KR920000749A - 1-인돌일알킬-4-(알콕시피리미딘일)피페라진 - Google Patents

1-인돌일알킬-4-(알콕시피리미딘일)피페라진 Download PDF

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KR920000749A
KR920000749A KR1019910010810A KR910010810A KR920000749A KR 920000749 A KR920000749 A KR 920000749A KR 1019910010810 A KR1019910010810 A KR 1019910010810A KR 910010810 A KR910010810 A KR 910010810A KR 920000749 A KR920000749 A KR 920000749A
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compound
indol
pyrimidinyl
methoxy
propyl
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KR1019910010810A
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더블유. 스미드 데이비드
디. 요카 프랭크
피. 예비치 조셉
제이. 매트슨 로날드
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도미닉 엠. 매자펠
브리스톨-마이어즈 스퀴브 컴페니
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Publication of KR920000749A publication Critical patent/KR920000749A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03B—APPARATUS OR ARRANGEMENTS FOR TAKING PHOTOGRAPHS OR FOR PROJECTING OR VIEWING THEM; APPARATUS OR ARRANGEMENTS EMPLOYING ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ACCESSORIES THEREFOR
    • G03B7/00—Control of exposure by setting shutters, diaphragms or filters, separately or conjointly
    • G03B7/08—Control effected solely on the basis of the response, to the intensity of the light received by the camera, of a built-in light-sensitive device
    • G03B7/099—Arrangement of photoelectric elements in or on the camera
    • G03B7/0993—Arrangement of photoelectric elements in or on the camera in the camera
    • G03B7/0997—Through the lens [TTL] measuring
    • G03B7/09971—Through the lens [TTL] measuring in mirror-reflex cameras
    • G03B7/09976—Through the lens [TTL] measuring in mirror-reflex cameras the sensor being mounted in, before, or behind the porro-prism

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Psychiatry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

내용 없음

Description

1-인돌일알킬-4-(알콕시피리미딘일)피페라진
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (21)

  1. 다음 일반식(I) 화합물 또는 약리적으로 허용되는 그의 산부가염.
    상기식에서, R1은 수소, 및 저급 알킬 중에서 선택되며 저급 알킬은 C1-4를 의미하며; R2와 R5는 각각 수소 및 저급 알킬 중에서 선택되며; R3와 R4는 각각 수소, 저급 알킬, 저급 알콕시, 저급 알킬티오, 카르복사미드, 할로겐 및 트리플루오로메틸 중에서 선택되며; R5은 저급 알콕시이며, n은 2또는 3의 정수이다.
  2. 제1항에 있어서, R4가 5-플루오로인 화합물.
  3. 제1항에 있어서, R5가 5-메톡시인 화합물.
  4. 제1항에 있어서, 1-[3-(1H-인돌-3-일)프로필]-4-[5-메톡시-4-피리미딘일)피레라진인 화합물.
  5. 제1항에 있어서, 1-[2-(5-플루오로-1H-인돌-3-일)에틸]-4-(5-메톡시-4-피리미딘일)피페라진인 화합물.
  6. 제1항에 있어서, 1-[2-(5-플루오로-1H-인돌-3-일)에틸]-4-(5-메톡시-4-피리미딘일)-2-메틸피페라진인 화합물.
  7. 제1항에 있어서, 1-[3-(5-플루오로-1H-인돌-3-일)프로필]-4-(5-메톡시-4-피리미딘일)-2-메틸피페라진인 화합물.
  8. 제1항에 있어서, 1-[3-(5-플루오로-1H-인돌-3-일)프로필]-4-(5-메톡시-4-피리미딘일)피페라진인 화합물.
  9. 제1항에 있어서, 4-(5-메톡시-4-피리미딘일)-1-[3-(1-메틸-1H-인돌-3-일)프로필]-2-메틸피페라진인 화합물.
  10. 제1항에 있어서, 1-[3-(6-플루오로-1H-인돌-3-일)프로필]-4-(5-메톡시-4-피리미딘일)-2-메틸피페라진인 화합물.
  11. 제1항에 있어서, 1-[3-(5-클로로-1H-인돌-3-일)프로필]-4-(5-메톡시-4-피리미딘일)-2-메틸피페라진인 화합물.
  12. 제1항에 있어서, 1-[3-(1H-인돌-3-일)프로필]-4-(6-메톡시-4-피리미딘일)피페라진인 화합물.
  13. 제1항에 있어서, 1-[3-(1H-인돌-3-일)프로필]-4-(6-메톡시-4-피리미딘일)-2-메틸피페라진인 화합물.
  14. 제1항에 있어서, 1-[3-(5-플루오로-1H-인돌-3-일)프로필]-4-(5-메톡시-4-피리미딘일)피페라진인 화합물.
  15. 제1항에 있어서, 1-[3-(5,6-디플루오로-1H-인돌-3-일)프로필]-4-(5-메톡시-4-피리미딘일)-2-메틸피페라진인 화합물.
  16. 제1항에 있어서, 1-[3-(5,6-디플루오로-1H-인돌-3-일)프로필]-4-(5-메톡시-4-피리미딘일)피페라진인 화합물.
  17. 제1항에 있어서, 2-에틸-1-[3-(1H-인돌-3-일)프로필]-4-(5-메톡시-4-피리미딘일)피페라진인 화합물.
  18. 제1항에 있어서, 4-[5-(5-에톡시-4-피리미딘일)-1-[3-(1H-인돌-3-일)프로필]피페라진인 화합물.
  19. 제1항에 있어서, 4-[5-에톡시-4-피리미딘일)-1-(3-(1H-인돌-3-일)프로필]-2-메틸피페라진인 화합물.
  20. 포유류에 제1항의 화합물의 항우울증 유효량을 투여하는 것으로 된 포유류의 우울증 증상의 개선방법.
  21. 약리학적 담체 및 제1항의 화합물중에서 선택된 항우울증 화합물 약 1-500mg으로 이루어진 포유류 숙주의 전신투여에 적합한 단위 투여향 형태의 약제 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910010810A 1990-06-29 1991-06-27 1-인돌일알킬-4-(알콕시피리미딘일)피페라진 KR920000749A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US546,121 1990-06-29
US07/546,121 US5077293A (en) 1990-06-29 1990-06-29 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines

Publications (1)

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KR920000749A true KR920000749A (ko) 1992-01-29

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Country Link
US (1) US5077293A (ko)
EP (1) EP0464604B1 (ko)
JP (1) JPH0819123B2 (ko)
KR (1) KR920000749A (ko)
AT (1) ATE120462T1 (ko)
AU (1) AU643765B2 (ko)
CA (1) CA2045359C (ko)
CY (1) CY1857A (ko)
DE (1) DE69108461T2 (ko)
DK (1) DK0464604T3 (ko)
ES (1) ES2071169T3 (ko)
FI (1) FI100241B (ko)
GR (1) GR3015585T3 (ko)
HK (1) HK109695A (ko)
IE (1) IE67288B1 (ko)
MX (1) MX9202844A (ko)
PT (1) PT98114B (ko)
TW (1) TW198030B (ko)
ZA (1) ZA915036B (ko)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2043709C (en) * 1990-06-29 2002-01-22 David W. Smith Antimigraine alkoxypyrimidine derivatives
FR2673628B1 (fr) * 1991-03-07 1993-07-09 Esteve Labor Dr Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles.
CA2084531A1 (en) * 1991-12-19 1993-06-20 David W. Smith Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines
CA2130078A1 (en) * 1993-09-16 1995-03-17 Jonas A. Gylys Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines
US5521188A (en) * 1993-09-16 1996-05-28 Bristol-Myers Squibb Company Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines
GB9423682D0 (en) * 1994-11-23 1995-01-11 Merck Sharp & Dohme Therapeutic agents
GB9501865D0 (en) * 1995-01-31 1995-03-22 Merck Sharp & Dohme Therapeutic agents
US5618816A (en) * 1995-03-02 1997-04-08 Bristol-Myers Squibb Company Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines
JPH09124643A (ja) * 1995-08-14 1997-05-13 Bristol Myers Squibb Co 抗うつ作用を有する１−アリールアルキル−４−（アルコキシピリジニル）−又は４−（アルコキシピリミジニル）ピペラジン誘導体
JP4076234B2 (ja) 1996-06-28 2008-04-16 明治製菓株式会社 テトラヒドロベンズインドール化合物
SE9603283D0 (sv) * 1996-09-10 1996-09-10 Astra Ab New compounds
TW472045B (en) * 1996-09-25 2002-01-11 Astra Ab Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation
AR017200A1 (es) 1997-12-23 2001-08-22 Astrazeneca Ab Compuestos inhibidores de la proteina cinasa c, sales farmaceuticamente aceptables de los mismos, formulaciones farmaceuitcas que los comprenden, usode las mismas y proceso para la sintesis de dichos compuestos
SE9800835D0 (sv) 1998-03-13 1998-03-13 Astra Ab New Compounds
US6492406B1 (en) 1999-05-21 2002-12-10 Astrazeneca Ab Pharmaceutically active compounds
US6346625B1 (en) 1999-06-23 2002-02-12 Astrazeneca Ab Protein kinase inhibitors
GB0119797D0 (en) * 2001-08-14 2001-10-03 Glaxo Group Ltd Chemical compounds
US20040023977A1 (en) * 2002-07-15 2004-02-05 Larsen Robert D. Process for making substituted thiazolyl-amino pyrimidinyl
DE10252102A1 (de) * 2002-11-08 2004-05-27 Merck Patent Gmbh Indolderivate
WO2010075273A1 (en) 2008-12-23 2010-07-01 Schering Corporation Bicyclic heterocycle derivatives and methods of use thereof
EP3027607B1 (en) * 2013-07-29 2020-08-26 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use thereof
CN106243088B (zh) 2015-06-03 2019-01-04 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
CN109574993B (zh) 2017-09-29 2020-12-18 广东东阳光药业有限公司 取代的嘧啶哌嗪化合物及其用途
CN108658871B (zh) * 2018-06-19 2020-10-30 舞阳威森生物医药有限公司 周效磺胺中间体4,6-二氯-5-甲氧基嘧啶的制备方法

Family Cites Families (8)

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GB944443A (ko) * 1959-09-25 1900-01-01
GB1189064A (en) * 1967-05-01 1970-04-22 Sterling Drug Inc Indole Derivatives
IT1170387B (it) * 1982-06-07 1987-06-03 Glaxo Group Ltd Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
GB2162522B (en) * 1984-08-01 1988-02-24 Glaxo Group Ltd An indole derivative
US4954502A (en) * 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines
FR2635104B1 (fr) * 1988-08-03 1992-04-30 Synthelabo Derives d'indolone, leur preparation et leur application en therapeutique
CA2043709C (en) * 1990-06-29 2002-01-22 David W. Smith Antimigraine alkoxypyrimidine derivatives

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AU7403791A (en) 1992-01-02
FI913117A (fi) 1991-12-30
DE69108461T2 (de) 1995-07-27
ATE120462T1 (de) 1995-04-15
DE69108461D1 (de) 1995-05-04
FI913117A0 (fi) 1991-06-26
JPH0819123B2 (ja) 1996-02-28
JPH04230377A (ja) 1992-08-19
DK0464604T3 (da) 1995-06-12
AU643765B2 (en) 1993-11-25
EP0464604B1 (en) 1995-03-29
GR3015585T3 (en) 1995-06-30
MX9202844A (es) 1992-06-30
US5077293A (en) 1991-12-31
CA2045359A1 (en) 1991-12-30
FI100241B (fi) 1997-10-31
PT98114A (pt) 1992-03-31
EP0464604A2 (en) 1992-01-08
ES2071169T3 (es) 1995-06-16
IE67288B1 (en) 1996-03-20
EP0464604A3 (en) 1992-02-26
HK109695A (en) 1995-07-14
CA2045359C (en) 2001-09-04
PT98114B (pt) 1998-12-31
TW198030B (ko) 1993-01-11
CY1857A (en) 1996-04-05
ZA915036B (en) 1993-02-24
IE912279A1 (en) 1992-01-01

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