publication of ES2048109B1 publication Critical patent/ES2048109B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE NUEVOS PIPERIDINICOS DEL BENCIMIDAZOL. SE DESCRIBE UN PROCEDIMIENTO DE PREPARACION DE NUEVOS DERIVADOS PIPERIDINICOS DEL BENCIMIDAZOL CON ACTIVIDAD ANTIHISTAMINICA Y ANTIALERGICA Y DE BAJA TOXICIDAD QUE SE CORRESPONDEN CON LA ESTRUCTURA DE LA FORMULA I.
ES09201512A 1992-07-20 1992-07-20 Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol. Expired - Lifetime ES2048109B1 (es)

Priority Applications (14)

Application Number Priority Date Filing Date Title
ES09201512A ES2048109B1 (es) 1992-07-20 1992-07-20 Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
US08/064,424 US5322850A (en) 1992-07-20 1993-05-21 Antiallergic piperidine derivatives of benzimidazole
MX9304215A MX9304215A (es) 1992-07-20 1993-07-13 Nuevos derivados piperidinicos del bencimidazol.
AU41946/93A AU667920B2 (en) 1992-07-20 1993-07-14 New piperidine derivatives of benzimidazole
CA002100503A CA2100503C (en) 1992-07-20 1993-07-14 Piperidine derivatives of benzimidazole
FI933213A FI933213A (fi) 1992-07-20 1993-07-15 Nya piperidinderivat av bensimidazolin
DE69326650T DE69326650T2 (de) 1992-07-20 1993-07-16 Piperidinderivate von Benzimidazole als antihistaminische und antiallergische Mittel
AT93500105T ATE185344T1 (de) 1992-07-20 1993-07-16 Piperidinderivate von benzimidazole als antihistaminische und antiallergische mittel
KR1019930013436A KR940005609A (ko) 1992-07-20 1993-07-16 벤즈이미다졸의 피페리딘 유도체
EP93500105A EP0580541B1 (en) 1992-07-20 1993-07-16 Piperidine derivatives of benzimidazole as antihistaminic and antiallergic agents
JP5178199A JPH07291964A (ja) 1992-07-20 1993-07-19 新規ベンズイミダゾ−ルのピペリジン誘導体
ZA935195A ZA935195B (en) 1992-07-20 1993-07-19 New piperidine derivatives of benzimidazole
NO932607A NO303014B1 (no) 1992-07-20 1993-07-19 2-(piperidin-4-yl)-1H-benzimidazolforbindelser med antihistamin- og antiallergisk aktivitet
TW082106440A TW225529B (es) 1992-07-20 1993-08-11

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09201512A ES2048109B1 (es) 1992-07-20 1992-07-20 Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.

Publications (2)

Publication Number Publication Date
ES2048109A1 true ES2048109A1 (es) 1994-03-01
ES2048109B1 ES2048109B1 (es) 1994-12-16

Family

ID=8277712

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09201512A Expired - Lifetime ES2048109B1 (es) 1992-07-20 1992-07-20 Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.

Country Status (14)

Country Link
US (1) US5322850A (es)
EP (1) EP0580541B1 (es)
JP (1) JPH07291964A (es)
KR (1) KR940005609A (es)
AT (1) ATE185344T1 (es)
AU (1) AU667920B2 (es)
CA (1) CA2100503C (es)
DE (1) DE69326650T2 (es)
ES (1) ES2048109B1 (es)
FI (1) FI933213A (es)
MX (1) MX9304215A (es)
NO (1) NO303014B1 (es)
TW (1) TW225529B (es)
ZA (1) ZA935195B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0818454A1 (en) * 1996-06-04 1998-01-14 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) Benzimidazole derivatives with antihistaminic activity

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2097317C (en) * 1990-12-14 2002-02-12 Albert A. Carr Antiallergic piperdinyl benzimidazoles
MX9701305A (es) 1994-08-25 1998-05-31 Merrell Pharma Inc Piperidinas sustituidas novedosas utiles para el tratamiento de enfermedades alergicas.
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) * 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
KR100494448B1 (ko) * 1996-06-04 2005-12-02 화브리까 에스파놀라 데 프로둑또스 뀌미꼬스 이 화르마세우띠꼬스 쏘시에떼 아노님 항히스타민활성을가지는신규한벤조이미다졸유도체
US6136807A (en) * 1998-11-10 2000-10-24 3M Innovative Properties Company Composition for the transdermal delivery of lerisetron
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
NZ535763A (en) * 2002-04-18 2007-06-29 Schering Corp (1-4-piperidinyl) benzimidazole derivatives useful as histamine H3 antagonists
US7105505B2 (en) 2002-04-18 2006-09-12 Schering Corporation Benzimidazole derivatives useful as histamine H3 antagonists
JP4355917B2 (ja) 2003-10-29 2009-11-04 信越化学工業株式会社 含窒素有機化合物、レジスト材料及びパターン形成方法
JP5629214B2 (ja) * 2008-02-12 2014-11-19 ユーハン・コーポレイションＹＵＨＡＮ Ｃｏｒｐｏｒａｔｉｏｎ ２−メチル−２′−フェニルプロピオン酸誘導体の製造方法およびこれに使用される新規な中間体化合物
ES2612934T3 (es) * 2011-09-26 2017-05-19 Merck Patent Gmbh Compuestos de piperidin bencilo como antagonista del receptor del ácido lisofosfatídico (LPA)
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
EP3040334A1 (en) * 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106146308A (zh) * 2015-04-09 2016-11-23 南京长澳医药科技有限公司 α,α-二甲基-4-（2-卤乙酰基）苯乙酸酯的纯化方法
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
LT3681475T (lt) 2017-10-16 2021-02-25 Faes Farma, S.A. Vandeninės kompozicijos, apimančios bilastiną ir mometazoną
AU2019209214B2 (en) 2018-01-18 2023-11-23 Faes Farma, S.A. Ophthalmic compositions comprising bilastine, a beta-cyclodextrin and at least one gelling agent
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
EP4188339A1 (en) 2020-07-30 2023-06-07 Faes Farma, S.A. Decongestant drug delivery system
WO2023156559A1 (en) 2022-02-17 2023-08-24 Faes Farma, S.A. Bilastine composition for once-daily parenteral administration

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8706668A1 (es) * 1984-01-09 1987-06-16 Janssen Pharmaceutica Nv Un procedimiento para la preparacion de derivados de piperidina.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5879983A (ja) * 1981-11-06 1983-05-13 Kanebo Ltd 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
ES8604934A1 (es) * 1985-11-19 1986-03-01 Inke Sa Procedimiento para la obtencion de la 1-((4-fluorfenil)me- til)-n-(1-(2-(4-metoxifenil)etil)-4-piperidinil)-1h-bencimi-dazol-2-amina
US5215974A (en) * 1986-11-21 1993-06-01 Aktiebolaget Hassle Certain pyridyl[(methylthio- or methyl sulfinyl)-2 benzimidazol-2-yl]N-methyl phosphonates useful for treating gastric-acid secretion related diseases
US4988689A (en) * 1987-07-01 1991-01-29 Janssen Pharmaceutica N.V. ((Pharmacologically active bicyclic heterocyclic)methyl and -heteroatom) substituted hexahydro-1H-azepines and pyrrolidines
NZ238863A (en) * 1990-07-19 1993-03-26 Janssen Pharmaceutica Nv Substituted thiazolyl and pyridinyl derivatives
FR2668150B1 (fr) * 1990-10-17 1994-11-18 Theramex Nouveaux derives du terbutylphenyl 1-amino 4-hydroxybutane, leurs procedes de preparation et les compositions pharmaceutiques en renfermant.

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
ES8706668A1 (es) * 1984-01-09 1987-06-16 Janssen Pharmaceutica Nv Un procedimiento para la preparacion de derivados de piperidina.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL HETEROCYCLIC CHEM., Vol. 24 (1), 1987, p. 31, IEMURA et al., "Synthesis of benzimidazole derivatives as potential H1-antihistaminic agents". *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0818454A1 (en) * 1996-06-04 1998-01-14 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) Benzimidazole derivatives with antihistaminic activity
ES2124167A1 (es) * 1996-06-04 1999-01-16 Espanola Prod Quimicos Nuevos derivados del bencimidazol con actividad antihistaminica.

Also Published As

Publication number Publication date
AU667920B2 (en) 1996-04-18
NO303014B1 (no) 1998-05-18
ATE185344T1 (de) 1999-10-15
EP0580541A1 (en) 1994-01-26
CA2100503A1 (en) 1994-01-21
TW225529B (es) 1994-06-21
CA2100503C (en) 1998-09-29
JPH07291964A (ja) 1995-11-07
KR940005609A (ko) 1994-03-21
MX9304215A (es) 1994-02-28
ES2048109B1 (es) 1994-12-16
NO932607D0 (no) 1993-07-19
DE69326650D1 (de) 1999-11-11
NO932607L (no) 1994-01-21
DE69326650T2 (de) 2000-06-08
US5322850A (en) 1994-06-21
EP0580541B1 (en) 1999-10-06
ZA935195B (en) 1994-09-19
AU4194693A (en) 1994-01-27
FI933213A0 (fi) 1993-07-15
FI933213A (fi) 1994-01-21

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Effective date: 19981218