KR940005609A - 벤즈이미다졸의 피페리딘 유도체 - Google Patents

벤즈이미다졸의 피페리딘 유도체 Download PDF

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Publication number
KR940005609A
KR940005609A KR1019930013436A KR930013436A KR940005609A KR 940005609 A KR940005609 A KR 940005609A KR 1019930013436 A KR1019930013436 A KR 1019930013436A KR 930013436 A KR930013436 A KR 930013436A KR 940005609 A KR940005609 A KR 940005609A
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South Korea
Prior art keywords
compound
benzimidazole
ethyl
pharmaceutically acceptable
dimethylethyl
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KR1019930013436A
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English (en)
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아우렐리오 오르할레스-베네로 데
빅토르 루비오-료오요 데
Original Assignee
자비엘 가르시아 데 라마
파브리까 에스파뇨라 데 쁘로독또스 끼미꼬스 이 빠르마세우띠꼬스 소시에다드 아노니마
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Publication of KR940005609A publication Critical patent/KR940005609A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

본 발명은 항히스탄민제 및 항알레르기제로서 유용한 벤즈이미다졸의 피페리딘 유도체 및 약제학적으로 허용되고 이것의 염에 관한 것이다.
(여기에서 n은 1 또는 2이고, R은 저급알킬, 저급알켄일 또는 저급시클로알킬이다)

Description

벤즈이미다졸의 피페리딘 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 하기식외 화합물 및 약제학적으로 허용되는 이것외 염.
    (여기에서 n은 1 또는 2이고, R은 저급알킬, 저급알켄일 또는 저급시클로알킬이다).
  2. 제1항에 있어서, 상기 화합물이 2-[1-((4-(1,1-디메틸에틸)페닐)메틸)피페리딘-4-일]-1-(2-메톡시에틸)-lH-벤즈이미다졸 및 약제학적으로 허용되는 이것의 염인 것을 특징으로 하는 화합물.
  3. 제1항에 있어서, 상기 화합물이 2-[1-((4-(1,1-디메틸에틸)페닐)메틸)피페리딘-4-일]-1-(2-에록시에틸)-1H-벤즈이미다졸 및 약제학적으로 허용되는 이것의 염인 것을 특징으로 하는 화합물.
  4. 제1항에 있어서, 상기 화합물이 2-[1-((4-(1,1-디메틸에틸)페닐)에틸)피페리딘-4-일]-1-[2-(1(메톡시에틸)에틸]-lH-벤즈이미다졸 및 약제학적으로 허용되는 이것의 염인 것을 특징으로하는 화합물.
  5. 제1항에 있어서, 상기 화합물이 2-[l-(2-(4-(1,1-디메틸에틸)페닐)에틸)피페리딘-4-일]-1-[2-(1-(메톡시에틸)에틸)-lH-벤즈이미다졸 및 약제학적으로 허용되는 이것의 염인 것을 특징으로 하는 화합물.
  6. 제1항에 있어서, 상기 화합물이 2-[1-(2-(4-(1.1-디메틸에틸)페닐)에틸)피페리딘-4-일]-1-[2-(1-(에톡시에틸)에틸)-lH-벤즈이미다졸 및 약제학적으로 허용되는 이 것의 염인 것을 륵징으로 하는 화합물.
  7. 비활성 담체물질 및 제2항 내지 제6항중 어느 한 항에 따르는 화합물의 유효량을 포함하는 항알레기성 약제학적 조성물.
    ※참고사항 :최초출원 내용에 의하여 공개하는 것임
KR1019930013436A 1992-07-20 1993-07-16 벤즈이미다졸의 피페리딘 유도체 KR940005609A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES9201512 1992-07-20
ES09201512A ES2048109B1 (es) 1992-07-20 1992-07-20 Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.

Publications (1)

Publication Number Publication Date
KR940005609A true KR940005609A (ko) 1994-03-21

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KR1019930013436A KR940005609A (ko) 1992-07-20 1993-07-16 벤즈이미다졸의 피페리딘 유도체

Country Status (14)

Country Link
US (1) US5322850A (ko)
EP (1) EP0580541B1 (ko)
JP (1) JPH07291964A (ko)
KR (1) KR940005609A (ko)
AT (1) ATE185344T1 (ko)
AU (1) AU667920B2 (ko)
CA (1) CA2100503C (ko)
DE (1) DE69326650T2 (ko)
ES (1) ES2048109B1 (ko)
FI (1) FI933213A (ko)
MX (1) MX9304215A (ko)
NO (1) NO303014B1 (ko)
TW (1) TW225529B (ko)
ZA (1) ZA935195B (ko)

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CA2097317C (en) * 1990-12-14 2002-02-12 Albert A. Carr Antiallergic piperdinyl benzimidazoles
NZ292683A (en) 1994-08-25 1998-07-28 Merrell Pharma Inc Piperidine derivatives
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US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
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US5998439A (en) 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
ES2124167B1 (es) * 1996-06-04 1999-09-16 Espanola Prod Quimicos Nuevos derivados del bencimidazol con actividad antihistaminica.
KR100494448B1 (ko) * 1996-06-04 2005-12-02 화브리까 에스파놀라 데 프로둑또스 뀌미꼬스 이 화르마세우띠꼬스 쏘시에떼 아노님 항히스타민활성을가지는신규한벤조이미다졸유도체
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US7105505B2 (en) 2002-04-18 2006-09-12 Schering Corporation Benzimidazole derivatives useful as histamine H3 antagonists
EP1499316B1 (en) * 2002-04-18 2008-03-19 Schering Corporation (1-4-piperidinyl)benzimidazole derivatives useful as histamine h3 antagonists
JP4355917B2 (ja) 2003-10-29 2009-11-04 信越化学工業株式会社 含窒素有機化合物、レジスト材料及びパターン形成方法
CN104402773A (zh) 2008-02-12 2015-03-11 柳韩洋行 2-甲基-2’-苯基丙酸衍生物的制备方法和中间体化合物
US9527850B2 (en) * 2011-09-26 2016-12-27 Merck Patent Gmbh Benzyl piperidine compounds as lysophosphatidic acid (LPA) receptor antagonist
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106146308A (zh) * 2015-04-09 2016-11-23 南京长澳医药科技有限公司 α,α-二甲基-4-（2-卤乙酰基）苯乙酸酯的纯化方法
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
MA50247B1 (fr) 2017-10-16 2021-02-26 Faes Farma Sa Compositions aqueuses comprenant de la bilastine et du mométasone
CN111727035B (zh) 2018-01-18 2024-05-28 费斯制药股份有限公司 包含比拉斯汀、β-环糊精和至少一种胶凝剂的眼用组合物
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
EP4188339A1 (en) 2020-07-30 2023-06-07 Faes Farma, S.A. Decongestant drug delivery system
WO2023156559A1 (en) 2022-02-17 2023-08-24 Faes Farma, S.A. Bilastine composition for once-daily parenteral administration

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Also Published As

Publication number Publication date
EP0580541A1 (en) 1994-01-26
ES2048109B1 (es) 1994-12-16
MX9304215A (es) 1994-02-28
NO303014B1 (no) 1998-05-18
US5322850A (en) 1994-06-21
JPH07291964A (ja) 1995-11-07
NO932607L (no) 1994-01-21
FI933213A (fi) 1994-01-21
ATE185344T1 (de) 1999-10-15
CA2100503A1 (en) 1994-01-21
TW225529B (ko) 1994-06-21
ZA935195B (en) 1994-09-19
AU667920B2 (en) 1996-04-18
NO932607D0 (no) 1993-07-19
DE69326650T2 (de) 2000-06-08
EP0580541B1 (en) 1999-10-06
FI933213A0 (fi) 1993-07-15
DE69326650D1 (de) 1999-11-11
ES2048109A1 (es) 1994-03-01
CA2100503C (en) 1998-09-29
AU4194693A (en) 1994-01-27

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