PT89020A - Processo para a preparacao de 3-(4(1-substituidas-4-piperazinil)butil)-4-tiazolidinonas e de composicoes farmaceuticas que as contem - Google Patents
Processo para a preparacao de 3-(4(1-substituidas-4-piperazinil)butil)-4-tiazolidinonas e de composicoes farmaceuticas que as contemInfo
- Publication number
- PT89020A PT89020A PT89020A PT8902088A PT89020A PT 89020 A PT89020 A PT 89020A PT 89020 A PT89020 A PT 89020A PT 8902088 A PT8902088 A PT 8902088A PT 89020 A PT89020 A PT 89020A
- Authority
- PT
- Portugal
- Prior art keywords
- loweralkyl
- preparation
- substituides
- pyerazinyl
- thiazolidinones
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12362287A | 1987-11-20 | 1987-11-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
PT89020A true PT89020A (pt) | 1988-12-01 |
PT89020B PT89020B (pt) | 1993-02-26 |
Family
ID=22409774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT89020A PT89020B (pt) | 1987-11-20 | 1988-11-17 | Processo para a preparacao de 3-{4(1-substituidas -4-piperazinil)butil}-4-tiazolidinonas e de composicoes farmaceuticas que as contem |
Country Status (20)
Country | Link |
---|---|
US (5) | US4933453A (pt) |
EP (1) | EP0316723B1 (pt) |
JP (1) | JP2617546B2 (pt) |
KR (1) | KR0130976B1 (pt) |
AT (1) | ATE81123T1 (pt) |
AU (1) | AU624092B2 (pt) |
CA (1) | CA1317955C (pt) |
DE (1) | DE3875073T2 (pt) |
DK (1) | DK645688A (pt) |
ES (1) | ES2052675T3 (pt) |
FI (1) | FI89916C (pt) |
GR (1) | GR3006698T3 (pt) |
HU (1) | HU206709B (pt) |
IE (1) | IE62229B1 (pt) |
IL (1) | IL88414A (pt) |
NO (1) | NO176143C (pt) |
NZ (1) | NZ226999A (pt) |
PH (1) | PH27330A (pt) |
PT (1) | PT89020B (pt) |
ZA (1) | ZA888651B (pt) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5801186A (en) | 1987-11-20 | 1998-09-01 | Hoechst Marion Roussel, Inc. | 3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds |
ATE81123T1 (de) * | 1987-11-20 | 1992-10-15 | Hoechst Roussel Pharma | 3-(4(1-substituierte-4-piperazinyl)butyl>-4thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel. |
WO1991000863A1 (en) * | 1989-07-07 | 1991-01-24 | Pfizer Inc. | Heteroaryl piperazine antipsychotic agents |
HU205092B (en) * | 1989-11-24 | 1992-03-30 | Richter Gedeon Vegyeszet | Process for producing new thiazolidinone derivatives and pharmaceutical compositions comprising same |
US5216002A (en) * | 1989-12-21 | 1993-06-01 | Eli Lilly And Company | Method of treating inflammatory bowel disease |
US5034392A (en) * | 1990-04-16 | 1991-07-23 | Hoechst-Roussel Pharmaceuticals Incorporated | 4-(3-(4-oxothiazolidinyl)butynylamines |
US5041445A (en) * | 1990-05-21 | 1991-08-20 | Hoechst-Roussel Pharmaceuticals Incorporated | 3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles |
US5045546A (en) * | 1990-10-26 | 1991-09-03 | Hoechst-Roussel Pharmaceuticals Inc. | 8-azabicyclo[3.2.1]octylalkylthiazolidines |
US5130315A (en) * | 1991-01-10 | 1992-07-14 | Raymond R. Wittekind | 1-piperazinyl-2-butenes and -2-butynes |
US5194436A (en) * | 1991-01-10 | 1993-03-16 | Hoechst-Roussel Pharmaceuticals Inc. | 1-piperazinyl-2-butenes and -2-butynes |
US5240927A (en) * | 1992-05-19 | 1993-08-31 | Hoechst-Roussel Pharmaceuticals Incorporated | Benzo[β]thiophen-3-yl piperazines as antipsychotic agents |
AU664084B2 (en) * | 1992-06-03 | 1995-11-02 | Ciba-Geigy Ag | Novel thiosemicarbazonic acid esters |
US5272148A (en) * | 1992-09-09 | 1993-12-21 | Hoechst-Roussel Pharmaceuticals Incorporated | Heteroarenylpiperazines |
KR0179063B1 (ko) * | 1993-02-04 | 1999-03-20 | 사사이 아키라 | 항정신병 작용을 갖는 화합물 |
US5391570A (en) * | 1993-10-14 | 1995-02-21 | Bristol-Myers Squibb | Aminomethyl-benzodioxane and benzopyran serotonergic agents |
CA2157348A1 (en) * | 1994-09-01 | 1996-03-02 | Aventis Pharmaceuticals Inc. | 3-¬4-(1-substituted-4-piperazinyl)butyl|-4-thiazolidinone and related compounds |
KR960022486A (ko) * | 1994-12-29 | 1996-07-18 | 김준웅 | 신규 티아졸리딘-4-온 유도체 |
PT732332E (pt) * | 1995-03-17 | 2002-06-28 | Aventis Pharma Inc | Benzotienilpiperazinas substituidas sua utilizacao como medicamentos e processos para a sua preparacao |
KR970032857A (ko) * | 1995-12-29 | 1997-07-22 | 김준웅 | 약제 조성물 |
US5880121A (en) * | 1996-01-05 | 1999-03-09 | Hoechst Marion Roussel Inc. | 4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof |
ZA9711376B (en) * | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
US6506751B1 (en) | 1999-11-12 | 2003-01-14 | Millennium Pharmaceuticals, Inc. | Thiazolidinone compounds useful as chemokine inhibitors |
US7122376B2 (en) * | 2001-11-01 | 2006-10-17 | Facet Analytical Services And Technology, Llc | Calibration standards, methods, and kits for water determination |
US7049146B2 (en) * | 2000-11-14 | 2006-05-23 | Facet Analytical Services And Technology, Llc | Calibration standards, methods, and kits for water determination |
JP2004538285A (ja) * | 2001-07-16 | 2004-12-24 | ユーロ−セルティック エス. ア. | アリール置換チアゾリジノンおよびその使用 |
US20040131504A1 (en) * | 2002-09-17 | 2004-07-08 | Landers James P. | Remote temperature sensing of small volume and related apparatus thereof |
EP2159226B1 (de) * | 2007-03-29 | 2016-08-31 | Joint-stock Company "Obninsk Chemical Pharmaceutical Company" | Antihistamin- und antiallergienmittel sowie verfahren zu seiner herstellung |
US8044069B2 (en) * | 2008-10-02 | 2011-10-25 | Abbott Laboratories | Compounds as calcium channel blockers |
WO2011115813A1 (en) * | 2010-03-18 | 2011-09-22 | Abbott Laboratories | Lactam acetamides as calcium channel blockers |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2520179A (en) * | 1949-02-02 | 1950-08-29 | Sterling Drug Inc | 4-thiazolidones and a method for preparation thereof |
JPS51125389A (en) * | 1975-04-09 | 1976-11-01 | Yoshitomi Pharmaceut Ind Ltd | A process for preparing heterocyclic compovnds |
US4456756A (en) * | 1981-08-03 | 1984-06-26 | Mead Johnson & Company | Spirothiazolidinyl piperazine derivatives |
US4411901A (en) * | 1981-12-23 | 1983-10-25 | Mead Johnson & Company | Benzisothiazole and benzisoxazole piperazine derivatives |
US4619930A (en) * | 1985-01-16 | 1986-10-28 | Bristol-Myers Company | Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use |
GB8512163D0 (en) * | 1985-05-14 | 1985-06-19 | Fujisawa Pharmaceutical Co | Oxothiazolidine compound |
ATE81123T1 (de) * | 1987-11-20 | 1992-10-15 | Hoechst Roussel Pharma | 3-(4(1-substituierte-4-piperazinyl)butyl>-4thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel. |
US5041445A (en) * | 1990-05-21 | 1991-08-20 | Hoechst-Roussel Pharmaceuticals Incorporated | 3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles |
-
1988
- 1988-11-09 AT AT88118614T patent/ATE81123T1/de not_active IP Right Cessation
- 1988-11-09 ES ES88118614T patent/ES2052675T3/es not_active Expired - Lifetime
- 1988-11-09 DE DE8888118614T patent/DE3875073T2/de not_active Expired - Fee Related
- 1988-11-09 EP EP88118614A patent/EP0316723B1/en not_active Expired - Lifetime
- 1988-11-17 PT PT89020A patent/PT89020B/pt not_active IP Right Cessation
- 1988-11-17 FI FI885332A patent/FI89916C/fi not_active IP Right Cessation
- 1988-11-18 JP JP63290346A patent/JP2617546B2/ja not_active Expired - Lifetime
- 1988-11-18 CA CA000583546A patent/CA1317955C/en not_active Expired - Fee Related
- 1988-11-18 DK DK645688A patent/DK645688A/da not_active Application Discontinuation
- 1988-11-18 PH PH37834A patent/PH27330A/en unknown
- 1988-11-18 IL IL88414A patent/IL88414A/xx not_active IP Right Cessation
- 1988-11-18 AU AU25694/88A patent/AU624092B2/en not_active Ceased
- 1988-11-18 IE IE346388A patent/IE62229B1/en not_active IP Right Cessation
- 1988-11-18 NZ NZ226999A patent/NZ226999A/en unknown
- 1988-11-18 KR KR1019880015210A patent/KR0130976B1/ko not_active IP Right Cessation
- 1988-11-18 NO NO885152A patent/NO176143C/no not_active IP Right Cessation
- 1988-11-18 ZA ZA888651A patent/ZA888651B/xx unknown
- 1988-11-18 HU HU885964A patent/HU206709B/hu not_active IP Right Cessation
-
1989
- 1989-10-31 US US07/430,688 patent/US4933453A/en not_active Expired - Lifetime
-
1990
- 1990-03-02 US US07/487,328 patent/US5037984A/en not_active Expired - Fee Related
-
1991
- 1991-06-07 US US07/713,247 patent/US5136037A/en not_active Expired - Fee Related
- 1991-11-21 US US07/795,608 patent/US5229388A/en not_active Expired - Fee Related
-
1992
- 1992-12-30 GR GR920402519T patent/GR3006698T3/el unknown
-
1993
- 1993-06-29 US US08/085,273 patent/US5371087A/en not_active Expired - Fee Related
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG3A | Patent granted, date of granting |
Effective date: 19920806 |
|
MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20050207 |