KR890008137A - 3-[4(1-치환된-4-피페라지닐)부틸]-4-티아졸리디노 이의 제조방법 및 약제로서의 이의 용도 - Google Patents

3-[4(1-치환된-4-피페라지닐)부틸]-4-티아졸리디노 이의 제조방법 및 약제로서의 이의 용도 Download PDF

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KR890008137A
KR890008137A KR1019880015210A KR880015210A KR890008137A KR 890008137 A KR890008137 A KR 890008137A KR 1019880015210 A KR1019880015210 A KR 1019880015210A KR 880015210 A KR880015210 A KR 880015210A KR 890008137 A KR890008137 A KR 890008137A
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South Korea
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compound according
piperazinyl
butyl
compound
pharmaceutically acceptable
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KR1019880015210A
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KR0130976B1 (ko
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제이.흐립 니콜라스
게라드 주르캑 죤
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도날드 알.톨센
훽스트-럿셀 파마슈티칼스 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

내용 없음

Description

3-[4(1-치환된-4- 피페라지닐)부틸]-4- 티아졸리디노 이의 제조방법 및 약제로서의 이의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 일반식(Ⅰ)의 화합물 및 이의 약제학적으로 허용되는 산 부가염.
    상기식에서, n은 0또는 1이고;
    U, V, W, Q, S 및 T는 각각 수소, 할로겐, 저급알킬, 하이드록시, 니트로, 저급알콕시, 아미노, 시아노 또는 트리플루오로메틸이고, m 은 1 또는 2이다)이며, R1및 R2는 각기 독립적으로 수소, 저급알킬 또는 아릴(여기에서, 아릴은 비치환된 페닐 그룹, 또는 저급알킬, 저급알콕시, 하이드록시, 할로겐, 저급알킬티오, 시아노, 아미노 및 트리플루오로메틸 중에서 각각 독립적으로 선택된 1, 2 또는 3개로 치환된 페닐 그룹을 의미한다)이거나, R1및 R2가 이들이 결합된 탄소와 함께는 사이클로펜탄, 사이클로헥산, 사이클로헵탄, 피란, 티오피란, 피롤리딘 또는 피페리딘 환을 형성하고, R3및 R4는 각기 독립적으로 수소 또는 저급알킬 이거나, R3및 R4가 이들이 결합된 탄소와 함께는 사이클로펜탄, 사이클로헥산, 사이클로헵탄, 피란, 티오피란, 피롤리딘 또는 피페리딘환을 형성한다.
  2. 제1항에 있어서, n 이 C 인 화합물.
  3. 제2항에 있어서, R1, R2, R3및 R4가 각기 독립적으로 수소, 저급알킬 또는 아릴이고, A 는 라디칼
    (여기에서, X, S 및 T는 상기에서 정의한 바와 같다)인 화합물.
  4. 제3항에 있어서, R1, R2, R3및 R4가 각기 독립적으로 수소, 메틸 또는 페닐이고, A가 라디칼
    (여기에서, X 는 메틸, 메톡시, Cl, F 또는 (F3이다)인 화합물.
  5. 제1항에 있어서, 2-메틸-3-[4-[1(4-플루오르페닐)-4-피페라지닐]부틸]-4-티아졸리디논인 화합물 및 이의 약제학적으로 허용되는 산 부가염.
  6. 제1항에 있어서, 3-[4-[1-(3-메틸페닐)-4-피페라지닐]-부틸]-4-티아졸리디논인 화합물 및 이의 약제학적으로 허용되는 산 부가염.
  7. 제1항에 있어서, 3-[4-(2,3디메틸페닐)-4-피페라지닐]-부틸]-4-티아졸리디논인 화합물 및 이의 약제학적으로 허용되는 산 부가염.
  8. 제1항에 있어서, 3-[4-[1-(4-클로로페닐)-4-피페라지닐]부틸]-4-티아졸리디논인 화합물 및 이의 약제학적으로 허용되는 산 부가염.
  9. 제1항에 있어서, 3-[4-[1-(1,2-벤즈이소티아졸-3-일)-4-피페라지닐]부틸]-5,5-디메틸-4-티아졸리디논 인 화합물 및 이의 약제학적으로 허용되는 산 부가염.
  10. 활성 성분으로서 제1항에 따르는 화합물 및 이에 적합한 담체를 함유함을 특징으로 하는 약제학적 조성물.
  11. 정신병 치료, 진통 및/또는 진경 활성을 지닌 약제를 제조하기 위한 제1항에 따른 화합물의 용도.
  12. a) 일반식(Ⅲ)화합물을 일반식(Ⅳ) 화합물과 반응시키거나, b) n 이 C인 일반식(Ⅰ)의 화합물을 임의로 반응시켜 n 이 1인 일반식(Ⅰ)의 화합물을 수둑함을 특징으로 하는 제1항에 따른 화합물의 제조방법.
    상기식에서 n, R1, R2, R3, R4및 A 는 상기에 정의된 바와같다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880015210A 1987-11-20 1988-11-18 3-[4-(1-치환된-4-피페라지닐)부틸]-4-티아졸리디논, 이의 제조방법 및 이를 포함하는 약제학적 조성물 KR0130976B1 (ko)

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US12362287A 1987-11-20 1987-11-20
US123,622 1987-11-20
US123.622 1987-11-20

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KR0130976B1 KR0130976B1 (ko) 1998-04-16

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US (5) US4933453A (ko)
EP (1) EP0316723B1 (ko)
JP (1) JP2617546B2 (ko)
KR (1) KR0130976B1 (ko)
AT (1) ATE81123T1 (ko)
AU (1) AU624092B2 (ko)
CA (1) CA1317955C (ko)
DE (1) DE3875073T2 (ko)
DK (1) DK645688A (ko)
ES (1) ES2052675T3 (ko)
FI (1) FI89916C (ko)
GR (1) GR3006698T3 (ko)
HU (1) HU206709B (ko)
IE (1) IE62229B1 (ko)
IL (1) IL88414A (ko)
NO (1) NO176143C (ko)
NZ (1) NZ226999A (ko)
PH (1) PH27330A (ko)
PT (1) PT89020B (ko)
ZA (1) ZA888651B (ko)

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JPH01160975A (ja) 1989-06-23
US5136037A (en) 1992-08-04
IE62229B1 (en) 1995-01-11
AU2569488A (en) 1989-05-25
PT89020B (pt) 1993-02-26
JP2617546B2 (ja) 1997-06-04
HUT54149A (en) 1991-01-28
NO885152L (no) 1989-05-22
IE883463L (en) 1989-05-20
EP0316723B1 (en) 1992-09-30
HU206709B (en) 1992-12-28
US4933453A (en) 1990-06-12
ZA888651B (en) 1989-09-27
DK645688A (da) 1989-05-21
FI885332A (fi) 1989-05-21
US5371087A (en) 1994-12-06
FI89916C (fi) 1993-12-10
ATE81123T1 (de) 1992-10-15
PH27330A (en) 1993-06-08
EP0316723A1 (en) 1989-05-24
DK645688D0 (da) 1988-11-18
NO176143C (no) 1995-02-08
DE3875073T2 (de) 1993-03-11
NZ226999A (en) 1991-05-28
DE3875073D1 (ko) 1992-11-05
US5037984A (en) 1991-08-06
ES2052675T3 (es) 1994-07-16
KR0130976B1 (ko) 1998-04-16
NO176143B (no) 1994-10-31
NO885152D0 (no) 1988-11-18
PT89020A (pt) 1988-12-01
FI89916B (fi) 1993-08-31
CA1317955C (en) 1993-05-18
IL88414A (en) 1993-07-08
FI885332A0 (fi) 1988-11-17
AU624092B2 (en) 1992-06-04
US5229388A (en) 1993-07-20
IL88414A0 (en) 1989-06-30
GR3006698T3 (ko) 1993-06-30

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